RT1-CE11 (RT1 class I, locus CE11) - Rat Genome Database

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Gene: RT1-CE11 (RT1 class I, locus CE11) Rattus norvegicus
Analyze
No known orthologs.
Symbol: RT1-CE11 (Ensembl: RT1-A1)
Name: RT1 class I, locus CE11 (Ensembl:RT1 class Ia, locus A1)
RGD ID: 1359483
Description: Predicted to be located in lumenal side of endoplasmic reticulum membrane and phagocytic vesicle membrane. Predicted to be part of MHC class I protein complex; PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; autoimmune thyroiditis pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: H-2 class I histocompatibility antigen, alpha chain-like; LOC108353240; RT1 class I, CE10; RT1 class I, CE11; RT1-CE10
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,355,422 - 3,385,063 (-)NCBIGRCr8
mRatBN7.2203,355,393 - 3,358,520 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,350,937 - 3,380,362 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0202,622,733 - 2,637,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera203,623,868 - 3,626,821 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:29531166  


Genomics

Variants

.
Variants in RT1-CE11
404 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013624629Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat

Markers in Region
RH143921  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,437,218 - 3,437,388 (+)MAPPERmRatBN7.2
mRatBN7.2203,504,546 - 3,504,716 (+)MAPPERmRatBN7.2
Rnor_6.0204,921,406 - 4,921,575NCBIRnor6.0
Rnor_6.0204,698,779 - 4,698,948NCBIRnor6.0
Rnor_5.0206,997,550 - 6,997,719UniSTSRnor5.0
Rnor_5.0206,779,353 - 6,779,522UniSTSRnor5.0
RGSC_v3.4203,539,679 - 3,539,848UniSTSRGSC3.4
Celera203,422,784 - 3,422,946UniSTS
Celera203,626,888 - 3,627,057UniSTS
Celera202,974,135 - 2,974,304UniSTS
RH 3.4 Map2054.73UniSTS
Cytogenetic Map20p12UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_001008834   ⟹   NP_001008834
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,360,071 - 3,363,198 (-)NCBI
mRatBN7.2203,355,393 - 3,358,520 (-)NCBI
Celera203,623,868 - 3,626,821 (-)RGD
Sequence:
RefSeq Acc Id: XM_063279409   ⟹   XP_063135479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,356,390 - 3,363,303 (-)NCBI
RefSeq Acc Id: XM_063279410   ⟹   XP_063135480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,356,390 - 3,363,303 (-)NCBI
RefSeq Acc Id: XM_063279411   ⟹   XP_063135481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,356,390 - 3,363,303 (-)NCBI
RefSeq Acc Id: XM_063279412   ⟹   XP_063135482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,356,390 - 3,363,193 (-)NCBI
RefSeq Acc Id: XM_063279413   ⟹   XP_063135483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,356,390 - 3,385,052 (-)NCBI
RefSeq Acc Id: XM_063279414   ⟹   XP_063135484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,381,377 - 3,385,052 (-)NCBI
RefSeq Acc Id: XM_063279415   ⟹   XP_063135485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,356,390 - 3,363,245 (-)NCBI
RefSeq Acc Id: XM_063279416   ⟹   XP_063135486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,381,377 - 3,385,063 (-)NCBI
RefSeq Acc Id: XR_010060749
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,355,422 - 3,385,052 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001008834   ⟸   NM_001008834
- Peptide Label: precursor
- UniProtKB: Q6MG33 (UniProtKB/TrEMBL),   A0A2P1NRY1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_063135483   ⟸   XM_063279413
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063135480   ⟸   XM_063279410
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135481   ⟸   XM_063279411
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063135479   ⟸   XM_063279409
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063135485   ⟸   XM_063279415
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063135482   ⟸   XM_063279412
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063135486   ⟸   XM_063279416
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063135484   ⟸   XM_063279414
- Peptide Label: isoform X6
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K1E1-F1-model_v2 AlphaFold A0A0G2K1E1 1-382 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-4702 BioCyc
Ensembl Genes ENSRNOG00000038999 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078972 ENTREZGENE
  ENSRNOT00000078972.2 UniProtKB/TrEMBL
  ENSRNOT00000080900.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.30.500.10 UniProtKB/TrEMBL
InterPro Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
  MHC_I-like_Ag-recog UniProtKB/TrEMBL
  MHC_I-like_Ag-recog_sf UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/TrEMBL
  MHC_I_a_a1/a2 UniProtKB/TrEMBL
KEGG Report rno:414791 UniProtKB/TrEMBL
NCBI Gene 414791 ENTREZGENE
PANTHER CLASS IB MHC ANTIGEN QA-2-RELATED UniProtKB/TrEMBL
  MHC CLASS I-RELATED UniProtKB/TrEMBL
Pfam C1-set UniProtKB/TrEMBL
  MHC_I UniProtKB/TrEMBL
PhenoGen RT1-CE11 PhenoGen
PRINTS MHCCLASSI UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038999 RatGTEx
SMART IGc1 UniProtKB/TrEMBL
Superfamily-SCOP MHC_I/II-like_Ag-recog UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2K1E1_RAT UniProtKB/TrEMBL
  A0A2P1NRY1 ENTREZGENE, UniProtKB/TrEMBL
  Q6MG33 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 RT1-CE11  RT1 class I, locus CE11  LOC108353240  H-2 class I histocompatibility antigen, alpha chain-like  Data merged from RGD:11435455 737654 PROVISIONAL
2016-08-02 LOC108353240  H-2 class I histocompatibility antigen, alpha chain-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-09-15 RT1-CE11  RT1 class I, locus CE11  RT1-CE11  RT1 class I, CE11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RT1-CE11  RT1 class I, CE11      Symbol and Name updated 1559027 APPROVED
2005-07-29 RT1-CE11  RT1 class I, CE11      Symbol and Name status set to provisional 70820 PROVISIONAL