Mib2 (MIB E3 ubiquitin protein ligase 2) - Rat Genome Database

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Gene: Mib2 (MIB E3 ubiquitin protein ligase 2) Rattus norvegicus
Analyze
Symbol: Mib2
Name: MIB E3 ubiquitin protein ligase 2
RGD ID: 1359469
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction and protein ubiquitination. Predicted to be located in early endosome and plasma membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human MIB2 (MIB E3 ubiquitin protein ligase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dystrophin-like; E3 ubiquitin-protein ligase MIB2; LOC474147; mind bomb homolog 2; mindbomb E3 ubiquitin protein ligase 2; RBSC-skeletrophin; RBSC-skeletrophin/dystrophin-like polypeptide; RING-type E3 ubiquitin transferase MIB2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,526,037 - 171,542,479 (-)NCBIGRCr8
mRatBN7.25166,243,776 - 166,259,944 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,243,776 - 166,259,650 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5168,948,781 - 168,964,652 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,770,200 - 170,786,071 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,732,739 - 170,748,610 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,082,943 - 173,099,353 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,082,943 - 173,098,816 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,558,657 - 176,574,530 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,490,963 - 172,497,379 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15172,507,501 - 172,515,596 (-)NCBI
Celera5164,444,700 - 164,460,443 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12761501   PMID:15057822   PMID:15824097   PMID:19028597   PMID:27573246  


Genomics

Comparative Map Data
Mib2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,526,037 - 171,542,479 (-)NCBIGRCr8
mRatBN7.25166,243,776 - 166,259,944 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,243,776 - 166,259,650 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5168,948,781 - 168,964,652 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,770,200 - 170,786,071 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,732,739 - 170,748,610 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,082,943 - 173,099,353 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,082,943 - 173,098,816 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,558,657 - 176,574,530 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,490,963 - 172,497,379 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15172,507,501 - 172,515,596 (-)NCBI
Celera5164,444,700 - 164,460,443 (-)NCBICelera
Cytogenetic Map5q36NCBI
MIB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811,613,731 - 1,630,605 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11,615,454 - 1,630,605 (+)EnsemblGRCh38hg38GRCh38
GRCh3711,550,880 - 1,565,985 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611,540,747 - 1,555,848 (+)NCBINCBI36Build 36hg18NCBI36
Celera11,016,532 - 1,030,942 (-)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef1824,580 - 841,846 (+)NCBIHuRef
CHM1_111,537,413 - 1,553,030 (+)NCBICHM1_1
T2T-CHM13v2.011,048,236 - 1,065,110 (+)NCBIT2T-CHM13v2.0
Mib2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,738,925 - 155,753,711 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,739,134 - 155,753,655 (-)EnsemblGRCm39 Ensembl
GRCm384155,654,468 - 155,669,254 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,654,677 - 155,669,198 (-)EnsemblGRCm38mm10GRCm38
MGSCv374155,028,579 - 155,043,336 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364154,498,482 - 154,512,614 (-)NCBIMGSCv36mm8
Celera4157,929,347 - 157,944,090 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map486.86NCBI
Mib2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554869,271,099 - 9,285,682 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554869,273,580 - 9,285,682 (-)NCBIChiLan1.0ChiLan1.0
MIB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21226,586,500 - 226,604,001 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11225,242,442 - 225,261,089 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01379,326 - 395,041 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111,539,640 - 1,552,913 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11,539,634 - 1,557,517 (+)Ensemblpanpan1.1panPan2
MIB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,680,526 - 56,693,551 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl556,581,550 - 56,693,544 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha556,756,140 - 56,769,077 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0556,882,471 - 56,895,406 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,882,507 - 56,895,503 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,873,293 - 56,886,228 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0556,765,635 - 56,778,536 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,155,552 - 57,168,487 (+)NCBIUU_Cfam_GSD_1.0
Mib2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,819,341 - 27,832,454 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367371,633,495 - 1,646,598 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,787,201 - 63,800,423 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1663,787,200 - 63,800,425 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,216,225 - 58,229,985 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MIB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120129,878,014 - 129,893,239 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20129,877,142 - 129,884,894 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605434,333,028 - 34,349,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mib2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248188,077,851 - 8,099,547 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248188,078,677 - 8,091,448 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mib2
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:43
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000023696
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
RH141852  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,244,449 - 166,244,726 (+)MAPPERmRatBN7.2
Rnor_6.05173,083,617 - 173,083,893NCBIRnor6.0
Rnor_5.05176,559,331 - 176,559,607UniSTSRnor5.0
RGSC_v3.45172,491,636 - 172,491,912UniSTSRGSC3.4
Celera5164,445,374 - 164,445,650UniSTS
RH 3.4 Map51144.9UniSTS
Cytogenetic Map5q36UniSTS
Mib2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,248,695 - 166,250,175 (+)MAPPERmRatBN7.2
Rnor_6.05173,087,863 - 173,089,342NCBIRnor6.0
Rnor_5.05176,563,577 - 176,565,056UniSTSRnor5.0
RGSC_v3.45172,495,872 - 172,497,351UniSTSRGSC3.4
Celera5164,449,578 - 164,451,057UniSTS
Cytogenetic Map5q36UniSTS
Mib2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,243,997 - 166,244,730 (+)MAPPERmRatBN7.2
Rnor_6.05173,083,165 - 173,083,897NCBIRnor6.0
Rnor_5.05176,558,879 - 176,559,611UniSTSRnor5.0
RGSC_v3.45172,491,184 - 172,491,916UniSTSRGSC3.4
Celera5164,444,922 - 164,445,654UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 14 3 5 3 2 74 29 41 11
Low 3 8 43 38 14 38 8 9 6 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001005901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC105662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000023696   ⟹   ENSRNOP00000023696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5166,243,776 - 166,259,650 (-)Ensembl
Rnor_6.0 Ensembl5173,082,943 - 173,098,816 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100849   ⟹   ENSRNOP00000082241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5166,243,776 - 166,259,650 (-)Ensembl
RefSeq Acc Id: NM_001005901   ⟹   NP_001005901
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,037 - 171,541,910 (-)NCBI
mRatBN7.25166,243,776 - 166,259,650 (-)NCBI
Rnor_6.05173,082,943 - 173,098,816 (-)NCBI
Rnor_5.05176,558,657 - 176,574,530 (-)NCBI
Celera5164,444,700 - 164,460,443 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006239594   ⟹   XP_006239656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,541,823 (-)NCBI
mRatBN7.25166,243,776 - 166,259,885 (-)NCBI
Rnor_6.05173,082,944 - 173,099,353 (-)NCBI
Rnor_5.05176,558,657 - 176,574,530 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593553   ⟹   XP_017449042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,542,479 (-)NCBI
mRatBN7.25166,243,776 - 166,259,892 (-)NCBI
Rnor_6.05173,082,944 - 173,099,353 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593554   ⟹   XP_017449043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,542,479 (-)NCBI
mRatBN7.25166,243,776 - 166,259,944 (-)NCBI
Rnor_6.05173,082,944 - 173,099,353 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593555   ⟹   XP_017449044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,541,823 (-)NCBI
mRatBN7.25166,243,776 - 166,259,620 (-)NCBI
Rnor_6.05173,082,944 - 173,098,545 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593558   ⟹   XP_017449047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,532,488 (-)NCBI
mRatBN7.25166,243,776 - 166,259,619 (-)NCBI
Rnor_6.05173,082,944 - 173,098,545 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063288160   ⟹   XP_063144230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,532,488 (-)NCBI
RefSeq Acc Id: XM_063288161   ⟹   XP_063144231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,541,881 (-)NCBI
RefSeq Acc Id: XM_063288162   ⟹   XP_063144232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,532,488 (-)NCBI
RefSeq Acc Id: XM_063288163   ⟹   XP_063144233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,532,488 (-)NCBI
RefSeq Acc Id: XM_063288165   ⟹   XP_063144235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,541,823 (-)NCBI
RefSeq Acc Id: XM_063288166   ⟹   XP_063144236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,541,823 (-)NCBI
RefSeq Acc Id: NP_001005901   ⟸   NM_001005901
- UniProtKB: A0A140TAC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239656   ⟸   XM_006239594
- Peptide Label: isoform X7
- UniProtKB: A0A140TAC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449043   ⟸   XM_017593554
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZTL8 (UniProtKB/TrEMBL),   A0A140TAC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449042   ⟸   XM_017593553
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZTL8 (UniProtKB/TrEMBL),   A0A140TAC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449044   ⟸   XM_017593555
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZTL8 (UniProtKB/TrEMBL),   A0A140TAC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449047   ⟸   XM_017593558
- Peptide Label: isoform X2
- UniProtKB: A0A140TAC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023696   ⟸   ENSRNOT00000023696
RefSeq Acc Id: ENSRNOP00000082241   ⟸   ENSRNOT00000100849
RefSeq Acc Id: XP_063144231   ⟸   XM_063288161
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063144236   ⟸   XM_063288166
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063144235   ⟸   XM_063288165
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063144233   ⟸   XM_063288163
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063144232   ⟸   XM_063288162
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063144230   ⟸   XM_063288160
- Peptide Label: isoform X1
Protein Domains
MIB/HERC2   RING-type   ZZ-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q68LP1-F1-model_v2 AlphaFold Q68LP1 1-971 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694324
Promoter ID:EPDNEW_R4849
Type:multiple initiation site
Name:Mib2_1
Description:mindbomb E3 ubiquitin protein ligase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05173,098,759 - 173,098,819EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359469 AgrOrtholog
BioCyc Gene G2FUF-38914 BioCyc
Ensembl Genes ENSRNOG00000017564 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023696.8 UniProtKB/TrEMBL
  ENSRNOT00000100849.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIB1/2_ZZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mib_Herc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mib_Herc2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_ZZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_ZZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 474147 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE MIB2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIB_HERC2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00569 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mib2 PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIB_HERC2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_ZZ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_ZZ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017564 RatGTEx
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_ZZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF159034 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TAC8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZTL8 ENTREZGENE, UniProtKB/TrEMBL
  A6IUR4_RAT UniProtKB/TrEMBL
  MIB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-11-12 Mib2  MIB E3 ubiquitin protein ligase 2  Mib2  mindbomb E3 ubiquitin protein ligase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-09-18 Mib2  mindbomb E3 ubiquitin protein ligase 2  LOC474147  RBSC-skeletrophin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC474147  RBSC-skeletrophin      Symbol and Name status set to provisional 70820 PROVISIONAL