Ces5a (carboxylesterase 5A) - Rat Genome Database

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Gene: Ces5a (carboxylesterase 5A) Rattus norvegicus
Analyze
Symbol: Ces5a
Name: carboxylesterase 5A
RGD ID: 1549717
Description: Predicted to enable carboxylesterase activity. Predicted to be located in extracellular region. Orthologous to human CES5A (carboxylesterase 5A); INTERACTS WITH 6-propyl-2-thiouracil; alachlor; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carboxylesterase 615; carboxylesterase 7; carboxylesterase-like urinary excreted protein homolog; cauxin; Ces5; Ces7; epididymis-specific gene 615 protein; LOC307660
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81911,198,829 - 11,504,887 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1911,419,189 - 11,504,887 (+)EnsemblGRCr8
mRatBN7.21911,469,431 - 11,499,007 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1911,469,469 - 11,499,006 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1911,439,773 - 11,469,365 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01912,204,949 - 12,234,549 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01911,491,969 - 11,521,561 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01912,097,529 - 12,136,579 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1912,097,632 - 12,136,240 (+)Ensemblrn6Rnor6.0
Rnor_5.01923,219,490 - 23,258,836 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41911,910,728 - 11,938,702 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1911,350,251 - 11,378,348 (+)NCBICelera
Cytogenetic Map19p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19727319   PMID:19727521   PMID:19779645   PMID:25475668  


Genomics

Comparative Map Data
Ces5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81911,198,829 - 11,504,887 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1911,419,189 - 11,504,887 (+)EnsemblGRCr8
mRatBN7.21911,469,431 - 11,499,007 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1911,469,469 - 11,499,006 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1911,439,773 - 11,469,365 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01912,204,949 - 12,234,549 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01911,491,969 - 11,521,561 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01912,097,529 - 12,136,579 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1912,097,632 - 12,136,240 (+)Ensemblrn6Rnor6.0
Rnor_5.01923,219,490 - 23,258,836 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41911,910,728 - 11,938,702 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1911,350,251 - 11,378,348 (+)NCBICelera
Cytogenetic Map19p12NCBI
CES5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381655,846,154 - 55,956,031 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1655,846,154 - 55,956,031 (-)Ensemblhg38GRCh38
GRCh371655,880,066 - 55,989,943 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,437,629 - 54,466,783 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1640,376,529 - 40,486,410 (-)NCBICelera
Cytogenetic Map16q12.2NCBI
HuRef1641,751,628 - 41,861,514 (-)NCBIHuRef
CHM1_11657,286,966 - 57,397,358 (-)NCBICHM1_1
T2T-CHM13v2.01661,641,137 - 61,751,051 (-)NCBIT2T-CHM13v2.0
Ces5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39894,225,691 - 94,262,507 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,225,692 - 94,262,458 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38893,499,063 - 93,535,879 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl893,499,064 - 93,535,830 (-)Ensemblmm10GRCm38
MGSCv37896,038,093 - 96,059,607 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36896,386,477 - 96,424,836 (-)NCBIMGSCv36mm8
Celera897,827,705 - 97,864,075 (-)NCBICelera
Cytogenetic Map8C5NCBI
cM Map845.67NCBI
Ces5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543313,715,758 - 13,769,078 (-)Ensembl
ChiLan1.0NW_00495543313,715,780 - 13,745,580 (-)NCBIChiLan1.0ChiLan1.0
CES5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21865,320,011 - 65,419,656 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11671,238,840 - 71,319,354 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01636,125,542 - 36,235,345 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11655,259,038 - 55,288,255 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1655,259,335 - 55,368,534 (-)EnsemblpanPan2panpan1.1
CES5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1260,235,986 - 60,265,584 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl260,236,150 - 60,321,178 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha256,869,474 - 56,898,662 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0260,780,901 - 60,810,520 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,780,757 - 60,850,933 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,608,425 - 57,637,609 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,626,276 - 58,655,460 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,511,291 - 59,540,479 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ces5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934951,326,269 - 51,357,613 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364758,231,681 - 8,261,517 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364758,231,560 - 8,261,517 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CES5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl629,842,658 - 29,873,792 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1629,842,142 - 29,874,073 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2627,179,450 - 27,230,259 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233017
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1541,758,592 - 41,788,500 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl541,758,590 - 41,788,465 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604734,582,299 - 34,611,008 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ces5a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v117435,348 - 464,000 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ces5a
2557 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000049452
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131969901Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127361636Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124694445Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 3 38 109 16 14 8 5 101 55 1 101 30 63 14 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000049452   ⟹   ENSRNOP00000045129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1911,475,318 - 11,504,887 (+)Ensembl
mRatBN7.2 Ensembl1911,469,469 - 11,499,006 (+)Ensembl
Rnor_6.0 Ensembl1912,097,632 - 12,136,240 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129117   ⟹   ENSRNOP00000103973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1911,422,051 - 11,504,887 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000150273   ⟹   ENSRNOP00000104084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1911,443,059 - 11,504,887 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000159570   ⟹   ENSRNOP00000107684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1911,475,847 - 11,504,887 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000162517   ⟹   ENSRNOP00000109147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1911,419,189 - 11,504,887 (+)Ensembl
RefSeq Acc Id: NM_001012056   ⟹   NP_001012056
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,475,318 - 11,504,887 (+)NCBI
mRatBN7.21911,469,431 - 11,499,007 (+)NCBI
Rnor_6.01912,097,529 - 12,136,579 (+)NCBI
Rnor_5.01923,219,490 - 23,258,836 (+)NCBI
RGSC_v3.41911,910,728 - 11,938,702 (+)RGD
Celera1911,350,251 - 11,378,348 (+)RGD
Sequence:
RefSeq Acc Id: XM_063277996   ⟹   XP_063134066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,414,713 - 11,504,887 (+)NCBI
RefSeq Acc Id: XM_063277997   ⟹   XP_063134067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,198,829 - 11,504,887 (+)NCBI
RefSeq Acc Id: XM_063277998   ⟹   XP_063134068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,414,713 - 11,504,887 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001012056 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134066 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134067 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134068 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ05814 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045129
GenBank Protein Q5GRG2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012056   ⟸   NM_001012056
- Peptide Label: precursor
- UniProtKB: Q5GRG2 (UniProtKB/Swiss-Prot),   F1M786 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045129   ⟸   ENSRNOT00000049452
RefSeq Acc Id: XP_063134067   ⟸   XM_063277997
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063134066   ⟸   XM_063277996
- Peptide Label: isoform X1
- UniProtKB: Q5GRG2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063134068   ⟸   XM_063277998
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000109147   ⟸   ENSRNOT00000162517
Ensembl Acc Id: ENSRNOP00000107684   ⟸   ENSRNOT00000159570
Ensembl Acc Id: ENSRNOP00000103973   ⟸   ENSRNOT00000129117
Ensembl Acc Id: ENSRNOP00000104084   ⟸   ENSRNOT00000150273
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5GRG2-F1-model_v2 AlphaFold Q5GRG2 1-575 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1549717 AgrOrtholog
BioCyc Gene G2FUF-6459 BioCyc
BioCyc Pathway PWY-8001 [felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis] BioCyc
BioCyc Pathway Image PWY-8001 BioCyc
Ensembl Genes ENSRNOG00000025710 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000049452 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  CarbesteraseB UniProtKB/Swiss-Prot
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot
  Type-B_Carboxylest/Lipase UniProtKB/Swiss-Prot
KEGG Report rno:307660 UniProtKB/Swiss-Prot
NCBI Gene 307660 ENTREZGENE
PANTHER CARBOXYLESTERASE UniProtKB/Swiss-Prot
Pfam COesterase UniProtKB/Swiss-Prot
PhenoGen Ces5a PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000025710 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt A0ABK0L443_RAT UniProtKB/TrEMBL
  A0ABK0LPS6_RAT UniProtKB/TrEMBL
  A0ABK0LUP6_RAT UniProtKB/TrEMBL
  A0ABK0LXH4_RAT UniProtKB/TrEMBL
  EST5A_RAT UniProtKB/Swiss-Prot
  F1M786 ENTREZGENE, UniProtKB/TrEMBL
  Q5GRG2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-18 Ces5a  carboxylesterase 5A  Ces7  carboxylesterase 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Ces7  carboxylesterase 7  LOC307660  carboxylesterase 615  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-15 LOC307660  carboxylesterase 615      Symbol and Name status set to provisional 70820 PROVISIONAL