Hba-a2 (hemoglobin alpha, adult chain 2) - Rat Genome Database

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Gene: Hba-a2 (hemoglobin alpha, adult chain 2) Rattus norvegicus
Analyze
Symbol: Hba-a2 (Ensembl: Hba-a3)
Name: hemoglobin alpha, adult chain 2 (Ensembl:hemoglobin alpha, adult chain 3)
RGD ID: 1359364
Description: Enables G protein-coupled receptor binding activity and amyloid-beta binding activity. Involved in negative regulation of blood pressure. Predicted to be part of hemoglobin complex. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to several human genes including HBA1 (hemoglobin subunit alpha 1); INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2-alpha globin; 2-alpha-1 globin; Alpha-1/2-globin; Glnc2; Glnc3; globin c2; globin c3; Hba-a1; Hba1; Hba2; hemoglobin alpha 2 chain; Hemoglobin alpha-1/2 chain; Hemoglobin subunit alpha-1/2; hemoglobin, alpha 2; LOC360504
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,828,291 - 15,829,138 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1015,828,377 - 15,829,141 (-)EnsemblGRCr8
mRatBN7.21015,323,830 - 15,324,677 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,311,634 - 15,312,481 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1015,307,815 - 15,338,392 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1020,070,156 - 20,071,003 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,559,041 - 19,559,888 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01015,051,812 - 15,052,659 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,589,364 - 15,590,207 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,589,364 - 15,590,220 (-)Ensemblrn6Rnor6.0
Rnor_5.01015,484,459 - 15,485,302 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41015,570,930 - 15,571,773 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,991,420 - 14,992,263 (-)NCBICelera
RGSC_v3.11015,571,977 - 15,572,821 (-)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
aconitine  (EXP)
actinomycin D  (ISO)
aldehydo-D-glucose  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
barium sulfate  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
biotin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
capecitabine  (ISO)
carbon nanotube  (ISO)
ceric oxide  (EXP)
cetilistat  (ISO)
chlorpyrifos  (EXP,ISO)
chromium atom  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumarin  (EXP)
Cuprizon  (EXP)
cyanocob(III)alamin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dibromoacetic acid  (EXP)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
flutamide  (EXP)
furan  (EXP)
glucose  (ISO)
hydralazine  (ISO)
hydroquinone  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
L-ethionine  (EXP)
Licochalcone B  (ISO)
linezolid  (EXP)
maneb  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel subsulfide  (EXP)
nicotinamide  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
orlistat  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl isothiocyanate  (EXP)
PhIP  (EXP)
picolinic acid  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sarin  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
streptozocin  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
toluene  (EXP)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
tris(picolinato)chromium  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Hemoglobin and its derived peptides may play a role in the antibacterial mechanism of the vagina. Deng L, etal., Hum Reprod. 2009 Jan;24(1):211-8. doi: 10.1093/humrep/den318. Epub 2008 Sep 10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Heimann AS, etal., Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20588-93. doi: 10.1073/pnas.0706980105. Epub 2007 Dec 12.
4. Translational regulation of human papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha(1)-globin and human cytokeratin 7. Kanduc D J Virol. 2002 Jul;76(14):7040-8.
5. Compensatory increase in alpha 1-globin gene expression in individuals heterozygous for the alpha-thalassemia-2 deletion. Liebhaber SA, etal., J Clin Invest. 1985 Sep;76(3):1057-64.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Initiation codon mutation as a cause of alpha thalassemia. Pirastu M, etal., J Biol Chem. 1984 Oct 25;259(20):12315-7.
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Functional alterations in adult and fetal hemoglobin Sassari Asp-alpha 126(H9)-->His. The role of alpha 1 alpha 2 contact. Sanna MT, etal., J Biol Chem. 1994 Jul 15;269(28):18338-42.
12. Estradiol replacement alters expression of genes related to neurotransmission and immune surveillance in the frontal cortex of middle-aged, ovariectomized rats. Sarvari M, etal., Endocrinology. 2010 Aug;151(8):3847-62. doi: 10.1210/en.2010-0375. Epub 2010 Jun 9.
13. Molecular cloning and characterization of two sets of alpha-theta genes in the rat alpha-like globin gene cluster. Satoh H, etal., Gene 1999 Apr 1;230(1):91-9.
Additional References at PubMed
PMID:7550311   PMID:8706699   PMID:11004532   PMID:12477932   PMID:15962106   PMID:19740759   PMID:19946888   PMID:20458337   PMID:21805676   PMID:22516433   PMID:23012479   PMID:23376485  
PMID:23533145   PMID:25002582   PMID:26316108  


Genomics

Comparative Map Data
Hba-a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,828,291 - 15,829,138 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1015,828,377 - 15,829,141 (-)EnsemblGRCr8
mRatBN7.21015,323,830 - 15,324,677 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,311,634 - 15,312,481 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1015,307,815 - 15,338,392 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1020,070,156 - 20,071,003 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,559,041 - 19,559,888 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01015,051,812 - 15,052,659 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,589,364 - 15,590,207 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,589,364 - 15,590,220 (-)Ensemblrn6Rnor6.0
Rnor_5.01015,484,459 - 15,485,302 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41015,570,930 - 15,571,773 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,991,420 - 14,992,263 (-)NCBICelera
RGSC_v3.11015,571,977 - 15,572,821 (-)NCBI
Cytogenetic Map10q12NCBI
HBA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816176,680 - 177,522 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16176,680 - 177,522 (+)Ensemblhg38GRCh38
GRCh3716226,679 - 227,521 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616166,679 - 167,520 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3416166,678 - 167,520NCBI
Celera16426,194 - 427,035 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16144,721 - 145,562 (+)NCBIHuRef
CHM1_116226,686 - 227,527 (+)NCBICHM1_1
T2T-CHM13v2.016170,722 - 171,564 (+)NCBIT2T-CHM13v2.0
Hba-a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,246,492 - 32,247,310 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1132,246,489 - 32,247,298 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381132,296,492 - 32,297,310 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,296,489 - 32,297,298 (+)Ensemblmm10GRCm38
MGSCv371132,196,492 - 32,197,310 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera1134,701,680 - 34,701,823 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.87NCBI
HBA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218387,821 - 388,716 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,180,776 - 4,181,647 (+)NCBINHGRI_mPanPan1
PanPan1.116164,614 - 165,476 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16164,618 - 165,476 (+)EnsemblpanPan2panpan1.1
LOC100855540
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,324,378 - 40,325,427 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,588,015 - 41,589,066 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0640,667,527 - 40,668,582 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl640,577,773 - 40,672,545 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1640,355,646 - 40,356,696 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0640,316,610 - 40,317,658 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,795,235 - 40,796,286 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC110259958
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1341,482,353 - 41,483,564 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Hba-a2
8 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:34
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000048977, ENSRNOT00000051483
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)101576223019737486Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
BI278462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21015,323,916 - 15,324,261 (+)MAPPERmRatBN7.2
mRatBN7.21015,337,360 - 15,337,705 (+)MAPPERmRatBN7.2
Rnor_6.01015,602,889 - 15,603,233NCBIRnor6.0
Rnor_6.01015,589,447 - 15,589,791NCBIRnor6.0
Rnor_5.01015,497,984 - 15,498,328UniSTSRnor5.0
Rnor_5.01015,484,542 - 15,484,886UniSTSRnor5.0
RGSC_v3.41015,571,013 - 15,571,357UniSTSRGSC3.4
RGSC_v3.41015,584,455 - 15,584,799UniSTSRGSC3.4
Celera1015,004,952 - 15,005,296UniSTS
Celera1014,991,503 - 14,991,847UniSTS
Cytogenetic Map10q12UniSTS
BI282742  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21015,324,396 - 15,324,668 (+)MAPPERmRatBN7.2
Rnor_6.01015,589,927 - 15,590,198NCBIRnor6.0
Rnor_5.01015,485,022 - 15,485,293UniSTSRnor5.0
RGSC_v3.41015,571,493 - 15,571,764UniSTSRGSC3.4
Celera1014,991,983 - 14,992,254UniSTS
RH 3.4 Map10151.46UniSTS
Cytogenetic Map10q12UniSTS
UniSTS:465391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21015,324,015 - 15,324,388 (+)MAPPERmRatBN7.2
mRatBN7.21015,337,459 - 15,337,832 (+)MAPPERmRatBN7.2
Rnor_6.01015,602,988 - 15,603,360NCBIRnor6.0
Rnor_6.01015,589,546 - 15,589,918NCBIRnor6.0
Rnor_5.01015,498,083 - 15,498,455UniSTSRnor5.0
Rnor_5.01015,484,641 - 15,485,013UniSTSRnor5.0
RGSC_v3.41015,571,112 - 15,571,484UniSTSRGSC3.4
RGSC_v3.41015,584,554 - 15,584,926UniSTSRGSC3.4
Celera1015,005,051 - 15,005,423UniSTS
Celera1014,991,602 - 14,991,974UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 16 16

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001007722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC096051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC091567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT548169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT548170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U29528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000048977   ⟹   ENSRNOP00000044081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1015,311,634 - 15,312,481 (-)Ensembl
Rnor_6.0 Ensembl1015,589,364 - 15,590,220 (-)Ensembl
RefSeq Acc Id: NM_001007722   ⟹   NP_001007723
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,828,291 - 15,829,138 (-)NCBI
mRatBN7.21015,323,830 - 15,324,677 (-)NCBI
Rnor_6.01015,589,364 - 15,590,207 (-)NCBI
Rnor_5.01015,484,459 - 15,485,302 (-)NCBI
RGSC_v3.41015,570,930 - 15,571,773 (-)RGD
Celera1014,991,420 - 14,992,263 (-)RGD
Sequence:
RefSeq Acc Id: NP_001007723   ⟸   NM_001007722
- UniProtKB: A0A1K0FUH3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044081   ⟸   ENSRNOT00000048977
Protein Domains
GLOBIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JSV6-F1-model_v2 AlphaFold A0A0G2JSV6 1-142 view protein structure
AF-P01946-F1-model_v2 AlphaFold P01946 1-142 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697074
Promoter ID:EPDNEW_R7599
Type:multiple initiation site
Name:Hba-a2_1
Description:hemoglobin alpha, adult chain 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7601  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01015,590,205 - 15,590,265EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359364 AgrOrtholog
BioCyc Gene G2FUF-25708 BioCyc
Ensembl Genes ENSRNOG00000029886 Ensembl
  ENSRNOG00000047321 Ensembl
Gene3D-CATH 1.10.490.10 UniProtKB/Swiss-Prot
InterPro Globin UniProtKB/Swiss-Prot
  Globin-like_sf UniProtKB/Swiss-Prot
  Globin/Proto UniProtKB/Swiss-Prot
  Haemoglobin_a-typ UniProtKB/Swiss-Prot
  Haemoglobin_pi UniProtKB/Swiss-Prot
  Hemoglobin_oxygen_transport UniProtKB/Swiss-Prot
KEGG Report rno:25632 UniProtKB/Swiss-Prot
  rno:360504 UniProtKB/Swiss-Prot
NCBI Gene 360504 ENTREZGENE
PANTHER HEMOGLOBIN FAMILY MEMBER UniProtKB/Swiss-Prot
  HEMOGLOBIN SUBUNIT ALPHA UniProtKB/Swiss-Prot
Pfam Globin UniProtKB/Swiss-Prot
PhenoGen Hba-a2 PhenoGen
PRINTS ALPHAHAEM UniProtKB/Swiss-Prot
  PIHAEM UniProtKB/Swiss-Prot
PROSITE GLOBIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029886 RatGTEx
  ENSRNOG00000047321 RatGTEx
Superfamily-SCOP SSF46458 UniProtKB/Swiss-Prot
UniProt A0A1K0FUH3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYH2_RAT UniProtKB/TrEMBL
  A0A8L2QLW7_RAT UniProtKB/TrEMBL
  HBA_RAT UniProtKB/Swiss-Prot
UniProt Secondary P33583 UniProtKB/Swiss-Prot
  Q63243 UniProtKB/Swiss-Prot
  Q80XV2 UniProtKB/Swiss-Prot
  Q91V15 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-31 Hba-a1  hemoglobin alpha, adult chain 1  Hba-a2  hemoglobin alpha, adult chain 2  Name and Symbol changed 629549 APPROVED
2015-12-31 Hba-a2  hemoglobin alpha, adult chain 2  Hba-a1  hemoglobin alpha, adult chain 1  Name and Symbol changed 629549 APPROVED
2015-10-06 Hba-a2  hemoglobin alpha, adult chain 2  Hba2  hemoglobin, alpha 2  Name and Symbol changed 629549 APPROVED
2010-05-05 Hba2  hemoglobin, alpha 2  LOC360504  hemoglobin alpha 2 chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 LOC360504  hemoglobin alpha 2 chain      Symbol and Name updated 1559027 APPROVED
2005-07-29 LOC360504  hemoglobin alpha 2 chain      Symbol and Name status set to provisional 70820 PROVISIONAL