Zrsr2 (zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2) - Rat Genome Database

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Gene: Zrsr2 (zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2) Rattus norvegicus
Analyze
Symbol: Zrsr2
Name: zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2
RGD ID: 1559763
Description: Predicted to enable identical protein binding activity and pre-mRNA 3'-splice site binding activity. Involved in mRNA splicing, via spliceosome. Predicted to be located in nucleolus. Predicted to be part of U12-type spliceosomal complex and U2AF complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to several human genes including ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3-bis(4-hydroxyphenyl)propionitrile.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC302670; RGD1559763; similar to U2af1-rs2; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
RGD Orthologs
Human
Mouse
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Zrsr2-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X34,179,279 - 34,201,989 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX34,179,311 - 34,201,986 (+)EnsemblGRCr8
mRatBN7.2X30,547,424 - 30,571,613 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,547,536 - 30,570,125 (+)EnsemblmRatBN7.2
Rnor_6.0X32,304,707 - 32,327,419 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,304,757 - 32,328,364 (+)Ensemblrn6Rnor6.0
Rnor_5.0X32,666,577 - 32,689,276 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X51,304,090 - 51,327,172 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX30,890,633 - 30,913,278 (+)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes. Damm F, etal., Blood. 2012 Apr 5;119(14):3211-8. doi: 10.1182/blood-2011-12-400994. Epub 2012 Feb 17.
2. Refractory macrocytic anemias in patients with clonal hematopoietic disorders and isolated mutations of the spliceosome gene ZRSR2. Fleischman RA, etal., Leuk Res. 2017 Oct;61:104-107. doi: 10.1016/j.leukres.2017.09.002. Epub 2017 Sep 8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Acute myeloid leukemia ontogeny is defined by distinct somatic mutations. Lindsley RC, etal., Blood. 2015 Feb 26;125(9):1367-76. doi: 10.1182/blood-2014-11-610543. Epub 2014 Dec 30.
5. ZRSR1 cooperates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells. Madan V, etal., Haematologica. 2021 Mar 11. doi: 10.3324/haematol.2020.260562.
6. Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome. Madan V, etal., Nat Commun. 2015 Jan 14;6:6042. doi: 10.1038/ncomms7042.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. [Comparision of Mutational Spectrum between Elderly and Young Adults with Acute Myeloid Leukemia Based on Next Generation Sequencing]. Wang WM, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Feb;28(1):12-17. doi: 10.19746/j.cnki.issn.1009-2137.2020.01.003.
10. Exploration of the role of gene mutations in myelodysplastic syndromes through a sequencing design involving a small number of target genes. Xu F, etal., Sci Rep. 2017 Feb 21;7:43113. doi: 10.1038/srep43113.
Additional References at PubMed
PMID:9237760   PMID:11555636   PMID:15146077   PMID:21041408  


Genomics

Comparative Map Data
Zrsr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X34,179,279 - 34,201,989 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX34,179,311 - 34,201,986 (+)EnsemblGRCr8
mRatBN7.2X30,547,424 - 30,571,613 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,547,536 - 30,570,125 (+)EnsemblmRatBN7.2
Rnor_6.0X32,304,707 - 32,327,419 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,304,757 - 32,328,364 (+)Ensemblrn6Rnor6.0
Rnor_5.0X32,666,577 - 32,689,276 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X51,304,090 - 51,327,172 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX30,890,633 - 30,913,278 (+)NCBICelera
Cytogenetic MapXq14NCBI
ZRSR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X15,790,484 - 15,823,260 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX15,790,106 - 15,830,694 (+)Ensemblhg38GRCh38
GRCh37X15,808,607 - 15,841,383 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,718,495 - 15,751,304 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X15,568,251 - 15,601,037NCBI
CeleraX19,926,058 - 19,958,865 (+)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX13,562,244 - 13,595,036 (+)NCBIHuRef
CHM1_1X15,839,547 - 15,872,350 (+)NCBICHM1_1
T2T-CHM13v2.0X15,373,416 - 15,406,182 (+)NCBIT2T-CHM13v2.0
Zrsr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,719,268 - 162,741,662 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX162,718,439 - 162,741,657 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X163,932,594 - 163,958,666 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX163,935,443 - 163,958,661 (-)Ensemblmm10GRCm38
MGSCv37X160,373,375 - 160,396,598 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X159,279,548 - 159,302,703 (-)NCBIMGSCv36mm8
CeleraX147,154,858 - 147,178,306 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX75.99NCBI
ZRSR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,336,677 - 12,367,227 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X12,336,635 - 12,365,071 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,229,285 - 13,309,297 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZRSR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,247,231 - 14,279,466 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX14,247,287 - 14,279,448 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605616,101,555 - 16,133,813 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zrsr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624829578,326 - 604,594 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624829578,380 - 605,119 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Zrsr2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X24,524,827 - 24,549,333 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Zrsr2
55 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:295
Count of miRNA genes:178
Interacting mature miRNAs:208
Transcripts:ENSRNOT00000045300, ENSRNOT00000075331
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2447036044931007Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2447036045082063Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat

Markers in Region
RH138807  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X30,569,992 - 30,570,116 (+)MAPPERmRatBN7.2
Rnor_6.0X32,327,274 - 32,327,397NCBIRnor6.0
Rnor_5.0X32,689,131 - 32,689,254UniSTSRnor5.0
RGSC_v3.4X51,327,027 - 51,327,150UniSTSRGSC3.4
CeleraX30,913,133 - 30,913,256UniSTS
Cytogenetic MapXq21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000045300   ⟹   ENSRNOP00000049816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX34,179,311 - 34,201,986 (+)Ensembl
mRatBN7.2 EnsemblX30,547,536 - 30,570,125 (+)Ensembl
Rnor_6.0 EnsemblX32,304,757 - 32,328,364 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096793   ⟹   ENSRNOP00000087691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX34,179,340 - 34,185,088 (+)Ensembl
mRatBN7.2 EnsemblX30,547,544 - 30,553,217 (+)Ensembl
RefSeq Acc Id: NM_001427289   ⟹   NP_001414218
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,179,366 - 34,201,989 (+)NCBI
RefSeq Acc Id: XM_006256887   ⟹   XP_006256949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,179,279 - 34,201,989 (+)NCBI
mRatBN7.2X30,547,424 - 30,571,613 (+)NCBI
Rnor_6.0X32,304,707 - 32,327,419 (+)NCBI
Rnor_5.0X32,666,577 - 32,689,276 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001414218 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256949 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL90509 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000049816
  ENSRNOP00000049816.5
  ENSRNOP00000087691.1
RefSeq Acc Id: XP_006256949   ⟸   XM_006256887
- Peptide Label: isoform X1
- UniProtKB: D3ZHQ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049816   ⟸   ENSRNOT00000045300
Ensembl Acc Id: ENSRNOP00000087691   ⟸   ENSRNOT00000096793
RefSeq Acc Id: NP_001414218   ⟸   NM_001427289
- UniProtKB: D3ZHQ8 (UniProtKB/TrEMBL)
Protein Domains
C3H1-type   RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHQ8-F1-model_v2 AlphaFold D3ZHQ8 1-541 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701805
Promoter ID:EPDNEW_R12324
Type:initiation region
Name:Zrsr2_1
Description:zinc finger , RNA binding motif and serine/arginine rich 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X32,304,788 - 32,304,848EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559763 AgrOrtholog
BioCyc Gene G2FUF-2570 BioCyc
Ensembl Genes ENSRNOG00000033176 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045300 ENTREZGENE
  ENSRNOT00000045300.7 UniProtKB/TrEMBL
  ENSRNOT00000096793.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
  RRM_dom_euk UniProtKB/TrEMBL
  U2_small UniProtKB/TrEMBL
  Znf_CCCH UniProtKB/TrEMBL
NCBI Gene 302670 ENTREZGENE
PANTHER PTHR12620 UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
  zf-CCCH UniProtKB/TrEMBL
PhenoGen Zrsr2 PhenoGen
PRINTS U2AUXFACTOR UniProtKB/TrEMBL
PROSITE RRM UniProtKB/TrEMBL
  ZF_C3H1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033176 RatGTEx
SMART RRM_1 UniProtKB/TrEMBL
  ZnF_C3H1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A8I6A6B1_RAT UniProtKB/TrEMBL
  D3ZHQ8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-28 Zrsr2  zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2  RGD1559763_predicted  similar to U2af1-rs2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559763_predicted  similar to U2af1-rs2 (predicted)  LOC302670  similar to U2af1-rs2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302670  similar to U2af1-rs2      Symbol and Name status set to provisional 70820 PROVISIONAL