Rnase2 (ribonuclease A family member 2) - Rat Genome Database

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Gene: Rnase2 (ribonuclease A family member 2) Rattus norvegicus
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Symbol: Rnase2
Name: ribonuclease A family member 2
RGD ID: 1359432
Description: Predicted to enable RNA nuclease activity. Predicted to be involved in chemotaxis; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be active in extracellular space. Orthologous to human RNASE2 (ribonuclease A family member 2); INTERACTS WITH acrylamide; ammonium chloride; amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ear4; eosinophil-associated, ribonuclease A family, member 4; LOC474169; pre-eosinophil-associated ribonuclease-2; R14; R15; R5; Raf1; ribonuclease 14; ribonuclease 15; ribonuclease 5; ribonuclease A f1; ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RGD Orthologs
Human
Mouse
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,923,125 - 26,923,934 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1526,923,134 - 26,923,955 (-)EnsemblGRCr8
mRatBN7.21524,449,618 - 24,450,427 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,449,611 - 24,450,479 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1527,220,768 - 27,221,577 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,182,202 - 28,183,011 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,429,330 - 26,430,139 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,154,482 - 28,155,291 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,154,482 - 28,155,291 (-)Ensemblrn6Rnor6.0
Rnor_5.01531,984,003 - 31,984,812 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41527,209,877 - 27,210,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1524,766,498 - 24,767,307 (-)NCBICelera
RGSC_v3.11527,225,576 - 27,226,386 (-)NCBI
Cytogenetic Map15p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Preparation of recombinant rat eosinophil-associated ribonuclease-1 and -2 and analysis of their biological activities. Ishihara K, etal., Biochim Biophys Acta 2003 Jul 14;1638(2):164-72.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9758888   PMID:9826755   PMID:10594173   PMID:11490157   PMID:12855582   PMID:15676279   PMID:23376485   PMID:23533145   PMID:23992292   PMID:24270810   PMID:24337645  


Genomics

Comparative Map Data
Rnase2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,923,125 - 26,923,934 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1526,923,134 - 26,923,955 (-)EnsemblGRCr8
mRatBN7.21524,449,618 - 24,450,427 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,449,611 - 24,450,479 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1527,220,768 - 27,221,577 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,182,202 - 28,183,011 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,429,330 - 26,430,139 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,154,482 - 28,155,291 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,154,482 - 28,155,291 (-)Ensemblrn6Rnor6.0
Rnor_5.01531,984,003 - 31,984,812 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41527,209,877 - 27,210,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1524,766,498 - 24,767,307 (-)NCBICelera
RGSC_v3.11527,225,576 - 27,226,386 (-)NCBI
Cytogenetic Map15p14NCBI
RNASE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,955,487 - 20,956,436 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,955,487 - 20,956,436 (+)Ensemblhg38GRCh38
GRCh371421,423,646 - 21,424,595 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,493,470 - 20,494,434 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341420,493,469 - 20,494,434NCBI
Celera141,284,485 - 1,285,449 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,544,743 - 1,545,707 (+)NCBIHuRef
CHM1_11421,425,751 - 21,426,715 (+)NCBICHM1_1
T2T-CHM13v2.01415,152,872 - 15,153,821 (+)NCBIT2T-CHM13v2.0
Rnase2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,492,718 - 51,493,569 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,492,719 - 51,493,569 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381451,255,261 - 51,256,112 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,255,262 - 51,256,112 (-)Ensemblmm10GRCm38
MGSCv371451,874,936 - 51,875,787 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361450,177,212 - 50,178,063 (-)NCBIMGSCv36mm8
Celera1447,567,524 - 47,568,375 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.44NCBI
LOC100981889
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,394,999 - 22,396,712 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,611,486 - 21,613,199 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,759,482 - 1,760,873 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,841,044 - 19,842,028 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,841,364 - 19,841,849 (+)EnsemblpanPan2panpan1.1
LOC103231363
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,411,633 - 21,412,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,412,062 - 21,412,544 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605925,023,402 - 25,024,342 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Rnase2
27 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:37
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000050820
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
D15Got28  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21524,449,348 - 24,449,638 (+)MAPPERmRatBN7.2
Rnor_6.01528,154,213 - 28,154,502NCBIRnor6.0
Rnor_5.01531,983,734 - 31,984,023UniSTSRnor5.0
RGSC_v3.41527,209,607 - 27,209,897RGDRGSC3.4
RGSC_v3.41527,209,608 - 27,209,897UniSTSRGSC3.4
Celera1524,766,237 - 24,766,518UniSTS
RGSC_v3.11527,225,307 - 27,225,597RGD
RH 2.0 Map15137.8RGD
Cytogenetic Map15p14UniSTS
RH133047  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1524,766,542 - 24,766,758UniSTS
Celera1524,864,784 - 24,865,001UniSTS
Cytogenetic Map15p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 13 53 65 65 35 83 35 6 214 127 11 26 36 40 30 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000050820   ⟹   ENSRNOP00000039262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1526,923,134 - 26,923,955 (-)Ensembl
mRatBN7.2 Ensembl1524,449,611 - 24,450,479 (-)Ensembl
Rnor_6.0 Ensembl1528,154,482 - 28,155,291 (-)Ensembl
RefSeq Acc Id: NM_001007015   ⟹   NP_001007016
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,923,125 - 26,923,934 (-)NCBI
mRatBN7.21524,449,618 - 24,450,427 (-)NCBI
Rnor_6.01528,154,482 - 28,155,291 (-)NCBI
Rnor_5.01531,984,003 - 31,984,812 (-)NCBI
RGSC_v3.41527,209,877 - 27,210,686 (-)RGD
Celera1524,766,498 - 24,767,307 (-)RGD
Sequence:
RefSeq Acc Id: NP_001007016   ⟸   NM_001007015
- Peptide Label: precursor
- UniProtKB: Q5WN11 (UniProtKB/TrEMBL),   Q9R132 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039262   ⟸   ENSRNOT00000050820
Protein Domains
Ribonuclease A-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5WN11-F1-model_v2 AlphaFold Q5WN11 1-155 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359432 AgrOrtholog
BioCyc Gene G2FUF-14013 BioCyc
Ensembl Genes ENSRNOG00000032133 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050820 ENTREZGENE
  ENSRNOT00000050820.3 UniProtKB/TrEMBL
Gene3D-CATH 3.10.130.10 UniProtKB/TrEMBL
InterPro RNaseA UniProtKB/TrEMBL
  RNaseA-like_dom_sf UniProtKB/TrEMBL
  RNaseA_AS UniProtKB/TrEMBL
  RNaseA_domain UniProtKB/TrEMBL
KEGG Report rno:474169 UniProtKB/TrEMBL
NCBI Gene 474169 ENTREZGENE
PANTHER EOSINOPHIL CATIONIC PROTEIN UniProtKB/TrEMBL
  RNaseA UniProtKB/TrEMBL
Pfam RnaseA UniProtKB/TrEMBL
PharmGKB RNASE3 RGD
PhenoGen Rnase2 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  RNASE_PANCREATIC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032133 RatGTEx
SMART RNAse_Pc UniProtKB/TrEMBL
Superfamily-SCOP RNaseA UniProtKB/TrEMBL
UniProt Q5WN11 ENTREZGENE, UniProtKB/TrEMBL
  Q9R132 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Rnase2  ribonuclease A family member 2  Rnase2  ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Rnase2  ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)  Ear4  eosinophil-associated, ribonuclease A family, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Ear4  eosinophil-associated, ribonuclease A family, member 4  LOC474169  pre-eosinophil-associated ribonuclease-2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC474169  pre-eosinophil-associated ribonuclease-2      Symbol and Name status set to provisional 70820 PROVISIONAL