Prps1l3 (phosphoribosyl pyrophosphate synthetase 1-like 3) - Rat Genome Database

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Gene: Prps1l3 (phosphoribosyl pyrophosphate synthetase 1-like 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prps1l3
Name: phosphoribosyl pyrophosphate synthetase 1-like 3
RGD ID: 1359636
Description: Predicted to enable ribose phosphate diphosphokinase activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1); INTERACTS WITH amitrole; methimazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC314140; ribose-phosphate pyrophosphokinase 1; ribose-phosphate pyrophosphokinase I -like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8680,490,353 - 80,498,539 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl680,486,185 - 80,513,612 (+)EnsemblGRCr8
mRatBN7.2674,755,331 - 74,763,493 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl674,755,310 - 74,766,465 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx675,174,695 - 75,182,842 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0675,474,007 - 75,482,154 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0674,901,490 - 74,909,637 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd682,050,221 - 82,058,368 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive681,467,915 - 81,476,062 (+)NCBILyon_Normotensive
Lyon_Hypertensive679,263,506 - 79,271,653 (+)NCBILyon_Hypertensive
F344_StmMcwi678,373,335 - 78,381,510 (+)NCBIF344_StmMcwi
Rnor_6.0678,172,762 - 78,181,608 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl678,172,762 - 78,180,924 (+)Ensemblrn6Rnor6.0
Rnor_5.0687,689,010 - 87,697,170 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4677,685,499 - 77,693,687 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera673,554,016 - 73,562,177 (+)NCBICelera
RGSC_v3.1677,688,624 - 77,696,789 (+)NCBI
Cytogenetic Map6q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
amitrole  (EXP)
methimazole  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Variants

.
Variants in Prps1l3
85 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat

Markers in Region
RH143437  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2674,754,168 - 74,754,373 (+)MAPPERmRatBN7.2
Rnor_6.0678,171,601 - 78,171,805NCBIRnor6.0
Rnor_5.0687,687,649 - 87,687,853UniSTSRnor5.0
RGSC_v3.4677,684,338 - 77,684,542UniSTSRGSC3.4
Celera673,552,855 - 73,553,059UniSTS
RH 3.4 Map6528.39UniSTS
Cytogenetic Map6q23UniSTS
RH143688  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2674,763,566 - 74,763,712 (+)MAPPERmRatBN7.2
Rnor_6.0678,180,996 - 78,181,141NCBIRnor6.0
Rnor_5.0687,697,242 - 87,697,387UniSTSRnor5.0
RGSC_v3.4677,693,735 - 77,693,880UniSTSRGSC3.4
Celera673,562,250 - 73,562,395UniSTS
RH 3.4 Map6541.8UniSTS
Cytogenetic Map6q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
22 12 73 195 125 120 77 98 77 12 414 216 11 162 91 111 43 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000083110   ⟹   ENSRNOP00000069706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl674,755,319 - 74,764,251 (+)Ensembl
Rnor_6.0 Ensembl678,172,762 - 78,180,924 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096140   ⟹   ENSRNOP00000092432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl674,755,556 - 74,764,251 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109586   ⟹   ENSRNOP00000083067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl674,755,310 - 74,766,465 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128345   ⟹   ENSRNOP00000111231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl680,490,546 - 80,510,278 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129578   ⟹   ENSRNOP00000103849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl680,486,185 - 80,512,523 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000150875   ⟹   ENSRNOP00000100130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl680,490,049 - 80,505,128 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000157728   ⟹   ENSRNOP00000108847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl680,486,460 - 80,510,278 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000160025   ⟹   ENSRNOP00000112180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl680,486,453 - 80,513,612 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000171517   ⟹   ENSRNOP00000109275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl680,486,654 - 80,510,278 (+)Ensembl
RefSeq Acc Id: NM_001009694   ⟹   NP_001009694
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8680,490,353 - 80,498,539 (+)NCBI
mRatBN7.2674,755,331 - 74,763,493 (+)NCBI
Dahl_SR_JrHsd682,050,221 - 82,058,368 (+)NCBI
Lyon_Normotensive681,467,915 - 81,476,062 (+)NCBI
Lyon_Hypertensive679,263,506 - 79,271,653 (+)NCBI
F344_StmMcwi678,373,335 - 78,381,510 (+)NCBI
Rnor_6.0678,172,762 - 78,180,948 (+)NCBI
Rnor_5.0687,689,010 - 87,697,170 (+)NCBI
RGSC_v3.4677,685,499 - 77,693,687 (+)RGD
Celera673,554,016 - 73,562,177 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001009694 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88149 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071101.2
  ENSRNOP00000100130.1
  ENSRNOP00000103849.1
  ENSRNOP00000108847
  ENSRNOP00000108847.1
  ENSRNOP00000109275.1
  ENSRNOP00000111231.1
  ENSRNOP00000112180.1
RefSeq Acc Id: NP_001009694   ⟸   NM_001009694
- UniProtKB: A0A0G2JSV3 (UniProtKB/TrEMBL),   A0A8L2R3X1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069706   ⟸   ENSRNOT00000083110
Ensembl Acc Id: ENSRNOP00000092432   ⟸   ENSRNOT00000096140
Ensembl Acc Id: ENSRNOP00000083067   ⟸   ENSRNOT00000109586
Ensembl Acc Id: ENSRNOP00000109275   ⟸   ENSRNOT00000171517
Ensembl Acc Id: ENSRNOP00000112180   ⟸   ENSRNOT00000160025
Ensembl Acc Id: ENSRNOP00000111231   ⟸   ENSRNOT00000128345
Ensembl Acc Id: ENSRNOP00000100130   ⟸   ENSRNOT00000150875
Ensembl Acc Id: ENSRNOP00000108847   ⟸   ENSRNOT00000157728
Ensembl Acc Id: ENSRNOP00000103849   ⟸   ENSRNOT00000129578
Protein Domains
Ribose-phosphate pyrophosphokinase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JSV3-F1-model_v2 AlphaFold A0A0G2JSV3 1-318 view protein structure
AF-P60892-F1-model_v2 AlphaFold P60892 1-318 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359636 AgrOrtholog
BioCyc Gene G2FUF-37411 BioCyc
BioCyc Pathway PWY0-662 [PRPP biosynthesis] BioCyc
BioCyc Pathway Image PWY0-662 BioCyc
Ensembl Genes ENSRNOG00000056011 Ensembl
  ENSRNOG00000060262 UniProtKB/TrEMBL
  ENSRNOG00000088620 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078582.3 UniProtKB/TrEMBL
  ENSRNOT00000128345.1 UniProtKB/TrEMBL
  ENSRNOT00000129578.1 UniProtKB/TrEMBL
  ENSRNOT00000150875.1 UniProtKB/TrEMBL
  ENSRNOT00000157728 ENTREZGENE
  ENSRNOT00000157728.1 UniProtKB/TrEMBL
  ENSRNOT00000160025.1 UniProtKB/TrEMBL
  ENSRNOT00000171517.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.2020 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7380332 IMAGE-MGC_LOAD
InterPro PRib_PP_synth_CS UniProtKB/TrEMBL
  Pribosyltran_N UniProtKB/TrEMBL
  PRibTrfase_dom UniProtKB/TrEMBL
  PRTase-like UniProtKB/TrEMBL
  Rib-P_diPkinase UniProtKB/TrEMBL
  Rib-P_diPkinase_bac UniProtKB/TrEMBL
MGC_CLONE MGC:108713 IMAGE-MGC_LOAD
NCBI Gene 314140 ENTREZGENE
PANTHER RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER UniProtKB/TrEMBL
  RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 1 UniProtKB/TrEMBL
Pfam Pribosyl_synth UniProtKB/TrEMBL
  Pribosyltran_N UniProtKB/TrEMBL
PhenoGen Prps1l3 PhenoGen
PROSITE PRPP_SYNTHASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056011 RatGTEx
  ENSRNOG00000060262 RatGTEx
  ENSRNOG00000088620 RatGTEx
SMART Pribosyltran_N UniProtKB/TrEMBL
Superfamily-SCOP PRTase-like UniProtKB/TrEMBL
UniProt A0A0G2JSV3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R3X1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Prps1l3  phosphoribosyl pyrophosphate synthetase 1-like 3  LOC314140  ribose-phosphate pyrophosphokinase I -like  Symbol and Name Changed 1299863 APPROVED
2005-07-29 LOC314140  ribose-phosphate pyrophosphokinase I -like      Symbol and Name status set to provisional 70820 PROVISIONAL