Purb (purine rich element binding protein B)

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Gene: Purb (purine rich element binding protein B) Rattus norvegicus

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Symbol:

Purb

Name:

purine rich element binding protein B

RGD ID:

1559465

Description:

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; mRNA regulatory element binding translation repressor activity; and purine-rich negative regulatory element binding activity. Involved in negative regulation of transcription by RNA polymerase II. Is active in nucleus. Orthologous to human PURB (purine rich element binding protein B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

pur-beta; purine-rich element-binding protein B; transcription factor Pur-beta; transcriptional activator protein Pur-beta; transcriptional regulator protein Pur-beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PURB (purine rich element binding protein B)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Purb (purine rich element binding protein B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Purb (purine rich element binding protein B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PURB (purine rich element binding protein B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PURB (purine rich element binding protein B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Purb (purine rich element binding protein B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PURB (purine rich element binding protein B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PURB (purine rich element binding protein B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Purb (purine rich element binding protein B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PURB (purine rich element binding protein B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Purb (purine rich element binding protein B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	purba (purine-rich element binding protein Ba)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	purbb (purine-rich element binding protein Bb)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	plp-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Pur-alpha	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	purb	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	85,556,296 - 85,558,779 (-)	NCBI		GRCr8
mRatBN7.2	14	81,342,374 - 81,344,857 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	81,336,448 - 81,351,432 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	85,743,668 - 85,746,151 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	86,983,466 - 86,985,949 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	83,433,062 - 83,435,545 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	86,736,876 - 86,739,335 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	86,736,878 - 86,739,335 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	80,371,417 - 80,373,876 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	87,230,346 - 87,232,805 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	14	80,223,695 - 80,226,154 (-)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

Aroclor 1254 (ISO)

atrazine (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

cocaine (EXP)

coumarin (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP,ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

fenthion (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

haloperidol (ISO)

leflunomide (EXP,ISO)

mercury atom (ISO)

mercury(0) (ISO)

methamphetamine (ISO)

methidathion (ISO)

methimazole (EXP)

miconazole (ISO)

paracetamol (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

propiconazole (EXP)

rotenone (EXP)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

tetrachloromethane (EXP)

thimerosal (ISO)

titanium dioxide (ISO)

toluene (EXP)

torcetrapib (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (EXP,ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of DNA-templated transcription (ISO)

negative regulation of transcription by RNA polymerase II (IDA,IEA,ISO)

negative regulation of translation (IEA)

positive regulation of transcription by RNA polymerase II (IEA,ISO,ISS)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

nucleoplasm (IEA,ISO)

nucleus (IBA,IDA,ISO)

Molecular Function

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription factor binding (IEA,ISO,ISS)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IDA,IEA,ISO,ISS)

double-stranded DNA binding (ISO)

mRNA binding (IEA,ISO,ISS)

mRNA regulatory element binding translation repressor activity (IDA)

protein binding (ISO)

purine-rich negative regulatory element binding (IBA,IDA,IEA)

RNA binding (ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IBA,IEA,ISO)

single-stranded DNA binding (IEA,ISO,ISS)

SMAD binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure.	Gupta M, etal., J Biol Chem. 2003 Nov 7;278(45):44935-48. Epub 2003 Aug 21.
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9334258	PMID:10318844	PMID:11032866	PMID:15282343	PMID:16309856	PMID:16376299	PMID:21700703	PMID:22658674	PMID:22681889	PMID:23723417	PMID:25002582	PMID:25931508
PMID:29476059	PMID:33450132

Genomics

Comparative Map Data

Purb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	85,556,296 - 85,558,779 (-)	NCBI		GRCr8
mRatBN7.2	14	81,342,374 - 81,344,857 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	81,336,448 - 81,351,432 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	85,743,668 - 85,746,151 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	86,983,466 - 86,985,949 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	83,433,062 - 83,435,545 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	86,736,876 - 86,739,335 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	86,736,878 - 86,739,335 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	80,371,417 - 80,373,876 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	87,230,346 - 87,232,805 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	14	80,223,695 - 80,226,154 (-)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

PURB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	44,876,299 - 44,885,530 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	44,876,299 - 44,885,530 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	44,915,898 - 44,925,129 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	44,882,417 - 44,891,485 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	44,689,133 - 44,698,200	NCBI
Celera	7	45,014,669 - 45,023,741 (-)	NCBI		Celera
Cytogenetic Map	7	p13	NCBI
HuRef	7	44,801,230 - 44,810,302 (-)	NCBI		HuRef
CHM1_1	7	44,920,237 - 44,929,309 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	45,036,709 - 45,045,943 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	44,955,325 - 44,964,397 (-)	NCBI

Purb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	6,417,599 - 6,426,076 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	6,417,599 - 6,425,917 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	6,467,599 - 6,476,076 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	6,467,599 - 6,475,917 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	6,374,776 - 6,375,920 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	6,374,776 - 6,375,920 (-)	NCBI		MGSCv36	mm8
Celera	11	6,960,150 - 6,961,293 (-)	NCBI		Celera
Cytogenetic Map	11	A1	NCBI
cM Map	11	4.16	NCBI

Purb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955456	7,322,973 - 7,323,529 (+)	NCBI	ChiLan1.0	ChiLan1.0

PURB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	49,789,512 - 49,802,328 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	98,114,250 - 98,127,055 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	45,590,183 - 45,600,089 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	45,659,121 - 45,673,991 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	45,667,233 - 45,668,159 (-)	Ensembl	panpan1.1		panPan2

PURB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	16	2,512,329 - 2,520,763 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	14,340,299 - 14,348,729 (+)	NCBI		ROS_Cfam_1.0
UNSW_CanFamBas_1.0	16	13,973,590 - 13,982,018 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	13,952,878 - 13,961,316 (+)	NCBI		UU_Cfam_GSD_1.0

Purb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	100,526,521 - 100,551,530 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936478	19,738,252 - 19,747,345 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PURB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	50,510,182 - 50,511,108 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	50,510,010 - 50,518,965 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	55,333,599 - 55,342,149 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PURB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	13,796,087 - 13,805,162 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	13,796,118 - 13,797,056 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666062	8,731,839 - 8,741,238 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Purb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	7,398,481 - 7,399,434 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	7,398,481 - 7,406,923 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Purb
9 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	42
Count of miRNA genes:	41
Interacting mature miRNAs:	42
Transcripts:	ENSRNOT00000009214
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313089	Bss81	Bone structure and strength QTL 81	3.4	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	14	37669719	82669719	Rat
9590294	Uminl4	Urine mineral level QTL 4	5.66	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	14	55624247	100624247	Rat
1582236	Gluco22	Glucose level QTL 22	3.3	0.0164	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	73415323	92554092	Rat
631213	Bw60	Body weight QTL60	4.51		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	14	79950921	95876975	Rat
2300197	Scl59	Serum cholesterol level QTL 59			blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	55147478	100147478	Rat
70153	Bp59	Blood pressure QTL 59	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	14	68757796	83368335	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	40793460	98037301	Rat
1582259	Gluco23	Glucose level QTL 23	3.1	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	70053989	104886043	Rat
1582197	Gluco27	Glucose level QTL 27	3.4	0.0006	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	73415323	92554092	Rat
2313100	Bss82	Bone structure and strength QTL 82	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	14	37669719	82669719	Rat
634328	Hc5	Hypercalciuria QTL 5	2.3		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	14	58184885	103184885	Rat
1582250	Gluco26	Glucose level QTL 26	3.3	0.0009	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	73415323	95876975	Rat
2317879	Alcrsp27	Alcohol response QTL 27	3.3	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	14	56631369	101631369	Rat
1641900	Alcrsp11	Alcohol response QTL 11			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	14	70053989	104886043	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
1582255	Gluco29	Glucose level QTL 29	3.1	0.0025	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	14	73415323	92554092	Rat
9589034	Epfw11	Epididymal fat weight QTL 11	6	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	14	55624247	100624247	Rat
1582209	Gluco20	Glucose level QTL 20	3.8	0.0005	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	73415323	92554092	Rat
2313048	Bss84	Bone structure and strength QTL 84	3.1	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	14	37669719	82669719	Rat
1300136	Rf22	Renal function QTL 22	3.9		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	14	42262529	95023211	Rat
1549834	Scl45	Serum cholesterol level QTL 45	5.8		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	50023211	95023211	Rat
738037	Hcas6	Hepatocarcinoma susceptibility QTL 6	2.93		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	14	39057237	83368335	Rat
2313084	Bss83	Bone structure and strength QTL 83	2.9	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	14	37669719	82669719	Rat

Markers in Region

SGC32761

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	81,342,422 - 81,342,548 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	86,736,901 - 86,737,026	NCBI	Rnor6.0
Rnor_5.0	14	80,371,442 - 80,371,567	UniSTS	Rnor5.0
RGSC_v3.4	14	87,230,371 - 87,230,496	UniSTS	RGSC3.4
Celera	14	80,223,720 - 80,223,845	UniSTS
Cytogenetic Map	14	q21	UniSTS

AA859841

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	81,343,936 - 81,344,135 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	86,738,415 - 86,738,613	NCBI	Rnor6.0
Rnor_5.0	14	80,372,956 - 80,373,154	UniSTS	Rnor5.0
RGSC_v3.4	14	87,231,885 - 87,232,083	UniSTS	RGSC3.4
Celera	14	80,225,234 - 80,225,432	UniSTS
RH 3.4 Map	14	579.0	UniSTS
Cytogenetic Map	14	q21	UniSTS

BI284455

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	81,342,881 - 81,343,048 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	86,737,360 - 86,737,526	NCBI	Rnor6.0
Rnor_5.0	14	80,371,901 - 80,372,067	UniSTS	Rnor5.0
RGSC_v3.4	14	87,230,830 - 87,230,996	UniSTS	RGSC3.4
Celera	14	80,224,179 - 80,224,345	UniSTS
RH 3.4 Map	14	586.6	UniSTS
Cytogenetic Map	14	q21	UniSTS

Expression

RNA-SEQ Expression

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alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001017503	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB182574	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC106663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000078282 ⟹ ENSRNOP00000069267

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	14	86,736,878 - 86,739,335 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096069 ⟹ ENSRNOP00000083797

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	81,336,448 - 81,351,432 (-)	Ensembl

RefSeq Acc Id:

NM_001017503 ⟹ NP_001017503

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	85,556,296 - 85,558,779 (-)	NCBI
mRatBN7.2	14	81,342,374 - 81,344,857 (-)	NCBI
Rnor_6.0	14	86,736,876 - 86,739,335 (-)	NCBI
Rnor_5.0	14	80,371,417 - 80,373,876 (-)	NCBI
RGSC_v3.4	14	87,230,346 - 87,232,805 (-)	RGD
Celera	14	80,223,695 - 80,226,154 (-)	RGD

Sequence:

show sequence

GGCGGCGGCGAGGCGGCGGCCGAGAAGATGGCGGACGGCGACAGCGGCAGCGAGCGCGGTGGCG
GCGGGCCCGGCAGCTTCCAGCCCGCGCCCCGCGGCGGCGGAGGGCCTGGCGGCGAGCAGGAGAC
GCAGGAGCTGGCCTCGAAGCGGCTGGACATCCAGAACAAGCGCTTCTACCTGGACGTGAAGCAG
AACGCCAAGGGCCGCTTCCTCAAGATCGCCGAGGTGGGCGCGGGCGGCTCCAAGAGCCGCCTCA
CGCTCTCGATGGCGGTGGCCGCCGAGTTCCGCGACTCGCTGGGCGACTTCATCGAGCACTACGC
GCAGCTGGGTCCCAGCAGCCCGGAGCAGCTGGCGGCGGGCGCCGAGGAGGGCGGCGGGCCGCGC
CGCGCGCTTAAGAGCGAATTCCTGGTGCGCGAGAACCGCAAGTACTACCTGGACCTCAAGGAGA
ACCAGCGCGGCCGCTTCCTGCGCATCCGTCAGACGGTAAACCGCGGCGGTGGAGGCTTCGGCGG
GGGACCCGGGCCCGGCGGCCTGCAGAGCGGCCAGACCATCGCGCTGCCCGCGCAGGGCCTCATC
GAGTTCCGCGACGCGCTCGCCAAGCTCATCGACGACTACGGGGGCGAGGATGACGAGCTGGCCG
GTGGCCCGGGAGGCGGCGCCGGCGGCCCTGGGGGCGGCCTGTACGGAGAGCTCCCGGAGGGCAC
CTCCATCACGGTGGACTCCAAGCGCTTCTTCTTCGACGTCGGCTGCAACAAGTACGGGGTGTTC
CTGCGAGTGAGCGAGGTGAAGCCATCCTACCGCAATGCCATCACCGTGCCCTTCAAGGCCTGGG
GCAAGTTTGGAGGCGCCTTCTGTCGGTATGCAGATGAAATGAAAGAAATCCAGGAGCGACAGAG
GGATAAGCTTTACGAGCGACGCGGTGGGGGCAGCGGCGGTGGCGACGAGTCCGAGGGTGAGGAA
GTGGATGAGGATTGAAGCGGCAGCTTCCCGTACTGGCCTCCCCCACCCCACCACCATCCCCTTG
GCTAGAGAGTTCCCTTTCCTACTCGTCCCCAGTGAGCTAGTGGAGAGGGATCAGGGGAGGCCGC
AGACGAAGAAAACAAAAAATAAAATAATATAGTTAAGAGAAATAACCATAAGAAAACAGTCACA
GACAATTAGAGAAAAGCAGTTAAGTTCCAAGGAACTGCCAGCAACCTGCAAAGAGGACAGCAGC
ATCTCCTCACCTGCGCAAGAGTCTCAGCTTCTGTTGTTTAAAACCGAGGTTCGTAAATTCATCA
GGAAAACATTGGAGGGGATAGATCTTCGAACGTCTGGGGCCAAAACCACATCTGGGTTACCCAG
ACTCATCCATTGGTGATAGTTGAATTTGTGTTGTAGCTGGGTAATCTGGTCTTAGGAGCCCTCC
CAGGCCTCACTACTGCAGCATCTATCCCTTCACCTCCATCGGCATTTTGGATCTAGGTCTTAAT
GGAATCTTTGAGAAGAAAGAGGCCTTTGCAGTTACCCGGTTCTGAGGGTACAAGTTTATGAAAA
GGAATGCAACTTTACACAATCATGGACAGGGCAAGAGAAGAATGCAAGAAGCCATTGGAGAATT
CAAAGGTTGGATCCATTTTAAAAAATGGTTTTGCATGGAACCTGGACCAAGGCCCCTGTCTTTT
CTTTGCAGAATTGTTTTCCGGGATGCAAATGAATTCAGATATCAAAGCTTGAACTAGAATCCAT
TTCTAAAATAGTTTAAAAGTTGGCAAAAAAAAATTTTTTTTCCAAAACAAAAGCATTTTTACAA
TGGGGATTGCTGAGGTAGGCACAAGAAGTCAGGCATAAAGCACAAGGTGGGACTGTTTGAGTGG
ATTGGTTGCTGCTCACTAAAGTTCTTCCCTTGATCTCTTAAGTATGGAGGTCATTACCAAGAAA
TGGCTTAGCGTGAGTGAGAGCTGGATCCAATGGCTCCACGGTAAGAGCTAGTGAATTATGGCTA
ATTCGGCTGTTACAGCCACTGGCTGGCTGCATTTTAAACCTTAAAACTTGACTATCTGCAAAAA
GGAACTGTGGCCACAACTGAGCTTTAATGAGATACACATCCTCGCAGAGAAGTTGGAAATAACC
AGAACTGAAGTCTCAGTTCACCTTCAGTTTCATCTCTGGATTTACTGAATACTGACGATCGATC
CTCAGGTCCAGAATTCCAGCATCATTTATTCTTTTAAAATAAATTTTTAAGAACTTGATCCATC
ATATTCAGTACCTCACAATCAAAGTTGGCAAATGGTGGATGAATGATTCAAGCATTGCACCCGG
TGGAAGCTGAATCCATCTGTGAATGGAACTGAAGTGAACACGAATGCTGACTCTATCCTGGAAG
CATTTTTATACCATCTTGAAATTTCAACAAACTGGCATTTGCCAGTTTATCCAGCTGTCTTTCA
AGAATAAAAGTTGGGGTTTTCAAAAAAAAAAAAAAAAAAAA

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Protein Sequences


Protein RefSeqs	NP_001017503	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAD38899	(Get FASTA)	NCBI Sequence Viewer
	EDM00360	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000083797.1
GenBank Protein	Q68A21	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001017503 ⟸ NM_001017503

- UniProtKB:

A0A8I5ZZX6 (UniProtKB/TrEMBL), A6IKU6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADGDSGSERGGGGPGSFQPAPRGGGGPGGEQETQELASKRLDIQNKRFYLDVKQNAKGRFLKI
AEVGAGGSKSRLTLSMAVAAEFRDSLGDFIEHYAQLGPSSPEQLAAGAEEGGGPRRALKSEFLV
RENRKYYLDLKENQRGRFLRIRQTVNRGGGGFGGGPGPGGLQSGQTIALPAQGLIEFRDALAKL
IDDYGGEDDELAGGPGGGAGGPGGGLYGELPEGTSITVDSKRFFFDVGCNKYGVFLRVSEVKPS
YRNAITVPFKAWGKFGGAFCRYADEMKEIQERQRDKLYERRGGGSGGGDESEGEEVDED

hide sequence

Ensembl Acc Id:

ENSRNOP00000069267 ⟸ ENSRNOT00000078282

Ensembl Acc Id:

ENSRNOP00000083797 ⟸ ENSRNOT00000096069

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q68A21-F1-model_v2	AlphaFold	Q68A21	1-315	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1559465	AgrOrtholog
BioCyc Gene	G2FUF-15085	BioCyc
Ensembl Genes	ENSRNOG00000056150	Ensembl
	ENSRNOG00000069265	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000096069.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.450.700	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.2450.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	PUR-bd_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:498407	UniProtKB/Swiss-Prot
NCBI Gene	498407	ENTREZGENE
PANTHER	PTHR12611	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR12611:SF4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PurA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Purb	PhenoGen
RatGTEx	ENSRNOG00000056150	RatGTEx
	ENSRNOG00000069265	RatGTEx
SMART	PUR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZZX6	ENTREZGENE, UniProtKB/TrEMBL
	A6IKU6	ENTREZGENE, UniProtKB/TrEMBL
	PURB_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Purb	purine rich element binding protein B	pur-beta	transcription factor Pur-beta	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	pur-beta	transcription factor Pur-beta			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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