Myl6l2 (myosin light chain 6 like 2) - Rat Genome Database

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Gene: Myl6l2 (myosin light chain 6 like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Myl6l2
Name: myosin light chain 6 like 2
RGD ID: 1559821
Description: Predicted to enable microfilament motor activity. Predicted to be a structural constituent of muscle. Predicted to be involved in muscle filament sliding and skeletal muscle tissue development. Predicted to be located in brush border. Predicted to be part of myosin II complex and unconventional myosin complex. Orthologous to human MYL6 (myosin light chain 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; paracetamol.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC304447; myosin light polypeptide 6-like; RGD1559821; similar to myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81235,124,013 - 35,124,668 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1235,124,005 - 35,124,673 (-)EnsemblGRCr8
mRatBN7.21229,488,091 - 29,488,746 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1229,488,256 - 29,488,711 (-)EnsemblmRatBN7.2
Rnor_6.01233,182,394 - 33,183,048 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1233,182,562 - 33,183,014 (-)Ensemblrn6Rnor6.0
Rnor_5.01235,081,272 - 35,081,906 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41230,532,437 - 30,562,599 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1231,174,849 - 31,175,503 (-)NCBICelera
Cytogenetic Map12q14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. Hailstones DL and Gunning PW, Mol Cell Biol. 1990 Mar;10(3):1095-104.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Myl6l2
6 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)123424347543352593Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)122963663737764351Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat

Markers in Region
MARC_5817-5818:991939742:3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21229,488,321 - 29,488,621 (+)MAPPERmRatBN7.2
Rnor_6.01233,182,625 - 33,182,924NCBIRnor6.0
Rnor_5.01235,081,483 - 35,081,782UniSTSRnor5.0
Rnor_5.072,881,097 - 2,881,396UniSTSRnor5.0
RGSC_v3.41230,532,503 - 30,532,802UniSTSRGSC3.4
Celera1231,175,080 - 31,175,379UniSTS
Cytogenetic Map12q14UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 38 82 50 48 18 79 18 4 244 146 11 63 57 71 30 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000011278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1235,124,005 - 35,124,673 (-)Ensembl
mRatBN7.2 Ensembl1229,488,256 - 29,488,711 (-)Ensembl
Rnor_6.0 Ensembl1233,182,562 - 33,183,014 (-)Ensembl
RefSeq Acc Id: XM_006249290   ⟹   XP_006249352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81235,124,013 - 35,124,668 (-)NCBI
mRatBN7.21229,488,091 - 29,488,746 (-)NCBI
Rnor_6.01233,182,394 - 33,183,048 (-)NCBI
Rnor_5.01235,081,272 - 35,081,906 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006249352 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000081417
RefSeq Acc Id: XP_006249352   ⟸   XM_006249290
- UniProtKB: Q64119 (UniProtKB/Swiss-Prot),   A0A8I6G5X1 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
EF-hand

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559821 AgrOrtholog
BioCyc Gene G2FUF-19437 BioCyc
Ensembl Genes ENSRNOG00000008521 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000011278 ENTREZGENE
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
InterPro Ca-Reg_Muscle_Contr_Cell_Proc UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
NCBI Gene 304447 ENTREZGENE
PANTHER MYOSIN LIGHT CHAIN 1, 3 UniProtKB/Swiss-Prot
  SIMILAR TO MYOSIN, LIGHT POLYPEPTIDE 6, ALKALI, SMOOTH MUSCLE AND NON-MUSCLE UniProtKB/Swiss-Prot
PhenoGen Myl6l2 PhenoGen
PROSITE EF_HAND_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008521 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
Superfamily-SCOP EF-hand UniProtKB/Swiss-Prot
UniProt A0A8I6G5X1 ENTREZGENE, UniProtKB/TrEMBL
  MYL6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Myl6l2  myosin light chain 6 like 2  RGD1559821  similar to myosin, light polypeptide 6, alkali, smooth muscle and non-muscle  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1559821  similar to myosin, light polypeptide 6, alkali, smooth muscle and non-muscle   RGD1559821_predicted  similar to myosin, light polypeptide 6, alkali, smooth muscle and non-muscle (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559821_predicted  similar to myosin, light polypeptide 6, alkali, smooth muscle and non-muscle (predicted)  LOC304447  similar to myosin, light polypeptide 6, alkali, smooth muscle and non-muscle  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC304447  similar to myosin, light polypeptide 6, alkali, smooth muscle and non-muscle      Symbol and Name status set to provisional 70820 PROVISIONAL