Dynlt3 (dynein light chain Tctex-type 3) - Rat Genome Database

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Gene: Dynlt3 (dynein light chain Tctex-type 3) Rattus norvegicus
Analyze
Symbol: Dynlt3
Name: dynein light chain Tctex-type 3
RGD ID: 1549755
Description: Predicted to enable dynein intermediate chain binding activity and identical protein binding activity. Involved in positive regulation of mitotic cell cycle. Located in kinetochore and mitotic spindle astral microtubule. Part of cytoplasmic dynein complex. Orthologous to human DYNLT3 (dynein light chain Tctex-type 3); PARTICIPATES IN mitochondria transport pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: T-complex associated-testis-expressed 1-like (Protein 91/23); Tcte1l
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X16,000,425 - 16,009,632 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX16,000,395 - 16,009,627 (+)EnsemblGRCr8
mRatBN7.2X13,327,933 - 13,337,139 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX13,327,892 - 13,337,139 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX13,515,051 - 13,524,263 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X17,011,983 - 17,021,195 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X13,268,568 - 13,277,780 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X14,633,342 - 14,642,356 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX14,633,342 - 14,642,424 (-)Ensemblrn6Rnor6.0
Rnor_5.0X15,414,610 - 15,423,884 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X25,480,916 - 25,490,479 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX14,088,617 - 14,097,885 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cytoplasmic dynein. Allan VJ, Biochem Soc Trans. 2011 Oct;39(5):1169-78. doi: 10.1042/BST0391169.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3. Lo KW, etal., J Biol Chem. 2007 Apr 13;282(15):11205-12. Epub 2007 Feb 7.
4. Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex. Lo KW, etal., J Biol Chem. 2007 Dec 21;282(51):36871-8. Epub 2007 Oct 27.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11425878   PMID:12947022   PMID:16189514   PMID:25416956  


Genomics

Comparative Map Data
Dynlt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X16,000,425 - 16,009,632 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX16,000,395 - 16,009,627 (+)EnsemblGRCr8
mRatBN7.2X13,327,933 - 13,337,139 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX13,327,892 - 13,337,139 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX13,515,051 - 13,524,263 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X17,011,983 - 17,021,195 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X13,268,568 - 13,277,780 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X14,633,342 - 14,642,356 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX14,633,342 - 14,642,424 (-)Ensemblrn6Rnor6.0
Rnor_5.0X15,414,610 - 15,423,884 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X25,480,916 - 25,490,479 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX14,088,617 - 14,097,885 (-)NCBICelera
Cytogenetic MapXq12NCBI
DYNLT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X37,838,836 - 37,847,571 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX37,836,757 - 37,847,571 (-)Ensemblhg38GRCh38
GRCh37X37,698,089 - 37,706,824 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X37,583,033 - 37,591,775 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X37,454,305 - 37,463,048NCBI
CeleraX41,835,775 - 41,844,575 (-)NCBICelera
Cytogenetic MapXp11.4NCBI
HuRefX35,443,356 - 35,452,111 (-)NCBIHuRef
CHM1_1X37,729,229 - 37,738,029 (-)NCBICHM1_1
T2T-CHM13v2.0X37,242,419 - 37,251,154 (-)NCBIT2T-CHM13v2.0
Dynlt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X9,520,509 - 9,529,222 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX9,520,506 - 9,529,242 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X9,654,270 - 9,662,983 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX9,654,267 - 9,663,003 (-)Ensemblmm10GRCm38
MGSCv37X9,231,396 - 9,240,109 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X8,811,229 - 8,819,942 (-)NCBIMGSCv36mm8
CeleraX7,370,355 - 7,379,067 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX4.47NCBI
Dynlt3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955587827,278 - 838,869 (-)Ensembl
ChiLan1.0NW_004955587828,730 - 838,614 (-)NCBIChiLan1.0ChiLan1.0
DYNLT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X39,487,750 - 39,496,644 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X39,491,124 - 39,499,945 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X30,289,242 - 30,298,033 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X37,998,059 - 38,006,855 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX37,996,729 - 38,006,855 (-)EnsemblpanPan2panpan1.1
DYNLT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X32,603,881 - 32,611,213 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX32,603,945 - 32,611,542 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX19,951,574 - 19,958,842 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X32,648,884 - 32,656,216 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX32,648,888 - 32,656,545 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X32,730,392 - 32,737,658 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X32,694,273 - 32,701,541 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X32,742,263 - 32,749,531 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dynlt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X24,850,099 - 24,860,957 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365024,690,776 - 4,701,750 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365024,690,810 - 4,701,615 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYNLT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX33,711,492 - 33,724,683 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X33,711,993 - 33,724,596 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X37,424,941 - 37,437,546 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DYNLT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605638,299,966 - 38,308,644 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dynlt3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476217,734,769 - 17,747,527 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476217,734,738 - 17,747,418 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dynlt3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X14,166,820 - 14,175,967 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dynlt3
41 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:633
Count of miRNA genes:293
Interacting mature miRNAs:380
Transcripts:ENSRNOT00000004808
Prediction methods:Microtar, Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X400149324470521Rat

Markers in Region
RH141986  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X16,006,719 - 16,007,537 (+)Marker Load Pipeline
mRatBN7.2X13,334,227 - 13,335,044 (-)MAPPERmRatBN7.2
Rnor_6.0X14,635,437 - 14,636,254NCBIRnor6.0
Rnor_5.0X15,416,705 - 15,417,522UniSTSRnor5.0
RGSC_v3.4X25,487,567 - 25,488,384UniSTSRGSC3.4
CeleraX14,090,712 - 14,091,529UniSTS
RH 3.4 MapX124.4UniSTS
Cytogenetic MapXq13UniSTS
RH140033  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X13,336,912 - 13,337,095 (-)MAPPERmRatBN7.2
Rnor_6.0X14,633,386 - 14,633,568NCBIRnor6.0
Rnor_5.0X15,414,654 - 15,414,836UniSTSRnor5.0
RGSC_v3.4X25,490,253 - 25,490,435UniSTSRGSC3.4
CeleraX14,088,661 - 14,088,843UniSTS
RH 3.4 MapX121.2UniSTS
Cytogenetic MapXq13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000004808   ⟹   ENSRNOP00000004808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX16,000,395 - 16,009,627 (+)Ensembl
mRatBN7.2 EnsemblX13,327,892 - 13,337,139 (+)Ensembl
Rnor_6.0 EnsemblX14,633,342 - 14,642,424 (-)Ensembl
RefSeq Acc Id: NM_001013228   ⟹   NP_001013246
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X16,000,425 - 16,009,632 (+)NCBI
mRatBN7.2X13,327,933 - 13,337,139 (+)NCBI
Rnor_6.0X14,633,342 - 14,642,356 (-)NCBI
Rnor_5.0X15,414,610 - 15,423,884 (-)NCBI
RGSC_v3.4X25,480,916 - 25,490,479 (+)RGD
CeleraX14,088,617 - 14,097,885 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001013246 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83797 (Get FASTA)   NCBI Sequence Viewer  
  EDL82807 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004808
  ENSRNOP00000004808.6
RefSeq Acc Id: NP_001013246   ⟸   NM_001013228
- UniProtKB: Q5XI90 (UniProtKB/TrEMBL),   F7FAB7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004808   ⟸   ENSRNOT00000004808

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI90-F1-model_v2 AlphaFold Q5XI90 1-116 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701724
Promoter ID:EPDNEW_R12248
Type:initiation region
Name:Dynlt3_1
Description:dynein light chain Tctex-type 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X14,642,379 - 14,642,439EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1549755 AgrOrtholog
BioCyc Gene G2FUF-2984 BioCyc
Ensembl Genes ENSRNOG00000003611 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004808 ENTREZGENE
  ENSRNOT00000004808.9 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1140.40 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7108507 IMAGE-MGC_LOAD
InterPro Tctex UniProtKB/TrEMBL
  Tctex-1-like_sf UniProtKB/TrEMBL
KEGG Report rno:363448 UniProtKB/TrEMBL
MGC_CLONE MGC:94819 IMAGE-MGC_LOAD
NCBI Gene 363448 ENTREZGENE
PANTHER DYNEIN LIGHT CHAIN TCTEX-TYPE 3 UniProtKB/TrEMBL
  Tctex UniProtKB/TrEMBL
Pfam Tctex-1 UniProtKB/TrEMBL
PhenoGen Dynlt3 PhenoGen
RatGTEx ENSRNOG00000003611 RatGTEx
UniProt F7FAB7 ENTREZGENE, UniProtKB/TrEMBL
  Q5XI90 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Dynlt3  dynein light chain Tctex-type 3  Tcte1l  T-complex associated-testis-expressed 1-like (Protein 91/23)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-15 Tcte1l  T-complex associated-testis-expressed 1-like (Protein 91/23)      Symbol and Name status set to provisional 70820 PROVISIONAL