Tuba4a (tubulin, alpha 4A) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Tuba4a (tubulin, alpha 4A) Rattus norvegicus
Analyze
Symbol: Tuba4a
Name: tubulin, alpha 4A
RGD ID: 1359623
Description: Predicted to enable GTP binding activity and protein kinase binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 22. Orthologous to human TUBA4A (tubulin alpha 4a); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; (S)-colchicine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-tubulin 4; MGC94628; similar to Tubulin alpha-4 chain (Alpha-tubulin 4); Tuba4; tubulin alpha-4 chain; tubulin alpha-4A chain; tubulin, alpha 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,158,871 - 84,174,041 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl984,158,280 - 84,162,584 (-)EnsemblGRCr8
mRatBN7.2976,709,617 - 76,714,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,709,614 - 76,713,918 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx985,155,014 - 85,158,697 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,283,905 - 90,287,588 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,670,120 - 88,673,803 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,415,599 - 82,419,918 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,415,605 - 82,419,288 (-)Ensemblrn6Rnor6.0
Rnor_5.0982,184,860 - 82,189,155 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4974,496,508 - 74,500,192 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera974,280,623 - 74,284,307 (-)NCBICelera
RGSC_v3.1974,643,490 - 74,647,174 (-)NCBI
Cytogenetic Map9q33NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
7,12-dimethyltetraphene  (ISO)
aconitine  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
bromoacetate  (ISO)
buspirone  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenamidone  (ISO)
ferroheme b  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP,ISO)
furfural  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
GSK-J4  (ISO)
heme b  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
N-nitrosodiethylamine  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
nobiletin  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (EXP)
phytoestrogen  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
resorcinol  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenic acid  (ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP,ISO)
vitamin E  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cilium  (ISO)
cytoplasm  (IBA)
cytoskeleton  (IEA,ISO)
membrane raft  (IEA)
microtubule  (IBA,IEA,ISO)
microtubule cytoskeleton  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A revised nomenclature for the human and rodent alpha-tubulin gene family. Khodiyar VK, etal., Genomics. 2007 May 31;.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Villasante A, etal., Mol Cell Biol 1986 Jul;6(7):2409-19.
Additional References at PubMed
PMID:19199708   PMID:20458337   PMID:21525035   PMID:22082260   PMID:22871113   PMID:23874210   PMID:24327345   PMID:25002582   PMID:25931508   PMID:26316108   PMID:29476059  


Genomics

Comparative Map Data
Tuba4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,158,871 - 84,174,041 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl984,158,280 - 84,162,584 (-)EnsemblGRCr8
mRatBN7.2976,709,617 - 76,714,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,709,614 - 76,713,918 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx985,155,014 - 85,158,697 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,283,905 - 90,287,588 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,670,120 - 88,673,803 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,415,599 - 82,419,918 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,415,605 - 82,419,288 (-)Ensemblrn6Rnor6.0
Rnor_5.0982,184,860 - 82,189,155 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4974,496,508 - 74,500,192 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera974,280,623 - 74,284,307 (-)NCBICelera
RGSC_v3.1974,643,490 - 74,647,174 (-)NCBI
Cytogenetic Map9q33NCBI
TUBA4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,249,710 - 219,254,740 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,249,710 - 219,277,902 (-)Ensemblhg38GRCh38
GRCh372220,114,432 - 220,119,462 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,823,245 - 219,826,882 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342219,940,505 - 219,944,143NCBI
Celera2213,884,708 - 213,888,345 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,967,348 - 211,972,245 (-)NCBIHuRef
CHM1_12220,120,276 - 220,125,176 (-)NCBICHM1_1
T2T-CHM13v2.02219,734,477 - 219,739,787 (-)NCBIT2T-CHM13v2.0
Tuba4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39175,190,867 - 75,197,905 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl175,190,872 - 75,196,509 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38175,214,972 - 75,221,261 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl175,214,228 - 75,219,865 (-)Ensemblmm10GRCm38
MGSCv37175,211,549 - 75,215,828 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36175,098,122 - 75,102,401 (-)NCBIMGSCv36mm8
Celera175,705,885 - 75,710,164 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.63NCBI
Tuba4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,175,866 - 14,182,023 (+)Ensembl
ChiLan1.0NW_00495545314,177,043 - 14,180,814 (+)NCBIChiLan1.0ChiLan1.0
TUBA4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,880,718 - 121,884,443 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,895,683 - 121,899,408 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,507,842 - 106,512,155 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B225,098,446 - 225,102,188 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B225,093,643 - 225,102,188 (-)EnsemblpanPan2panpan1.1
TUBA4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,799,075 - 25,803,257 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,796,107 - 25,802,892 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3726,624,976 - 26,629,142 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03725,814,305 - 25,818,478 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,813,707 - 25,818,101 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,718,693 - 25,722,858 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,653,811 - 25,657,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,674,711 - 25,678,885 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tuba4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,325,485 - 175,329,806 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,668,878 - 1,672,514 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,668,265 - 1,672,532 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TUBA4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,288,957 - 121,294,853 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115121,290,149 - 121,294,048 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,324,536 - 134,329,577 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103217904
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110105,154,928 - 105,159,340 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10105,153,933 - 105,158,655 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604094,236,773 - 94,241,516 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tuba4a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14148,572,269 - 148,576,630 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tuba4a
173 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:29
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000004797
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)98216882386720295Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
RH132688  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,709,631 - 76,709,815 (+)MAPPERmRatBN7.2
Rnor_6.0982,415,026 - 82,415,209NCBIRnor6.0
Rnor_5.0982,184,287 - 82,184,470UniSTSRnor5.0
RGSC_v3.4974,495,930 - 74,496,113UniSTSRGSC3.4
Celera974,280,045 - 74,280,228UniSTS
RH 3.4 Map9711.2UniSTS
Cytogenetic Map9q33UniSTS
RH78682  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04209,800,159 - 209,800,341UniSTSRnor5.0
Rnor_5.02218,687,079 - 218,687,261UniSTSRnor5.0
Cytogenetic Map7q36UniSTS
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001007004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC083726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000004797   ⟹   ENSRNOP00000004797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl984,158,280 - 84,162,584 (-)Ensembl
mRatBN7.2 Ensembl976,709,614 - 76,713,918 (-)Ensembl
Rnor_6.0 Ensembl982,415,605 - 82,419,288 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000127189   ⟹   ENSRNOP00000101677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl984,158,280 - 84,161,543 (-)Ensembl
RefSeq Acc Id: NM_001007004   ⟹   NP_001007005
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,158,871 - 84,162,584 (-)NCBI
mRatBN7.2976,710,205 - 76,713,918 (-)NCBI
Rnor_6.0982,415,604 - 82,419,288 (-)NCBI
Rnor_5.0982,184,860 - 82,189,155 (-)NCBI
RGSC_v3.4974,496,508 - 74,500,192 (-)RGD
Celera974,280,623 - 74,284,307 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245227   ⟹   XP_006245289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,158,876 - 84,163,451 (-)NCBI
mRatBN7.2976,710,205 - 76,714,327 (-)NCBI
Rnor_6.0982,415,599 - 82,419,918 (-)NCBI
Rnor_5.0982,184,860 - 82,189,155 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083681   ⟹   XP_038939609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,158,876 - 84,161,897 (-)NCBI
mRatBN7.2976,709,617 - 76,713,282 (-)NCBI
RefSeq Acc Id: XM_063267230   ⟹   XP_063123300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,158,876 - 84,174,041 (-)NCBI
RefSeq Acc Id: XM_063267231   ⟹   XP_063123301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,158,876 - 84,161,993 (-)NCBI
RefSeq Acc Id: NP_001007005   ⟸   NM_001007004
- UniProtKB: Q5XIF6 (UniProtKB/Swiss-Prot),   A6JVZ9 (UniProtKB/TrEMBL),   A0A8I6ALV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245289   ⟸   XM_006245227
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ALV8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004797   ⟸   ENSRNOT00000004797
RefSeq Acc Id: XP_038939609   ⟸   XM_039083681
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ALV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123300   ⟸   XM_063267230
- Peptide Label: isoform X1
- UniProtKB: Q5XIF6 (UniProtKB/Swiss-Prot),   A6JVZ9 (UniProtKB/TrEMBL),   A0A8I6ALV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123301   ⟸   XM_063267231
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ALV8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101677   ⟸   ENSRNOT00000127189
Protein Domains
Tubulin/FtsZ 2-layer sandwich   Tubulin/FtsZ GTPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIF6-F1-model_v2 AlphaFold Q5XIF6 1-448 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696775
Promoter ID:EPDNEW_R7299
Type:single initiation site
Name:Tuba4a_1
Description:tubulin, alpha 4A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0982,419,312 - 82,419,372EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359623 AgrOrtholog
BioCyc Gene G2FUF-27088 BioCyc
Ensembl Genes ENSRNOG00000003597 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004797 ENTREZGENE
  ENSRNOT00000004797.6 UniProtKB/Swiss-Prot
  ENSRNOT00000127189 ENTREZGENE
Gene3D-CATH 1.10.287.600 UniProtKB/Swiss-Prot
  3.30.1330.20 UniProtKB/Swiss-Prot
  3.40.50.1440 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7191229 IMAGE-MGC_LOAD
InterPro Alpha_tubulin UniProtKB/Swiss-Prot
  Tub_FtsZ_C UniProtKB/Swiss-Prot
  Tubulin UniProtKB/Swiss-Prot
  Tubulin/FtsZ_2-layer-sand-dom UniProtKB/Swiss-Prot
  Tubulin/FtsZ_C_sf UniProtKB/Swiss-Prot
  Tubulin/FtsZ_GTPase_sf UniProtKB/Swiss-Prot
  Tubulin_C UniProtKB/Swiss-Prot
  Tubulin_CS UniProtKB/Swiss-Prot
  Tubulin_FtsZ_GTPase UniProtKB/Swiss-Prot
KEGG Report rno:316531 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94628 IMAGE-MGC_LOAD
NCBI Gene 316531 ENTREZGENE
PANTHER PTHR11588 UniProtKB/Swiss-Prot
Pfam Tubulin UniProtKB/Swiss-Prot
  Tubulin_C UniProtKB/Swiss-Prot
PharmGKB TUBA4A RGD
PhenoGen Tuba4a PhenoGen
PRINTS ALPHATUBULIN UniProtKB/Swiss-Prot
  TUBULIN UniProtKB/Swiss-Prot
PROSITE TUBULIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003597 RatGTEx
SMART Tubulin UniProtKB/Swiss-Prot
  Tubulin_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52490 UniProtKB/Swiss-Prot
  SSF55307 UniProtKB/Swiss-Prot
UniProt A0A8I6ALV8 ENTREZGENE
  A6JVZ9 ENTREZGENE, UniProtKB/TrEMBL
  Q5XIF6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-05-17 Tuba4a  tubulin, alpha 4A  Tuba4  tubulin, alpha 4  Symbol and Name updated 1624988 APPROVED
2005-11-17 Tuba4  tubulin, alpha 4  MGC94628  similar to Tubulin alpha-4 chain (Alpha-tubulin 4)  Symbol and Name updated 1299863 APPROVED
2005-07-29 MGC94628  similar to Tubulin alpha-4 chain (Alpha-tubulin 4)      Symbol and Name status set to provisional 70820 PROVISIONAL