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Gene: Xk (X-linked Kx blood group antigen, Kell and VPS13A binding protein) Rattus norvegicus

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Symbol:

Name:

X-linked Kx blood group antigen, Kell and VPS13A binding protein

RGD ID:

1359650

Description:

Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in amino acid transport. Predicted to act upstream of or within several processes, including intracellular monoatomic cation homeostasis; regulation of axon diameter; and skeletal muscle fiber development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in McLeod syndrome and hematopoietic system disease. Orthologous to human XK (X-linked Kx blood group antigen, Kell and VPS13A binding protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

endoplasmic reticulum membrane adapter protein XK; Kell blood group precursor; Kell blood group precursor (mapped); Kell blood group precursor (McLeod phenotype); Kell blood group precursor (McLeod phenotype) homolog; LOC497078; membrane transport protein XK; X-linked Kx blood group; X-linked Kx blood group (McLeod syndrome); X-linked Kx blood group (McLeod syndrome) homolog; XK homolog; XK-related protein 1; Xk_mapped

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	16,108,913 - 16,145,322 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	16,108,915 - 16,145,409 (-)	Ensembl				GRCr8
mRatBN7.2	X	13,436,412 - 13,472,830 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	13,436,418 - 13,472,830 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	13,623,720 - 13,660,104 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	17,120,655 - 17,157,035 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	13,377,235 - 13,413,615 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	14,497,376 - 14,534,479 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	14,498,119 - 14,534,473 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	15,278,669 - 15,315,169 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	25,591,152 - 25,624,913 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	13,951,523 - 13,985,552 (+)	NCBI		Celera
RGSC_v3.1	X	25,644,621 - 25,678,382 (-)	NCBI
Cytogenetic Map	X	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

disease of mental health (ISO)

genetic disease (ISO)

hematopoietic system disease (ISO)

isolated elevated serum creatine phosphokinase levels (ISO)

McLeod syndrome (ISO)

movement disease (ISO)

neuroacanthocytosis (ISO)

neuromuscular disease (ISO)

peripheral nervous system disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,4'-trichlorobiphenyl (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (ISO)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amiodarone (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

avobenzone (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cantharidin (ISO)

CGP 52608 (ISO)

choline (ISO)

cobalt dichloride (ISO)

cyclosporin A (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

folic acid (ISO)

gentamycin (EXP)

glutathione (EXP)

L-methionine (ISO)

methylmercury chloride (ISO)

oxaliplatin (EXP)

ozone (ISO)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

rotenone (ISO)

SB 431542 (ISO)

serpentine asbestos (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

temozolomide (ISO)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

triclosan (ISO)

triphenyl phosphate (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid transport (IEA)

biological_process (ND)

intracellular calcium ion homeostasis (ISO)

intracellular magnesium ion homeostasis (ISO)

myelination (ISO)

regulation of axon diameter (ISO)

regulation of cell size (ISO)

skeletal muscle fiber development (ISO)

Cellular Component

endoplasmic reticulum membrane (IBA,IEA,ISO,ISS)

membrane (IEA)

plasma membrane (IEA,ISO,ISS)

Molecular Function

protein binding (ISO)

protein-macromolecule adaptor activity (IBA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Isolation of the gene for McLeod syndrome that encodes a novel membrane transport protein.	Ho M, etal., Cell 1994 Jun 17;77(6):869-80.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:1300515	PMID:9593744	PMID:12477932	PMID:17379193	PMID:23122227	PMID:24405768

Genomics

Comparative Map Data

Xk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	16,108,913 - 16,145,322 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	16,108,915 - 16,145,409 (-)	Ensembl				GRCr8
mRatBN7.2	X	13,436,412 - 13,472,830 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	13,436,418 - 13,472,830 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	13,623,720 - 13,660,104 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	17,120,655 - 17,157,035 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	13,377,235 - 13,413,615 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	14,497,376 - 14,534,479 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	14,498,119 - 14,534,473 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	15,278,669 - 15,315,169 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	25,591,152 - 25,624,913 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	13,951,523 - 13,985,552 (+)	NCBI		Celera
RGSC_v3.1	X	25,644,621 - 25,678,382 (-)	NCBI
Cytogenetic Map	X	q12	NCBI

XK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	37,685,791 - 37,732,130 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	37,685,791 - 37,732,130 (+)	Ensembl			hg38	GRCh38
GRCh37	X	37,545,044 - 37,591,383 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	37,430,052 - 37,476,322 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	X	37,301,324 - 37,347,594	NCBI
Celera	X	41,682,795 - 41,729,061 (+)	NCBI		Celera
Cytogenetic Map	X	p21.1	NCBI
HuRef	X	35,290,888 - 35,336,107 (+)	NCBI		HuRef
CHM1_1	X	37,576,264 - 37,622,522 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	37,089,348 - 37,135,703 (+)	NCBI		T2T-CHM13v2.0

Xk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	9,139,023 - 9,179,484 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	9,138,995 - 9,179,489 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	X	9,272,784 - 9,313,245 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	9,272,756 - 9,313,250 (+)	Ensembl			mm10	GRCm38
MGSCv37	X	8,849,910 - 8,890,371 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	X	8,429,873 - 8,468,132 (+)	NCBI		MGSCv36	mm8
Celera	X	7,012,285 - 7,052,336 (+)	NCBI		Celera
Cytogenetic Map	X	A1.1	NCBI
cM Map	X	4.22	NCBI

Xk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955587	668,070 - 728,959 (+)	Ensembl
ChiLan1.0	NW_004955587	668,871 - 725,829 (+)	NCBI	ChiLan1.0	ChiLan1.0

XK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	39,334,500 - 39,381,063 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	39,337,936 - 39,384,437 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	30,136,046 - 30,182,541 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	37,846,539 - 37,892,348 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	37,846,539 - 37,892,348 (+)	Ensembl			panPan2	panpan1.1

XK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	32,453,404 - 32,498,145 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	32,453,570 - 32,495,110 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	19,801,126 - 19,845,752 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	32,491,214 - 32,543,437 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	32,491,295 - 32,540,402 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	32,578,961 - 32,624,840 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	32,544,040 - 32,588,642 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	32,592,018 - 32,636,881 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Xk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	24,691,389 - 24,745,510 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936502	4,532,100 - 4,587,439 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936502	4,532,100 - 4,584,931 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

XK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	33,544,731 - 33,602,574 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	X	33,544,287 - 33,602,576 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	37,205,690 - 37,263,628 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

XK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666056	38,148,973 - 38,193,937 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Xk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624762	17,856,731 - 17,914,938 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624762	17,856,746 - 17,915,975 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Xk
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	X	11,863,951 - 11,898,911 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Xk
110 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	809
Count of miRNA genes:	326
Interacting mature miRNAs:	436
Transcripts:	ENSRNOT00000051135
Prediction methods:	Microtar, Miranda, Pita, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	4001493	44939387	Rat
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1970440	46970440	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	8111486	53111486	Rat
634325	Bw13	Body weight QTL 13	0		body mass (VT:0001259)	body weight (CMO:0000012)	X	4001493	24470521	Rat

Markers in Region

DXWox20

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	13,442,366 - 13,442,570 (-)	MAPPER	mRatBN7.2
Rnor_6.0	X	14,528,325 - 14,528,526	NCBI	Rnor6.0
Rnor_5.0	X	15,309,015 - 15,309,216	UniSTS	Rnor5.0
RGSC_v3.4	X	25,594,532 - 25,594,733	UniSTS	RGSC3.4
Celera	X	13,981,485 - 13,981,686	UniSTS
Cytogenetic Map	X	q13	UniSTS

RH130134

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	13,463,071 - 13,463,278 (-)	MAPPER	mRatBN7.2
Rnor_6.0	X	14,507,670 - 14,507,876	NCBI	Rnor6.0
Rnor_5.0	X	15,288,360 - 15,288,566	UniSTS	Rnor5.0
RGSC_v3.4	X	25,615,237 - 25,615,443	UniSTS	RGSC3.4
Celera	X	13,960,968 - 13,961,174	UniSTS
RH 3.4 Map	X	121.7	UniSTS
Cytogenetic Map	X	q13	UniSTS

RH143260

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	13,440,088 - 13,440,193 (-)	MAPPER	mRatBN7.2
Rnor_6.0	X	14,530,700 - 14,530,804	NCBI	Rnor6.0
Rnor_5.0	X	15,311,390 - 15,311,494	UniSTS	Rnor5.0
Celera	X	13,983,860 - 13,983,964	UniSTS
RH 3.4 Map	X	125.1	UniSTS
Cytogenetic Map	X	q13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	66	158	91	90	59	92	59	6	351	191	11	137	77	92	31	14	14

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012227	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006256692	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY534256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC107559	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000051135 ⟹ ENSRNOP00000039017

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	16,108,915 - 16,145,409 (-)	Ensembl
mRatBN7.2 Ensembl	X	13,436,418 - 13,472,830 (-)	Ensembl
Rnor_6.0 Ensembl	X	14,498,119 - 14,534,473 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092143 ⟹ ENSRNOP00000071189

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	14,498,283 - 14,534,431 (+)	Ensembl

RefSeq Acc Id:

NM_001012227 ⟹ NP_001012227

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	16,108,913 - 16,145,322 (-)	NCBI
mRatBN7.2	X	13,436,416 - 13,472,830 (-)	NCBI
Rnor_6.0	X	14,498,223 - 14,532,391 (+)	NCBI
Rnor_5.0	X	15,278,669 - 15,315,169 (+)	NCBI
RGSC_v3.4	X	25,591,152 - 25,624,913 (-)	RGD
Celera	X	13,951,523 - 13,985,552 (+)	RGD

Sequence:

show sequence

GGCTGGGCATGCTGGGAGCCGCTCTGGAAACCGCCACTGCCGCCGCCGCCGCCGCCACCACCCG
CCGCCACCCGCGGTGCGAGTCCCTGAGGCGCGGAGATGAAATTCCCGGCCTCAGTGTTAGCGTC
CGTGTTCCTGTTCGTGGCCGAGACAATGGCCGCGCTCTACCTGAGCAGCACCTACCGCTCTGCC
GGGGACCGCATGTGGCAGGCGCTGACGCTGTTCTTCTCCTTGATGCCCTGCACCCTGGTGCAGC
TCACGCTCCTCTTCGTCCACCGCGACCTCAGCCGCGATCGCCCACTGGTGTTGCTTATGCACCT
GCTCCAGCTGGGGCCCCTGTACAGGTGTTGTGAAGTCTTTTGTATCTACTGTCAGTCTGACCAG
AATGAAGAACCTTATGTGAGCATCACTAAGAAACGACAGATGCCAAAAGATGGCCTTTCAGAAG
AGGTCGAGAAAGAGGTTGGCCAGTCAGAAGGCAAGCTGTTTACCCACCGTTCTGCATTCAGTCG
GGCATCAGTGATACAGGCTTTCCTAGGTTCTGCCCCGCAACTGACCCTACAACTGTATATAACT
GTCTTGGAACAGAACATTACTACTGGAAGATTCATCATGGTCTTGTCCCTGCTGTCTATCGTCT
ACGGTGCCTTACGTTGCAACATCTTAGCCATCAAAATCAAGTATGATGAGTACGAGGTCAAAGT
CAAACCCCTGGCCTATGTCTGTATCTTCCTCTGGAGAAGCTTTGAGATTGCCACTCGGGTCATC
GTCCTGGTCCTCTTTACCTCTGTCCTGAAGATCTGGGTGGTGGTGGTCATACTTGTCAACTTCT
TCAGCTTCTTCTTGTACCCGTGGATCCTTTTCTGGAACAGTGGCTCCCCATTCCCTGAGAACAT
AGAGAAGGCCCTAACTAGGGTAGGTACCACCATCGTGCTCGGTTTCCTCACTTTACTCTACGCC
GGTATCAACATGTTCTGCTGGTCAGCCGTACAGCTGAAAATCGACAATCCAGAACTCATCAGCA
AGTCCCAGAATTGGTACCGGCTGCTGATTTACTACATGATGAGATTCGTCGAGAACTCCGTCCT
CCTGCTCCTGTGGTTTTTTTTTAAAACTGACATATACATGTATGTGTGTGCACCGCTGTTGATT
TTGCAGCTGCTCATTGGGTACTGCACCAGCATTCTTTTCATGCTTGTGTTCTATCAGTTTTTCC
ACCCTTGCAAAAAGCTCTTTTCTTCTAGTGTTTCTGAAAGCTTTAGCGCATGTCTCAGGTGTGT
CTGTTGGTCCTCCGCGAGGAGAAAATCCACTGAGCCAGTAGGAAGGATAGACACAGACTTAAAG
GCATGCACAGATCAAGGTGCACAGCCTTCTACCAGTAAACTAACTCCCGAGGCCACTGAGATTT
GGACCGCTGTGGACCTGTGCTCCACTTAATGGAACCTGAGGATTCTTACAAGGAATGAAACTTC
ATACACGTCACTAGCCCTGCACAGGGACTAAGGCACGAAGTTAGCTGTTCAGTTCCCTGTTGAG
CTGCTACCTTTTATAAACCCCTTGGCTTTGAGGCAGCTTTGAGTGCATTAAAGAAGCCTACTAC
CCCACAGTTTGTTTCGCATTTGACTCTGTTCTGTTCTTGCATCCTCACTGGCCATTTCATTGAT
TGACACAGTATCCCTGAAGTTTCAGTTGAGTGGTCCTATTCAACAGGTAAAATGAGGAGAAATG
CTTGTTTTCTACCTTTCAAGCCTGTTGTCTCAGAAGCGTGATGCTTTACTGCTAATGAATATAG
CTTAACATAAAAGTCCCCATGATGCGTGGACTAGGTTACTAGGGATTTTACAATGGTGTTCCAA
TTACAAGTTACAGGACAGCTATTTAAGTTTGTTTTAGCAGTATGTTCATTTTCACCCCATTAAG
ACTTTTATACACAACCAACTGTAGCCACTCTGGCATGCAATGTGCATTTTGCTTCAAACCCTAG
ATTTGGGGACTTTATTTCCTAGGATCCATTGATCCAGTTACTTAGGAAAGCCATGTTTCATTCC
ACGTGCTGAAGAAAGTAGTGATGAGGATGGATTGTTAGAACATCAAAATGACAGAAGCTTATAC
AAATATCCAAATGTTTAAAGATAGGAATTGGTTAGAAGGTAGGCTCAATTCACCTCATAACTCA
GTCTTGTCCTATAATTCTGCAAAATTTCTAGTAGAATTTTCTAAAATTAATATTTTAAGAAAGA
AAAAAATAAAACTAATAGTCTTCATACCTATCTCCCCCTTCCTCACTTGTCAGGAAAGTTTTAA
ACAAGGCTTACCTCAGTTCATTTGCTGTTGTTTCTAGAAAGCCCTATTGAAATCTTCTCCCTGA
TGCAAGTGTATAGGACAGTTTACTTTTCATGATTTTAAGAAAAAGAAGTGTTTTCCTCACTACC
ACCCTTAGTTAGAAATGTTGACCTTAGAAACTTTCTAAATTATAGAAAGTAATGAAATGATCAG
AAGTTTTTGTTCCTCATAAAATCCATTTTGACTTGATTTGAGTTCATTTTACTGAGATCTTAGT
TTTGTCCTCCACACCATTTCATCTAATGAATAATTTTTCTCTGATCTATTTATTTTAATTTAAA
ATGGTTGGATAGAATATTGTCAATAGTCTGACGAAAGTGCCAGCAACCAGTGCTACGATTTCTA
CCACTAAATGTAGATAGATGGTAAAATGTCTAGAAAGAAGTGACCATAAAATCCGCACCAACTT
AACATGAGAATTGTACCATAATTTAGTACATTTTCAAAGGCAACATTATTTGTGATTCTATGGG
ATAGAATAGATATTTAATTTTCTGGCCACATAAATTCATA

hide sequence

RefSeq Acc Id:

XM_039099957 ⟹ XP_038955885

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	16,108,913 - 16,145,013 (-)	NCBI
mRatBN7.2	X	13,436,412 - 13,472,519 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012227	(Get FASTA)	NCBI Sequence Viewer
	XP_038955885	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI07560	(Get FASTA)	NCBI Sequence Viewer
	AAT07105	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000039017
GenBank Protein	Q5GH61	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001012227 ⟸ NM_001012227

- UniProtKB:

Q5GH61 (UniProtKB/Swiss-Prot), F1LP18 (UniProtKB/TrEMBL), Q3B7L3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKFPASVLASVFLFVAETMAALYLSSTYRSAGDRMWQALTLFFSLMPCTLVQLTLLFVHRDLSR
DRPLVLLMHLLQLGPLYRCCEVFCIYCQSDQNEEPYVSITKKRQMPKDGLSEEVEKEVGQSEGK
LFTHRSAFSRASVIQAFLGSAPQLTLQLYITVLEQNITTGRFIMVLSLLSIVYGALRCNILAIK
IKYDEYEVKVKPLAYVCIFLWRSFEIATRVIVLVLFTSVLKIWVVVVILVNFFSFFLYPWILFW
NSGSPFPENIEKALTRVGTTIVLGFLTLLYAGINMFCWSAVQLKIDNPELISKSQNWYRLLIYY
MMRFVENSVLLLLWFFFKTDIYMYVCAPLLILQLLIGYCTSILFMLVFYQFFHPCKKLFSSSVS
ESFSACLRCVCWSSARRKSTEPVGRIDTDLKACTDQGAQPSTSKLTPEATEIWTAVDLCST

hide sequence

Ensembl Acc Id:

ENSRNOP00000071189 ⟸ ENSRNOT00000092143

Ensembl Acc Id:

ENSRNOP00000039017 ⟸ ENSRNOT00000051135

RefSeq Acc Id:	XP_038955885 ⟸ XM_039099957
- Peptide Label:	isoform X1
- UniProtKB:	A6KU81 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5GH61-F1-model_v2	AlphaFold	Q5GH61	1-445	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701726

Promoter ID:

EPDNEW_R12246

Type:

initiation region

Name:

Xk_1

Description:

X-linked Kx blood group

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	14,498,154 - 14,498,214	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359650	AgrOrtholog
BioCyc Gene	G2FUF-2977	BioCyc
Ensembl Genes	ENSRNOG00000003749	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000051135	ENTREZGENE
IMAGE_CLONE	IMAGE:7933294	IMAGE-MGC_LOAD
InterPro	XK-rel	UniProtKB/Swiss-Prot
	XK-related_adapter	UniProtKB/Swiss-Prot
KEGG Report	rno:497078	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:124512	IMAGE-MGC_LOAD
NCBI Gene	497078	ENTREZGENE
PANTHER	MEMBRANE TRANSPORT PROTEIN XK	UniProtKB/Swiss-Prot
	MEMBRANE TRANSPORT PROTEIN XK FAMILY MEMBER	UniProtKB/Swiss-Prot
Pfam	XK-related	UniProtKB/Swiss-Prot
PhenoGen	Xk	PhenoGen
RatGTEx	ENSRNOG00000003749	RatGTEx
UniProt	A0ABZ3NNF4_RAT	UniProtKB/TrEMBL
	A6KU81	ENTREZGENE, UniProtKB/TrEMBL
	F1LP18	ENTREZGENE
	Q3B7L3	ENTREZGENE, UniProtKB/TrEMBL
	Q5GH61	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-07-26	Xk	X-linked Kx blood group antigen, Kell and VPS13A binding protein	Xk	X-linked Kx blood group	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-06-25	Xk	X-linked Kx blood group	Xk	X-linked Kx blood group (McLeod syndrome)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-06-26	Xk	X-linked Kx blood group (McLeod syndrome)	Xk	X-linked Kx blood group (McLeod syndrome) homolog	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-14	Xk	X-linked Kx blood group (McLeod syndrome) homolog	Xk	Kell blood group precursor (McLeod phenotype) homolog	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2007-10-22	Xk	Kell blood group precursor (McLeod phenotype) homolog	LOC497078	XK-related protein 1	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2007-10-15	LOC497078	XK-related protein 1	Xk_mapped	Kell blood group precursor (mapped)	Data merged from RGD:3975	737654	APPROVED
2005-11-17	Xk_mapped	Kell blood group precursor (mapped)			Symbol and Name updated	1556543	APPROVED
2005-07-29	LOC497078	XK-related protein 1			Symbol and Name status set to provisional	70820	PROVISIONAL
2003-04-09	Xk	Kell blood group precursor		Kell blood group precursor (McLeod phenotype)	Name updated	629478	APPROVED
2002-06-10	Xk	Kell blood group precursor (McLeod phenotype)			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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