Ang2 (angiogenin, ribonuclease A family, member 2) - Rat Genome Database

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Gene: Ang2 (angiogenin, ribonuclease A family, member 2) Rattus norvegicus
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Symbol: Ang2
Name: angiogenin, ribonuclease A family, member 2
RGD ID: 1359373
Description: Predicted to enable RNA nuclease activity. Involved in cellular response to mechanical stimulus. Predicted to be located in extracellular region and nucleolus. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in diabetic retinopathy; myocardial infarction; neurodegenerative disease (multiple); and prostate cancer. Orthologous to human ANG (angiogenin); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ang; angiogenin ribonuclease 2; angiogenin, ribonuclease, RNase A family, 5; angiogenin-like; LOC108348324; Raa2; ribonuclease A a2
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,871,842 - 26,889,421 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1526,871,838 - 26,889,421 (-)EnsemblGRCr8
mRatBN7.21524,398,330 - 24,415,909 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,398,419 - 24,398,922 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1527,169,575 - 27,170,078 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,128,732 - 28,129,235 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,378,138 - 26,378,641 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1525,574,160 - 25,591,745 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1525,480,239 - 25,497,818 (-)NCBILyon_Normotensive
Lyon_Hypertensive1525,583,327 - 25,600,906 (-)NCBILyon_Hypertensive
F344_StmMcwi1526,184,617 - 26,202,196 (-)NCBIF344_StmMcwi
Rnor_6.01528,103,688 - 28,121,494 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,103,703 - 28,104,206 (-)Ensemblrn6Rnor6.0
Rnor_5.01531,932,500 - 31,950,362 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41527,160,401 - 27,160,904 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1524,715,687 - 24,716,190 (-)NCBICelera
RGSC_v3.11527,176,101 - 27,176,604 (-)NCBI
Cytogenetic Map15p14NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mechanical load induced by glass microspheres releases angiogenic factors from neonatal rat ventricular myocytes cultures and causes arrhythmias. Barac DY, etal., J Cell Mol Med. 2008 Oct;12(5B):2037-51. doi: 10.1111/j.1582-4934.2008.00193.x.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15676279   PMID:17670746   PMID:19666176   PMID:23073804   PMID:23170778   PMID:24337645   PMID:29065170   PMID:29769424  


Genomics

Comparative Map Data
Ang2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,871,842 - 26,889,421 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1526,871,838 - 26,889,421 (-)EnsemblGRCr8
mRatBN7.21524,398,330 - 24,415,909 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,398,419 - 24,398,922 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1527,169,575 - 27,170,078 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,128,732 - 28,129,235 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,378,138 - 26,378,641 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1525,574,160 - 25,591,745 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1525,480,239 - 25,497,818 (-)NCBILyon_Normotensive
Lyon_Hypertensive1525,583,327 - 25,600,906 (-)NCBILyon_Hypertensive
F344_StmMcwi1526,184,617 - 26,202,196 (-)NCBIF344_StmMcwi
Rnor_6.01528,103,688 - 28,121,494 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,103,703 - 28,104,206 (-)Ensemblrn6Rnor6.0
Rnor_5.01531,932,500 - 31,950,362 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41527,160,401 - 27,160,904 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1524,715,687 - 24,716,190 (-)NCBICelera
RGSC_v3.11527,176,101 - 27,176,604 (-)NCBI
Cytogenetic Map15p14NCBI
Ang2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,432,781 - 51,436,400 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,432,781 - 51,436,605 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381451,195,486 - 51,195,923 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,195,324 - 51,199,148 (-)Ensemblmm10GRCm38
MGSCv371451,815,161 - 51,815,598 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361450,117,437 - 50,117,874 (-)NCBIMGSCv36mm8
Celera1447,495,482 - 47,495,919 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.42NCBI

Variants

.
Variants in Ang2
302 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:42
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000032536
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 3 26 35 35 30 5 30 4 67 11 20 20 21 5

Sequence


Ensembl Acc Id: ENSRNOT00000032536   ⟹   ENSRNOP00000034383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1526,871,838 - 26,889,421 (-)Ensembl
mRatBN7.2 Ensembl1524,398,419 - 24,398,922 (-)Ensembl
Rnor_6.0 Ensembl1528,103,703 - 28,104,206 (-)Ensembl
RefSeq Acc Id: NM_001012359   ⟹   NP_001012359
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,871,842 - 26,889,421 (-)NCBI
mRatBN7.21524,398,330 - 24,415,909 (-)NCBI
Dahl_SR_JrHsd1525,574,160 - 25,591,745 (-)NCBI
Lyon_Normotensive1525,480,239 - 25,497,818 (-)NCBI
Lyon_Hypertensive1525,583,327 - 25,600,906 (-)NCBI
F344_StmMcwi1526,184,617 - 26,202,196 (-)NCBI
Rnor_6.01528,103,703 - 28,104,206 (-)NCBI
Rnor_5.01531,932,500 - 31,950,362 (-)NCBI
RGSC_v3.41527,160,401 - 27,160,904 (-)RGD
Celera1524,715,687 - 24,716,190 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001012359 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAV87194 (Get FASTA)   NCBI Sequence Viewer  
  CDG32032 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034383
  ENSRNOP00000034383.5
RefSeq Acc Id: NP_001012359   ⟸   NM_001012359
- Peptide Label: precursor
- UniProtKB: Q5GAM5 (UniProtKB/TrEMBL),   Q5WRG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034383   ⟸   ENSRNOT00000032536
Protein Domains
Ribonuclease A-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5GAM5-F1-model_v2 AlphaFold Q5GAM5 1-167 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359373 AgrOrtholog
BioCyc Gene G2FUF-14019 BioCyc
Ensembl Genes ENSRNOG00000025562 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032536 ENTREZGENE
  ENSRNOT00000032536.6 UniProtKB/TrEMBL
Gene3D-CATH 3.10.130.10 UniProtKB/TrEMBL
InterPro RNaseA UniProtKB/TrEMBL
  RNaseA-like_dom_sf UniProtKB/TrEMBL
  RNaseA_AS UniProtKB/TrEMBL
  RNaseA_domain UniProtKB/TrEMBL
KEGG Report rno:497229 UniProtKB/TrEMBL
NCBI Gene 497229 ENTREZGENE
PANTHER ANGIOGENIN UniProtKB/TrEMBL
  RNaseA UniProtKB/TrEMBL
Pfam RnaseA UniProtKB/TrEMBL
PhenoGen Ang2 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/TrEMBL
PROSITE RNASE_PANCREATIC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025562 RatGTEx
SMART RNAse_Pc UniProtKB/TrEMBL
Superfamily-SCOP RNaseA UniProtKB/TrEMBL
UniProt F7F7P3_RAT UniProtKB/TrEMBL
  Q5GAM5 ENTREZGENE, UniProtKB/TrEMBL
  Q5WRG2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ang2  angiogenin, ribonuclease A family, member 2  LOC108348324  angiogenin-like  Data merged from RGD:11486822 737654 PROVISIONAL
2016-08-02 LOC108348324  angiogenin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2014-02-03 Ang2  angiogenin, ribonuclease A family, member 2  Ang2  angiogenin ribonuclease 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-12 Ang  angiogenin, ribonuclease, RNase A family, 5  Ang2  angiogenin ribonuclease 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ang2  angiogenin ribonuclease 2      Symbol and Name updated 1559027 APPROVED
2005-07-29 Ang2  angiogenin ribonuclease 2      Symbol and Name status set to provisional 70820 PROVISIONAL