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Gene: Lrit3 (leucine-rich repeat, Ig-like and transmembrane domains 3) Rattus norvegicus

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Symbol:

Lrit3

Name:

leucine-rich repeat, Ig-like and transmembrane domains 3

RGD ID:

1559637

Description:

Predicted to be involved in regulation of fibroblast growth factor receptor signaling pathway. Predicted to act upstream of or within several processes, including synapse assembly involved in innervation; synaptic signaling; and visual perception. Predicted to be located in cell projection; endoplasmic reticulum membrane; and synapse. Predicted to be active in cell tip and dendrite. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1F. Orthologous to human LRIT3 (leucine rich repeat, Ig-like and transmembrane domains 3); INTERACTS WITH bisphenol A; lead diacetate; valproic acid.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

leucine-rich repeat, immunoglobulin-like and transmembrane domains 3; leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3; LOC502596; RGD1559637; similar to FLJ44691 protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	221,011,458 - 221,034,568 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	221,011,595 - 221,031,747 (-)	Ensembl				GRCr8
mRatBN7.2	2	218,337,215 - 218,360,318 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	218,337,819 - 218,357,307 (-)	Ensembl				mRatBN7.2
Rnor_6.0	2	235,213,017 - 235,232,894 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	235,213,027 - 235,232,530 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	74,690,543 - 74,711,663 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	227,230,815 - 227,250,498 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	210,622,754 - 210,642,612 (-)	NCBI		Celera
Cytogenetic Map	2	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital stationary night blindness (ISO)

congenital stationary night blindness 1F (ISO,ISS)

fundus dystrophy (ISO)

genetic disease (ISO)

optic atrophy (ISO)

retinitis pigmentosa 1 (ISO)

Stargardt disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

4,4'-sulfonyldiphenol (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

lead diacetate (EXP)

titanium dioxide (ISO)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

gene expression (ISO)

intracellular protein localization (ISO)

regulation of fibroblast growth factor receptor signaling pathway (IEA,ISO)

response to light stimulus (ISO)

synapse assembly involved in innervation (ISO)

synaptic signaling (ISO)

visual perception (IEA,ISO)

Cellular Component

cell tip (IEA,ISO)

dendrite (IEA,ISO)

endoplasmic reticulum membrane (IEA)

synapse (IEA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:22673519	PMID:24598786

Genomics

Comparative Map Data

Lrit3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	221,011,458 - 221,034,568 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	221,011,595 - 221,031,747 (-)	Ensembl				GRCr8
mRatBN7.2	2	218,337,215 - 218,360,318 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	218,337,819 - 218,357,307 (-)	Ensembl				mRatBN7.2
Rnor_6.0	2	235,213,017 - 235,232,894 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	235,213,027 - 235,232,530 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	74,690,543 - 74,711,663 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	227,230,815 - 227,250,498 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	210,622,754 - 210,642,612 (-)	NCBI		Celera
Cytogenetic Map	2	q43	NCBI

LRIT3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	109,848,107 - 109,872,315 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	109,846,013 - 109,872,315 (+)	Ensembl			hg38	GRCh38
GRCh37	4	110,769,263 - 110,793,471 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	110,991,935 - 111,012,919 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	4	108,066,231 - 108,087,218 (+)	NCBI		Celera
Cytogenetic Map	4	q25	NCBI
HuRef	4	106,501,463 - 106,525,615 (+)	NCBI		HuRef
CHM1_1	4	110,745,809 - 110,769,939 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	113,150,166 - 113,174,389 (+)	NCBI		T2T-CHM13v2.0

Lrit3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	129,577,590 - 129,597,785 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	129,581,530 - 129,597,679 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	129,783,941 - 129,804,136 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	129,787,881 - 129,804,030 (-)	Ensembl			mm10	GRCm38
MGSCv37	3	129,491,209 - 129,506,948 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	129,780,313 - 129,795,955 (-)	NCBI		MGSCv36	mm8
Celera	3	136,301,125 - 136,316,860 (-)	NCBI		Celera
Cytogenetic Map	3	G3	NCBI
cM Map	3	58.99	NCBI

Lrit3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955496	434,236 - 456,239 (-)	Ensembl
ChiLan1.0	NW_004955496	434,236 - 456,239 (-)	NCBI	ChiLan1.0	ChiLan1.0

LRIT3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	107,940,165 - 107,963,332 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	108,233,618 - 108,256,779 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	102,345,090 - 102,369,525 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	112,912,888 - 112,936,911 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	112,912,888 - 112,937,619 (+)	Ensembl			panPan2	panpan1.1

LRIT3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	30,024,765 - 30,044,845 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	30,026,897 - 30,041,996 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	11,985,138 - 12,005,245 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	30,245,558 - 30,265,027 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	30,247,710 - 30,262,999 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	30,239,814 - 30,259,071 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	29,982,829 - 30,002,291 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	9,846,854 - 9,866,284 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lrit3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	10,885,334 - 10,914,889 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936563	1,035,940 - 1,053,766 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936563	1,036,079 - 1,054,778 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRIT3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	112,360,222 - 112,376,410 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	112,349,485 - 112,381,992 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	120,442,530 - 120,459,775 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRIT3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	57,746,057 - 57,773,816 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	57,746,478 - 57,771,365 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	36,398,562 - 36,449,560 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrit3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624830	55,955 - 74,213 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624830	55,940 - 74,213 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lrit3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	29,500,204 - 29,517,712 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lrit3
262 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	129
Count of miRNA genes:	113
Interacting mature miRNAs:	118
Transcripts:	ENSRNOT00000043105
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	163997722	225110681	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170656145	239614549	Rat
631563	Hcuc3	Hepatic copper content QTL 3	3.87		liver copper amount (VT:0003065)	liver copper weight to liver dry weight ratio (CMO:0001512)	2	212145502	231732847	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	184482291	229482291	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	210956252	251712708	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	202029709	236904960	Rat
8693697	Alc36	Alcohol consumption QTL 36	2	0.592	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	219814164	239320906	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
631566	Bp90	Blood pressure QTL 90		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	149957381	221199885	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	214404877	251712708	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	205135267	225627153	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	204795005	249795005	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	214404877	251712708	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	218051934	251712708	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	186850607	231850607	Rat
1302789	Stl26	Serum triglyceride level QTL 26	3.1	0.0035	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	206613059	226891081	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	192287802	237287802	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	214404877	251712708	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	214404877	251712708	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	196140964	251540988	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	223841096	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	205135267	250135267	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	192287802	229609668	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	188565047	233565047	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	184856304	229856304	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	184856304	229856304	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	182635347	227635347	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
631203	Gluco14	Glucose level QTL 14		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	2	209350500	221678003	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	203664411	248664411	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	184856304	229856304	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	214404877	251712708	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
1331745	Bp203	Blood pressure QTL 203	4.377		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	192287802	221089121	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166372086	229820014	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	192287802	237287802	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	184856304	229856304	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	182024327	227024327	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	159440760	228950743	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
6	12	114	21	20	6	19	6	6	104	44	4	104	48	23	14	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_006224253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006232007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC117142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000079943 ⟹ ENSRNOP00000074330

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	235,213,033 - 235,232,530 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093386 ⟹ ENSRNOP00000076143

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	221,011,595 - 221,031,747 (-)	Ensembl
mRatBN7.2 Ensembl	2	218,337,819 - 218,357,307 (-)	Ensembl
Rnor_6.0 Ensembl	2	235,213,027 - 235,232,530 (-)	Ensembl

RefSeq Acc Id:

XM_006232007 ⟹ XP_006232069

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	221,011,458 - 221,034,568 (-)	NCBI
mRatBN7.2	2	218,337,215 - 218,360,318 (-)	NCBI
Rnor_6.0	2	235,213,017 - 235,232,894 (-)	NCBI
Rnor_5.0	2	74,690,543 - 74,711,663 (+)	NCBI

Sequence:

show sequence

ACTGATACTTTGTAACACCGGTTCTGTTTTTAAGCCACAGAAGCTCCAGGAAAGTTTTTAAGTT
CCATCTATAGGAAAGGTGCCTGAGGTGGGTTTCCTTGCAAATCTAGACGTGGGAGACTATTGAA
TTGACCTGATGGTTTGATTTTCACTTCCCTTAGCAAGTGTGTTACTTGGCTGAGCCCACGTTCA
AAGGCTGGGCGGATTGATCCCCTGCAAGACACTTGAAGGTTAAGTAACTTCAGATCTCAGCTAA
TCCCACTAAGCTGCTGATACTAAATGTCGGCCGGCATTCCCGGTGCAACAGCTTCTGCATGCTC
TTGGTTTGGACCTTACCTTTTGTTCAGAGAGCCACCTTGGAGCTATGTGGCTCTTTGCCTGCCT
GTGCCTTGTGCTTAGCTTCCTGGGAGGAGTGAATTGTACCTGCCCTTCTCAGTGCTCCTGTGAA
TATCACGGCAGACACGAAGGCTCAGGATCAAGGTCGGTGTTGTGTAACGACCTGGATATGAATG
AAGTCCCAACAAACCTTCCCGTGGACACCGCGAAGCTCCGTATAGAGAAGACCGTGGTCCGCAG
GATCCCCGCCGAGGCTTTCTACTACCTGGTGGAGCTGCAGTACCTCTGGCTGACTTACAACTCG
GTGGCCAGCATAGAGACCAGGAGCTTCTACAACCTAAAGCAGCTGCACGAGTTGCGTTTGGATG
GGAATTCTCTGACCGAGTTCCCGTGGGCGTCTCTGCTGGACATGCCCCACCTGAGGACGCTGGA
CTTGCACAATAACAGAATAACAAGTGTGACAAATGAGGCGGTCAGATATCTCAGGAACCTTACC
TGCTTGGATTTGTCAAGCAACAGACTAACCACACTGCCACCTGATTTCCTGGACAGCTGGTCTC
ATTTAGCGATGACACCTTCTAGAAGCCCGGACCTTCCACCGAAAAGAATTATTCTTGGTTTACA
GGACAACCCTTGGTTCTGTGACTGTCACATTTCCAAAGTGATCGAGCTGTCTAAAGTCGCCGAC
CACGCTGCTGTGCTTCTTGATCCCCTGATGGTCTGCAGCGAACCGGAGTACCTCCAAGGAATCG
CGTTTCAGAGGGTGGAGTTGGAAAAGTGTCTGAAGCCATCCGTGATGATGTCGGCCACCAAAAT
CACATCTGCTCTGGGGAGTAATGTTCTGCTGAGGTGTGACGCCAAAGGCTACCCCACCCCACAG
CTGATGTGGACCCGATCGGACAGCTCGCCAGTTAACGCTACAGTAATTCAGGAGTCTCCAGGAG
AAGGAGTCAGATGGTCCATCTTAAGCTTGACTGGTATCACGTACAGGGACGCTGGGGATTACAG
CTGTAAAGCCAAAAATCTGGCAGGGACGTCAGAGGCTGTGGTTACTGTGACAGTTGTCGGTGTT
GCTACGACCACCCTATCACCAGATACTTCAGAAAGAAGCCCTGGAGAGCACCCTGAACAGAACC
ATCCCCAGCCTGGATTAGGAAGATCAACCCCTCAGTCTAAGTCCTGGTTATGGCCAGGACTCTC
TTACACTTCTTCCCACCCCACTTCCTCAGCCGCCGCTCTCTCTACATCTACACTGTCTCCTCCC
CCCTCCTCTTTGCCTCCCATCTTCTCAGCTGCTTCTGCAACCACCAGTGTAAGAACCAGCATCT
CAGGAAGCACCGTCAGGACTAGCCACCGGCCACCCCTGCTCCACCCCGGTGGGAAAAGCAACGC
AAAGATAGAGAAGAACGGAAGGAAGTTTCCTCCACTCAGCGCAAGTAAGAAAGAAGAGTTGGCG
TTGATGGATCAGGCAGCGCCAATGGAAACAAACATCACTATCAAAGACCTCAGGGTGGCCCGCG
AAACCGGCGCGAGTGTGACTCTGACCTGGAGCAGTAGCAGCAGCAGCAGCAGCAGCAGCAGCAG
CAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCATACAGGAGTCTGCTGTGACTGTG
CTATATTCTAAGTATGGTGAGAAGGACCTGCTGCTAGTGGATGCAGACTACGGCAAGAACCAGG
CGACCATAAACGGCCTGGAGCCTGGCAGTCAGTATGTGGCATGTGTCTGTCCAAAAGGAGTGGG
GCCCCGAGAGGATCAGTGTATCACCTTCTCTACCGACAGAGTCGAAGGGCGGGACTCACAGTGG
TCATTGCTCATCGTGGTGACCAGCTCTGCCTGTGTTATAGTCGTGCCCCTAATTTGTTTTTTAT
TATATAAAGTCTGCAAACTGCAGTGCACGTCAGATCCTTTCTGGGAAGATGATTTGTCAAAAGA
GACGTATATCCAATTTGAGACGCTGTCACCCAGGTCACAGAGTATTGGGGAGCTCTGGACACGG
AGGCACAAAGATGATGGGGAAAAGTTGCTGCTATGCTCCCGGTCCAGTGTGGACTCTCAGATGA
ATCTTAAAAGCGATGGCCATAGAGCGGAGTATTACTGCTGAGGTTCGACAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_006232069	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000076143
	ENSRNOP00000076143.1

RefSeq Acc Id:

XP_006232069 ⟸ XM_006232007

- UniProtKB:

A0A1W2Q648 (UniProtKB/TrEMBL), A6HVP6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MWLFACLCLVLSFLGGVNCTCPSQCSCEYHGRHEGSGSRSVLCNDLDMNEVPTNLPVDTAKLRI
EKTVVRRIPAEAFYYLVELQYLWLTYNSVASIETRSFYNLKQLHELRLDGNSLTEFPWASLLDM
PHLRTLDLHNNRITSVTNEAVRYLRNLTCLDLSSNRLTTLPPDFLDSWSHLAMTPSRSPDLPPK
RIILGLQDNPWFCDCHISKVIELSKVADHAAVLLDPLMVCSEPEYLQGIAFQRVELEKCLKPSV
MMSATKITSALGSNVLLRCDAKGYPTPQLMWTRSDSSPVNATVIQESPGEGVRWSILSLTGITY
RDAGDYSCKAKNLAGTSEAVVTVTVVGVATTTLSPDTSERSPGEHPEQNHPQPGLGRSTPQSKS
WLWPGLSYTSSHPTSSAAALSTSTLSPPPSSLPPIFSAASATTSVRTSISGSTVRTSHRPPLLH
PGGKSNAKIEKNGRKFPPLSASKKEELALMDQAAPMETNITIKDLRVARETGASVTLTWSSSSS
SSSSSSSSSSSSSSSSSSSSIQESAVTVLYSKYGEKDLLLVDADYGKNQATINGLEPGSQYVAC
VCPKGVGPREDQCITFSTDRVEGRDSQWSLLIVVTSSACVIVVPLICFLLYKVCKLQCTSDPFW
EDDLSKETYIQFETLSPRSQSIGELWTRRHKDDGEKLLLCSRSSVDSQMNLKSDGHRAEYYC

hide sequence

Ensembl Acc Id:

ENSRNOP00000074330 ⟸ ENSRNOT00000079943

Ensembl Acc Id:

ENSRNOP00000076143 ⟸ ENSRNOT00000093386

Protein Domains

Ig-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A1W2Q648-F1-model_v2	AlphaFold	A0A1W2Q648	1-702	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1559637	AgrOrtholog
BioCyc Gene	G2FUF-51239	BioCyc
Ensembl Genes	ENSRNOG00000061097	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000093386	ENTREZGENE
	ENSRNOT00000093386.3	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
	3.80.10.10	UniProtKB/TrEMBL
InterPro	Ig-like_dom	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_sub2	UniProtKB/TrEMBL
	L_dom-like	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
	LRFN	UniProtKB/TrEMBL
KEGG Report	rno:502596	UniProtKB/TrEMBL
NCBI Gene	502596	ENTREZGENE
PANTHER	LEUCINE-RICH REPEAT, IMMUNOGLOBULIN-LIKE DOMAIN AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 3	UniProtKB/TrEMBL
	SYNAPTIC ADHESION-LIKE MOLECULE SALM	UniProtKB/TrEMBL
Pfam	Ig_3	UniProtKB/TrEMBL
	LRR_8	UniProtKB/TrEMBL
PhenoGen	Lrit3	PhenoGen
PRINTS	LEURICHRPT	UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/TrEMBL
	LRR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000061097	RatGTEx
SMART	IGc2	UniProtKB/TrEMBL
	LRR_TYP	UniProtKB/TrEMBL
	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/TrEMBL
	SSF48726	UniProtKB/TrEMBL
UniProt	A0A1W2Q648	ENTREZGENE, UniProtKB/TrEMBL
	A6HVP6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-01	Lrit3	leucine-rich repeat, Ig-like and transmembrane domains 3	Lrit3	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Lrit3	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	RGD1559637_predicted	similar to FLJ44691 protein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1559637_predicted	similar to FLJ44691 protein (predicted)	LOC502596	similar to FLJ44691 protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC502596	similar to FLJ44691 protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

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