Acat2 (acetyl-CoA acetyltransferase 2) - Rat Genome Database

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Gene: Acat2 (acetyl-CoA acetyltransferase 2) Rattus norvegicus
Analyze
Symbol: Acat2
Name: acetyl-CoA acetyltransferase 2
RGD ID: 1359366
Description: Enables acetyl-CoA C-acetyltransferase activity. Involved in several processes, including cellular response to fatty acid; ketone body catabolic process; and liver development. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ab2-076; Acat3; acetyl-CoA acetyltransferase, cytosolic; acetyl-Coenzyme A acetyltransferase 2; acetyl-Coenzyme A acetyltransferase 3; cytosolic acetoacetyl-CoA thiolase; LOC678796; MGC95138; similar to acetyl CoA transferase-like; similar to acetyl-Coenzyme A acetyltransferase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,100,840 - 50,118,886 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl150,100,817 - 50,135,095 (+)EnsemblGRCr8
mRatBN7.2147,695,833 - 47,713,879 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,695,788 - 47,752,821 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx148,244,680 - 48,262,723 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,232,698 - 54,250,748 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,320,196 - 48,338,239 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,972,399 - 47,992,654 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,972,399 - 47,992,653 (+)Ensemblrn6Rnor6.0
Rnor_5.0151,757,961 - 51,776,935 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4141,922,020 - 41,940,074 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera143,380,977 - 43,399,019 (+)NCBICelera
RGSC_v3.1141,924,964 - 41,943,018 (+)NCBI
Cytogenetic Map1q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
ampicillin  (EXP)
Archazolid B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP,ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
diuron  (EXP)
endosulfan  (EXP)
enniatin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
farnesol  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
GSK-J4  (ISO)
GW 4064  (ISO)
hyaluronic acid  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
indometacin  (EXP)
inulin  (ISO)
isoniazide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methylazoxymethanol  (ISO)
metronidazole  (EXP)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
neomycin  (EXP)
nickel atom  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
octocrylene  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
picoxystrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinolin-8-ol  (ISO)
rotenone  (EXP,ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tebuconazole  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
topotecan  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vincaleukoblastine  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IEA)
peroxisome  (TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification, purification and characterization of an acetoacetyl-CoA thiolase from rat liver peroxisomes. Antonenkov VD, etal., Eur J Biochem. 2000 May;267(10):2981-90.
2. Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice. Bell TA 3rd, etal., Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1814-20. Epub 2006 May 4.
3. The influence of chylomicron remnants on cholesteryl ester metabolism in cultured rat hepatocytes: comparison of the effects of particles enriched in n-3 or n-6 polyunsaturated fatty acids. Botham KM, etal., Biochim Biophys Acta. 2001 Dec 30;1534(2-3):96-109.
4. The effects of dietary n-3 polyunsaturated fatty acids delivered in chylomicron remnants on the transcription of genes regulating synthesis and secretion of very-low-density lipoprotein by the liver: modulation by cellular oxidative state. Botham KM, etal., Exp Biol Med (Maywood). 2003 Feb;228(2):143-51.
5. Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Buhman KK, etal., Nat Med 2000 Dec;6(12):1341-7.
6. Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? Côté I, etal., Br J Nutr. 2014 Nov 28;112(10):1592-600. doi: 10.1017/S0007114514002517. Epub 2014 Sep 29.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks. He X, etal., Hum Genet. 2005 Dec;118(3-4):393-403. Epub 2005 Sep 30.
9. ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice. Lee RG, etal., J Lipid Res 2005 Jun;46(6):1205-12. Epub 2005 Apr 1.
10. Dual action of neutral sphingomyelinase on rat hepatocytes: activation of cholesteryl ester metabolism and biliary cholesterol secretion and inhibition of VLDL secretion. Liza M, etal., Lipids. 2003 Jan;38(1):53-63.
11. The course of ketosis and the activity of key enzymes of ketogenesis and ketone-body utilization during development of the postnatal rat. Lockwood EA and Bailey E, Biochem J. 1971 Aug;124(1):249-54.
12. Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients. McCarthy JJ, etal., Hum Genet. 2003 Dec;114(1):87-98. Epub 2003 Oct 14.
13. The acetoacetyl-coenzyme A thiolases of rat brain and their relative activities during postnatal development. Middleton B Biochem J. 1973 Apr;132(4):731-7.
14. Cerebral ketone body metabolism. Morris AA J Inherit Metab Dis. 2005;28(2):109-21.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Activities of enzymes of ketone-body utilization in brain and other tissues of suckling rats. Page MA, etal., Biochem J. 1971 Jan;121(1):49-53.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
23. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
Additional References at PubMed
PMID:7911016   PMID:15489334   PMID:18614015   PMID:23533145   PMID:27809850   PMID:31647302  


Genomics

Comparative Map Data
Acat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,100,840 - 50,118,886 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl150,100,817 - 50,135,095 (+)EnsemblGRCr8
mRatBN7.2147,695,833 - 47,713,879 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,695,788 - 47,752,821 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx148,244,680 - 48,262,723 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,232,698 - 54,250,748 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,320,196 - 48,338,239 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,972,399 - 47,992,654 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,972,399 - 47,992,653 (+)Ensemblrn6Rnor6.0
Rnor_5.0151,757,961 - 51,776,935 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4141,922,020 - 41,940,074 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera143,380,977 - 43,399,019 (+)NCBICelera
RGSC_v3.1141,924,964 - 41,943,018 (+)NCBI
Cytogenetic Map1q11NCBI
ACAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,762,045 - 159,779,112 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,761,981 - 159,779,821 (+)Ensemblhg38GRCh38
GRCh376160,183,077 - 160,200,144 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,102,979 - 160,120,077 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346160,153,495 - 160,170,496NCBI
Celera6160,829,071 - 160,846,164 (+)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,652,350 - 157,670,330 (+)NCBIHuRef
CHM1_16160,445,318 - 160,462,378 (+)NCBICHM1_1
T2T-CHM13v2.06161,007,676 - 161,024,729 (+)NCBIT2T-CHM13v2.0
Acat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,161,929 - 13,179,612 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,161,777 - 13,179,634 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381712,943,042 - 12,960,725 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,942,890 - 12,960,747 (-)Ensemblmm10GRCm38
MGSCv371713,135,908 - 13,153,591 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361712,785,822 - 12,803,643 (-)NCBIMGSCv36mm8
Celera1712,974,572 - 12,992,259 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.73NCBI
Acat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543921,122,923 - 21,142,480 (-)Ensembl
ChiLan1.0NW_00495543921,123,886 - 21,142,562 (-)NCBIChiLan1.0ChiLan1.0
ACAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25179,860,401 - 179,877,462 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16177,765,362 - 177,782,416 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06157,644,894 - 157,661,965 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16162,656,497 - 162,673,606 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,656,497 - 162,673,606 (+)EnsemblpanPan2panpan1.1
ACAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,011,665 - 49,029,368 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,011,706 - 49,029,327 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha149,853,633 - 49,871,344 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0149,196,147 - 49,214,069 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,196,175 - 49,214,050 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,078,510 - 49,096,406 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,949,606 - 48,967,503 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,564,773 - 49,582,676 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,003,888 - 144,021,848 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,255,871 - 11,283,216 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,255,871 - 11,273,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,598,735 - 7,612,866 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.117,600,616 - 7,612,861 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,399,574 - 9,411,820 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,363,527 - 87,378,002 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604059,762,875 - 59,777,018 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,176,171 - 3,199,705 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248553,177,402 - 3,199,634 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Acat2
140 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:217
Count of miRNA genes:151
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000033408
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat

Markers in Region
D1Rat332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,746,929 - 47,747,057 (-)MAPPERmRatBN7.2
mRatBN7.2147,772,213 - 47,772,342 (-)MAPPERmRatBN7.2
Rnor_6.0154,424,371 - 54,424,496NCBIRnor6.0
Rnor_5.0155,644,514 - 55,644,639UniSTSRnor5.0
Celera143,397,178 - 43,397,283UniSTS
RGSC_v3.1141,941,176 - 41,941,281RGD
SHRSP x BN Map124.95UniSTS
SHRSP x BN Map124.95RGD
Cytogenetic Map1q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000033408   ⟹   ENSRNOP00000059561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl150,100,817 - 50,135,095 (+)Ensembl
mRatBN7.2 Ensembl147,695,788 - 47,713,873 (+)Ensembl
Rnor_6.0 Ensembl147,972,399 - 47,992,653 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076951   ⟹   ENSRNOP00000068312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl150,101,399 - 50,129,439 (+)Ensembl
mRatBN7.2 Ensembl147,695,788 - 47,752,821 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077707   ⟹   ENSRNOP00000069035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl147,972,425 - 47,991,846 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111916   ⟹   ENSRNOP00000085078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,695,788 - 47,730,867 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114086   ⟹   ENSRNOP00000083545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl150,100,817 - 50,118,885 (+)Ensembl
mRatBN7.2 Ensembl147,695,810 - 47,724,428 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117522   ⟹   ENSRNOP00000087001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl150,100,817 - 50,118,885 (+)Ensembl
mRatBN7.2 Ensembl147,695,810 - 47,724,428 (+)Ensembl
RefSeq Acc Id: NM_001006995   ⟹   NP_001006996
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,100,840 - 50,118,886 (+)NCBI
mRatBN7.2147,695,833 - 47,713,879 (+)NCBI
Rnor_6.0147,972,399 - 47,992,654 (+)NCBI
Rnor_5.0151,757,961 - 51,776,935 (-)NCBI
RGSC_v3.4141,922,020 - 41,940,074 (+)RGD
Celera143,380,977 - 43,399,019 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001006996 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83872 (Get FASTA)   NCBI Sequence Viewer  
  AAP92588 (Get FASTA)   NCBI Sequence Viewer  
  EDL83695 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000083545
  ENSRNOP00000083545.1
GenBank Protein Q5XI22 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001006996   ⟸   NM_001006995
- UniProtKB: Q5XI22 (UniProtKB/Swiss-Prot),   A6KP31 (UniProtKB/TrEMBL),   F1LS48 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059561   ⟸   ENSRNOT00000033408
Ensembl Acc Id: ENSRNOP00000069035   ⟸   ENSRNOT00000077707
Ensembl Acc Id: ENSRNOP00000068312   ⟸   ENSRNOT00000076951
Ensembl Acc Id: ENSRNOP00000085078   ⟸   ENSRNOT00000111916
Ensembl Acc Id: ENSRNOP00000087001   ⟸   ENSRNOT00000117522
Ensembl Acc Id: ENSRNOP00000083545   ⟸   ENSRNOT00000114086
Protein Domains
Thiolase C-terminal   Thiolase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI22-F1-model_v2 AlphaFold Q5XI22 1-397 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689614
Promoter ID:EPDNEW_R138
Type:multiple initiation site
Name:Acat2_1
Description:acetyl-CoA acetyltransferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0147,972,376 - 47,972,436EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359366 AgrOrtholog
BioCyc Gene G2FUF-61592 BioCyc
Ensembl Genes ENSRNOG00000019189 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000114086 ENTREZGENE
  ENSRNOT00000114086.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7128564 IMAGE-MGC_LOAD
InterPro Thiolase UniProtKB/Swiss-Prot
  Thiolase-like UniProtKB/Swiss-Prot
  Thiolase_AS UniProtKB/Swiss-Prot
  Thiolase_C UniProtKB/Swiss-Prot
  Thiolase_CS UniProtKB/Swiss-Prot
  Thiolase_N UniProtKB/Swiss-Prot
KEGG Report rno:308100 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95138 IMAGE-MGC_LOAD
NCBI Gene 308100 ENTREZGENE
PANTHER ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC UniProtKB/Swiss-Prot
  ACETYL-COA C-ACYLTRANSFERASE UniProtKB/Swiss-Prot
Pfam Thiolase_C UniProtKB/Swiss-Prot
  Thiolase_N UniProtKB/Swiss-Prot
PharmGKB ACAT2 RGD
PhenoGen Acat2 PhenoGen
PIRSF Ac-CoA_Ac_transf UniProtKB/Swiss-Prot
PROSITE THIOLASE_2 UniProtKB/Swiss-Prot
  THIOLASE_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019189 RatGTEx
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot
UniProt A0A096MJY8_RAT UniProtKB/TrEMBL
  A0A8I6AFP7_RAT UniProtKB/TrEMBL
  A6KP31 ENTREZGENE, UniProtKB/TrEMBL
  F1LS48 ENTREZGENE, UniProtKB/TrEMBL
  Q5XI22 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Acat2  acetyl-CoA acetyltransferase 2  LOC678796  similar to acetyl-Coenzyme A acetyltransferase 2  Data merged from RGD:1596891 737654 PROVISIONAL
2013-03-08 Acat2  acetyl-CoA acetyltransferase 2  Acat2  acetyl-Coenzyme A acetyltransferase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-07 Acat2  acetyl-Coenzyme A acetyltransferase 2  Acat3  acetyl-Coenzyme A acetyltransferase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC678796  similar to acetyl-Coenzyme A acetyltransferase 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Acat2  acetyl-Coenzyme A acetyltransferase 2  MGC95138  similar to acetyl CoA transferase-like  Symbol and Name updated 1299863 APPROVED
2005-07-29 MGC95138  similar to acetyl CoA transferase-like      Symbol and Name status set to provisional 70820 PROVISIONAL