Krt75 (keratin 75) - Rat Genome Database

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Gene: Krt75 (keratin 75) Rattus norvegicus
Analyze
Symbol: Krt75
Name: keratin 75
RGD ID: 1359576
Description: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in intermediate filament. Predicted to be active in cornified envelope and keratin filament. Orthologous to human KRT75 (keratin 75); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CK-75; cytokeratin-75; K75; Kb18; keratin 75, type II; keratin, type II cytoskeletal 75; keratin-6 hair follicle; keratin-75; type II keratin Kb18; type II keratin-18; type II keratin-K6hf; type-II keratin Kb18
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,565,826 - 134,576,074 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,565,826 - 134,576,074 (-)EnsemblGRCr8
mRatBN7.27132,687,101 - 132,697,360 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,688,237 - 132,697,345 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,489,129 - 134,499,370 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,718,651 - 136,728,892 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,628,311 - 136,638,552 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,219,012 - 143,228,237 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,219,012 - 143,228,060 (-)Ensemblrn6Rnor6.0
Rnor_5.07141,019,553 - 141,029,729 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,320,625 - 140,329,260 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,151,672 - 129,160,307 (-)NCBICelera
RGSC_v3.17140,397,061 - 140,405,697 (-)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, etal., Eur J Cell Biol 2004 Feb;83(1):19-26.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle. Winter H, etal., J Invest Dermatol 1998 Dec;111(6):955-62.
Additional References at PubMed
PMID:15086549   PMID:16489008   PMID:23376485   PMID:23533145   PMID:24029230   PMID:26316108  


Genomics

Comparative Map Data
Krt75
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,565,826 - 134,576,074 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,565,826 - 134,576,074 (-)EnsemblGRCr8
mRatBN7.27132,687,101 - 132,697,360 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,688,237 - 132,697,345 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,489,129 - 134,499,370 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,718,651 - 136,728,892 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,628,311 - 136,638,552 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,219,012 - 143,228,237 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,219,012 - 143,228,060 (-)Ensemblrn6Rnor6.0
Rnor_5.07141,019,553 - 141,029,729 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,320,625 - 140,329,260 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,151,672 - 129,160,307 (-)NCBICelera
RGSC_v3.17140,397,061 - 140,405,697 (-)NCBI
Cytogenetic Map7q36NCBI
KRT75
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,424,070 - 52,434,371 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,424,070 - 52,434,371 (-)Ensemblhg38GRCh38
GRCh371252,817,854 - 52,828,155 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,104,121 - 51,114,377 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1252,464,010 - 52,474,265 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,861,751 - 49,872,007 (-)NCBIHuRef
CHM1_11252,784,713 - 52,794,968 (-)NCBICHM1_1
T2T-CHM13v2.01252,388,336 - 52,398,636 (-)NCBIT2T-CHM13v2.0
Krt75
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,471,778 - 101,482,339 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,471,780 - 101,482,339 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3815101,563,343 - 101,573,904 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,563,345 - 101,573,904 (-)Ensemblmm10GRCm38
MGSCv3715101,393,774 - 101,404,335 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615101,391,377 - 101,401,938 (-)NCBIMGSCv36mm8
Celera15103,715,517 - 103,726,077 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1556.91NCBI
KRT75
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,762,624 - 41,772,932 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,759,387 - 41,769,695 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,330,039 - 36,340,498 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,107,062 - 37,117,519 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,107,062 - 37,117,519 (+)EnsemblpanPan2panpan1.1
KRT75
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,635,210 - 2,645,687 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,591,216 - 2,661,569 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2743,608,347 - 43,618,764 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0272,634,298 - 2,644,714 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,590,051 - 2,660,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,651,193 - 2,661,607 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,636,825 - 2,647,235 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,006,555 - 44,016,985 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
KRT75
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,749,493 - 17,760,524 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1517,749,493 - 17,760,620 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,274,588 - 18,285,740 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KRT75
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,569,406 - 48,581,490 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,570,893 - 48,580,692 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037197,511,356 - 197,521,825 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Krt75
23 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:63
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000012640
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH135363  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27132,688,256 - 132,688,468 (+)MAPPERmRatBN7.2
Rnor_6.07143,219,033 - 143,219,244NCBIRnor6.0
Rnor_5.07141,019,574 - 141,019,785UniSTSRnor5.0
RGSC_v3.47140,320,233 - 140,320,444UniSTSRGSC3.4
Celera7129,151,280 - 129,151,491UniSTS
RH 3.4 Map71061.5UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 6 36 142 53 56 25 92 25 6 273 152 11 118 75 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000012640   ⟹   ENSRNOP00000012640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7143,219,425 - 143,228,060 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088923   ⟹   ENSRNOP00000070762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,565,826 - 134,576,074 (-)Ensembl
mRatBN7.2 Ensembl7132,688,237 - 132,697,345 (-)Ensembl
Rnor_6.0 Ensembl7143,219,012 - 143,228,060 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000170992   ⟹   ENSRNOP00000105236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,565,826 - 134,576,074 (-)Ensembl
RefSeq Acc Id: NM_001008828   ⟹   NP_001008828
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,565,826 - 134,576,074 (-)NCBI
mRatBN7.27132,687,101 - 132,697,349 (-)NCBI
Rnor_6.07143,219,425 - 143,228,060 (-)NCBI
Rnor_5.07141,019,553 - 141,029,729 (-)NCBI
RGSC_v3.47140,320,625 - 140,329,260 (-)RGD
Celera7129,151,672 - 129,160,307 (-)RGD
Sequence:
RefSeq Acc Id: NM_001389262   ⟹   NP_001376191
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,565,826 - 134,576,074 (-)NCBI
mRatBN7.27132,687,101 - 132,697,349 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001008828 (Get FASTA)   NCBI Sequence Viewer  
  NP_001376191 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein DAA02225 (Get FASTA)   NCBI Sequence Viewer  
  EDL86885 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070762
  ENSRNOP00000070762.1
  ENSRNOP00000105236
GenBank Protein Q6IG05 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008828   ⟸   NM_001008828
- Peptide Label: isoform 1
- Sequence:
Ensembl Acc Id: ENSRNOP00000012640   ⟸   ENSRNOT00000012640
Ensembl Acc Id: ENSRNOP00000070762   ⟸   ENSRNOT00000088923
RefSeq Acc Id: NP_001376191   ⟸   NM_001389262
- Peptide Label: isoform 2
- UniProtKB: Q6IG05 (UniProtKB/Swiss-Prot),   A6KCQ7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105236   ⟸   ENSRNOT00000170992
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IG05-F1-model_v2 AlphaFold Q6IG05 1-542 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359576 AgrOrtholog
BioCyc Gene G2FUF-31976 BioCyc
Ensembl Genes ENSRNOG00000043203 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000088923 ENTREZGENE
  ENSRNOT00000088923.2 UniProtKB/Swiss-Prot
  ENSRNOT00000170992 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
  Keratin_II UniProtKB/Swiss-Prot
KEGG Report rno:300247 UniProtKB/Swiss-Prot
NCBI Gene 300247 ENTREZGENE
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  KERATIN, TYPE II CYTOSKELETAL 75 UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
PhenoGen Krt75 PhenoGen
PRINTS TYPE2KERATIN UniProtKB/Swiss-Prot
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000043203 RatGTEx
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
UniProt A0ABK0LUK9_RAT UniProtKB/TrEMBL
  A6KCQ7 ENTREZGENE, UniProtKB/TrEMBL
  K2C75_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Krt75  keratin 75  Krt75  keratin 75, type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-28 Krt75  keratin 75, type II  Krt75  keratin 75  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Krt75  keratin 75  Kb18  type II keratin Kb18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 Kb18  type II keratin Kb18      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression mouse gene is located in a region associated with a spontaneous hair mutation, but the gene itself was not found to be mutated 1549612