Amer2 (APC membrane recruitment protein 2) - Rat Genome Database

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Gene: Amer2 (APC membrane recruitment protein 2) Rattus norvegicus
Analyze
Symbol: Amer2
Name: APC membrane recruitment protein 2
RGD ID: 1559605
Description: Predicted to enable beta-catenin binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be active in plasma membrane. Orthologous to human AMER2 (APC membrane recruitment protein 2); INTERACTS WITH bisphenol A; cefaloridine; mercury dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam123a; family with sequence similarity 123A; LOC498529; RGD1559605; similar to hypothetical protein FLJ25477 isoform 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81538,701,509 - 38,711,817 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1538,701,657 - 38,705,633 (+)EnsemblGRCr8
mRatBN7.21534,525,352 - 34,535,660 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1534,524,542 - 34,528,455 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1536,387,500 - 36,397,825 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01537,538,132 - 37,548,457 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01535,986,485 - 35,996,793 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01540,663,183 - 40,667,705 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1540,665,041 - 40,667,173 (+)Ensemblrn6Rnor6.0
Rnor_5.01544,476,186 - 44,479,628 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41539,469,071 - 39,471,815 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1534,225,681 - 34,230,285 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22128170   PMID:22898821  


Genomics

Comparative Map Data
Amer2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81538,701,509 - 38,711,817 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1538,701,657 - 38,705,633 (+)EnsemblGRCr8
mRatBN7.21534,525,352 - 34,535,660 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1534,524,542 - 34,528,455 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1536,387,500 - 36,397,825 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01537,538,132 - 37,548,457 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01535,986,485 - 35,996,793 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01540,663,183 - 40,667,705 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1540,665,041 - 40,667,173 (+)Ensemblrn6Rnor6.0
Rnor_5.01544,476,186 - 44,479,628 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41539,469,071 - 39,471,815 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1534,225,681 - 34,230,285 (+)NCBICelera
Cytogenetic Map15p12NCBI
AMER2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381325,161,679 - 25,172,288 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1325,161,679 - 25,172,288 (-)Ensemblhg38GRCh38
GRCh371325,735,817 - 25,746,426 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361324,640,660 - 24,643,857 (-)NCBIBuild 36Build 36hg18NCBI36
Celera136,806,916 - 6,810,113 (-)NCBICelera
Cytogenetic Map13q12.13NCBI
HuRef136,556,685 - 6,559,882 (-)NCBIHuRef
CHM1_11325,710,908 - 25,714,105 (-)NCBICHM1_1
T2T-CHM13v2.01324,371,351 - 24,382,125 (-)NCBIT2T-CHM13v2.0
Amer2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391460,615,141 - 60,625,642 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1460,610,708 - 60,625,646 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381460,373,288 - 60,388,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1460,373,259 - 60,388,197 (+)Ensemblmm10GRCm38
MGSCv371460,997,123 - 60,999,840 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361459,332,456 - 59,335,107 (+)NCBIMGSCv36mm8
Celera1458,156,596 - 58,159,314 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1431.62NCBI
Amer2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554974,640,343 - 4,645,314 (-)NCBIChiLan1.0ChiLan1.0
AMER2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21424,757,957 - 24,768,597 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11315,867,634 - 15,878,275 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0136,453,492 - 6,464,127 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11324,808,749 - 24,815,910 (-)NCBIPanPan1.1PanPan1.1panPan2
AMER2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12514,281,391 - 14,296,885 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2514,366,397 - 14,376,245 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02514,417,596 - 14,427,519 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2514,417,596 - 14,419,652 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12514,299,599 - 14,309,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02514,301,630 - 14,311,510 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02514,350,576 - 14,360,464 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Amer2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945116,523,815 - 116,534,061 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366881,136,224 - 1,138,275 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366881,136,060 - 1,139,078 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMER2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl113,124,317 - 3,127,433 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1113,118,314 - 3,128,420 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2112,516,168 - 2,519,637 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AMER2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.134,559,549 - 4,567,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl34,564,141 - 4,566,159 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605739,878,100 - 39,888,769 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amer2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477613,376,677 - 13,381,037 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477613,376,849 - 13,387,540 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Amer2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11264,046,210 - 64,049,302 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Amer2
114 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:37
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000018300
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
BF400972  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21534,524,677 - 34,524,848 (+)MAPPERmRatBN7.2
Rnor_6.01540,663,940 - 40,664,110NCBIRnor6.0
Rnor_5.01544,475,863 - 44,476,033UniSTSRnor5.0
RGSC_v3.41539,468,050 - 39,468,220UniSTSRGSC3.4
Celera1534,226,433 - 34,226,603UniSTS
RH 3.4 Map15229.1UniSTS
Cytogenetic Map15p12UniSTS
RH135443  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81538,704,317 - 38,704,509 (+)Marker Load Pipeline
mRatBN7.21534,528,160 - 34,528,352 (+)MAPPERmRatBN7.2
Rnor_6.01540,667,423 - 40,667,614NCBIRnor6.0
Rnor_5.01544,479,346 - 44,479,537UniSTSRnor5.0
RGSC_v3.41539,471,533 - 39,471,724UniSTSRGSC3.4
Celera1534,230,003 - 34,230,194UniSTS
Cytogenetic Map15p12UniSTS
Fam123a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21534,527,173 - 34,527,236 (+)MAPPERmRatBN7.2
Rnor_6.01540,666,436 - 40,666,498NCBIRnor6.0
Rnor_5.01544,478,359 - 44,478,421UniSTSRnor5.0
Celera1534,229,016 - 34,229,078UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 7 53 153 63 62 35 19 35 6 226 94 2 139 80 82 27 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018300   ⟹   ENSRNOP00000069918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1538,701,657 - 38,705,633 (+)Ensembl
mRatBN7.2 Ensembl1534,524,542 - 34,528,455 (+)Ensembl
Rnor_6.0 Ensembl1540,665,041 - 40,667,173 (+)Ensembl
RefSeq Acc Id: NM_001399520   ⟹   NP_001386449
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81538,701,509 - 38,711,817 (+)NCBI
mRatBN7.21534,525,352 - 34,535,660 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386449 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069918.3
Ensembl Acc Id: ENSRNOP00000069918   ⟸   ENSRNOT00000018300
RefSeq Acc Id: NP_001386449   ⟸   NM_001399520
- UniProtKB: A0A0G2JWK6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JWK6-F1-model_v2 AlphaFold A0A0G2JWK6 1-509 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699740
Promoter ID:EPDNEW_R10259
Type:single initiation site
Name:Amer2_1
Description:APC membrane recruitment protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01540,664,973 - 40,665,033EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559605 AgrOrtholog
BioCyc Gene G2FUF-13533 BioCyc
Ensembl Genes ENSRNOG00000013623 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018300.7 UniProtKB/TrEMBL
InterPro Uncharacterised_FAM123 UniProtKB/TrEMBL
NCBI Gene 498529 ENTREZGENE
PANTHER APC MEMBRANE RECRUITMENT PROTEIN 2 UniProtKB/TrEMBL
  PTHR22237 UniProtKB/TrEMBL
Pfam WTX UniProtKB/TrEMBL
PhenoGen Amer2 PhenoGen
RatGTEx ENSRNOG00000013623 RatGTEx
UniProt A0A0G2JWK6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Amer2  APC membrane recruitment protein 2  Fam123a  family with sequence similarity 123A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Fam123a  family with sequence similarity 123A  RGD1559605_predicted  similar to hypothetical protein FLJ25477 isoform 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559605_predicted  similar to hypothetical protein FLJ25477 isoform 2 (predicted)  LOC498529  similar to hypothetical protein FLJ25477 isoform 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498529  similar to hypothetical protein FLJ25477 isoform 2      Symbol and Name status set to provisional 70820 PROVISIONAL