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Gene: Ddi1 (DDI proteasomal shuttling factor 1) Rattus norvegicus

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Symbol:

Ddi1

Name:

DDI proteasomal shuttling factor 1 (Ensembl:DNA-damage inducible 1 homolog 1)

RGD ID:

1559430

Description:

Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in several processes, including cellular response to hydroxyurea; regulation of DNA stability; and regulation of protein stability. Orthologous to human DDI1 (DNA damage inducible 1 homolog 1); INTERACTS WITH bisphenol A; aflatoxin B1 (ortholog); CGP 52608 (ortholog).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

DDI1, DNA-damage inducible 1, homolog 1; DDI1, DNA-damage inducible 1, homolog 1 (S. cerevisiae); DNA-damage inducible 1 homolog 1; DNA-damage inducible 1 homolog 1 (S. cerevisiae); LOC367012; protein DDI1 homolog 1; RGD1559430; similar to DNA-damage inducible protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DDI1 (DDI proteasomal shuttling factor 1)	HGNC	HomoloGene, NCBI, Panther
Mus musculus (house mouse):	Ddi1 (DNA-damage inducible 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ddi1 (DDI proteasomal shuttling factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DDI1 (DDI proteasomal shuttling factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DDI1 (DNA damage inducible 1 homolog 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ddi1 (DDI proteasomal shuttling factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DDI1 (DNA damage inducible 1 homolog 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DDI1 (DDI proteasomal shuttling factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ddi1 (DDI proteasomal shuttling factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ddi1 (DDI proteasomal shuttling factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DDI2 (DDI proteasomal shuttling factor 2)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	DDI1 (DDI proteasomal shuttling factor 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	DDI1 (DDI proteasomal shuttling factor 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ddi1 (DNA-damage inducible 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ddi1 (DNA-damage inducible 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ddi2 (DNA-damage inducible protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	ddi2 (DNA-damage inducible protein 2)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	DDI1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	DDI1	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ddi-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	ddi-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	rngo	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	rngo	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ddi2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ddi2	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	11,881,544 - 11,883,391 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	11,877,668 - 11,883,637 (-)	Ensembl				GRCr8
mRatBN7.2	8	3,596,658 - 3,598,505 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	3,595,149 - 3,598,533 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	7,558,453 - 7,560,300 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	5,856,235 - 5,858,082 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	3,856,298 - 3,858,145 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	4,547,725 - 4,549,573 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	4,547,725 - 4,549,573 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	4,561,559 - 4,563,407 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	3,237,986 - 3,239,833 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	5,168,510 - 5,170,357 (-)	NCBI		Celera
Cytogenetic Map	8	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

aflatoxin B1 (ISO)

bisphenol A (EXP,ISO)

CGP 52608 (ISO)

pirinixic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to hydroxyurea (IEA,ISO,ISS)

proteasomal protein catabolic process (IBA,IEA,ISO,ISS)

proteolysis (IEA)

proteolysis involved in protein catabolic process (IEA)

regulation of DNA stability (IEA,ISO,ISS)

regulation of protein stability (IBA,IEA,ISO,ISS)

Cellular Component

cytoplasm (IBA)

Molecular Function

aspartic-type endopeptidase activity (IBA,IEA)

hydrolase activity (IEA)

peptidase activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	GOA pipeline	RGD automated data pipeline
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:22871113	PMID:29290612

Genomics

Comparative Map Data

Ddi1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	11,881,544 - 11,883,391 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	11,877,668 - 11,883,637 (-)	Ensembl				GRCr8
mRatBN7.2	8	3,596,658 - 3,598,505 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	3,595,149 - 3,598,533 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	7,558,453 - 7,560,300 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	5,856,235 - 5,858,082 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	3,856,298 - 3,858,145 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	4,547,725 - 4,549,573 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	4,547,725 - 4,549,573 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	4,561,559 - 4,563,407 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	3,237,986 - 3,239,833 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	5,168,510 - 5,170,357 (-)	NCBI		Celera
Cytogenetic Map	8	q11	NCBI

DDI1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	104,036,640 - 104,039,196 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	104,036,640 - 104,039,196 (+)	Ensembl			hg38	GRCh38
GRCh37	11	103,907,368 - 103,909,924 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	103,412,518 - 103,415,132 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	11	101,068,396 - 101,071,010 (+)	NCBI		Celera
Cytogenetic Map	11	q22.3	NCBI
HuRef	11	99,836,907 - 99,839,521 (+)	NCBI		HuRef
CHM1_1	11	103,790,273 - 103,792,887 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	104,040,522 - 104,043,078 (+)	NCBI		T2T-CHM13v2.0

Ddi1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	6,265,028 - 6,266,547 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	6,262,733 - 6,269,846 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	6,265,028 - 6,266,547 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	6,262,733 - 6,269,846 (-)	Ensembl			mm10	GRCm38
MGSCv37	9	6,265,028 - 6,266,547 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	6,262,733 - 6,269,846 (-)	NCBI		MGSCv36	mm8
Celera	9	3,670,260 - 3,671,779 (-)	NCBI		Celera
Cytogenetic Map	9	A1	NCBI
cM Map	9	2.46	NCBI

Ddi1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	6,981,036 - 6,982,346 (+)	Ensembl
ChiLan1.0	NW_004955412	6,980,778 - 6,982,453 (+)	NCBI	ChiLan1.0	ChiLan1.0

DDI1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	104,814,654 - 104,891,889 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	105,920,410 - 105,924,574 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	98,981,511 - 98,983,500 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	102,465,983 - 102,467,513 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	102,466,220 - 102,467,398 (+)	Ensembl			panPan2	panpan1.1

DDI1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	27,976,439 - 27,977,959 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	27,965,768 - 27,977,749 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	27,915,715 - 27,917,219 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	28,023,167 - 28,024,671 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	28,023,275 - 28,024,477 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	28,056,953 - 28,058,457 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	27,943,554 - 27,945,058 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	28,117,729 - 28,119,233 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ddi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	87,448,278 - 87,449,872 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936551	4,086,744 - 4,088,006 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936551	4,086,113 - 4,088,860 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DDI1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	34,503,716 - 34,504,921 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	34,503,087 - 34,505,026 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	38,497,161 - 38,498,727 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DDI1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	95,423,135 - 95,425,366 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	95,423,431 - 95,424,621 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666043	30,463,747 - 30,466,101 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ddi1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624918	1,177,614 - 1,179,393 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624918	1,177,679 - 1,179,208 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ddi1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	2,930,591 - 2,932,432 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ddi1
19 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	29
Count of miRNA genes:	24
Interacting mature miRNAs:	29
Transcripts:	ENSRNOT00000039868
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	10382540	55382540	Rat
9590084	Insglur5	Insulin/glucose ratio QTL 5	18.54	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	8	1	32882639	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	10382540	55382540	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	10382540	55382540	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	10382540	55382540	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
1	9	17	40	33	35	11	17	11	5	97	50	3	24	27	35	24

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001085475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC127531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000039868

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	11,877,668 - 11,883,637 (-)	Ensembl
mRatBN7.2 Ensembl	8	3,595,149 - 3,598,533 (-)	Ensembl
Rnor_6.0 Ensembl	8	4,547,729 - 4,549,573 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076103

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	8	4,547,725 - 4,549,573 (-)	Ensembl

RefSeq Acc Id:

NM_001085475 ⟹ NP_001078944

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	11,881,544 - 11,883,391 (-)	NCBI
mRatBN7.2	8	3,596,658 - 3,598,505 (-)	NCBI
Rnor_6.0	8	4,547,725 - 4,549,573 (-)	NCBI
Rnor_5.0	8	4,561,559 - 4,563,407 (-)	NCBI
RGSC_v3.4	8	3,237,986 - 3,239,833 (-)	RGD
Celera	8	5,168,510 - 5,170,357 (-)	RGD

Sequence:

show sequence

ACATATATGAAATTGCTACTTTACGGCTCCATGGGGTATCAGCTGGCACTGGGGCTAGGAGGCA
ACCCCCACTCTAGCCACTGGCTTGCCTTTCTGAGAGTTGAATGAGTTTCACACCAAGGTGTGAG
GGGCAGGCCAAGTATACACCCAAACCAGCACTAGTCAGCCAGTGAGCCACCAGATGTTTTCTGC
CATCCTGGCCTCCCTGAGCATATATCATGCTGATCACTGTTTATTGTGTGCGTAGGGACCTCAC
AGAGGTAACCTTTTCCTTACAGGTCAACCCTGACTTTGAGCTCTCAAACTTCAGAGTCCTCTGT
GAGCTTGAATCTGGTGTGCCTGCGGAGGAGGCCCAGATCGTCTACATGGAGCAGCTCCTCACAG
ATGACCACTGCTCTCTGGGCTCCTATGGACTCAAAGATGGTGATATGGTTGTACTACTTCAGAA
GGATAATGTGGGACCTCGGCCTCCAGGAAGGGCTCCGAACCATCCTCGAACAGATTTCACTGGG
TCTGGGTCGGCTGTGCCTGGAACATCAAGTTCGCGACACCCACATCCGCATCAACACCATCATC
ACCAACATCAACGTATACCATCAACACAGCAAGCCCACGGATTGGCTTCTGGAGAGAATATGGC
TTTTGCTCAGGATCTCAACAGCCCTGCCCTGATTCGAAGCATGCTGCTTTCCAACCCCCATGAC
CTGTCCCTGTTGAAGGAACGGAATCCTGCTTTGGCGGAAGCTCTGCTTAGTGGAAACCTCGAGA
CATTTTCTCAGGTCCTGGTGGAACAGCAGAGAGAAAGGGCCATGAGAGAGCAAGAGATGTTTCG
TCTTTATTCTGCTGACCCATTTGATCAGGAGACACAGGCTAGAATAGAAGAAGAAATCCGACAG
CAGAATATTGAAGAAAATATGAATATAGCCATGGAAGAGGCTCCGGAGAGTTTTGGACAAGTGG
CTATGCTCTATATTAACTGCAAAGTGAACGGGCATCCTTTAAAGGCTTTTGTTGACTCAGGTGC
CCAGATGACTATCATGAGCCAAGCTTGTGCTGAGAGATGTAATATCATGAGACTGGTAGACCGA
CGGTGGGCTGGGGTTGCTAAGGGAGTAGGCACACAGAGGATTATGGGCCGCGTTCATCTGGCTC
AGATTCAGATTGAAGGTGATTTCTTACAGTGCTCTTTCTCTATACTTGAAGAGCAGCCCATGGA
TATCCTTCTAGGGCTTGATATGCTCAGGAGGCACCAGTGTTCCATTGACCTAAAGAAAAACGTG
CTGGTTATTGGCACTACAGGATCACAGACTCACTTCCTTCCCGAAGGAGAGTTGCCCTTGTGTG
CTAAGCTGCTGAGTGGAGCAGTGCAGGAAGACTCTTCAGACAAGGAAGTGGCAGGTAGTATCAA
ACATCCTGTCAAGGGTCCAGGACGGAAAAAGCATTGAAGGACGTCATATGTAAGCCACTGACAC
ACGGAAGCAAGCCTTAGGTCCCAAGGAAATTATAAGACATGAGCTCACTGGCAAAGTCATCATT
AAAAACAACTTAGCAACCAACCCTGGCCTTGTGACTGAGTTCACAGATGGGTGACTATGTAAGT
CATCAGTGATTCATCAGAGTGTGTATGTAGGCCCAGTCCTTCACTCCCAGATCACCGAACCTCA
TCCAGGGGACAGAATGGAGCTTCAAGTTGGCCTCTCAACAATCTAGGAGAAAGAAAACAAGTCT
CCCCTATCAGATTATAGGATGGCATGTCCAAGCCAAGGGTTATTTATTTTGTTCAAGTCCTTAG
AAAAGAAGCCATTCTTTAAGGCTAAAACTTCATGTAAACGAAATGTTTTCACATAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001078944	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A0JPP7	(Get FASTA)	NCBI Sequence Viewer
	AAI27532	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000091127
	ENSRNOP00000091127.1

RefSeq Acc Id:

NP_001078944 ⟸ NM_001085475

- UniProtKB:

A0JPP7 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MLITVYCVRRDLTEVTFSLQVNPDFELSNFRVLCELESGVPAEEAQIVYMEQLLTDDHCSLGSY
GLKDGDMVVLLQKDNVGPRPPGRAPNHPRTDFTGSGSAVPGTSSSRHPHPHQHHHHQHQRIPST
QQAHGLASGENMAFAQDLNSPALIRSMLLSNPHDLSLLKERNPALAEALLSGNLETFSQVLVEQ
QRERAMREQEMFRLYSADPFDQETQARIEEEIRQQNIEENMNIAMEEAPESFGQVAMLYINCKV
NGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGVAKGVGTQRIMGRVHLAQIQIEGDFL
QCSFSILEEQPMDILLGLDMLRRHQCSIDLKKNVLVIGTTGSQTHFLPEGELPLCAKLLSGAVQ
EDSSDKEVAGSIKHPVKGPGRKKH

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Protein Domains

Ubiquitin-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0JPP7-F1-model_v2	AlphaFold	A0JPP7	1-408	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1559430	AgrOrtholog
BioCyc Gene	G2FUF-31803	BioCyc
Ensembl Genes	ENSRNOG00000022081	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000039868	ENTREZGENE
	ENSRNOT00000039868.4	UniProtKB/Swiss-Prot
Gene3D-CATH	2.40.70.10	UniProtKB/Swiss-Prot
	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7131649	IMAGE-MGC_LOAD
InterPro	DDI1_N	UniProtKB/Swiss-Prot
	Peptidase_aspartic_DDI1-type	UniProtKB/Swiss-Prot
	Peptidase_aspartic_dom_sf	UniProtKB/Swiss-Prot
	Ubiquitin-like_domsf	UniProtKB/Swiss-Prot
	Ubiquitin_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:367012	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:156792	IMAGE-MGC_LOAD
NCBI Gene	367012	ENTREZGENE
PANTHER	DNA DAMAGE-INDUCIBLE 1 HOMOLOG 2	UniProtKB/Swiss-Prot
	SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED	UniProtKB/Swiss-Prot
Pfam	Asp_protease	UniProtKB/Swiss-Prot
	Ddi2_HDD	UniProtKB/Swiss-Prot
	ubiquitin	UniProtKB/Swiss-Prot
PhenoGen	Ddi1	PhenoGen
PROSITE	UBIQUITIN_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000022081	RatGTEx
Superfamily-SCOP	SSF50630	UniProtKB/Swiss-Prot
	SSF54236	UniProtKB/Swiss-Prot
UniProt	A0JPP7	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2025-11-13	Ddi1	DDI proteasomal shuttling factor 1	Ddi1	DNA-damage inducible 1 homolog 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-07-09	Ddi1	DNA-damage inducible 1 homolog 1	Ddi1	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-02	Ddi1	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	Ddi1	DDI1, DNA-damage inducible 1, homolog 1 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Ddi1	DDI1, DNA-damage inducible 1, homolog 1 (S. cerevisiae)	RGD1559430_predicted	similar to DNA-damage inducible protein 1 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1559430_predicted	similar to DNA-damage inducible protein 1 (predicted)	LOC367012	similar to DNA-damage inducible protein 1	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC367012	similar to DNA-damage inducible protein 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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