Ces5a (carboxylesterase 5A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ces5a (carboxylesterase 5A) Rattus norvegicus
Analyze
Symbol: Ces5a
Name: carboxylesterase 5A
RGD ID: 1549717
Description: Predicted to enable carboxylesterase activity. Predicted to be located in extracellular region and membrane. Orthologous to human CES5A (carboxylesterase 5A); INTERACTS WITH 6-propyl-2-thiouracil; alachlor; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carboxylesterase 615; carboxylesterase 7; carboxylesterase-like urinary excreted protein homolog; cauxin; Ces5; Ces7; epididymis-specific gene 615 protein; LOC307660
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81911,198,829 - 11,504,887 (+)NCBIGRCr8
mRatBN7.21911,469,431 - 11,499,007 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1911,469,469 - 11,499,006 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1911,439,773 - 11,469,365 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01912,204,949 - 12,234,549 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01911,491,969 - 11,521,561 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01912,097,529 - 12,136,579 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1912,097,632 - 12,136,240 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01923,219,490 - 23,258,836 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,910,728 - 11,938,702 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1911,350,251 - 11,378,348 (+)NCBICelera
Cytogenetic Map19p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19727319   PMID:19727521   PMID:19779645   PMID:25475668  


Genomics

Comparative Map Data
Ces5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81911,198,829 - 11,504,887 (+)NCBIGRCr8
mRatBN7.21911,469,431 - 11,499,007 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1911,469,469 - 11,499,006 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1911,439,773 - 11,469,365 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01912,204,949 - 12,234,549 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01911,491,969 - 11,521,561 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01912,097,529 - 12,136,579 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1912,097,632 - 12,136,240 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01923,219,490 - 23,258,836 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,910,728 - 11,938,702 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1911,350,251 - 11,378,348 (+)NCBICelera
Cytogenetic Map19p12NCBI
CES5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381655,846,154 - 55,956,031 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1655,846,154 - 55,956,031 (-)EnsemblGRCh38hg38GRCh38
GRCh371655,880,066 - 55,989,943 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,437,629 - 54,466,783 (-)NCBINCBI36Build 36hg18NCBI36
Celera1640,376,529 - 40,486,410 (-)NCBICelera
Cytogenetic Map16q12.2NCBI
HuRef1641,751,628 - 41,861,514 (-)NCBIHuRef
CHM1_11657,286,966 - 57,397,358 (-)NCBICHM1_1
T2T-CHM13v2.01661,641,137 - 61,751,051 (-)NCBIT2T-CHM13v2.0
Ces5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39894,225,691 - 94,262,507 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,225,692 - 94,262,458 (-)EnsemblGRCm39 Ensembl
GRCm38893,499,063 - 93,535,879 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl893,499,064 - 93,535,830 (-)EnsemblGRCm38mm10GRCm38
MGSCv37896,038,093 - 96,059,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36896,386,477 - 96,424,836 (-)NCBIMGSCv36mm8
Celera897,827,705 - 97,864,075 (-)NCBICelera
Cytogenetic Map8C5NCBI
cM Map845.67NCBI
Ces5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543313,715,758 - 13,769,078 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543313,715,780 - 13,745,580 (-)NCBIChiLan1.0ChiLan1.0
CES5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21865,320,011 - 65,419,656 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11671,238,840 - 71,319,354 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01636,125,542 - 36,235,345 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11655,259,038 - 55,288,255 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1655,259,335 - 55,368,534 (-)Ensemblpanpan1.1panPan2
CES5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1260,235,986 - 60,265,584 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl260,236,150 - 60,321,178 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,869,474 - 56,898,662 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0260,780,901 - 60,810,520 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,780,757 - 60,850,933 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,608,425 - 57,637,609 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,626,276 - 58,655,460 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,511,291 - 59,540,479 (+)NCBIUU_Cfam_GSD_1.0
Ces5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934951,326,269 - 51,357,613 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364758,231,681 - 8,261,517 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364758,231,560 - 8,261,517 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CES5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl629,842,658 - 29,873,792 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1629,842,142 - 29,874,073 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2627,179,450 - 27,230,259 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233017
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1541,758,592 - 41,788,500 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl541,758,590 - 41,788,465 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604734,582,299 - 34,611,008 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ces5a
189 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000049452
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2
Low 58 12 15
Below cutoff 24 1 2 3 3 10 6 13 2 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000049452   ⟹   ENSRNOP00000045129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1911,469,469 - 11,499,006 (+)Ensembl
Rnor_6.0 Ensembl1912,097,632 - 12,136,240 (+)Ensembl
RefSeq Acc Id: NM_001012056   ⟹   NP_001012056
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,475,318 - 11,504,887 (+)NCBI
mRatBN7.21911,469,431 - 11,499,007 (+)NCBI
Rnor_6.01912,097,529 - 12,136,579 (+)NCBI
Rnor_5.01923,219,490 - 23,258,836 (+)NCBI
RGSC_v3.41911,910,728 - 11,938,702 (+)RGD
Celera1911,350,251 - 11,378,348 (+)RGD
Sequence:
RefSeq Acc Id: XM_063277996   ⟹   XP_063134066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,414,713 - 11,504,887 (+)NCBI
RefSeq Acc Id: XM_063277997   ⟹   XP_063134067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,198,829 - 11,504,887 (+)NCBI
RefSeq Acc Id: XM_063277998   ⟹   XP_063134068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,414,713 - 11,504,887 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001012056 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134066 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134067 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134068 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ05814 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045129
  ENSRNOP00000045129.5
GenBank Protein Q5GRG2 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001012056   ⟸   NM_001012056
- Peptide Label: precursor
- UniProtKB: Q5GRG2 (UniProtKB/Swiss-Prot),   F1M786 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000045129   ⟸   ENSRNOT00000049452
RefSeq Acc Id: XP_063134067   ⟸   XM_063277997
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063134066   ⟸   XM_063277996
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063134068   ⟸   XM_063277998
- Peptide Label: isoform X2
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5GRG2-F1-model_v2 AlphaFold Q5GRG2 1-575 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1549717 AgrOrtholog
BioCyc Gene G2FUF-6459 BioCyc
BioCyc Pathway PWY-8001 [felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis] BioCyc
BioCyc Pathway Image PWY-8001 BioCyc
Ensembl Genes ENSRNOG00000025710 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049452 ENTREZGENE
  ENSRNOT00000049452.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:307660 UniProtKB/Swiss-Prot
NCBI Gene 307660 ENTREZGENE
PANTHER CARBOXYLESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYLESTERASE 5A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ces5a PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025710 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EST5A_RAT UniProtKB/Swiss-Prot
  F1M786 ENTREZGENE, UniProtKB/TrEMBL
  Q5GRG2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-18 Ces5a  carboxylesterase 5A  Ces7  carboxylesterase 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Ces7  carboxylesterase 7  LOC307660  carboxylesterase 615  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-15 LOC307660  carboxylesterase 615      Symbol and Name status set to provisional 70820 PROVISIONAL