Nhej1 (nonhomologous end-joining factor 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Nhej1 (nonhomologous end-joining factor 1) Rattus norvegicus
Analyze
Symbol: Nhej1
Name: nonhomologous end-joining factor 1
RGD ID: 1359338
Description: Predicted to enable DNA end binding activity and DNA polymerase binding activity. Predicted to be involved in DNA metabolic process; lymphocyte differentiation; and response to ionizing radiation. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Predicted to be active in site of double-strand break. Human ortholog(s) of this gene implicated in severe combined immunodeficiency. Orthologous to human NHEJ1 (non-homologous end joining factor 1); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-nitrofluorene; 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC363251; non-homologous end-joining factor 1; protein cernunnos; similar to 1700029B21Rik protein; XRCC4-like factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,974,995 - 84,071,161 (-)NCBIGRCr8
mRatBN7.2976,526,322 - 76,622,488 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,526,324 - 76,622,444 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,970,826 - 85,066,627 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,099,730 - 90,195,531 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,485,932 - 88,581,731 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,230,230 - 82,327,923 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,230,232 - 82,327,534 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,999,491 - 82,097,184 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,309,152 - 74,408,397 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,456,135 - 74,555,379 (-)NCBI
Celera974,096,462 - 74,192,613 (-)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
DNA binding  (IEA)
DNA end binding  (IBA,IEA,ISO,ISS)
DNA polymerase binding  (IEA,ISO)
protein binding  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Ahnesorg P, etal., Cell. 2006 Jan 27;124(2):301-13.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Lieber MR Annu Rev Biochem. 2010;79:181-211. doi: 10.1146/annurev.biochem.052308.093131.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:16439204   PMID:20383123   PMID:21821112   PMID:25288157   PMID:25941166  


Genomics

Comparative Map Data
Nhej1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,974,995 - 84,071,161 (-)NCBIGRCr8
mRatBN7.2976,526,322 - 76,622,488 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,526,324 - 76,622,444 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,970,826 - 85,066,627 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,099,730 - 90,195,531 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,485,932 - 88,581,731 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,230,230 - 82,327,923 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,230,232 - 82,327,534 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,999,491 - 82,097,184 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,309,152 - 74,408,397 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,456,135 - 74,555,379 (-)NCBI
Celera974,096,462 - 74,192,613 (-)NCBICelera
Cytogenetic Map9q33NCBI
NHEJ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,069,357 - 219,160,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,069,355 - 219,160,869 (-)EnsemblGRCh38hg38GRCh38
GRCh372219,934,079 - 220,025,537 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,648,292 - 219,733,767 (-)NCBINCBI36Build 36hg18NCBI36
Celera2213,709,738 - 213,795,304 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,793,894 - 211,879,149 (-)NCBIHuRef
CHM1_12219,947,414 - 220,032,919 (-)NCBICHM1_1
T2T-CHM13v2.02219,557,705 - 219,649,239 (-)NCBIT2T-CHM13v2.0
Nhej1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39175,006,505 - 75,101,870 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl175,006,298 - 75,101,844 (-)EnsemblGRCm39 Ensembl
GRCm38174,967,346 - 75,125,226 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,967,139 - 75,125,200 (-)EnsemblGRCm38mm10GRCm38
MGSCv37175,013,920 - 75,093,227 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,900,346 - 74,988,763 (-)NCBIMGSCv36mm8
Celera175,522,343 - 75,615,823 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.56NCBI
Nhej1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,281,069 - 14,363,876 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545314,278,773 - 14,362,167 (+)NCBIChiLan1.0ChiLan1.0
NHEJ1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,706,164 - 121,794,017 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,707,845 - 121,806,459 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,326,596 - 106,419,928 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,926,183 - 225,012,551 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,926,183 - 225,008,788 (-)Ensemblpanpan1.1panPan2
NHEJ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,637,214 - 25,719,241 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,637,601 - 25,715,372 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,463,707 - 26,546,065 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03725,652,649 - 25,735,139 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,651,942 - 25,730,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,557,221 - 25,639,564 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,492,303 - 25,574,670 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,513,157 - 25,595,616 (-)NCBIUU_Cfam_GSD_1.0
Nhej1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,151,965 - 175,235,788 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,495,446 - 1,578,590 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,494,783 - 1,578,587 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NHEJ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,100,628 - 121,190,062 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115121,100,624 - 121,190,086 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NHEJ1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,981,313 - 105,071,828 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,982,380 - 105,068,999 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604094,328,589 - 94,420,113 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nhej1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248235,864,003 - 5,946,583 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248235,859,157 - 5,944,573 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nhej1
327 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:218
Count of miRNA genes:146
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000024444
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat

Markers in Region
D9Mco48  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,618,117 - 76,618,297 (+)MAPPERmRatBN7.2
Rnor_6.0982,323,506 - 82,323,685NCBIRnor6.0
Rnor_5.0982,092,767 - 82,092,946UniSTSRnor5.0
RGSC_v3.4974,404,369 - 74,404,548UniSTSRGSC3.4
Cytogenetic Map9q33UniSTS
D9Mco49  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,602,760 - 76,602,961 (+)MAPPERmRatBN7.2
Rnor_6.0982,308,149 - 82,308,349NCBIRnor6.0
Rnor_5.0982,077,410 - 82,077,610UniSTSRnor5.0
RGSC_v3.4974,389,012 - 74,389,212UniSTSRGSC3.4
Celera974,173,244 - 74,173,444UniSTS
Cytogenetic Map9q33UniSTS
D9Mco50  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,582,216 - 76,582,401 (+)MAPPERmRatBN7.2
Rnor_6.0982,287,606 - 82,287,790NCBIRnor6.0
Rnor_5.0982,056,867 - 82,057,051UniSTSRnor5.0
RGSC_v3.4974,368,111 - 74,368,295UniSTSRGSC3.4
Celera974,152,748 - 74,152,932UniSTS
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001014217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC079033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024444   ⟹   ENSRNOP00000024444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,526,324 - 76,622,146 (-)Ensembl
Rnor_6.0 Ensembl982,230,232 - 82,327,534 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098045   ⟹   ENSRNOP00000077416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,526,324 - 76,622,444 (-)Ensembl
RefSeq Acc Id: NM_001014217   ⟹   NP_001014239
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,974,995 - 84,070,817 (-)NCBI
mRatBN7.2976,526,322 - 76,622,146 (-)NCBI
Rnor_6.0982,230,230 - 82,327,534 (-)NCBI
Rnor_5.0981,999,491 - 82,097,184 (-)NCBI
RGSC_v3.4974,309,152 - 74,408,397 (-)RGD
Celera974,096,462 - 74,192,613 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245240   ⟹   XP_006245302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,974,995 - 84,071,157 (-)NCBI
mRatBN7.2976,526,322 - 76,622,488 (-)NCBI
Rnor_6.0982,230,230 - 82,327,923 (-)NCBI
Rnor_5.0981,999,491 - 82,097,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245241   ⟹   XP_006245303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,974,995 - 84,070,950 (-)NCBI
mRatBN7.2976,526,322 - 76,622,001 (-)NCBI
Rnor_6.0982,230,230 - 82,327,734 (-)NCBI
Rnor_5.0981,999,491 - 82,097,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245242   ⟹   XP_006245304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,974,995 - 84,070,950 (-)NCBI
mRatBN7.2976,526,322 - 76,622,275 (-)NCBI
Rnor_6.0982,230,230 - 82,327,734 (-)NCBI
Rnor_5.0981,999,491 - 82,097,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596523   ⟹   XP_017452012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,974,995 - 84,070,669 (-)NCBI
mRatBN7.2976,526,322 - 76,622,001 (-)NCBI
Rnor_6.0982,230,230 - 82,327,734 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596524   ⟹   XP_017452013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,974,995 - 84,070,950 (-)NCBI
mRatBN7.2976,526,322 - 76,622,275 (-)NCBI
Rnor_6.0982,230,230 - 82,327,734 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083877   ⟹   XP_038939805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,974,995 - 84,071,149 (-)NCBI
mRatBN7.2976,526,322 - 76,622,475 (-)NCBI
RefSeq Acc Id: XM_063267391   ⟹   XP_063123461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,008,232 - 84,071,149 (-)NCBI
RefSeq Acc Id: XM_063267392   ⟹   XP_063123462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,028,880 - 84,071,149 (-)NCBI
RefSeq Acc Id: XM_063267393   ⟹   XP_063123463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,002,163 - 84,071,149 (-)NCBI
RefSeq Acc Id: XM_063267394   ⟹   XP_063123464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,002,163 - 84,071,161 (-)NCBI
RefSeq Acc Id: XM_063267395   ⟹   XP_063123465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,974,995 - 84,070,939 (-)NCBI
RefSeq Acc Id: XR_005488935
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,976,480 - 84,071,149 (-)NCBI
mRatBN7.2976,527,807 - 76,622,475 (-)NCBI
RefSeq Acc Id: NP_001014239   ⟸   NM_001014217
- UniProtKB: Q6AYI4 (UniProtKB/Swiss-Prot),   A6JVX2 (UniProtKB/TrEMBL),   A0A8L2QD40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245302   ⟸   XM_006245240
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006245304   ⟸   XM_006245242
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006245303   ⟸   XM_006245241
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017452013   ⟸   XM_017596524
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y7R3 (UniProtKB/TrEMBL),   A6JVX1 (UniProtKB/TrEMBL),   A0A8L2QD40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452012   ⟸   XM_017596523
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y7R3 (UniProtKB/TrEMBL),   A6JVX1 (UniProtKB/TrEMBL),   A0A8L2QD40 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024444   ⟸   ENSRNOT00000024444
RefSeq Acc Id: XP_038939805   ⟸   XM_039083877
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y7R3 (UniProtKB/TrEMBL),   A6JVX1 (UniProtKB/TrEMBL),   A0A8L2QD40 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077416   ⟸   ENSRNOT00000098045
RefSeq Acc Id: XP_063123465   ⟸   XM_063267395
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063123464   ⟸   XM_063267394
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063123463   ⟸   XM_063267393
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063123461   ⟸   XM_063267391
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063123462   ⟸   XM_063267392
- Peptide Label: isoform X4
Protein Domains
XLF-like coiled-coil region   XLF-like N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYI4-F1-model_v2 AlphaFold Q6AYI4 1-304 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359338 AgrOrtholog
BioCyc Gene G2FUF-27099 BioCyc
Ensembl Genes ENSRNOG00000018162 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024444.6 UniProtKB/TrEMBL
  ENSRNOT00000098045.1 UniProtKB/TrEMBL
Gene3D-CATH 2.170.210.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7114269 IMAGE-MGC_LOAD
InterPro NHEJ_factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XLF-like_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XLF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XRCC4-like_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:363251 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93961 IMAGE-MGC_LOAD
NCBI Gene 363251 ENTREZGENE
PANTHER NON-HOMOLOGOUS END-JOINING FACTOR 1 UniProtKB/Swiss-Prot
  NON-HOMOLOGOUS END-JOINING FACTOR 1 UniProtKB/Swiss-Prot
  NON-HOMOLOGOUS END-JOINING FACTOR 1 UniProtKB/TrEMBL
  NON-HOMOLOGOUS END-JOINING FACTOR 1 UniProtKB/TrEMBL
Pfam XLF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XLF_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nhej1 PhenoGen
RatGTEx ENSRNOG00000018162 RatGTEx
UniProt A0A8I5Y7R3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QD40 ENTREZGENE, UniProtKB/TrEMBL
  A6JVX1 ENTREZGENE, UniProtKB/TrEMBL
  A6JVX2 ENTREZGENE, UniProtKB/TrEMBL
  NHEJ1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Nhej1  nonhomologous end-joining factor 1  LOC363251  similar to 1700029B21Rik protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC363251  similar to 1700029B21Rik protein      Symbol and Name status set to provisional 70820 PROVISIONAL