Mef2a (myocyte enhancer factor 2a) - Rat Genome Database

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Gene: Mef2a (myocyte enhancer factor 2a) Rattus norvegicus
Analyze
Symbol: Mef2a
Name: myocyte enhancer factor 2a
RGD ID: 1359360
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including cellular response to calcium ion; cellular response to glucose stimulus; and dendrite morphogenesis. Located in nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human MEF2A (myocyte enhancer factor 2A); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC309957; myocyte-specific enhancer factor 2A; similar to myocyte enhancer factor 2C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81130,258,083 - 130,392,819 (-)NCBIGRCr8
mRatBN7.21120,847,874 - 120,982,488 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1120,850,080 - 120,981,948 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1128,846,933 - 128,978,666 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01136,017,035 - 136,148,765 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01128,821,335 - 128,953,169 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01128,207,715 - 128,341,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1128,209,971 - 128,341,263 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01129,273,893 - 129,407,071 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11122,128,377 - 122,183,406 (-)NCBI
Celera1113,052,879 - 113,157,227 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-azacytidine  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
alpha-pinene  (ISO)
arsenite(3-)  (ISO)
benzene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
carbamazepine  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
choline  (ISO)
cocaine  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dantrolene  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dimethylselenide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
hydrogen cyanide  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
metformin  (ISO)
methylmercury chloride  (ISO)
metoprolol  (EXP)
nickel atom  (ISO)
nitric oxide  (ISO)
oxytocin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pinostrobin  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
succimer  (ISO)
sulfates  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
torcetrapib  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO,TAS)
nucleus  (IDA,IEA,ISO,ISS)
transcription regulator complex  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2. Clark AL and Naya FJ, J Biol Chem. 2015 Sep 18;290(38):23162-72. doi: 10.1074/jbc.M115.672659. Epub 2015 Aug 3.
2. Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level. Feng B, etal., Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1119-26. Epub 2008 Apr 15.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. MEF2C DNA-binding activity is inhibited through its interaction with the regulatory protein Ki-1/57. Kobarg CB, etal., FEBS Lett. 2005 May 9;579(12):2615-22. Epub 2005 Apr 8.
5. Control of the SOST bone enhancer by PTH using MEF2 transcription factors. Leupin O, etal., J Bone Miner Res. 2007 Dec;22(12):1957-67.
6. Calcineurin enhances MEF2 DNA binding activity in calcium-dependent survival of cerebellar granule neurons. Mao Z and Wiedmann M, J Biol Chem. 1999 Oct 22;274(43):31102-7.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Shalizi A, etal., Science. 2006 Feb 17;311(5763):1012-7.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Advances in the genetic basis of coronary artery disease. Wang Q Curr Atheroscler Rep. 2005 May;7(3):235-41.
14. Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. Xu J, etal., J Biol Chem. 2006 Apr 7;281(14):9152-62. Epub 2006 Feb 9.
Additional References at PubMed
PMID:7760790   PMID:8096811   PMID:8900141   PMID:9013788   PMID:9430690   PMID:9738004   PMID:9858528   PMID:10458488   PMID:10748098   PMID:10835359   PMID:11160896   PMID:12097321  
PMID:12130539   PMID:12379849   PMID:12826611   PMID:15132737   PMID:15466416   PMID:15491989   PMID:15735306   PMID:16024167   PMID:16043483   PMID:16407236   PMID:16484497   PMID:16985263  
PMID:17431507   PMID:17630987   PMID:17785444   PMID:17855618   PMID:18198354   PMID:19197241   PMID:19362076   PMID:20363751   PMID:20399744   PMID:20590529   PMID:20833138   PMID:21379568  
PMID:21468593   PMID:21724844   PMID:22194471   PMID:22622902   PMID:23261540   PMID:23349925   PMID:23424201   PMID:23486945   PMID:24161931   PMID:25089838   PMID:25147362   PMID:28263745  
PMID:28473466   PMID:29588465   PMID:29606596   PMID:29678571   PMID:29783071   PMID:29928931   PMID:32485181   PMID:37660209  


Genomics

Comparative Map Data
Mef2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81130,258,083 - 130,392,819 (-)NCBIGRCr8
mRatBN7.21120,847,874 - 120,982,488 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1120,850,080 - 120,981,948 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1128,846,933 - 128,978,666 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01136,017,035 - 136,148,765 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01128,821,335 - 128,953,169 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01128,207,715 - 128,341,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1128,209,971 - 128,341,263 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01129,273,893 - 129,407,071 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11122,128,377 - 122,183,406 (-)NCBI
Celera1113,052,879 - 113,157,227 (-)NCBICelera
Cytogenetic Map1q22NCBI
MEF2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381599,565,417 - 99,716,488 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1599,565,417 - 99,716,488 (+)EnsemblGRCh38hg38GRCh38
GRCh3715100,105,622 - 100,256,693 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361597,956,185 - 98,071,524 (+)NCBINCBI36Build 36hg18NCBI36
Build 341597,956,184 - 98,071,524NCBI
Celera1576,525,015 - 76,675,549 (+)NCBICelera
Cytogenetic Map15q26.3NCBI
HuRef1576,235,794 - 76,386,442 (+)NCBIHuRef
CHM1_11599,947,526 - 100,097,943 (+)NCBICHM1_1
T2T-CHM13v2.01597,329,154 - 97,480,250 (+)NCBIT2T-CHM13v2.0
Mef2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39766,880,911 - 67,026,435 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl766,880,911 - 67,022,606 (-)EnsemblGRCm39 Ensembl
GRCm38767,231,163 - 67,376,456 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl767,231,163 - 67,372,858 (-)EnsemblGRCm38mm10GRCm38
MGSCv37774,378,710 - 74,517,744 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36767,112,774 - 67,251,808 (-)NCBIMGSCv36mm8
Celera764,692,674 - 64,806,488 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map736.72NCBI
Mef2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541626,953,798 - 27,051,171 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541626,926,753 - 27,051,171 (+)NCBIChiLan1.0ChiLan1.0
MEF2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21689,108,247 - 89,258,902 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11592,805,248 - 92,955,775 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01578,246,439 - 78,396,720 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11597,428,808 - 97,579,092 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1597,428,744 - 97,579,092 (+)Ensemblpanpan1.1panPan2
MEF2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1341,012,103 - 41,177,588 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl341,015,713 - 41,179,448 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha343,686,343 - 43,878,500 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0341,389,861 - 41,582,392 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl341,397,662 - 41,582,402 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1340,922,313 - 41,112,375 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0341,153,499 - 41,343,252 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0341,373,135 - 41,563,186 (-)NCBIUU_Cfam_GSD_1.0
Mef2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640142,352,128 - 142,499,799 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364833,834,700 - 3,919,766 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364833,837,891 - 3,982,334 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEF2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1138,341,158 - 138,511,314 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11138,398,270 - 138,508,639 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21154,615,130 - 154,689,503 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEF2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12918,150,315 - 18,312,975 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2918,150,854 - 18,309,247 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605928,253,312 - 28,416,154 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mef2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247684,704,799 - 4,796,719 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247684,701,734 - 4,852,833 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mef2a
404 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:898
Count of miRNA genes:222
Interacting mature miRNAs:289
Transcripts:ENSRNOT00000070864, ENSRNOT00000072915
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847121834139Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat

Markers in Region
BF390775  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21120,863,112 - 120,863,262 (+)MAPPERmRatBN7.2
Rnor_6.01128,222,938 - 128,223,087NCBIRnor6.0
Rnor_5.01129,288,675 - 129,288,824UniSTSRnor5.0
Celera1113,065,868 - 113,066,017UniSTS
RH 3.4 Map11466.59UniSTS
Cytogenetic Map1q22UniSTS
AU048441  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21120,856,288 - 120,856,447 (+)MAPPERmRatBN7.2
Rnor_6.01128,216,130 - 128,216,288NCBIRnor6.0
Rnor_5.01129,282,308 - 129,282,466UniSTSRnor5.0
Celera1113,059,044 - 113,059,202UniSTS
Cytogenetic Map1q22UniSTS
Mef2a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21120,882,766 - 120,882,900 (+)MAPPERmRatBN7.2
Rnor_6.01128,242,704 - 128,242,837NCBIRnor6.0
Rnor_5.01129,308,375 - 129,308,508UniSTSRnor5.0
Celera1113,085,480 - 113,085,613UniSTS
Cytogenetic Map1q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 36 20 19 20 8 10 74 35 38 11 8
Low 1 21 21 21 1 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001014035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC081907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ323505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU646868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000070864   ⟹   ENSRNOP00000065122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1120,850,098 - 120,981,948 (-)Ensembl
Rnor_6.0 Ensembl1128,211,192 - 128,341,240 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000072915   ⟹   ENSRNOP00000064552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1120,850,080 - 120,981,914 (-)Ensembl
Rnor_6.0 Ensembl1128,209,971 - 128,341,263 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084946   ⟹   ENSRNOP00000068554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1120,850,080 - 120,981,914 (-)Ensembl
Rnor_6.0 Ensembl1128,211,391 - 128,287,151 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089723   ⟹   ENSRNOP00000068690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1120,850,080 - 120,981,914 (-)Ensembl
Rnor_6.0 Ensembl1128,211,391 - 128,287,151 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113672   ⟹   ENSRNOP00000094055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1120,850,098 - 120,981,948 (-)Ensembl
RefSeq Acc Id: NM_001014035   ⟹   NP_001014057
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,260,332 - 130,392,162 (-)NCBI
mRatBN7.21120,850,123 - 120,981,960 (-)NCBI
Rnor_6.01128,209,964 - 128,341,263 (-)NCBI
Rnor_5.01129,273,893 - 129,407,071 (-)NCBI
Celera1113,052,879 - 113,157,227 (-)RGD
Sequence:
RefSeq Acc Id: XM_008759541   ⟹   XP_008757763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,258,083 - 130,392,342 (-)NCBI
mRatBN7.21120,847,874 - 120,982,472 (-)NCBI
Rnor_6.01128,207,715 - 128,341,681 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080825   ⟹   XP_038936753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,258,083 - 130,392,819 (-)NCBI
mRatBN7.21120,847,874 - 120,982,484 (-)NCBI
RefSeq Acc Id: XM_039080830   ⟹   XP_038936758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,258,083 - 130,391,927 (-)NCBI
mRatBN7.21120,851,550 - 120,981,723 (-)NCBI
RefSeq Acc Id: XM_039080833   ⟹   XP_038936761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,258,083 - 130,392,347 (-)NCBI
mRatBN7.21120,851,550 - 120,982,488 (-)NCBI
RefSeq Acc Id: XM_039080839   ⟹   XP_038936767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,258,083 - 130,392,819 (-)NCBI
mRatBN7.21120,847,874 - 120,982,481 (-)NCBI
RefSeq Acc Id: XM_039080843   ⟹   XP_038936771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,258,083 - 130,391,922 (-)NCBI
mRatBN7.21120,847,874 - 120,981,715 (-)NCBI
RefSeq Acc Id: XM_063265595   ⟹   XP_063121665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,258,083 - 130,392,346 (-)NCBI
RefSeq Acc Id: XM_063265606   ⟹   XP_063121676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,258,083 - 130,391,924 (-)NCBI
RefSeq Acc Id: XM_063265611   ⟹   XP_063121681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,258,083 - 130,392,344 (-)NCBI
RefSeq Acc Id: XM_063265617   ⟹   XP_063121687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,258,083 - 130,392,342 (-)NCBI
RefSeq Acc Id: XM_063265619   ⟹   XP_063121689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,258,083 - 130,392,347 (-)NCBI
RefSeq Acc Id: XM_063265624   ⟹   XP_063121694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81130,258,083 - 130,392,819 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001014057   ⟸   NM_001014035
- UniProtKB: Q66HD7 (UniProtKB/Swiss-Prot),   Q2MJT0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008757763   ⟸   XM_008759541
- Peptide Label: isoform X3
- UniProtKB: Q66HD7 (UniProtKB/Swiss-Prot),   Q2MJT0 (UniProtKB/Swiss-Prot),   M0R6R7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065122   ⟸   ENSRNOT00000070864
RefSeq Acc Id: ENSRNOP00000064552   ⟸   ENSRNOT00000072915
RefSeq Acc Id: ENSRNOP00000068554   ⟸   ENSRNOT00000084946
RefSeq Acc Id: ENSRNOP00000068690   ⟸   ENSRNOT00000089723
RefSeq Acc Id: XP_038936753   ⟸   XM_039080825
- Peptide Label: isoform X1
- UniProtKB: Q66HD7 (UniProtKB/Swiss-Prot),   Q2MJT0 (UniProtKB/Swiss-Prot),   A0A0G2JSZ4 (UniProtKB/TrEMBL),   D8X2M2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936767   ⟸   XM_039080839
- Peptide Label: isoform X2
- UniProtKB: Q66HD7 (UniProtKB/Swiss-Prot),   Q2MJT0 (UniProtKB/Swiss-Prot),   A0A8I6AYJ3 (UniProtKB/TrEMBL),   A6JBR9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936771   ⟸   XM_039080843
- Peptide Label: isoform X3
- UniProtKB: Q66HD7 (UniProtKB/Swiss-Prot),   Q2MJT0 (UniProtKB/Swiss-Prot),   M0R6R7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936761   ⟸   XM_039080833
- Peptide Label: isoform X1
- UniProtKB: Q66HD7 (UniProtKB/Swiss-Prot),   Q2MJT0 (UniProtKB/Swiss-Prot),   A0A0G2JSZ4 (UniProtKB/TrEMBL),   D8X2M2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936758   ⟸   XM_039080830
- Peptide Label: isoform X1
- UniProtKB: Q66HD7 (UniProtKB/Swiss-Prot),   Q2MJT0 (UniProtKB/Swiss-Prot),   A0A0G2JSZ4 (UniProtKB/TrEMBL),   D8X2M2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000094055   ⟸   ENSRNOT00000113672
RefSeq Acc Id: XP_063121694   ⟸   XM_063265624
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063121689   ⟸   XM_063265619
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063121665   ⟸   XM_063265595
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AYJ3 (UniProtKB/TrEMBL),   A6JBR9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121681   ⟸   XM_063265611
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063121687   ⟸   XM_063265617
- Peptide Label: isoform X3
- UniProtKB: M0R6R7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121676   ⟸   XM_063265606
- Peptide Label: isoform X4
Protein Domains
MADS-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2MJT0-F1-model_v2 AlphaFold Q2MJT0 1-495 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690107
Promoter ID:EPDNEW_R631
Type:multiple initiation site
Name:Mef2a_1
Description:myocyte enhancer factor 2a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01128,341,272 - 128,341,332EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359360 AgrOrtholog
BioCyc Gene G2FUF-58996 BioCyc
Ensembl Genes ENSRNOG00000047756 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070864.4 UniProtKB/TrEMBL
  ENSRNOT00000072915.3 UniProtKB/TrEMBL
  ENSRNOT00000084946.2 UniProtKB/TrEMBL
  ENSRNOT00000089723 ENTREZGENE
  ENSRNOT00000089723.2 UniProtKB/TrEMBL
  ENSRNOT00000113672.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1810.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111112 IMAGE-MGC_LOAD
InterPro HJURP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MADS_MEF2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_MADSbox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_MADSbox_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:309957 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93837 IMAGE-MGC_LOAD
NCBI Gene 309957 ENTREZGENE
PANTHER MYOCYTE-SPECIFIC ENHANCER FACTOR 2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERUM RESPONSE FACTOR HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HJURP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRF-TF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mef2a PhenoGen
PRINTS MADSDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MADS_BOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MADS_BOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047756 RatGTEx
SMART MADS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55455 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSZ4 ENTREZGENE
  A0A0G2JT35_RAT UniProtKB/TrEMBL
  A0A0G2JTF4_RAT UniProtKB/TrEMBL
  A0A8I6AYJ3 ENTREZGENE, UniProtKB/TrEMBL
  A6JBR9 ENTREZGENE, UniProtKB/TrEMBL
  D8X2M2 ENTREZGENE, UniProtKB/TrEMBL
  M0R6R7 ENTREZGENE, UniProtKB/TrEMBL
  MEF2A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HD7 ENTREZGENE
UniProt Secondary A0A0G2JSZ4 UniProtKB/TrEMBL
  Q66HD7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-12 Mef2a   myocyte enhancer factor 2a  LOC309957  similar to myocyte enhancer factor 2C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC309957  similar to myocyte enhancer factor 2C      Symbol and Name status set to provisional 70820 PROVISIONAL