Wdr88 (WD repeat domain 88) - Rat Genome Database

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Pathways
Gene: Wdr88 (WD repeat domain 88) Rattus norvegicus
Analyze
Symbol: Wdr88
Name: WD repeat domain 88
RGD ID: 1560122
Description: Orthologous to human WDR88 (WD repeat domain 88); INTERACTS WITH bisphenol A; copper atom; copper(0).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical LOC292809; LOC292809; RGD1560122; WD repeat-containing protein 88
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8197,021,259 - 97,061,646 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl197,020,943 - 97,061,790 (-)EnsemblGRCr8
mRatBN7.2187,884,316 - 87,924,719 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl187,884,323 - 87,924,695 (-)EnsemblmRatBN7.2
Rnor_6.0191,487,807 - 91,528,318 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl191,488,066 - 91,526,570 (-)Ensemblrn6Rnor6.0
Rnor_5.0192,618,095 - 92,658,146 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera182,234,739 - 82,274,610 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Wdr88
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8197,021,259 - 97,061,646 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl197,020,943 - 97,061,790 (-)EnsemblGRCr8
mRatBN7.2187,884,316 - 87,924,719 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl187,884,323 - 87,924,695 (-)EnsemblmRatBN7.2
Rnor_6.0191,487,807 - 91,528,318 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl191,488,066 - 91,526,570 (-)Ensemblrn6Rnor6.0
Rnor_5.0192,618,095 - 92,658,146 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera182,234,739 - 82,274,610 (-)NCBICelera
Cytogenetic Map1q21NCBI
WDR88
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381933,132,114 - 33,175,799 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1933,132,090 - 33,175,799 (+)Ensemblhg38GRCh38
GRCh371933,623,020 - 33,666,705 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361938,314,838 - 38,358,545 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1930,316,626 - 30,360,287 (+)NCBICelera
Cytogenetic Map19q13.11NCBI
HuRef1930,125,344 - 30,168,768 (+)NCBIHuRef
CHM1_11933,624,067 - 33,667,719 (+)NCBICHM1_1
T2T-CHM13v2.01935,650,799 - 35,694,435 (+)NCBIT2T-CHM13v2.0
Wdr88
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39734,935,658 - 34,975,919 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl734,938,216 - 34,974,958 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38735,236,233 - 35,275,556 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl735,238,791 - 35,275,533 (-)Ensemblmm10GRCm38
MGSCv37736,021,252 - 36,060,410 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36734,947,655 - 34,984,151 (-)NCBIMGSCv36mm8
Celera730,376,336 - 30,417,399 (-)NCBICelera
Cytogenetic Map7B2NCBI
cM Map721.21NCBI
Wdr88
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955468551,574 - 563,630 (+)NCBIChiLan1.0ChiLan1.0
WDR88
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22039,104,095 - 39,149,192 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11941,104,016 - 41,147,911 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01930,054,254 - 30,099,464 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11938,810,390 - 38,827,972 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1938,797,253 - 38,842,843 (+)EnsemblpanPan2panpan1.1
WDR88
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11118,962,602 - 119,007,836 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1118,962,605 - 119,007,759 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1118,362,799 - 118,407,991 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01119,560,796 - 119,606,385 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1119,560,799 - 119,606,552 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11119,120,811 - 119,172,258 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01118,747,334 - 118,793,162 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01119,806,760 - 119,852,290 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Wdr88
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093498,941,181 - 8,990,729 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365702,655,740 - 2,704,811 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDR88
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl642,942,193 - 42,968,436 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1642,942,231 - 42,967,828 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2638,519,654 - 38,545,485 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WDR88
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1628,169,291 - 28,213,533 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl628,169,562 - 28,213,518 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660735,756,735 - 5,801,268 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wdr88
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247949,932,754 - 9,954,529 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Wdr88
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12163,400,860 - 163,439,947 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Wdr88
134 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:40
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000056583
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
RH137317  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,925,650 - 87,925,810 (+)MAPPERmRatBN7.2
Rnor_6.0191,529,141 - 91,529,300NCBIRnor6.0
Rnor_5.0192,659,111 - 92,659,270UniSTSRnor5.0
RGSC_v3.4187,793,241 - 87,793,400UniSTSRGSC3.4
Celera182,275,433 - 82,275,592UniSTS
RH 3.4 Map1865.7UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 4 7 84 44 43 22 22 22 6 98 42 71 21 45 21 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000056583   ⟹   ENSRNOP00000053423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl197,020,943 - 97,061,790 (-)Ensembl
mRatBN7.2 Ensembl187,884,323 - 87,924,695 (-)Ensembl
Rnor_6.0 Ensembl191,488,066 - 91,526,570 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115036   ⟹   ENSRNOP00000077103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl197,020,943 - 97,061,790 (-)Ensembl
mRatBN7.2 Ensembl187,884,323 - 87,924,695 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138719   ⟹   ENSRNOP00000099888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl197,020,943 - 97,061,790 (-)Ensembl
RefSeq Acc Id: XM_006228899   ⟹   XP_006228961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8197,021,259 - 97,061,644 (-)NCBI
mRatBN7.2187,884,316 - 87,924,716 (-)NCBI
Rnor_6.0191,487,807 - 91,528,318 (-)NCBI
Rnor_5.0192,618,095 - 92,658,146 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039100859   ⟹   XP_038956787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8197,021,259 - 97,061,645 (-)NCBI
mRatBN7.2187,884,316 - 87,924,716 (-)NCBI
RefSeq Acc Id: XM_063280923   ⟹   XP_063136993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8197,048,729 - 97,061,646 (-)NCBI
RefSeq Acc Id: XP_006228961   ⟸   XM_006228899
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000053423   ⟸   ENSRNOT00000056583
RefSeq Acc Id: XP_038956787   ⟸   XM_039100859
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000077103   ⟸   ENSRNOT00000115036
RefSeq Acc Id: XP_063136993   ⟸   XM_063280923
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000099888   ⟸   ENSRNOT00000138719

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LZ35-F1-model_v2 AlphaFold F1LZ35 1-429 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560122 AgrOrtholog
BioCyc Gene G2FUF-59978 BioCyc
Ensembl Genes ENSRNOG00000037393 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056583.3 UniProtKB/TrEMBL
  ENSRNOT00000115036 ENTREZGENE
  ENSRNOT00000115036.2 UniProtKB/TrEMBL
  ENSRNOT00000138719.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  Methyl-accepting chemotaxis protein UniProtKB/TrEMBL
InterPro G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  PQQ_beta_propeller_repeat UniProtKB/TrEMBL
  Serralysin-like_metalloprot_C UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report rno:292809 UniProtKB/TrEMBL
NCBI Gene 292809 ENTREZGENE
PANTHER PTHR45048 UniProtKB/TrEMBL
  WD REPEAT-CONTAINING PROTEIN 88 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PhenoGen Wdr88 PhenoGen
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037393 RatGTEx
SMART PQQ UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF101967 UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
UniProt A0A8I5Y5D0_RAT UniProtKB/TrEMBL
  A0ABK0LEK5_RAT UniProtKB/TrEMBL
  F1LZ35_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-28 Wdr88  WD repeat domain 88  RGD1560122_predicted  RGD1560122 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560122_predicted  RGD1560122 (predicted)  LOC292809  hypothetical LOC292809  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC292809  hypothetical LOC292809      Symbol and Name status set to provisional 70820 PROVISIONAL