Tars1 (threonyl-tRNA synthetase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tars1 (threonyl-tRNA synthetase 1) Rattus norvegicus
Analyze
Symbol: Tars1
Name: threonyl-tRNA synthetase 1
RGD ID: 1359527
Description: Predicted to enable several functions, including ATP binding activity; threonine-tRNA ligase activity; and zinc ion binding activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 7. Orthologous to human TARS1 (threonyl-tRNA synthetase 1); PARTICIPATES IN aminoacyl-tRNA biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC95288; Tars; threonine--tRNA ligase; threonine--tRNA ligase 1, cytoplasmic; threonine--tRNA ligase, cytoplasmic; threonyl-tRNA synthetase; threonyl-tRNA synthetase, cytoplasmic; thrRS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8262,095,978 - 62,114,802 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl262,087,763 - 62,114,802 (-)EnsemblGRCr8
mRatBN7.2260,368,893 - 60,387,715 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl260,367,796 - 60,387,717 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx267,486,539 - 67,505,360 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0265,608,075 - 65,626,896 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0260,609,454 - 60,628,275 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0261,394,632 - 61,414,115 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl261,394,770 - 61,414,102 (-)Ensemblrn6Rnor6.0
Rnor_5.0283,279,708 - 83,299,254 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4260,765,899 - 60,784,665 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera258,303,445 - 58,322,211 (+)NCBICelera
RGSC_v3.1260,694,140 - 60,712,898 (-)NCBI
Cytogenetic Map2q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ampicillin  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
borrelidin  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
fenofibrate  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
ifosfamide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
lithium chloride  (ISO)
mercury dichloride  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
metronidazole  (EXP)
N(4)-hydroxycytidine  (ISO)
neomycin  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxycodone  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nucleotide and deduced amino acid sequence of human threonyl-tRNA synthetase reveals extensive homology to the Escherichia coli and yeast enzymes. Cruzen ME and Arfin SM, J Biol Chem 1991 May 25;266(15):9919-23.
2. Threonyl-tRNA synthetase. Freist W and Gauss DH, Biol Chem Hoppe Seyler. 1995 Apr;376(4):213-24.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Presence of role of the 5SrRNA-L5 protein complex (5SRNP) in the threonyl- and histidyl-tRNA synthetase complex in rat liver cytosol. Ogata K, etal., Biochim Biophys Acta 1994 Aug 2;1218(3):388-400.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12060739   PMID:15489334   PMID:20458337   PMID:22082260   PMID:25824639   PMID:29579307  


Genomics

Comparative Map Data
Tars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8262,095,978 - 62,114,802 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl262,087,763 - 62,114,802 (-)EnsemblGRCr8
mRatBN7.2260,368,893 - 60,387,715 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl260,367,796 - 60,387,717 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx267,486,539 - 67,505,360 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0265,608,075 - 65,626,896 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0260,609,454 - 60,628,275 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0261,394,632 - 61,414,115 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl261,394,770 - 61,414,102 (-)Ensemblrn6Rnor6.0
Rnor_5.0283,279,708 - 83,299,254 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4260,765,899 - 60,784,665 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera258,303,445 - 58,322,211 (+)NCBICelera
RGSC_v3.1260,694,140 - 60,712,898 (-)NCBI
Cytogenetic Map2q16NCBI
TARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38533,440,696 - 33,468,091 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl533,440,696 - 33,469,531 (+)Ensemblhg38GRCh38
GRCh37533,440,802 - 33,468,196 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36533,476,655 - 33,503,953 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34533,476,654 - 33,503,953NCBI
Celera533,321,918 - 33,349,216 (+)NCBICelera
Cytogenetic Map5p13.3NCBI
HuRef533,409,576 - 33,436,969 (+)NCBIHuRef
CHM1_1533,442,410 - 33,469,806 (+)NCBICHM1_1
T2T-CHM13v2.0533,555,295 - 33,582,692 (+)NCBIT2T-CHM13v2.0
Tars1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391511,383,749 - 11,399,744 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1511,382,387 - 11,399,751 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381511,383,663 - 11,399,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1511,382,301 - 11,399,665 (-)Ensemblmm10GRCm38
MGSCv371511,313,418 - 11,329,413 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361511,328,388 - 11,344,383 (-)NCBIMGSCv36mm8
Celera1511,167,393 - 11,183,912 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map155.6NCBI
Tars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542619,087,389 - 19,110,609 (+)Ensembl
ChiLan1.0NW_00495542619,086,817 - 19,110,609 (+)NCBIChiLan1.0ChiLan1.0
TARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2476,839,547 - 76,867,546 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1574,993,322 - 75,019,527 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0576,874,096 - 76,901,208 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1582,258,960 - 82,286,179 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl582,256,706 - 82,286,179 (-)EnsemblpanPan2panpan1.1
TARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1474,213,475 - 74,239,056 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl474,213,772 - 74,238,971 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha473,838,693 - 73,864,242 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0474,724,661 - 74,750,271 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl474,724,664 - 74,750,266 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1474,470,041 - 74,495,641 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0474,598,119 - 74,623,709 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0475,128,157 - 75,153,735 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213223,835,129 - 223,859,335 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365187,512,854 - 7,533,189 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365187,512,498 - 7,536,854 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1619,455,092 - 19,486,732 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11619,455,294 - 19,486,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21620,336,784 - 20,350,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1432,670,020 - 32,697,608 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl432,670,203 - 32,699,168 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607122,947,080 - 22,976,025 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475921,132,116 - 21,154,620 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475921,132,104 - 21,154,533 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Tars1
97 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:37
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000051910
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)261556902106556902Rat
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25838820177302351Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)261051883104684275Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)261051541105724065Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)261051541105724065Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260861391105861391Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000051910   ⟹   ENSRNOP00000044467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl262,095,989 - 62,114,802 (-)Ensembl
mRatBN7.2 Ensembl260,368,904 - 60,387,657 (-)Ensembl
Rnor_6.0 Ensembl261,395,285 - 61,414,038 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088202   ⟹   ENSRNOP00000075146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl262,093,948 - 62,114,802 (-)Ensembl
mRatBN7.2 Ensembl260,367,796 - 60,387,717 (-)Ensembl
Rnor_6.0 Ensembl261,394,770 - 61,414,102 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113724   ⟹   ENSRNOP00000084087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl262,095,989 - 62,113,600 (-)Ensembl
mRatBN7.2 Ensembl260,367,796 - 60,386,513 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118066   ⟹   ENSRNOP00000096069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl262,095,989 - 62,110,043 (-)Ensembl
mRatBN7.2 Ensembl260,367,796 - 60,382,956 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000160990   ⟹   ENSRNOP00000112211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl262,095,989 - 62,114,802 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000173613   ⟹   ENSRNOP00000106677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl262,087,763 - 62,114,802 (-)Ensembl
RefSeq Acc Id: NM_001006976   ⟹   NP_001006977
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8262,095,978 - 62,114,802 (-)NCBI
mRatBN7.2260,368,893 - 60,387,715 (-)NCBI
Rnor_6.0261,395,274 - 61,414,038 (-)NCBI
Rnor_5.0283,279,708 - 83,299,254 (+)NCBI
RGSC_v3.4260,765,899 - 60,784,665 (-)RGD
Celera258,303,445 - 58,322,211 (+)RGD
Sequence:
RefSeq Acc Id: NM_001399216   ⟹   NP_001386145
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8262,095,978 - 62,114,802 (-)NCBI
mRatBN7.2260,368,893 - 60,387,715 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001006977 (Get FASTA)   NCBI Sequence Viewer  
  NP_001386145 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83914 (Get FASTA)   NCBI Sequence Viewer  
  EDL82977 (Get FASTA)   NCBI Sequence Viewer  
  EDL82978 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044467
  ENSRNOP00000044467.2
  ENSRNOP00000112211
GenBank Protein Q5XHY5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001006977   ⟸   NM_001006976
- Peptide Label: isoform 2
- UniProtKB: Q5XHY5 (UniProtKB/Swiss-Prot),   A0A8I6AQ83 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044467   ⟸   ENSRNOT00000051910
Ensembl Acc Id: ENSRNOP00000075146   ⟸   ENSRNOT00000088202
Ensembl Acc Id: ENSRNOP00000096069   ⟸   ENSRNOT00000118066
Ensembl Acc Id: ENSRNOP00000084087   ⟸   ENSRNOT00000113724
RefSeq Acc Id: NP_001386145   ⟸   NM_001399216
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K9V6 (UniProtKB/TrEMBL),   A6KJR7 (UniProtKB/TrEMBL),   A0A8I5ZX23 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112211   ⟸   ENSRNOT00000160990
Ensembl Acc Id: ENSRNOP00000106677   ⟸   ENSRNOT00000173613
Protein Domains
Aminoacyl-transfer RNA synthetases class-II family   TGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XHY5-F1-model_v2 AlphaFold Q5XHY5 1-695 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691191
Promoter ID:EPDNEW_R1715
Type:initiation region
Name:Tars_1
Description:threonyl-tRNA synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0261,414,074 - 61,414,134EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359527 AgrOrtholog
BioCyc Gene G2FUF-54060 BioCyc
BioCyc Pathway TRNA-CHARGING-PWY [tRNA charging] BioCyc
BioCyc Pathway Image TRNA-CHARGING-PWY BioCyc
Ensembl Genes ENSRNOG00000019023 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000051910 ENTREZGENE
  ENSRNOT00000051910.3 UniProtKB/Swiss-Prot
  ENSRNOT00000160990 ENTREZGENE
Gene3D-CATH 3.10.20.30 UniProtKB/Swiss-Prot
  3.40.50.800 UniProtKB/Swiss-Prot
  Bira Bifunctional Protein, Domain 2 UniProtKB/Swiss-Prot
  Threonyl-trna Synthetase, Chain A, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134406 IMAGE-MGC_LOAD
InterPro aa-tRNA-synt_IIb UniProtKB/Swiss-Prot
  aa-tRNA-synth_II UniProtKB/Swiss-Prot
  aa-tRNA-synth_II/BPL/LPL UniProtKB/Swiss-Prot
  Anticodon-bd UniProtKB/Swiss-Prot
  Anticodon-bd_dom_sf UniProtKB/Swiss-Prot
  Beta-grasp_dom_sf UniProtKB/Swiss-Prot
  TGS UniProtKB/Swiss-Prot
  TGS-like UniProtKB/Swiss-Prot
  Thr-tRNA-ligase_IIa UniProtKB/Swiss-Prot
  Thr/Ala-tRNA-synth_IIc_edit UniProtKB/Swiss-Prot
  ThrRS_anticodon UniProtKB/Swiss-Prot
  ThrRS_core UniProtKB/Swiss-Prot
  tRNA_SAD UniProtKB/Swiss-Prot
KEGG Report rno:294810 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95288 IMAGE-MGC_LOAD
NCBI Gene 294810 ENTREZGENE
PANTHER PTHR11451 UniProtKB/Swiss-Prot
  THREONINE--TRNA LIGASE 1, CYTOPLASMIC UniProtKB/Swiss-Prot
Pfam HGTP_anticodon UniProtKB/Swiss-Prot
  TGS UniProtKB/Swiss-Prot
  tRNA-synt_2b UniProtKB/Swiss-Prot
  tRNA_SAD UniProtKB/Swiss-Prot
PhenoGen Tars1 PhenoGen
PRINTS TRNASYNTHTHR UniProtKB/Swiss-Prot
PROSITE AA_TRNA_LIGASE_II UniProtKB/Swiss-Prot
  TGS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019023 RatGTEx
SMART tRNA_SAD UniProtKB/Swiss-Prot
Superfamily-SCOP Class II aaRS ABD-related UniProtKB/Swiss-Prot
  SSF55186 UniProtKB/Swiss-Prot
  SSF55681 UniProtKB/Swiss-Prot
  SSF81271 UniProtKB/Swiss-Prot
UniProt A0A0G2K9V6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZX23 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQ83 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LTQ5_RAT UniProtKB/TrEMBL
  A0ABK0M2G2_RAT UniProtKB/TrEMBL
  A6KJR7 ENTREZGENE, UniProtKB/TrEMBL
  Q5XHY5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Tars1  threonyl-tRNA synthetase 1  Tars  threonyl-tRNA synthetase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tars  threonyl-tRNA synthetase      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Tars  threonyl-tRNA synthetase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction complex formation with ribosomal protein L5 appears to enhance the activity of Tars 1556518
gene_protein both monomer and dimer forms are active 1556518