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Gene: Tmed5 (transmembrane p24 trafficking protein 5) Rattus norvegicus

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Symbol:

Tmed5

Name:

transmembrane p24 trafficking protein 5

RGD ID:

1359437

Description:

Predicted to be involved in Golgi ribbon formation; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in cis-Golgi network and endoplasmic reticulum exit site. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human TMED5 (transmembrane p24 trafficking protein 5); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

CGI-100-like; LRRG00120; MGC95001; p24 family protein gamma-2; p24gamma2; similar to CGI-100-like protein; transmembrane emp24 domain-containing protein 5; transmembrane emp24 protein transport domain containing 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMED5 (transmembrane p24 trafficking protein 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Tmed5 (transmembrane p24 trafficking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmed5 (transmembrane p24 trafficking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMED5 (transmembrane p24 trafficking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMED5 (transmembrane p24 trafficking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmed5 (transmembrane p24 trafficking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMED5 (transmembrane p24 trafficking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMED5 (transmembrane p24 trafficking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmed5 (transmembrane p24 trafficking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tmed5 (transmembrane p24 trafficking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TMED5 (transmembrane p24 trafficking protein 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tmed5 (transmembrane p24 trafficking protein 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmed5 (transmembrane p24 trafficking protein 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ERP2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	ERP2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG31787	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	K08E4.6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	opm	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ERP3	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ERP4	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	ERP4	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tmed5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	1,752,857 - 1,763,990 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	1,752,745 - 1,773,389 (+)	Ensembl				GRCr8
mRatBN7.2	14	1,607,895 - 1,619,028 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	1,607,819 - 1,628,426 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	1,486,848 - 1,497,987 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	2,788,621 - 2,799,760 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	1,485,296 - 1,496,437 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	2,613,318 - 2,624,773 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	2,613,406 - 2,633,950 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	2,612,362 - 2,623,817 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	2,155,594 - 2,167,280 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	1,628,691 - 1,639,884 (+)	NCBI		Celera
RGSC_v3.1	14	2,155,593 - 2,167,271 (+)	NCBI
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

4-phenylbutyric acid (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (EXP)

amitrole (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (EXP)

carbon nanotube (ISO)

carnosic acid (ISO)

chloropicrin (ISO)

chloroprene (EXP)

chlorpyrifos (ISO)

chromium(6+) (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

clofibrate (ISO)

clorgyline (ISO)

cocaine (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dichloroacetic acid (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

entinostat (ISO)

folic acid (ISO)

formaldehyde (ISO)

isotretinoin (ISO)

ivermectin (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methimazole (EXP)

methoxyacetic acid (EXP)

methylmercury chloride (EXP,ISO)

miconazole (ISO)

mono(2-ethylhexyl) phthalate (ISO)

monobenzyl phthalate (ISO)

Monobutylphthalate (EXP,ISO)

monoethyl phthalate (ISO)

oxaliplatin (EXP)

panobinostat (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

tetrachloroethene (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (ISO)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

xylitol (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endoplasmic reticulum to Golgi vesicle-mediated transport (IBA)

Golgi ribbon formation (IBA,ISO,ISS)

intracellular protein transport (IBA)

protein transport (IEA)

Cellular Component

cis-Golgi network (ISO,ISS)

COPII-coated ER to Golgi transport vesicle (IBA)

endoplasmic reticulum (IBA)

endoplasmic reticulum exit site (ISO,ISS)

endoplasmic reticulum membrane (IEA)

endoplasmic reticulum-Golgi intermediate compartment (IBA,ISO,ISS)

endoplasmic reticulum-Golgi intermediate compartment membrane (IEA)

Golgi apparatus (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15308636	PMID:15489334	PMID:19948005

Genomics

Comparative Map Data

Tmed5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	1,752,857 - 1,763,990 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	1,752,745 - 1,773,389 (+)	Ensembl				GRCr8
mRatBN7.2	14	1,607,895 - 1,619,028 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	1,607,819 - 1,628,426 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	1,486,848 - 1,497,987 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	2,788,621 - 2,799,760 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	1,485,296 - 1,496,437 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	2,613,318 - 2,624,773 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	2,613,406 - 2,633,950 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	2,612,362 - 2,623,817 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	2,155,594 - 2,167,280 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	1,628,691 - 1,639,884 (+)	NCBI		Celera
RGSC_v3.1	14	2,155,593 - 2,167,271 (+)	NCBI
Cytogenetic Map	14	p22	NCBI

TMED5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	93,149,742 - 93,180,413 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	93,149,742 - 93,180,516 (-)	Ensembl			hg38	GRCh38
GRCh37	1	93,615,299 - 93,645,970 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	93,389,999 - 93,418,834 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	93,329,427 - 93,358,267	NCBI
Celera	1	91,869,455 - 91,900,413 (-)	NCBI		Celera
Cytogenetic Map	1	p22.1	NCBI
HuRef	1	91,736,849 - 91,767,806 (-)	NCBI		HuRef
CHM1_1	1	93,730,202 - 93,761,150 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	92,995,327 - 93,026,003 (-)	NCBI		T2T-CHM13v2.0

Tmed5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	108,269,422 - 108,280,486 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	108,254,232 - 108,280,486 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	108,121,556 - 108,132,620 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	108,106,366 - 108,132,620 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	108,550,666 - 108,561,610 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	108,361,949 - 108,372,893 (-)	NCBI		MGSCv36	mm8
Celera	5	105,239,859 - 105,250,741 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	52.49	NCBI

Tmed5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	1,436,628 - 1,456,970 (+)	Ensembl
ChiLan1.0	NW_004955423	1,436,628 - 1,456,970 (+)	NCBI	ChiLan1.0	ChiLan1.0

TMED5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	133,835,694 - 133,864,516 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	132,990,585 - 133,019,411 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	95,821,324 - 95,850,099 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	94,552,590 - 94,582,875 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	94,552,590 - 94,582,875 (-)	Ensembl			panPan2	panpan1.1

TMED5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	55,917,842 - 55,934,880 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	55,918,077 - 55,932,169 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	58,618,896 - 58,635,690 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	56,293,071 - 56,309,877 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	56,291,987 - 56,309,868 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	55,973,295 - 55,990,051 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	55,951,620 - 55,968,403 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	56,410,717 - 56,427,517 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tmed5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	102,889,539 - 102,909,871 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936537	6,038,207 - 6,058,437 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936537	6,038,109 - 6,058,434 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMED5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	124,009,816 - 124,030,773 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	124,009,825 - 124,027,445 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	135,564,674 - 135,581,598 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMED5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	40,074,505 - 40,102,773 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	40,074,545 - 40,099,963 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	77,924,333 - 77,952,991 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmed5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	4,508,777 - 4,535,416 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624742	4,508,988 - 4,558,909 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tmed5
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	17,922,444 - 17,941,550 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tmed5
117 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	324
Count of miRNA genes:	204
Interacting mature miRNAs:	232
Transcripts:	ENSRNOT00000000083
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9589814	Gluco67	Glucose level QTL 67	4.54	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	40068101	Rat
7411573	Bw139	Body weight QTL 139	4.7	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	14	1	40068101	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41415516	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	11334906	Rat
71117	Niddm17	Non-insulin dependent diabetes mellitus QTL 17	2.35		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	17877928	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1	31893212	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	355	192	11	144	80	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007619	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY539871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079452	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000083 ⟹ ENSRNOP00000000083

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	1,752,745 - 1,773,389 (+)	Ensembl
mRatBN7.2 Ensembl	14	1,607,819 - 1,628,426 (+)	Ensembl
Rnor_6.0 Ensembl	14	2,613,406 - 2,633,950 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119350 ⟹ ENSRNOP00000084338

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	1,607,819 - 1,620,873 (+)	Ensembl

RefSeq Acc Id:

NM_001007619 ⟹ NP_001007620

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	1,752,857 - 1,763,990 (+)	NCBI
mRatBN7.2	14	1,607,895 - 1,619,028 (+)	NCBI
Rnor_6.0	14	2,613,318 - 2,624,773 (+)	NCBI
Rnor_5.0	14	2,612,362 - 2,623,817 (+)	NCBI
RGSC_v3.4	14	2,155,594 - 2,167,280 (+)	RGD
Celera	14	1,628,691 - 1,639,884 (+)	RGD

Sequence:

show sequence

CTCGGATCGGGATTTCACAGCGGAGGCGCCGGCATCCCGCACCTCCCTATACACGTCCAGTGTG
AAATCGACAGGGATGGGCGTCAGGATGTGGTTGCCATTCCCCATGCTGCTCCTGTCCGCTCTGC
CCGCAACGTTGCTGAGCGGGGCGGCCGGCTTCACACCCTCTTTGGATAGTGACTTCACCTTCAC
GCTGCCCGCCGGCCAGAAGGAGTGCTTCTACCAGCCCATGCCCCTGAAGGCGTCGTTGGAGATC
GAGTACCAAGTTTTAGATGGAGGAGAATTAGATATTGATTTCCACCTTGCCTCTCCAGAGGGCA
GAACCTTAGTTTTTGAACAAAGAAAATCAGATGGCGTTCATACTGTAGAGACTGAAGATGGCGA
CTACATGTTCTGCTTTGACAACACATTCAGCACCATCTCTGAGAAGGTCATTTTCTTTGAGTTG
ATCCTGGATAACATGGGAGAAGAAGTTGAAGGACAAGAAGACTGGAAAAAGTATATTACTAACA
CAGATGTTCTGGAGATGAAACTAGAAGACATCCTGGAATCCATCAACAGCATCAAGTCCAGACT
AAGCAAAAGTGGCCACATACAGACTCTGCTTAGAGCATTTGAAGCTCGTGATCGAAACATACAA
GAAAGCAACTTTGATAGAGTCAATTTCTGGTCTGTGGTGAACTTGATGGTCATGGTGGTGGTGT
CAGCTATTCAAGTTTATACACTGAAAAGTCTATTTGAAGATAAGAGGAAAAGTAGAACTTGAAA
CTCCAGCACAGATTACTTAATGTTGAAAAAAAGAGGTAGAAAATTCTAATACACTGTCACAGTC
AAAAGATAGTCATATTTCCCATAACATTTTCAGAAATGTATGTAAGTGTAAGATATGTAAATTT
TAATATGAAAGGAAAATCATCACTTTATGTCCAGATAACTTTATTGACCCAGTTATACTTAAAA
ATAAAACAAGATGTCATATACAATTTATATTTAATTGAATGAAGCCATATTAACTATTTTCCTA
AGGTTAAAAATCTTTCCTAGATATCACATATGAATGAAATGAAATAACAATGTTCATAAACATG
CCACCAGTTTGCTTTTACCTAGAATTTTCTCTGTACATGTGGCAGCTACAAATTAATTAATTAA
AGAAGTTTCCTATACATTACATTATAAATCACTTGAGAATTATATAATCATGGACTGGATAGAT
CAGCTTTTCTCTACCAAATCTCTCCATAAAAATAGAAGCATACCACTGAAAAAATATTTCCAAT
ATTTTTACAACCAAATATAATGTGAAATATCCACTAGTATTATTTTATATACTTATCTATATTT
CCAAAAGCTAACATTTTTATAATTAAAACCGGAAAGGCATTCTTTCCTCATAAAATTTAGGCTA
GGCTGCGTCTTTGTCTTTGATAATAAGATATATAAAGGGTGGTTGATGTTTGTGAATAAGATGC
ATTCTGTCTAGACATTAGCTGGGATTAGGGATAAGATGAATTTATTTTTATATTACGCATCAAC
AGTGTTATGCTGGCTTCTGCACAGCTGTTGGTCTTGGCAATGCATTCTCACAAGCAGGTGTGAG
GGACGGACATACTACTGAAGAGATGTGATGTGAGTGTAAATAGACAGCTCCTTTCTAAAGTCTC
AGTCATGAGAAACACGAACAACAAGTTTACCTAAGAGAAGTGTAATATCTGGAATCAGAAGGGC
TCTTCTTAGGGGCTGGGGATTTAGCTCAGTGGTAGAGCCCTTACCTAGGAAGCACAAGGCCCTG
GGTTCGGTCCCCAGCTCCGAAAAAAAAA

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Protein Sequences


Protein RefSeqs	NP_001007620	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79452	(Get FASTA)	NCBI Sequence Viewer
	AAS66211	(Get FASTA)	NCBI Sequence Viewer
	EDL83997	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000084338.1
GenBank Protein	Q6AXN3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001007620 ⟸ NM_001007619
- Peptide Label:	precursor
- UniProtKB:	Q6AXN3 (UniProtKB/Swiss-Prot), A6KPG8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGVRMWLPFPMLLLSALPATLLSGAAGFTPSLDSDFTFTLPAGQKECFYQPMPLKASLEIEYQV LDGGELDIDFHLASPEGRTLVFEQRKSDGVHTVETEDGDYMFCFDNTFSTISEKVIFFELILDN MGEEVEGQEDWKKYITNTDVLEMKLEDILESINSIKSRLSKSGHIQTLLRAFEARDRNIQESNF DRVNFWSVVNLMVMVVVSAIQVYTLKSLFEDKRKSRT hide sequence

Ensembl Acc Id:

ENSRNOP00000000083 ⟸ ENSRNOT00000000083

Ensembl Acc Id:

ENSRNOP00000084338 ⟸ ENSRNOT00000119350

Protein Domains

GOLD

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AXN3-F1-model_v2	AlphaFold	Q6AXN3	1-229	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359437	AgrOrtholog
BioCyc Gene	G2FUF-16653	BioCyc
Ensembl Genes	ENSRNOG00000000073	Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000119350.1	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7121068	IMAGE-MGC_LOAD
InterPro	GOLD_dom	UniProtKB/Swiss-Prot
	GOLD_dom_sf	UniProtKB/Swiss-Prot
	TMP21-related	UniProtKB/Swiss-Prot
KEGG Report	rno:289883	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:95001	IMAGE-MGC_LOAD
NCBI Gene	289883	ENTREZGENE
PANTHER	PTHR22811	UniProtKB/Swiss-Prot
Pfam	EMP24_GP25L	UniProtKB/Swiss-Prot
PhenoGen	Tmed5	PhenoGen
PROSITE	GOLD	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000000073	RatGTEx
SMART	EMP24_GP25L	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF101576	UniProtKB/Swiss-Prot
UniProt	A0A0H2UH88_RAT	UniProtKB/TrEMBL
	A6KPG8	ENTREZGENE, UniProtKB/TrEMBL
	Q6AXN3	ENTREZGENE
	Q6QI88_RAT	UniProtKB/TrEMBL
	TMED5_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-08-19	Tmed5	transmembrane p24 trafficking protein 5	Tmed5	transmembrane emp24 protein transport domain containing 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Tmed5	transmembrane emp24 protein transport domain containing 5	MGC95001	similar to CGI-100-like protein	Symbol and Name updated	1299863	APPROVED
2005-07-29	MGC95001	similar to CGI-100-like protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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