Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Sspn | Rat | 1,1-dichloroethene | increases expression | ISO | Sspn (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of SSPN mRNA | CTD | PMID:26682919 | Sspn | Rat | 1,2-dichloroethane | decreases expression | ISO | Sspn (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of SSPN mRNA | CTD | PMID:28960355 | Sspn | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Sspn (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SSPN mRNA | CTD | PMID:22206623 | Sspn | Rat | 17beta-estradiol | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of SSPN mRNA | CTD | PMID:20660070 | Sspn | Rat | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Sspn (Mus musculus) | 6480464 | 2,3',4,4',5-pentachlorobiphenyl results in increased expression of SSPN mRNA | CTD | PMID:31388691 | Sspn | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SSPN mRNA | CTD | PMID:33387578 | Sspn | Rat | 2-palmitoylglycerol | increases expression | ISO | SSPN (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of SSPN mRNA | CTD | PMID:37199045 | Sspn | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Sspn (Mus musculus) | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SSPN mRNA | CTD | PMID:26251327 | Sspn | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SSPN mRNA | CTD | PMID:30071829 | Sspn | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Sspn | Rat | 4,4'-diaminodiphenylmethane | increases expression | ISO | Sspn (Mus musculus) | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of SSPN mRNA | CTD | PMID:18648102 | Sspn | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... | CTD | PMID:28628672 | Sspn | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Sspn (Mus musculus) | 6480464 | bisphenol S results in increased expression of SSPN mRNA | CTD | PMID:30951980 | Sspn | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Sspn (Mus musculus) | 6480464 | Fenretinide results in decreased expression of SSPN mRNA | CTD | PMID:28973697 | Sspn | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of SSPN mRNA | CTD | PMID:28959563 | Sspn | Rat | all-trans-retinoic acid | increases expression | ISO | SSPN (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SSPN mRNA | CTD | PMID:21934132 | Sspn | Rat | antirheumatic drug | increases expression | ISO | SSPN (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of SSPN mRNA | CTD | PMID:24449571 | Sspn | Rat | aristolochic acid A | decreases expression | ISO | SSPN (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SSPN mRNA | CTD | PMID:33212167 | Sspn | Rat | belinostat | decreases expression | ISO | SSPN (Homo sapiens) | 6480464 | belinostat results in decreased expression of SSPN mRNA | CTD | PMID:27188386 | Sspn | Rat | benzo[a]pyrene | decreases expression | ISO | Sspn (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of SSPN mRNA | CTD | PMID:19770486 | Sspn | Rat | benzo[a]pyrene | decreases methylation | ISO | SSPN (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of SSPN 5' UTR | CTD | PMID:27901495 | Sspn | Rat | benzo[a]pyrene | affects methylation | ISO | SSPN (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SSPN promoter | CTD | PMID:27901495 | Sspn | Rat | benzo[a]pyrene | multiple interactions | ISO | Sspn (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Sspn | Rat | benzo[b]fluoranthene | multiple interactions | ISO | Sspn (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Sspn | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SSPN mRNA | CTD | PMID:25181051 | Sspn | Rat | bisphenol A | increases expression | ISO | Sspn (Mus musculus) | 6480464 | bisphenol A results in increased expression of SSPN mRNA | CTD | PMID:35479511 | Sspn | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SSPN mRNA | CTD | PMID:30816183|PMID:34947998 | Sspn | Rat | bisphenol A | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Sspn | Rat | bisphenol AF | increases expression | EXP | | 6480464 | bisphenol AF results in increased expression of SSPN mRNA | CTD | PMID:27567155 | Sspn | Rat | bisphenol F | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Sspn | Rat | Butylbenzyl phthalate | increases expression | ISO | Sspn (Mus musculus) | 6480464 | butylbenzyl phthalate results in increased expression of SSPN mRNA | CTD | PMID:28392331 | Sspn | Rat | Butylbenzyl phthalate | increases methylation | ISO | Sspn (Mus musculus) | 6480464 | butylbenzyl phthalate results in increased methylation of SSPN intron | CTD | PMID:28392331 | Sspn | Rat | cadmium dichloride | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated more ... | CTD | PMID:12634122 | Sspn | Rat | calcitriol | decreases expression | ISO | SSPN (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of SSPN mRNA | CTD | PMID:26485663 | Sspn | Rat | cantharidin | decreases expression | ISO | Sspn (Mus musculus) | 6480464 | Cantharidin results in decreased expression of SSPN mRNA | CTD | PMID:36907384 | Sspn | Rat | carbamazepine | affects expression | ISO | SSPN (Homo sapiens) | 6480464 | Carbamazepine affects the expression of SSPN mRNA | CTD | PMID:25979313 | Sspn | Rat | carbon nanotube | decreases expression | ISO | Sspn (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of SSPN mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681 | Sspn | Rat | chlordecone | increases expression | ISO | Sspn (Mus musculus) | 6480464 | Chlordecone results in increased expression of SSPN mRNA | CTD | PMID:33711761 | Sspn | Rat | chlorpyrifos | decreases expression | ISO | Sspn (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of SSPN mRNA | CTD | PMID:37019170 | Sspn | Rat | chrysene | increases expression | ISO | Sspn (Mus musculus) | 6480464 | chrysene results in increased expression of SSPN mRNA | CTD | PMID:26377693 | Sspn | Rat | chrysene | multiple interactions | ISO | Sspn (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Sspn | Rat | clofibrate | increases expression | ISO | Sspn (Mus musculus) | 6480464 | Clofibrate results in increased expression of SSPN mRNA | CTD | PMID:17585979 | Sspn | Rat | clotrimazole | decreases expression | EXP | | 6480464 | Clotrimazole results in decreased expression of SSPN mRNA | CTD | PMID:30047161 | Sspn | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of SSPN mRNA | CTD | PMID:27523638 | Sspn | Rat | DDT | decreases expression | EXP | | 6480464 | DDT results in decreased expression of SSPN mRNA | CTD | PMID:30207508 | Sspn | Rat | dexamethasone | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Sspn | Rat | dibenz[a,h]anthracene | increases expression | ISO | Sspn (Mus musculus) | 6480464 | 1,2,5,6-dibenzanthracene results in increased expression of SSPN mRNA | CTD | PMID:26377693 | Sspn | Rat | Dibutyl phosphate | affects expression | ISO | SSPN (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of SSPN mRNA | CTD | PMID:37042841 | Sspn | Rat | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of SSPN mRNA | CTD | PMID:21266533 | Sspn | Rat | dichromium trioxide | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated more ... | CTD | PMID:12634122 | Sspn | Rat | dioxygen | multiple interactions | ISO | Sspn (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of SSPN mRNA | CTD | PMID:30529165 | Sspn | Rat | dioxygen | multiple interactions | EXP | | 6480464 | [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression more ... | CTD | PMID:33729688 | Sspn | Rat | disodium selenite | decreases expression | ISO | SSPN (Homo sapiens) | 6480464 | Sodium Selenite results in decreased expression of SSPN mRNA | CTD | PMID:18175754 | Sspn | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of SSPN mRNA | CTD | PMID:25152437 | Sspn | Rat | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of SSPN mRNA | CTD | PMID:21551480 | Sspn | Rat | dorsomorphin | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Sspn | Rat | doxorubicin | decreases expression | ISO | Sspn (Mus musculus) | 6480464 | Doxorubicin results in decreased expression of SSPN mRNA | CTD | PMID:39631538 | Sspn | Rat | epoxiconazole | increases expression | ISO | Sspn (Mus musculus) | 6480464 | epoxiconazole results in increased expression of SSPN mRNA | CTD | PMID:35436446 | Sspn | Rat | ethanol | multiple interactions | ISO | Sspn (Mus musculus) | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of SSPN mRNA | CTD | PMID:30517762 | Sspn | Rat | ethanol | increases expression | ISO | Sspn (Mus musculus) | 6480464 | Ethanol results in increased expression of SSPN mRNA | CTD | PMID:30319688 | Sspn | Rat | folic acid | multiple interactions | ISO | Sspn (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SSPN mRNA | CTD | PMID:22206623 | Sspn | Rat | fonofos | increases methylation | ISO | SSPN (Homo sapiens) | 6480464 | Fonofos results in increased methylation of SSPN promoter | CTD | PMID:22847954 | Sspn | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of SSPN mRNA | CTD | PMID:33387578 | Sspn | Rat | hydralazine | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of SSPN mRNA | CTD | PMID:17183730 | Sspn | Rat | indometacin | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Sspn | Rat | lead diacetate | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated more ... | CTD | PMID:12634122 | Sspn | Rat | lead(0) | increases expression | ISO | SSPN (Homo sapiens) | 6480464 | Lead results in increased expression of SSPN mRNA | CTD | PMID:19921347 | Sspn | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of SSPN mRNA | CTD | PMID:30047161 | Sspn | Rat | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | decreases expression | ISO | Sspn (Mus musculus) | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SSPN mRNA | CTD | PMID:25566086 | Sspn | Rat | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | multiple interactions | ISO | Sspn (Mus musculus) | 6480464 | MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SSPN mRNA] | CTD | PMID:25566086 | Sspn | Rat | nickel atom | decreases expression | ISO | SSPN (Homo sapiens) | 6480464 | Nickel results in decreased expression of SSPN mRNA | CTD | PMID:24768652|PMID:25583101 | Sspn | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of SSPN mRNA | CTD | PMID:25729387 | Sspn | Rat | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of SSPN mRNA | CTD | PMID:32680482 | Sspn | Rat | parathion | increases methylation | ISO | SSPN (Homo sapiens) | 6480464 | Parathion results in increased methylation of SSPN promoter | CTD | PMID:22847954 | Sspn | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Sspn (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of SSPN mRNA | CTD | PMID:36331819 | Sspn | Rat | phenylmercury acetate | increases expression | ISO | SSPN (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of SSPN mRNA | CTD | PMID:26272509 | Sspn | Rat | phenylmercury acetate | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Sspn | Rat | progesterone | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of SSPN mRNA | CTD | PMID:20660070 | Sspn | Rat | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of SSPN mRNA | CTD | PMID:27979718 | Sspn | Rat | SB 431542 | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Sspn | Rat | sodium arsenite | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated more ... | CTD | PMID:12634122 | Sspn | Rat | sodium arsenite | decreases expression | ISO | SSPN (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SSPN mRNA | CTD | PMID:28595984|PMID:34032870 | Sspn | Rat | sunitinib | decreases expression | ISO | SSPN (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of SSPN mRNA | CTD | PMID:31533062 | Sspn | Rat | terbufos | increases methylation | ISO | SSPN (Homo sapiens) | 6480464 | terbufos results in increased methylation of SSPN promoter | CTD | PMID:22847954 | Sspn | Rat | testosterone enanthate | affects expression | ISO | SSPN (Homo sapiens) | 6480464 | testosterone enanthate affects the expression of SSPN mRNA | CTD | PMID:17440010 | Sspn | Rat | tetrachloromethane | multiple interactions | ISO | Sspn (Mus musculus) | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of SSPN mRNA | CTD | PMID:30517762 | Sspn | Rat | tetraphene | multiple interactions | ISO | Sspn (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Sspn | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of SSPN mRNA | CTD | PMID:25729387 | Sspn | Rat | trichostatin A | decreases expression | ISO | SSPN (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of SSPN mRNA | CTD | PMID:24935251 | Sspn | Rat | triphenyl phosphate | affects expression | ISO | SSPN (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of SSPN mRNA | CTD | PMID:37042841 | Sspn | Rat | valproic acid | multiple interactions | ISO | SSPN (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of SSPN mRNA | CTD | PMID:17183730 | Sspn | Rat | valproic acid | decreases expression | ISO | SSPN (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SSPN mRNA | CTD | PMID:23179753|PMID:24935251|PMID:25192806 | Sspn | Rat | valproic acid | affects expression | ISO | SSPN (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SSPN mRNA | CTD | PMID:25979313 | Sspn | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of SSPN mRNA | CTD | PMID:19015723 | Sspn | Rat | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of SSPN mRNA | CTD | PMID:30207508 | | |||||||||||||||||||||||||||||||||||||||






















