Apool (apolipoprotein O-like) - Rat Genome Database

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Pathways
Gene: Apool (apolipoprotein O-like) Rattus norvegicus
Analyze
Symbol: Apool
Name: apolipoprotein O-like
RGD ID: 1549725
Description: Predicted to be involved in cristae formation. Predicted to be located in mitochondrion. Predicted to be part of MICOS complex. Orthologous to human APOOL (apolipoprotein O like); PARTICIPATES IN mitochondrial protein import pathway; INTERACTS WITH (+)-schisandrin B; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC317191; MICOS complex subunit MIC27; RGD1549725; similar to RIKEN cDNA 9430083G14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X81,569,960 - 81,635,906 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX81,570,053 - 81,640,036 (+)EnsemblGRCr8
mRatBN7.2X77,377,723 - 77,443,672 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX77,377,781 - 77,443,900 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX79,035,091 - 79,101,043 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X82,466,054 - 82,531,979 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X80,054,183 - 80,120,122 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X83,678,269 - 83,750,550 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX83,678,339 - 83,750,549 (+)Ensemblrn6Rnor6.0
Rnor_5.0X83,639,368 - 83,708,627 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X100,911,059 - 100,979,133 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX78,677,758 - 78,743,289 (+)NCBICelera
Cytogenetic MapXq31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
5. Mitofilin complexes: conserved organizers of mitochondrial membrane architecture. Zerbes RM, etal., Biol Chem. 2012 Nov;393(11):1247-61. doi: 10.1515/hsz-2012-0239.
Additional References at PubMed
PMID:12865426   PMID:14651853   PMID:18614015   PMID:25781180   PMID:25997101  


Genomics

Comparative Map Data
Apool
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X81,569,960 - 81,635,906 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX81,570,053 - 81,640,036 (+)EnsemblGRCr8
mRatBN7.2X77,377,723 - 77,443,672 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX77,377,781 - 77,443,900 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX79,035,091 - 79,101,043 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X82,466,054 - 82,531,979 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X80,054,183 - 80,120,122 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X83,678,269 - 83,750,550 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX83,678,339 - 83,750,549 (+)Ensemblrn6Rnor6.0
Rnor_5.0X83,639,368 - 83,708,627 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X100,911,059 - 100,979,133 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX78,677,758 - 78,743,289 (+)NCBICelera
Cytogenetic MapXq31NCBI
APOOL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X85,003,877 - 85,093,315 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX85,003,871 - 85,093,315 (+)Ensemblhg38GRCh38
GRCh37X84,258,883 - 84,348,321 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X84,145,561 - 84,231,643 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X84,065,049 - 84,148,918NCBI
CeleraX84,498,355 - 84,587,725 (+)NCBICelera
Cytogenetic MapXq21.1NCBI
HuRefX77,832,958 - 77,921,872 (+)NCBIHuRef
CHM1_1X84,152,919 - 84,242,042 (+)NCBICHM1_1
T2T-CHM13v2.0X83,432,345 - 83,522,274 (+)NCBIT2T-CHM13v2.0
Apool
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X111,221,049 - 111,282,452 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX111,221,031 - 111,282,452 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X112,311,352 - 112,372,755 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX112,311,334 - 112,372,755 (+)Ensemblmm10GRCm38
MGSCv37X109,425,017 - 109,486,039 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X108,428,352 - 108,489,374 (+)NCBIMGSCv36mm8
CeleraX98,952,746 - 99,013,937 (+)NCBICelera
Cytogenetic MapXE1NCBI
cM MapX48.76NCBI
Apool
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555293,849,256 - 3,929,648 (+)Ensembl
ChiLan1.0NW_0049555293,849,326 - 3,929,588 (+)NCBIChiLan1.0ChiLan1.0
APOOL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X84,482,909 - 84,572,125 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X84,486,526 - 84,575,732 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X74,075,468 - 74,159,315 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X84,186,044 - 84,270,217 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX84,186,060 - 84,334,662 (+)EnsemblpanPan2panpan1.1
APOOL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X65,850,365 - 65,953,013 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX65,850,440 - 65,952,649 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX56,606,833 - 56,709,451 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X67,179,177 - 67,281,976 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX67,179,120 - 67,281,974 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X64,828,761 - 64,931,623 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X66,461,262 - 66,564,007 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X66,057,721 - 66,160,379 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Apool
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X59,469,822 - 59,537,982 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365475,790,283 - 5,860,198 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365475,790,287 - 5,858,054 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOOL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX68,281,869 - 68,355,006 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X68,281,781 - 68,355,009 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X78,031,543 - 78,104,742 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APOOL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X73,844,065 - 73,925,754 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660676,912,002 - 7,002,594 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apool
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248523,458,028 - 3,520,853 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248523,457,776 - 3,577,857 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Apool
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X62,152,725 - 62,182,945 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Apool
217 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:71
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000005997
Prediction methods:Miranda, Pita, Pita,Targetscan, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X4493088389930883Rat

Markers in Region
RH139753  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map1522.9UniSTS
Cytogenetic MapXq31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005997   ⟹   ENSRNOP00000005997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX77,377,781 - 77,443,900 (+)Ensembl
Rnor_6.0 EnsemblX83,678,339 - 83,750,549 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103551   ⟹   ENSRNOP00000095644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX77,377,820 - 77,443,664 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000141133   ⟹   ENSRNOP00000109025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX81,570,057 - 81,640,036 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000162360   ⟹   ENSRNOP00000099658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX81,570,053 - 81,640,036 (+)Ensembl
RefSeq Acc Id: NM_001014105   ⟹   NP_001014127
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X81,570,035 - 81,635,906 (+)NCBI
mRatBN7.2X77,377,798 - 77,443,672 (+)NCBI
Rnor_6.0X83,678,339 - 83,750,550 (+)NCBI
Rnor_5.0X83,639,368 - 83,708,627 (+)NCBI
RGSC_v3.4X100,911,059 - 100,979,133 (+)RGD
CeleraX78,677,758 - 78,743,289 (+)RGD
Sequence:
RefSeq Acc Id: NM_001393716   ⟹   NP_001380645
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X81,569,960 - 81,635,906 (+)NCBI
mRatBN7.2X77,377,723 - 77,443,672 (+)NCBI
RefSeq Acc Id: NP_001014127   ⟸   NM_001014105
- Peptide Label: isoform 2
- UniProtKB: F1M7F3 (UniProtKB/TrEMBL),   Q5U1W6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005997   ⟸   ENSRNOT00000005997
Ensembl Acc Id: ENSRNOP00000095644   ⟸   ENSRNOT00000103551
RefSeq Acc Id: NP_001380645   ⟸   NM_001393716
- Peptide Label: isoform 1
- UniProtKB: A0A8J8YNE4 (UniProtKB/TrEMBL),   A6IV95 (UniProtKB/TrEMBL),   F1M7F3 (UniProtKB/TrEMBL),   Q5U1W6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000109025   ⟸   ENSRNOT00000141133
Ensembl Acc Id: ENSRNOP00000099658   ⟸   ENSRNOT00000162360

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U1W6-F1-model_v2 AlphaFold Q5U1W6 1-254 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701914
Promoter ID:EPDNEW_R12438
Type:initiation region
Name:Apool_1
Description:apolipoprotein O-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X83,678,291 - 83,678,351EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1549725 AgrOrtholog
BioCyc Gene G2FUF-1835 BioCyc
Ensembl Genes ENSRNOG00000004512 Ensembl
  ENSRNOG00000082020 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000141133.1 UniProtKB/TrEMBL
  ENSRNOT00000162360 ENTREZGENE
  ENSRNOT00000162360.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7302620 IMAGE-MGC_LOAD
InterPro Apolipoprotein_O UniProtKB/TrEMBL
  MIC26/MIC27_animal UniProtKB/TrEMBL
KEGG Report rno:317191 UniProtKB/TrEMBL
MGC_CLONE MGC:105970 IMAGE-MGC_LOAD
NCBI Gene 317191 ENTREZGENE
PANTHER PTHR14564 UniProtKB/TrEMBL
Pfam ApoO UniProtKB/TrEMBL
PhenoGen Apool PhenoGen
RatGTEx ENSRNOG00000004512 RatGTEx
  ENSRNOG00000082020 RatGTEx
UniProt A0A8J8YNE4 ENTREZGENE
  A0ABK0LSK2_RAT UniProtKB/TrEMBL
  A6IV95 ENTREZGENE, UniProtKB/TrEMBL
  F1M7F3 ENTREZGENE
  Q5U1W6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1M7F3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Apool  apolipoprotein O-like  RGD1549725  similar to RIKEN cDNA 9430083G14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 RGD1549725  similar to RIKEN cDNA 9430083G14  LOC317191    Symbol updated 1299863 APPROVED
2005-09-15 LOC317191  similar to RIKEN cDNA 9430083G14      Symbol and Name status set to provisional 70820 PROVISIONAL