Palldl1 (palladin-like 1) - Rat Genome Database

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Gene: Palldl1 (palladin-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Palldl1 (Ensembl: Palld)
Name: palladin-like 1 (Ensembl:palladin, cytoskeletal associated protein)
RGD ID: 1359390
Description: FOUND IN actin cytoskeleton (inferred); actin filament (inferred); cytoskeleton (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; gentamycin; paracetamol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hypothetical protein LOC364558; LOC108348198; LOC364558; palladin; palladin, cytoskeletal associated protein; Palld; similar to palladin, CGI-151 protein; uncharacterized LOC108348198
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Allele / Splice: PalldTn(sb-T2/Bart3)2.341Mcwi
Genetic Models: F344-PalldTn(sb-T2/Bart3)2.341Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81632,985,252 - 33,154,619 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21627,981,315 - 28,143,129 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1627,981,354 - 28,621,337 (+)EnsemblmRatBN7.2
Rnor_6.01631,349,140 - 31,390,340 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1631,349,184 - 31,390,340 (+)Ensemblrn6Rnor6.0
Rnor_5.01631,198,863 - 31,240,064 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41631,144,028 - 31,144,544 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
RGSC_v3.11631,118,213 - 31,193,638 (-)NCBI
Cytogenetic Map16p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. A critical role for palladin in astrocyte morphology and response to injury. Boukhelifa M, etal., Mol Cell Neurosci. 2003 Aug;23(4):661-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells. Goicoechea S, etal., J Cell Sci. 2006 Aug 15;119(Pt 16):3316-24. Epub 2006 Jul 25.
4. Isoform-specific upregulation of palladin in human and murine pancreas tumors. Goicoechea SM, etal., PLoS One. 2010 Apr 26;5(4):e10347.
5. Hypoxia inhibits differentiation of lineage-specific Rcho-1 trophoblast giant cells. Gultice AD, etal., Biol Reprod. 2006 Jun;74(6):1041-50. Epub 2006 Feb 15.
6. Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism. Pogue-Geile KL, etal., PLoS Med. 2006 Dec;3(12):e516.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Isoform-specific regulation of the actin-organizing protein palladin during TGF-beta1-induced myofibroblast differentiation. Ronty MJ, etal., J Invest Dermatol. 2006 Nov;126(11):2387-96. Epub 2006 Jun 22.
10. Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells. Salaria SN, etal., Cancer Biol Ther. 2007 Mar;6(3):324-8. Epub 2007 Mar 24.
Additional References at PubMed
PMID:12477932   PMID:20381583   PMID:20877641   PMID:23546604   PMID:29739492  


Genomics

Variants

.
Variants in Palldl1
935 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat


Genetic Models
This gene Palldl1 is modified in the following models/strains:
F344-PalldTn(sb-T2/Bart3)2.341Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 12 61 53 72 74 50 49 50 6 266 137 11 30 58 68 24 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000064850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1631,349,184 - 31,390,340 (+)Ensembl
RefSeq Acc Id: XM_039095177   ⟹   XP_038951105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81632,985,252 - 33,019,697 (+)NCBI
mRatBN7.21627,981,315 - 28,005,846 (+)NCBI
RefSeq Acc Id: XM_039095178   ⟹   XP_038951106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81632,985,252 - 33,026,503 (+)NCBI
mRatBN7.21627,981,316 - 28,022,581 (+)NCBI
RefSeq Acc Id: XM_039095179   ⟹   XP_038951107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81632,985,252 - 33,154,619 (+)NCBI
mRatBN7.21627,981,316 - 28,143,129 (+)NCBI
RefSeq Acc Id: XM_039095181   ⟹   XP_038951109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81632,985,253 - 33,026,503 (+)NCBI
mRatBN7.21627,981,316 - 28,022,581 (+)NCBI
RefSeq Acc Id: XM_039095182   ⟹   XP_038951110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81632,985,253 - 33,026,219 (+)NCBI
mRatBN7.21627,981,316 - 28,019,875 (+)NCBI
RefSeq Acc Id: XM_063275968   ⟹   XP_063132038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81632,985,252 - 33,154,619 (+)NCBI
RefSeq Acc Id: XM_063275969   ⟹   XP_063132039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81632,985,253 - 33,026,303 (+)NCBI
RefSeq Acc Id: XP_038951105   ⟸   XM_039095177
- Peptide Label: isoform X1
- UniProtKB: Q5M7W2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951107   ⟸   XM_039095179
- Peptide Label: isoform X3
- UniProtKB: Q5M7W2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951109   ⟸   XM_039095181
- Peptide Label: isoform X4
- UniProtKB: Q5M7W2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951106   ⟸   XM_039095178
- Peptide Label: isoform X2
- UniProtKB: Q5M7W2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951110   ⟸   XM_039095182
- Peptide Label: isoform X4
- UniProtKB: Q5M7W2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132038   ⟸   XM_063275968
- Peptide Label: isoform X3
- UniProtKB: Q5M7W2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132039   ⟸   XM_063275969
- Peptide Label: isoform X5
- UniProtKB: Q5M7W2 (UniProtKB/TrEMBL)
Protein Domains
Immunoglobulin I-set

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M265-F1-model_v2 AlphaFold F1M265 1-1002 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359390 AgrOrtholog
BioCyc Gene G2FUF-11597 BioCyc
Ensembl Genes ENSRNOG00000010107 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000042312 Ensembl
  ENSRNOG00000082157 ENTREZGENE
Ensembl Transcript ENSRNOT00000064850 ENTREZGENE
  ENSRNOT00000111769.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7189104 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Palladin_C UniProtKB/TrEMBL
MGC_CLONE MGC:94544 IMAGE-MGC_LOAD
NCBI Gene 364558 ENTREZGENE
PANTHER CAVP-TARGET PROTEIN-LIKE UniProtKB/TrEMBL
  IMMUNOGLOBULIN UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
PhenoGen Palldl1 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010107 RatGTEx
  ENSRNOG00000042312 RatGTEx
  ENSRNOG00000082157 RatGTEx
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A8I6ADX4_RAT UniProtKB/TrEMBL
  Q5M7W2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Palldl1  palladin-like 1  LOC108348198  uncharacterized LOC108348198  Data merged from RGD:11457236 737654 PROVISIONAL
2016-08-02 LOC108348198  uncharacterized LOC108348198      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-08-01 Palldl1  palladin-like 1  Palld  palladin, cytoskeletal associated protein  Name and Symbol changed 629549 APPROVED
2010-04-20 Palld  palladin, cytoskeletal associated protein  LOC364558  similar to palladin; CGI-151 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC364558  similar to palladin; CGI-151 protein      Symbol and Name status set to provisional 70820 PROVISIONAL