Eva1a (eva-1 homolog A, regulator of programmed cell death) - Rat Genome Database

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Gene: Eva1a (eva-1 homolog A, regulator of programmed cell death) Rattus norvegicus
Analyze
Symbol: Eva1a
Name: eva-1 homolog A, regulator of programmed cell death
RGD ID: 1559797
Description: Predicted to be involved in TOR signaling and autophagy. Predicted to act upstream of or within several processes, including cardiac left ventricle morphogenesis; connective tissue replacement; and energy reserve metabolic process. Predicted to be located in plasma membrane. Orthologous to human EVA1A (eva-1 homolog A, regulator of programmed cell death); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eva-1 homolog A; Fam176a; family with sequence similarity 176, member A; LOC102547494; LOC500221; RGD1559797; similar to CDNA sequence BC014699; Tmem166; transmembrane protein 166; uncharacterized LOC102547494
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Eva1aTn(sb-T2/Bart3)2.233Mcwi
Genetic Models: F344-Eva1aTn(sb-T2/Bart3)2.233Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84116,151,595 - 116,200,827 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4116,151,173 - 116,200,827 (+)EnsemblGRCr8
mRatBN7.24114,593,773 - 114,643,011 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4114,593,341 - 114,643,011 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4120,048,186 - 120,097,229 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04115,823,355 - 115,872,408 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04114,443,579 - 114,492,630 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04112,714,023 - 112,823,659 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4112,773,938 - 112,823,659 (+)Ensemblrn6Rnor6.0
Rnor_5.04177,461,600 - 177,511,382 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44116,280,880 - 116,330,122 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4103,592,203 - 103,641,231 (+)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CCCP  (ISO)
chloroprene  (EXP,ISO)
chloroquine  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fipronil  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:22227058  


Genomics

Comparative Map Data
Eva1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84116,151,595 - 116,200,827 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4116,151,173 - 116,200,827 (+)EnsemblGRCr8
mRatBN7.24114,593,773 - 114,643,011 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4114,593,341 - 114,643,011 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4120,048,186 - 120,097,229 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04115,823,355 - 115,872,408 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04114,443,579 - 114,492,630 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04112,714,023 - 112,823,659 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4112,773,938 - 112,823,659 (+)Ensemblrn6Rnor6.0
Rnor_5.04177,461,600 - 177,511,382 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44116,280,880 - 116,330,122 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4103,592,203 - 103,641,231 (+)NCBICelera
Cytogenetic Map4q34NCBI
EVA1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38275,492,318 - 75,569,719 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl275,469,302 - 75,571,036 (-)Ensemblhg38GRCh38
GRCh37275,719,444 - 75,796,845 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36275,572,952 - 75,650,356 (-)NCBIBuild 36Build 36hg18NCBI36
Celera275,550,740 - 75,628,141 (-)NCBICelera
Cytogenetic Map2p12NCBI
HuRef275,457,364 - 75,534,681 (-)NCBIHuRef
CHM1_1275,648,737 - 75,726,128 (-)NCBICHM1_1
T2T-CHM13v2.0275,501,601 - 75,579,027 (-)NCBIT2T-CHM13v2.0
Eva1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39682,018,058 - 82,070,079 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl682,018,024 - 82,070,080 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38682,041,048 - 82,093,099 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl682,041,043 - 82,093,099 (+)Ensemblmm10GRCm38
MGSCv37681,991,622 - 82,043,093 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36682,007,331 - 82,058,756 (+)NCBIMGSCv36mm8
Celera684,034,678 - 84,086,332 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.81NCBI
Eva1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542410,340,214 - 10,357,557 (+)Ensembl
ChiLan1.0NW_00495542410,308,586 - 10,358,477 (+)NCBIChiLan1.0ChiLan1.0
EVA1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21250,736,389 - 50,890,939 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A50,739,143 - 50,893,693 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A75,564,684 - 75,718,677 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A77,068,221 - 77,206,594 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A77,068,221 - 77,136,854 (-)EnsemblpanPan2panpan1.1
EVA1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11747,769,808 - 47,818,449 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1747,769,875 - 47,817,560 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1747,413,447 - 47,462,149 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01748,632,667 - 48,681,354 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1748,656,401 - 48,681,262 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11747,648,128 - 47,697,025 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01747,712,232 - 47,760,915 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01748,274,870 - 48,323,553 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Eva1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,018,944 - 9,078,741 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365561,658,858 - 1,694,822 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365561,659,203 - 1,728,245 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EVA1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl367,680,736 - 67,734,222 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1367,710,915 - 67,730,554 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
EVA1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11431,693,196 - 31,761,317 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1431,732,129 - 31,761,329 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604580,435,308 - 80,503,398 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eva1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474927,798,827 - 27,855,008 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474927,798,705 - 27,854,588 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Eva1a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1664,033,381 - 64,055,017 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Eva1a
288 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:377
Count of miRNA genes:217
Interacting mature miRNAs:251
Transcripts:ENSRNOT00000009321
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat

Markers in Region
D4Rat176  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84116,184,844 - 116,185,060 (+)Marker Load Pipeline
mRatBN7.24114,627,026 - 114,627,242 (+)MAPPERmRatBN7.2
Rnor_6.04112,807,675 - 112,807,890NCBIRnor6.0
Rnor_5.04177,495,398 - 177,495,613UniSTSRnor5.0
RGSC_v3.44116,314,137 - 116,314,353RGDRGSC3.4
RGSC_v3.44116,314,138 - 116,314,353UniSTSRGSC3.4
Celera4103,625,246 - 103,625,461UniSTS
RGSC_v3.14116,558,618 - 116,558,834RGD
SHRSP x BN Map449.87UniSTS
SHRSP x BN Map449.87RGD
Cytogenetic Map4q34UniSTS
D4Rat268  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84116,162,621 - 116,162,858 (+)Marker Load Pipeline
mRatBN7.24114,604,799 - 114,605,036 (+)MAPPERmRatBN7.2
Rnor_6.04112,785,013 - 112,785,248NCBIRnor6.0
Rnor_5.04177,472,736 - 177,472,971UniSTSRnor5.0
RGSC_v3.44116,291,914 - 116,292,151RGDRGSC3.4
RGSC_v3.44116,291,915 - 116,292,151UniSTSRGSC3.4
Celera4103,603,093 - 103,603,329UniSTS
RGSC_v3.14116,536,348 - 116,536,780RGD
SHRSP x BN Map449.83UniSTS
SHRSP x BN Map449.83RGD
Cytogenetic Map4q34UniSTS


Genetic Models
This gene Eva1a is modified in the following models/strains:
F344-Eva1aTn(sb-T2/Bart3)2.233Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 30 59 6 294 130 11 132 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000009321   ⟹   ENSRNOP00000009321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4116,151,591 - 116,200,816 (+)Ensembl
mRatBN7.2 Ensembl4114,593,773 - 114,643,011 (+)Ensembl
Rnor_6.0 Ensembl4112,773,938 - 112,823,659 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100911   ⟹   ENSRNOP00000089195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4116,151,173 - 116,200,827 (+)Ensembl
mRatBN7.2 Ensembl4114,593,341 - 114,643,011 (+)Ensembl
RefSeq Acc Id: NM_001109243   ⟹   NP_001102713
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84116,151,595 - 116,200,827 (+)NCBI
mRatBN7.24114,593,773 - 114,643,011 (+)NCBI
Rnor_6.04112,773,938 - 112,823,659 (+)NCBI
Rnor_5.04177,461,600 - 177,511,382 (+)NCBI
RGSC_v3.44116,280,880 - 116,330,122 (+)RGD
Celera4103,592,203 - 103,641,231 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236708   ⟹   XP_006236770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84116,178,754 - 116,200,823 (+)NCBI
mRatBN7.24114,620,996 - 114,643,009 (+)NCBI
Rnor_6.04112,799,418 - 112,823,659 (+)NCBI
Rnor_5.04177,461,600 - 177,511,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039108149   ⟹   XP_038964077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84116,192,280 - 116,200,823 (+)NCBI
mRatBN7.24114,634,480 - 114,643,011 (+)NCBI
RefSeq Acc Id: XM_039108150   ⟹   XP_038964078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84116,151,733 - 116,200,823 (+)NCBI
mRatBN7.24114,593,925 - 114,643,009 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102713 (Get FASTA)   NCBI Sequence Viewer  
  XP_006236770 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964077 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964078 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL91092 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009321
  ENSRNOP00000009321.5
  ENSRNOP00000089195.1
RefSeq Acc Id: NP_001102713   ⟸   NM_001109243
- UniProtKB: D4A3V0 (UniProtKB/TrEMBL),   A6IAH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236770   ⟸   XM_006236708
- Peptide Label: isoform X1
- UniProtKB: D4A3V0 (UniProtKB/TrEMBL),   A6IAH4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009321   ⟸   ENSRNOT00000009321
RefSeq Acc Id: XP_038964078   ⟸   XM_039108150
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038964077   ⟸   XM_039108149
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000089195   ⟸   ENSRNOT00000100911
Protein Domains
EVA1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A3V0-F1-model_v2 AlphaFold D4A3V0 1-159 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693159
Promoter ID:EPDNEW_R3683
Type:initiation region
Name:Eva1a_1
Description:eva-1 homolog A, regulator of programmed cell death
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04112,773,988 - 112,774,048EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559797 AgrOrtholog
BioCyc Gene G2FUF-44053 BioCyc
Ensembl Genes ENSRNOG00000007118 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009321 ENTREZGENE
  ENSRNOT00000009321.7 UniProtKB/TrEMBL
  ENSRNOT00000100911.2 UniProtKB/TrEMBL
InterPro EVA1_cell_death_regulators UniProtKB/TrEMBL
  EVA1_dom UniProtKB/TrEMBL
KEGG Report rno:500221 UniProtKB/TrEMBL
NCBI Gene 500221 ENTREZGENE
PANTHER PROTEIN EVA-1 HOMOLOG A UniProtKB/TrEMBL
  PROTEIN EVA-1 HOMOLOG B-RELATED UniProtKB/TrEMBL
Pfam FAM176 UniProtKB/TrEMBL
PhenoGen Eva1a PhenoGen
RatGTEx ENSRNOG00000007118 RatGTEx
UniProt A0A8I6GHW1_RAT UniProtKB/TrEMBL
  A6IAH4 ENTREZGENE, UniProtKB/TrEMBL
  D4A3V0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Eva1a  eva-1 homolog A  LOC102547494  uncharacterized LOC102547494  Data merged from RGD:7682317 737654 PROVISIONAL
2013-12-18 LOC102547494  uncharacterized LOC102547494      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-25 Fam176a  family with sequence similarity 176, member A  Tmem166  transmembrane protein 166  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Tmem166  transmembrane protein 166  RGD1559797_predicted  similar to CDNA sequence BC014699 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559797_predicted  similar to CDNA sequence BC014699 (predicted)  LOC500221  similar to CDNA sequence BC014699  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500221  similar to CDNA sequence BC014699      Symbol and Name status set to provisional 70820 PROVISIONAL