Dnaaf8 (dynein axonemal assembly factor 8) - Rat Genome Database

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Gene: Dnaaf8 (dynein axonemal assembly factor 8) Rattus norvegicus
Analyze
Symbol: Dnaaf8
Name: dynein axonemal assembly factor 8
RGD ID: 1359596
Description: Predicted to enable dynein complex binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be located in cytoplasm. Predicted to be active in dynein axonemal particle. Orthologous to human DNAAF8 (dynein axonemal assembly factor 8); INTERACTS WITH bisphenol A; paracetamol; butanal (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Daap1; dynein axonemal-associated protein 1; hypothetical protein LOC360479; LOC360479; similar to hypothetical protein; uncharacterized protein C16orf71 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81011,107,988 - 11,121,475 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1011,107,404 - 11,121,345 (-)EnsemblGRCr8
mRatBN7.21010,600,747 - 10,614,891 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1010,600,734 - 10,614,891 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1015,309,989 - 15,323,321 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01014,798,810 - 14,812,138 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01010,467,941 - 10,481,268 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01010,794,441 - 10,808,665 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1010,794,445 - 10,808,585 (-)Ensemblrn6Rnor6.0
Rnor_5.0109,561,369 - 9,575,577 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41010,718,515 - 10,731,871 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera109,565,747 - 9,579,103 (-)NCBICelera
RGSC_v3.11010,718,514 - 10,731,871 (-)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO,ISS)
dynein axonemal particle  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data
Dnaaf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81011,107,988 - 11,121,475 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1011,107,404 - 11,121,345 (-)EnsemblGRCr8
mRatBN7.21010,600,747 - 10,614,891 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1010,600,734 - 10,614,891 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1015,309,989 - 15,323,321 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01014,798,810 - 14,812,138 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01010,467,941 - 10,481,268 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01010,794,441 - 10,808,665 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1010,794,445 - 10,808,585 (-)Ensemblrn6Rnor6.0
Rnor_5.0109,561,369 - 9,575,577 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41010,718,515 - 10,731,871 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera109,565,747 - 9,579,103 (-)NCBICelera
RGSC_v3.11010,718,514 - 10,731,871 (-)NCBI
Cytogenetic Map10q12NCBI
DNAAF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38164,734,537 - 4,749,396 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl164,734,344 - 4,749,396 (+)Ensemblhg38GRCh38
GRCh37164,784,538 - 4,799,397 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36164,724,290 - 4,739,398 (+)NCBIBuild 36Build 36hg18NCBI36
Celera164,993,069 - 5,008,177 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef164,750,817 - 4,765,925 (+)NCBIHuRef
CHM1_1164,785,051 - 4,800,161 (+)NCBICHM1_1
T2T-CHM13v2.0164,763,994 - 4,778,854 (+)NCBIT2T-CHM13v2.0
Dnaaf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39164,782,152 - 4,796,827 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl164,782,090 - 4,796,826 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38164,964,288 - 4,978,963 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,964,289 - 4,978,962 (+)Ensemblmm10GRCm38
MGSCv37164,964,382 - 4,979,056 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36164,879,798 - 4,894,284 (+)NCBIMGSCv36mm8
Celera165,595,622 - 5,610,527 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.49NCBI
Dnaaf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544212,738,888 - 12,752,306 (-)NCBIChiLan1.0ChiLan1.0
DNAAF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2185,263,500 - 5,278,601 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1169,053,655 - 9,069,500 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0163,659,525 - 3,674,557 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1164,825,030 - 4,840,117 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl164,825,030 - 4,840,117 (+)EnsemblpanPan2panpan1.1
DNAAF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1636,665,193 - 36,678,860 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl636,665,455 - 36,678,680 (-)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.0636,868,227 - 36,881,900 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl636,868,489 - 36,881,719 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1636,662,613 - 36,675,964 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0636,555,373 - 36,568,854 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0636,957,534 - 36,971,008 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dnaaf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344106,879,844 - 106,893,106 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365304,725,279 - 4,738,554 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365304,725,294 - 4,738,515 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAAF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl337,652,539 - 37,665,474 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1337,652,535 - 37,665,497 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2338,713,538 - 38,726,406 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNAAF8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.154,413,292 - 4,427,925 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606826,232,859 - 26,248,640 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnaaf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248242,507,454 - 2,518,610 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dnaaf8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1916,930,155 - 16,943,291 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dnaaf8
65 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:293
Count of miRNA genes:198
Interacting mature miRNAs:221
Transcripts:ENSRNOT00000036954
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
RH131259  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21010,601,612 - 10,601,818 (+)MAPPERmRatBN7.2
Rnor_6.01010,795,307 - 10,795,512NCBIRnor6.0
Rnor_5.0109,562,235 - 9,562,440UniSTSRnor5.0
RGSC_v3.41010,718,593 - 10,718,798UniSTSRGSC3.4
Celera109,565,825 - 9,566,030UniSTS
Cytogenetic Map10q12UniSTS
RH141492  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21010,608,607 - 10,608,825 (+)MAPPERmRatBN7.2
Rnor_6.01010,802,302 - 10,802,519NCBIRnor6.0
Rnor_5.0109,569,230 - 9,569,447UniSTSRnor5.0
RGSC_v3.41010,725,588 - 10,725,805UniSTSRGSC3.4
Celera109,572,820 - 9,573,037UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
22 10 65 185 91 90 59 120 59 6 414 225 18 161 100 107 31 29 29

Sequence


Ensembl Acc Id: ENSRNOT00000036954   ⟹   ENSRNOP00000037410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1011,107,989 - 11,121,345 (-)Ensembl
mRatBN7.2 Ensembl1010,601,535 - 10,614,891 (-)Ensembl
Rnor_6.0 Ensembl1010,795,229 - 10,808,585 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087029   ⟹   ENSRNOP00000074365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1011,107,404 - 11,121,345 (-)Ensembl
mRatBN7.2 Ensembl1010,600,734 - 10,614,891 (-)Ensembl
Rnor_6.0 Ensembl1010,794,445 - 10,807,079 (-)Ensembl
RefSeq Acc Id: NM_001014115   ⟹   NP_001014137
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,107,989 - 11,121,345 (-)NCBI
mRatBN7.21010,601,535 - 10,614,891 (-)NCBI
Rnor_6.01010,795,229 - 10,808,585 (-)NCBI
Rnor_5.0109,561,369 - 9,575,577 (-)NCBI
RGSC_v3.41010,718,515 - 10,731,871 (-)RGD
Celera109,565,747 - 9,579,103 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245807   ⟹   XP_006245869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,107,988 - 11,121,225 (-)NCBI
mRatBN7.21010,600,747 - 10,614,776 (-)NCBI
Rnor_6.01010,794,441 - 10,808,530 (-)NCBI
Rnor_5.0109,561,369 - 9,575,577 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597364   ⟹   XP_017452853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,107,988 - 11,121,379 (-)NCBI
mRatBN7.21010,600,747 - 10,614,555 (-)NCBI
Rnor_6.01010,794,441 - 10,808,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063269292   ⟹   XP_063125362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,107,988 - 11,121,225 (-)NCBI
RefSeq Acc Id: XM_063269293   ⟹   XP_063125363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,107,988 - 11,121,475 (-)NCBI
RefSeq Acc Id: NP_001014137   ⟸   NM_001014115
- UniProtKB: Q5XIK6 (UniProtKB/Swiss-Prot),   A6K4Q0 (UniProtKB/TrEMBL),   A0A8L2R8P6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245869   ⟸   XM_006245807
- Peptide Label: isoform X1
- UniProtKB: Q5XIK6 (UniProtKB/Swiss-Prot),   A6K4Q0 (UniProtKB/TrEMBL),   A0A8L2R8P6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452853   ⟸   XM_017597364
- Peptide Label: isoform X1
- UniProtKB: Q5XIK6 (UniProtKB/Swiss-Prot),   A6K4Q0 (UniProtKB/TrEMBL),   A0A8L2R8P6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074365   ⟸   ENSRNOT00000087029
Ensembl Acc Id: ENSRNOP00000037410   ⟸   ENSRNOT00000036954
RefSeq Acc Id: XP_063125363   ⟸   XM_063269293
- Peptide Label: isoform X1
- UniProtKB: Q5XIK6 (UniProtKB/Swiss-Prot),   A6K4Q0 (UniProtKB/TrEMBL),   A0A8L2R8P6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125362   ⟸   XM_063269292
- Peptide Label: isoform X1
- UniProtKB: Q5XIK6 (UniProtKB/Swiss-Prot),   A6K4Q0 (UniProtKB/TrEMBL),   A0A8L2R8P6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIK6-F1-model_v2 AlphaFold Q5XIK6 1-481 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696967
Promoter ID:EPDNEW_R7492
Type:multiple initiation site
Name:LOC360479_1
Description:similar to hypothetical protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01010,808,651 - 10,808,711EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359596 AgrOrtholog
BioCyc Gene G2FUF-26054 BioCyc
Ensembl Genes ENSRNOG00000028075 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000036954 ENTREZGENE
  ENSRNOT00000036954.5 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7135711 IMAGE-MGC_LOAD
InterPro DUF4701 UniProtKB/Swiss-Prot
KEGG Report rno:360479 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94519 IMAGE-MGC_LOAD
NCBI Gene 360479 ENTREZGENE
PANTHER DYNEIN AXONEMAL ASSEMBLY FACTOR 8 UniProtKB/Swiss-Prot
  PTHR35977 UniProtKB/Swiss-Prot
Pfam DUF4701 UniProtKB/Swiss-Prot
PhenoGen Dnaaf8 PhenoGen
RatGTEx ENSRNOG00000028075 RatGTEx
UniProt A0A8L2R8P6 ENTREZGENE, UniProtKB/TrEMBL
  A6K4Q0 ENTREZGENE, UniProtKB/TrEMBL
  CP071_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-28 Dnaaf8  dynein axonemal assembly factor 8  LOC360479  similar to hypothetical protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC360479  similar to hypothetical protein      Symbol and Name status set to provisional 70820 PROVISIONAL