Tob2 (transducer of ERBB2, 2) - Rat Genome Database

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Gene: Tob2 (transducer of ERBB2, 2) Rattus norvegicus
Analyze
Symbol: Tob2
Name: transducer of ERBB2, 2
RGD ID: 1359722
Description: Predicted to enable nuclear vitamin D receptor binding activity and transcription corepressor activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within negative regulation of osteoclast differentiation and positive regulation of ossification. Predicted to be active in cytoplasm and nucleus. Orthologous to human TOB2 (transducer of ERBB2, 2); PARTICIPATES IN RNA degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC105824
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,242,843 - 115,251,563 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7115,239,895 - 115,258,155 (-)EnsemblGRCr8
mRatBN7.27113,362,703 - 113,371,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,361,148 - 113,372,688 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7115,125,170 - 115,133,852 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,348,666 - 117,357,348 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,318,106 - 117,326,788 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07123,079,520 - 123,088,240 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,079,537 - 123,088,279 (-)Ensemblrn6Rnor6.0
Rnor_5.07123,054,915 - 123,063,635 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47120,200,815 - 120,209,535 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,681,380 - 109,690,101 (-)NCBICelera
RGSC_v3.17120,235,060 - 120,243,765 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
clobetasol  (ISO)
cocaine  (EXP)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
FR900359  (ISO)
furan  (EXP)
geldanamycin  (ISO)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
isotretinoin  (ISO)
leflunomide  (ISO)
levofloxacin  (EXP)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. Ikematsu N, etal., Oncogene 1999 Dec 9;18(52):7432-41.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:16554297   PMID:18358842   PMID:38165569  


Genomics

Comparative Map Data
Tob2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,242,843 - 115,251,563 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7115,239,895 - 115,258,155 (-)EnsemblGRCr8
mRatBN7.27113,362,703 - 113,371,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,361,148 - 113,372,688 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7115,125,170 - 115,133,852 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,348,666 - 117,357,348 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,318,106 - 117,326,788 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07123,079,520 - 123,088,240 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,079,537 - 123,088,279 (-)Ensemblrn6Rnor6.0
Rnor_5.07123,054,915 - 123,063,635 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47120,200,815 - 120,209,535 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,681,380 - 109,690,101 (-)NCBICelera
RGSC_v3.17120,235,060 - 120,243,765 (-)NCBI
Cytogenetic Map7q34NCBI
TOB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,433,494 - 41,446,801 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,433,489 - 41,446,801 (-)Ensemblhg38GRCh38
GRCh372241,829,498 - 41,842,805 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362240,159,438 - 40,172,973 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342240,153,991 - 40,167,527NCBI
Celera2225,635,881 - 25,649,416 (-)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2224,795,461 - 24,808,986 (-)NCBIHuRef
CHM1_12241,789,383 - 41,802,909 (-)NCBICHM1_1
T2T-CHM13v2.02241,912,328 - 41,926,961 (-)NCBIT2T-CHM13v2.0
Tob2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391581,732,471 - 81,744,742 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1581,732,473 - 81,742,997 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381581,848,270 - 81,858,326 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,848,272 - 81,858,796 (-)Ensemblmm10GRCm38
MGSCv371581,678,700 - 81,688,756 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361581,676,169 - 81,679,400 (-)NCBIMGSCv36mm8
Celera1583,967,342 - 83,977,403 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.26NCBI
Tob2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541326,999,955 - 27,010,156 (-)Ensembl
ChiLan1.0NW_00495541326,999,955 - 27,010,091 (-)NCBIChiLan1.0ChiLan1.0
TOB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22351,266,010 - 51,282,651 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12253,965,292 - 53,980,583 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02222,329,783 - 22,344,795 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12240,418,845 - 40,432,735 (-)NCBIPanPan1.1PanPan1.1panPan2
TOB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11023,817,778 - 23,830,330 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1023,826,437 - 23,827,447 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1023,750,252 - 23,762,864 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01024,562,440 - 24,574,603 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1024,563,274 - 24,574,596 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11024,279,209 - 24,291,370 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01024,600,087 - 24,612,303 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01024,774,549 - 24,786,712 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tob2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049457,458,068 - 7,467,435 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936492468,077 - 477,829 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936492467,221 - 477,838 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl57,086,651 - 7,098,637 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.157,086,397 - 7,098,643 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TOB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11923,975,676 - 23,985,701 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1923,975,979 - 23,977,013 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045101,432,491 - 101,446,470 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tob2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247527,129,550 - 7,140,668 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247527,129,464 - 7,190,718 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tob2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11251,585,774 - 251,596,639 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tob2
55 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:101
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000056077, ENSRNOT00000071998
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
BF399642  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,370,649 - 113,370,799 (+)MAPPERmRatBN7.2
Rnor_6.07123,087,467 - 123,087,616NCBIRnor6.0
Rnor_5.07123,062,862 - 123,063,011UniSTSRnor5.0
RGSC_v3.47120,208,762 - 120,208,911UniSTSRGSC3.4
Celera7109,689,328 - 109,689,477UniSTS
RH 3.4 Map7887.2UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000071998   ⟹   ENSRNOP00000067132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,241,184 - 115,251,736 (-)Ensembl
mRatBN7.2 Ensembl7113,361,148 - 113,372,688 (-)Ensembl
Rnor_6.0 Ensembl7123,079,537 - 123,088,279 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000153594   ⟹   ENSRNOP00000105299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,239,895 - 115,252,463 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000156215   ⟹   ENSRNOP00000099041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,241,402 - 115,244,975 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167451   ⟹   ENSRNOP00000112017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,241,073 - 115,244,975 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000168768   ⟹   ENSRNOP00000105451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,241,091 - 115,252,463 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000172252   ⟹   ENSRNOP00000112464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,241,173 - 115,258,155 (-)Ensembl
RefSeq Acc Id: NM_001007146   ⟹   NP_001007147
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87115,242,843 - 115,251,563 (-)NCBI
mRatBN7.27113,362,703 - 113,371,423 (-)NCBI
Rnor_6.07123,079,520 - 123,088,240 (-)NCBI
Rnor_5.07123,054,915 - 123,063,635 (-)NCBI
RGSC_v3.47120,200,815 - 120,209,535 (-)RGD
Celera7109,681,380 - 109,690,101 (-)RGD
Sequence:
RefSeq Acc Id: NP_001007147   ⟸   NM_001007146
- UniProtKB: Q5U4F2 (UniProtKB/TrEMBL),   A6HT23 (UniProtKB/TrEMBL),   M0RC26 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067132   ⟸   ENSRNOT00000071998
Ensembl Acc Id: ENSRNOP00000105299   ⟸   ENSRNOT00000153594
Ensembl Acc Id: ENSRNOP00000105451   ⟸   ENSRNOT00000168768
Ensembl Acc Id: ENSRNOP00000099041   ⟸   ENSRNOT00000156215
Ensembl Acc Id: ENSRNOP00000112464   ⟸   ENSRNOT00000172252
Ensembl Acc Id: ENSRNOP00000112017   ⟸   ENSRNOT00000167451
Protein Domains
Anti-proliferative protein

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U4F2-F1-model_v2 AlphaFold Q5U4F2 1-346 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359722 AgrOrtholog
BioCyc Gene G2FUF-32661 BioCyc
Ensembl Genes ENSRNOG00000050500 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071998 ENTREZGENE
  ENSRNOT00000071998.4 UniProtKB/TrEMBL
  ENSRNOT00000153594.1 UniProtKB/TrEMBL
  ENSRNOT00000156215.1 UniProtKB/TrEMBL
  ENSRNOT00000167451.1 UniProtKB/TrEMBL
  ENSRNOT00000168768.1 UniProtKB/TrEMBL
  ENSRNOT00000172252.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.640.90 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7107186 IMAGE-MGC_LOAD
InterPro Anti_prolifrtn UniProtKB/TrEMBL
  Ataxin-2_C UniProtKB/TrEMBL
  BTG-like_sf UniProtKB/TrEMBL
  Tob UniProtKB/TrEMBL
KEGG Report rno:315159 UniProtKB/TrEMBL
MGC_CLONE MGC:105824 IMAGE-MGC_LOAD
NCBI Gene 315159 ENTREZGENE
PANTHER PTHR17537 UniProtKB/TrEMBL
  PTHR17537:SF3 UniProtKB/TrEMBL
Pfam BTG UniProtKB/TrEMBL
  PAM2 UniProtKB/TrEMBL
PharmGKB TOB2 RGD
PhenoGen Tob2 PhenoGen
PRINTS ANTIPRLFBTG1 UniProtKB/TrEMBL
PROSITE BTG_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050500 RatGTEx
SMART btg1 UniProtKB/TrEMBL
Superfamily-SCOP SSF160696 UniProtKB/TrEMBL
UniProt A6HT23 ENTREZGENE, UniProtKB/TrEMBL
  M0RC26 ENTREZGENE, UniProtKB/TrEMBL
  Q5U4F2 ENTREZGENE
UniProt Secondary Q5U4F2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Tob2  transducer of ERBB2, 2      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Tob2  transducer of ERBB2, 2      Symbol and Name status set to provisional 70820 PROVISIONAL