Map3k7cl (MAP3K7 C-terminal like) - Rat Genome Database

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Gene: Map3k7cl (MAP3K7 C-terminal like) Rattus norvegicus
Analyze
Symbol: Map3k7cl
Name: MAP3K7 C-terminal like
RGD ID: 1359474
Description: Orthologous to human MAP3K7CL (MAP3K7 C-terminal like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC304131; LOC304131; similar to C21ORF7; TAK1-like protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81140,276,839 - 40,321,848 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1140,277,688 - 40,321,847 (+)EnsemblGRCr8
mRatBN7.21126,791,044 - 26,835,605 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1126,791,316 - 26,835,602 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1135,489,376 - 35,533,749 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01128,189,634 - 28,234,011 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01127,378,551 - 27,422,901 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01127,208,177 - 27,251,802 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1127,208,564 - 27,251,801 (+)Ensemblrn6Rnor6.0
Rnor_5.01130,833,713 - 30,877,235 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41127,316,515 - 27,360,823 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1126,536,949 - 26,579,484 (+)NCBICelera
RGSC_v3.11127,316,514 - 27,360,820 (+)NCBI
Cytogenetic Map11q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:16780588  


Genomics

Comparative Map Data
Map3k7cl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81140,276,839 - 40,321,848 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1140,277,688 - 40,321,847 (+)EnsemblGRCr8
mRatBN7.21126,791,044 - 26,835,605 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1126,791,316 - 26,835,602 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1135,489,376 - 35,533,749 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01128,189,634 - 28,234,011 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01127,378,551 - 27,422,901 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01127,208,177 - 27,251,802 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1127,208,564 - 27,251,801 (+)Ensemblrn6Rnor6.0
Rnor_5.01130,833,713 - 30,877,235 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41127,316,515 - 27,360,823 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1126,536,949 - 26,579,484 (+)NCBICelera
RGSC_v3.11127,316,514 - 27,360,820 (+)NCBI
Cytogenetic Map11q11NCBI
MAP3K7CL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382129,077,114 - 29,175,887 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2129,077,060 - 29,175,889 (+)Ensemblhg38GRCh38
GRCh372130,449,435 - 30,548,208 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362129,374,744 - 29,470,075 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342129,374,743 - 29,470,071NCBI
Celera2115,636,331 - 15,731,645 (+)NCBICelera
Cytogenetic Map21q21.3NCBI
HuRef2115,859,086 - 15,957,030 (+)NCBIHuRef
CHM1_12130,015,215 - 30,110,541 (+)NCBICHM1_1
T2T-CHM13v2.02127,440,554 - 27,542,501 (+)NCBIT2T-CHM13v2.0
Map3k7cl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391687,350,208 - 87,392,224 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1687,350,218 - 87,392,224 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381687,553,330 - 87,595,336 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1687,553,330 - 87,595,336 (+)Ensemblmm10GRCm38
MGSCv371687,553,575 - 87,595,581 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361687,442,526 - 87,484,529 (+)NCBIMGSCv36mm8
Celera1687,747,742 - 87,789,444 (+)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1649.58NCBI
Map3k7cl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540728,460,177 - 28,534,923 (+)Ensembl
ChiLan1.0NW_00495540728,460,198 - 28,534,898 (+)NCBIChiLan1.0ChiLan1.0
MAP3K7CL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22225,268,469 - 25,363,781 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12120,126,882 - 20,221,565 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02115,507,556 - 15,612,695 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12128,899,594 - 29,001,155 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2128,907,911 - 29,001,155 (+)EnsemblpanPan2panpan1.1
MAP3K7CL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13124,087,840 - 24,168,357 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3124,132,629 - 24,167,494 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3124,068,568 - 24,160,904 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03124,189,045 - 24,281,429 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3124,237,898 - 24,280,563 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13124,139,470 - 24,231,857 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03124,141,107 - 24,233,902 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03124,612,441 - 24,704,994 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Map3k7cl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497124,576,984 - 24,616,569 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650012,852,002 - 12,890,839 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650012,851,254 - 12,890,839 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K7CL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13192,489,751 - 192,534,821 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113192,488,937 - 192,534,826 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213202,879,052 - 202,894,743 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K7CL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1263,047,557 - 63,092,118 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl263,047,562 - 63,091,829 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660715,632,779 - 5,677,184 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k7cl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474517,114,492 - 17,156,839 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Map3k7cl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1456,272,337 - 56,313,120 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Map3k7cl
421 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:73
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000002158
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11381815448818154Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)111080612555806125Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)113532319955805892Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)112995899657754989Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)112631803155806125Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 12 67 150 87 86 55 29 55 6 284 129 11 123 81 92 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000002158   ⟹   ENSRNOP00000002158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1140,277,717 - 40,321,847 (+)Ensembl
mRatBN7.2 Ensembl1126,791,338 - 26,835,597 (+)Ensembl
Rnor_6.0 Ensembl1127,208,564 - 27,251,794 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084580   ⟹   ENSRNOP00000075139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1140,277,688 - 40,321,847 (+)Ensembl
mRatBN7.2 Ensembl1126,791,316 - 26,835,602 (+)Ensembl
Rnor_6.0 Ensembl1127,210,593 - 27,251,801 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129178   ⟹   ENSRNOP00000108180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1140,281,659 - 40,321,847 (+)Ensembl
RefSeq Acc Id: NM_001013979   ⟹   NP_001014001
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81140,277,581 - 40,321,843 (+)NCBI
mRatBN7.21126,791,338 - 26,835,600 (+)NCBI
Rnor_6.01127,208,564 - 27,251,797 (+)NCBI
Rnor_5.01130,833,713 - 30,877,235 (+)NCBI
RGSC_v3.41127,316,515 - 27,360,823 (+)RGD
Celera1126,536,949 - 26,579,484 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248016   ⟹   XP_006248078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81140,276,839 - 40,321,848 (+)NCBI
mRatBN7.21126,791,166 - 26,835,605 (+)NCBI
Rnor_6.01127,208,177 - 27,251,802 (+)NCBI
Rnor_5.01130,833,713 - 30,877,235 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088440   ⟹   XP_038944368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81140,276,839 - 40,321,848 (+)NCBI
mRatBN7.21126,791,044 - 26,835,605 (+)NCBI
RefSeq Acc Id: NP_001014001   ⟸   NM_001013979
- UniProtKB: Q6DGF7 (UniProtKB/TrEMBL),   F7FAX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248078   ⟸   XM_006248016
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K9U9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075139   ⟸   ENSRNOT00000084580
Ensembl Acc Id: ENSRNOP00000002158   ⟸   ENSRNOT00000002158
RefSeq Acc Id: XP_038944368   ⟸   XM_039088440
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000108180   ⟸   ENSRNOT00000129178

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K9U9-F1-model_v2 AlphaFold A0A0G2K9U9 1-158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698025
Promoter ID:EPDNEW_R8549
Type:initiation region
Name:Map3k7cl_1
Description:MAP3K7 C-terminal like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01127,208,540 - 27,208,600EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359474 AgrOrtholog
BioCyc Gene G2FUF-22046 BioCyc
Ensembl Genes ENSRNOG00000001584 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002158 ENTREZGENE
  ENSRNOT00000002158.8 UniProtKB/TrEMBL
  ENSRNOT00000084580 ENTREZGENE
  ENSRNOT00000084580.3 UniProtKB/TrEMBL
  ENSRNOT00000129178.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110014 IMAGE-MGC_LOAD
InterPro Map3k7cl UniProtKB/TrEMBL
KEGG Report rno:304131 UniProtKB/TrEMBL
MGC_CLONE MGC:93801 IMAGE-MGC_LOAD
NCBI Gene 304131 ENTREZGENE
PANTHER MAP3K7 C-TERMINAL-LIKE PROTEIN UniProtKB/TrEMBL
  PTHR47140 UniProtKB/TrEMBL
PhenoGen Map3k7cl PhenoGen
RatGTEx ENSRNOG00000001584 RatGTEx
UniProt A0A0G2K9U9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LTI0_RAT UniProtKB/TrEMBL
  F7FAX9 ENTREZGENE, UniProtKB/TrEMBL
  Q6DGF7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-02-04 Map3k7cl  MAP3K7 C-terminal like  LOC304131  similar to C21ORF7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC304131  similar to C21ORF7      Symbol and Name status set to provisional 70820 PROVISIONAL