Mib2 (MIB E3 ubiquitin protein ligase 2) - Rat Genome Database

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Gene: Mib2 (MIB E3 ubiquitin protein ligase 2) Rattus norvegicus
Analyze
Symbol: Mib2
Name: MIB E3 ubiquitin protein ligase 2
RGD ID: 1359469
Description: Predicted to enable ubiquitin protein ligase activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization and regulation protein catabolic process at postsynapse. Is active in glutamatergic synapse and postsynapse. Orthologous to human MIB2 (MIB E3 ubiquitin protein ligase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dystrophin-like; E3 ubiquitin-protein ligase MIB2; LOC474147; mind bomb homolog 2; mindbomb E3 ubiquitin protein ligase 2; RBSC-skeletrophin; RBSC-skeletrophin/dystrophin-like polypeptide; RING-type E3 ubiquitin transferase MIB2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,526,037 - 171,542,479 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5171,526,037 - 171,541,910 (-)EnsemblGRCr8
mRatBN7.25166,243,776 - 166,259,944 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,243,776 - 166,259,650 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5168,948,781 - 168,964,652 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,770,200 - 170,786,071 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,732,739 - 170,748,610 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,082,943 - 173,099,353 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,082,943 - 173,098,816 (-)Ensemblrn6Rnor6.0
Rnor_5.05176,558,657 - 176,574,530 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45172,490,963 - 172,497,379 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5164,444,700 - 164,460,443 (-)NCBICelera
RGSC_v3.15172,507,501 - 172,515,596 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diquat  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzalutamide  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner. Jurd R, etal., J Biol Chem. 2008 Jan 4;283(1):301-310. doi: 10.1074/jbc.M705580200. Epub 2007 Oct 25.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12761501   PMID:15057822   PMID:15824097   PMID:19028597   PMID:27573246  


Genomics

Comparative Map Data
Mib2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,526,037 - 171,542,479 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5171,526,037 - 171,541,910 (-)EnsemblGRCr8
mRatBN7.25166,243,776 - 166,259,944 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,243,776 - 166,259,650 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5168,948,781 - 168,964,652 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,770,200 - 170,786,071 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,732,739 - 170,748,610 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,082,943 - 173,099,353 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,082,943 - 173,098,816 (-)Ensemblrn6Rnor6.0
Rnor_5.05176,558,657 - 176,574,530 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45172,490,963 - 172,497,379 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5164,444,700 - 164,460,443 (-)NCBICelera
RGSC_v3.15172,507,501 - 172,515,596 (-)NCBI
Cytogenetic Map5q36NCBI
MIB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811,613,731 - 1,630,605 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11,615,434 - 1,630,610 (+)Ensemblhg38GRCh38
GRCh3711,550,880 - 1,565,985 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611,540,747 - 1,555,848 (+)NCBIBuild 36Build 36hg18NCBI36
Celera11,016,532 - 1,030,942 (-)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef1824,580 - 841,846 (+)NCBIHuRef
CHM1_111,537,413 - 1,553,030 (+)NCBICHM1_1
T2T-CHM13v2.011,048,236 - 1,065,110 (+)NCBIT2T-CHM13v2.0
Mib2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,738,925 - 155,753,711 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,739,134 - 155,753,655 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384155,654,468 - 155,669,254 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,654,677 - 155,669,198 (-)Ensemblmm10GRCm38
MGSCv374155,028,579 - 155,043,336 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364154,498,482 - 154,512,614 (-)NCBIMGSCv36mm8
Celera4157,929,347 - 157,944,090 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map486.86NCBI
Mib2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554869,271,099 - 9,285,682 (-)Ensembl
ChiLan1.0NW_0049554869,273,580 - 9,285,682 (-)NCBIChiLan1.0ChiLan1.0
MIB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21226,586,500 - 226,604,001 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11225,242,442 - 225,261,089 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01379,326 - 395,041 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111,539,640 - 1,552,913 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11,539,634 - 1,557,517 (+)EnsemblpanPan2panpan1.1
MIB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,680,526 - 56,693,551 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl556,581,550 - 56,693,544 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha556,756,140 - 56,769,077 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0556,882,471 - 56,895,406 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,882,507 - 56,895,503 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,873,293 - 56,886,228 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0556,765,635 - 56,778,536 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,155,552 - 57,168,487 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mib2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,819,341 - 27,832,454 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367371,633,495 - 1,646,598 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,787,201 - 63,800,423 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1663,787,200 - 63,800,425 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,216,225 - 58,229,985 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MIB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120129,878,014 - 129,893,239 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20129,877,142 - 129,884,894 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605434,333,028 - 34,349,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mib2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248188,077,851 - 8,099,547 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248188,078,677 - 8,091,448 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mib2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v115,026,270 - 5,041,873 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:43
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000023696
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat

Markers in Region
RH141852  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85171,526,710 - 171,526,987 (+)Marker Load Pipeline
mRatBN7.25166,244,449 - 166,244,726 (+)MAPPERmRatBN7.2
Rnor_6.05173,083,617 - 173,083,893NCBIRnor6.0
Rnor_5.05176,559,331 - 176,559,607UniSTSRnor5.0
RGSC_v3.45172,491,636 - 172,491,912UniSTSRGSC3.4
Celera5164,445,374 - 164,445,650UniSTS
RH 3.4 Map51144.9UniSTS
Cytogenetic Map5q36UniSTS
Mib2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,248,695 - 166,250,175 (+)MAPPERmRatBN7.2
Rnor_6.05173,087,863 - 173,089,342NCBIRnor6.0
Rnor_5.05176,563,577 - 176,565,056UniSTSRnor5.0
RGSC_v3.45172,495,872 - 172,497,351UniSTSRGSC3.4
Celera5164,449,578 - 164,451,057UniSTS
Cytogenetic Map5q36UniSTS
Mib2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,243,997 - 166,244,730 (+)MAPPERmRatBN7.2
Rnor_6.05173,083,165 - 173,083,897NCBIRnor6.0
Rnor_5.05176,558,879 - 176,559,611UniSTSRnor5.0
RGSC_v3.45172,491,184 - 172,491,916UniSTSRGSC3.4
Celera5164,444,922 - 164,445,654UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001005901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC105662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023696   ⟹   ENSRNOP00000023696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5171,526,037 - 171,541,910 (-)Ensembl
mRatBN7.2 Ensembl5166,243,776 - 166,259,650 (-)Ensembl
Rnor_6.0 Ensembl5173,082,943 - 173,098,816 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100849   ⟹   ENSRNOP00000082241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5171,526,037 - 171,541,910 (-)Ensembl
mRatBN7.2 Ensembl5166,243,776 - 166,259,650 (-)Ensembl
RefSeq Acc Id: NM_001005901   ⟹   NP_001005901
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,037 - 171,541,910 (-)NCBI
mRatBN7.25166,243,776 - 166,259,650 (-)NCBI
Rnor_6.05173,082,943 - 173,098,816 (-)NCBI
Rnor_5.05176,558,657 - 176,574,530 (-)NCBI
Celera5164,444,700 - 164,460,443 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006239594   ⟹   XP_006239656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,541,823 (-)NCBI
mRatBN7.25166,243,776 - 166,259,885 (-)NCBI
Rnor_6.05173,082,944 - 173,099,353 (-)NCBI
Rnor_5.05176,558,657 - 176,574,530 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593553   ⟹   XP_017449042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,542,479 (-)NCBI
mRatBN7.25166,243,776 - 166,259,892 (-)NCBI
Rnor_6.05173,082,944 - 173,099,353 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593554   ⟹   XP_017449043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,542,479 (-)NCBI
mRatBN7.25166,243,776 - 166,259,944 (-)NCBI
Rnor_6.05173,082,944 - 173,099,353 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593555   ⟹   XP_017449044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,541,823 (-)NCBI
mRatBN7.25166,243,776 - 166,259,620 (-)NCBI
Rnor_6.05173,082,944 - 173,098,545 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593558   ⟹   XP_017449047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,532,488 (-)NCBI
mRatBN7.25166,243,776 - 166,259,619 (-)NCBI
Rnor_6.05173,082,944 - 173,098,545 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063288160   ⟹   XP_063144230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,532,488 (-)NCBI
RefSeq Acc Id: XM_063288161   ⟹   XP_063144231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,541,881 (-)NCBI
RefSeq Acc Id: XM_063288162   ⟹   XP_063144232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,532,488 (-)NCBI
RefSeq Acc Id: XM_063288163   ⟹   XP_063144233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,532,488 (-)NCBI
RefSeq Acc Id: XM_063288165   ⟹   XP_063144235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,541,823 (-)NCBI
RefSeq Acc Id: XM_063288166   ⟹   XP_063144236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,526,038 - 171,541,823 (-)NCBI
RefSeq Acc Id: NP_001005901   ⟸   NM_001005901
- UniProtKB: A0A140TAC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239656   ⟸   XM_006239594
- Peptide Label: isoform X7
- UniProtKB: A0A140TAC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449043   ⟸   XM_017593554
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZTL8 (UniProtKB/TrEMBL),   A0A140TAC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449042   ⟸   XM_017593553
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZTL8 (UniProtKB/TrEMBL),   A0A140TAC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449044   ⟸   XM_017593555
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZTL8 (UniProtKB/TrEMBL),   A0A140TAC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449047   ⟸   XM_017593558
- Peptide Label: isoform X2
- UniProtKB: A0A140TAC8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023696   ⟸   ENSRNOT00000023696
Ensembl Acc Id: ENSRNOP00000082241   ⟸   ENSRNOT00000100849
RefSeq Acc Id: XP_063144231   ⟸   XM_063288161
- Peptide Label: isoform X3
- UniProtKB: A0A140TAC8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144236   ⟸   XM_063288166
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZTL8 (UniProtKB/TrEMBL),   A0A140TAC8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144235   ⟸   XM_063288165
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZTL8 (UniProtKB/TrEMBL),   A0A140TAC8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144233   ⟸   XM_063288163
- Peptide Label: isoform X5
- UniProtKB: A6IUR4 (UniProtKB/TrEMBL),   A0A140TAC8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144232   ⟸   XM_063288162
- Peptide Label: isoform X4
- UniProtKB: A0A140TAC8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144230   ⟸   XM_063288160
- Peptide Label: isoform X1
- UniProtKB: A0A140TAC8 (UniProtKB/TrEMBL)
Protein Domains
MIB/HERC2   RING-type   ZZ-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q68LP1-F1-model_v2 AlphaFold Q68LP1 1-971 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694324
Promoter ID:EPDNEW_R4849
Type:multiple initiation site
Name:Mib2_1
Description:mindbomb E3 ubiquitin protein ligase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05173,098,759 - 173,098,819EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359469 AgrOrtholog
BioCyc Gene G2FUF-38914 BioCyc
Ensembl Genes ENSRNOG00000017564 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023696 ENTREZGENE
  ENSRNOT00000100849 ENTREZGENE
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/Swiss-Prot
  3.30.60.90 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  MIB1/2_ZZ UniProtKB/Swiss-Prot
  Mib_Herc2 UniProtKB/Swiss-Prot
  Mib_Herc2_sf UniProtKB/Swiss-Prot
  SH3_15 UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_ZZ UniProtKB/Swiss-Prot
  Znf_ZZ_sf UniProtKB/Swiss-Prot
NCBI Gene 474147 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE MIB2 UniProtKB/Swiss-Prot
  E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED UniProtKB/Swiss-Prot
Pfam Ank UniProtKB/Swiss-Prot
  Ank_2 UniProtKB/Swiss-Prot
  Ank_5 UniProtKB/Swiss-Prot
  MIB_HERC2 UniProtKB/Swiss-Prot
  PF00569 UniProtKB/Swiss-Prot
  SH3_15 UniProtKB/Swiss-Prot
  zf-C3HC4_3 UniProtKB/Swiss-Prot
PhenoGen Mib2 PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  MIB_HERC2 UniProtKB/Swiss-Prot
  ZF_RING_2 UniProtKB/Swiss-Prot
  ZF_ZZ_1 UniProtKB/Swiss-Prot
  ZF_ZZ_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017564 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
  RING UniProtKB/Swiss-Prot
  ZnF_ZZ UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
  SSF159034 UniProtKB/Swiss-Prot
  SSF48403 UniProtKB/Swiss-Prot
UniProt A0A140TAC8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZTL8 ENTREZGENE, UniProtKB/TrEMBL
  A6IUR4 ENTREZGENE, UniProtKB/TrEMBL
  MIB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-11-12 Mib2  MIB E3 ubiquitin protein ligase 2  Mib2  mindbomb E3 ubiquitin protein ligase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-09-18 Mib2  mindbomb E3 ubiquitin protein ligase 2  LOC474147  RBSC-skeletrophin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC474147  RBSC-skeletrophin      Symbol and Name status set to provisional 70820 PROVISIONAL