Tmem204 (transmembrane protein 204) - Rat Genome Database

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Gene: Tmem204 (transmembrane protein 204) Rattus norvegicus
Analyze
Symbol: Tmem204
Name: transmembrane protein 204
RGD ID: 1359314
Description: Predicted to be involved in lymph vessel development; regulation of vascular endothelial growth factor receptor signaling pathway; and smooth muscle cell differentiation. Predicted to be located in adherens junction and membrane. Predicted to be active in plasma membrane. Orthologous to human TMEM204 (transmembrane protein 204); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: claudin-like protein 24; MGC105601; similar to hypothetical protein FLJ20898
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,581,025 - 14,608,878 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,581,026 - 14,606,427 (-)EnsemblGRCr8
mRatBN7.21014,076,518 - 14,104,849 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,076,519 - 14,101,920 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1018,817,294 - 18,842,657 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,306,158 - 18,331,521 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,805,377 - 13,830,738 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,417,608 - 14,446,272 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,417,609 - 14,443,010 (-)Ensemblrn6Rnor6.0
Rnor_5.01014,233,030 - 14,258,432 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,304,565 - 14,329,967 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1013,749,195 - 13,774,597 (-)NCBICelera
RGSC_v3.11014,304,565 - 14,329,967 (-)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
adherens junction  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:20439428  


Genomics

Comparative Map Data
Tmem204
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,581,025 - 14,608,878 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,581,026 - 14,606,427 (-)EnsemblGRCr8
mRatBN7.21014,076,518 - 14,104,849 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,076,519 - 14,101,920 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1018,817,294 - 18,842,657 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,306,158 - 18,331,521 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,805,377 - 13,830,738 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,417,608 - 14,446,272 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,417,609 - 14,443,010 (-)Ensemblrn6Rnor6.0
Rnor_5.01014,233,030 - 14,258,432 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,304,565 - 14,329,967 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1013,749,195 - 13,774,597 (-)NCBICelera
RGSC_v3.11014,304,565 - 14,329,967 (-)NCBI
Cytogenetic Map10q12NCBI
TMEM204
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,528,678 - 1,555,568 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,528,688 - 1,555,580 (+)Ensemblhg38GRCh38
GRCh37161,578,679 - 1,605,569 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,524,232 - 1,545,244 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34161,523,658 - 1,545,580NCBI
Celera161,796,505 - 1,817,517 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,504,212 - 1,531,051 (+)NCBIHuRef
CHM1_1161,578,684 - 1,605,523 (+)NCBICHM1_1
T2T-CHM13v2.0161,543,710 - 1,570,600 (+)NCBIT2T-CHM13v2.0
Tmem204
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,276,676 - 25,300,088 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,276,676 - 25,302,565 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381725,057,702 - 25,081,114 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,057,702 - 25,083,591 (-)Ensemblmm10GRCm38
MGSCv371725,194,647 - 25,218,059 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361724,785,302 - 24,808,714 (-)NCBIMGSCv36mm8
Celera1725,583,035 - 25,606,020 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
Tmem204
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,676,155 - 15,701,554 (-)Ensembl
ChiLan1.0NW_00495544215,678,938 - 15,701,554 (-)NCBIChiLan1.0ChiLan1.0
TMEM204
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,794,622 - 1,822,669 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,580,337 - 5,604,640 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016152,459 - 178,785 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1161,588,454 - 1,609,649 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl161,588,454 - 1,609,649 (+)EnsemblpanPan2panpan1.1
TMEM204
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,274,853 - 39,290,255 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,275,373 - 39,289,711 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha640,543,634 - 40,559,084 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0639,621,224 - 39,636,657 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,620,716 - 39,636,620 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1639,298,367 - 39,313,817 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,270,550 - 39,285,989 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,749,273 - 39,764,718 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmem204
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,306,636 - 104,326,791 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366942,382,662 - 2,402,981 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366942,382,672 - 2,402,798 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM204
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl340,342,961 - 40,355,726 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1340,342,957 - 40,355,887 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,806,127 - 41,821,183 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM204
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,443,132 - 1,469,973 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,446,321 - 1,472,785 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606829,617,900 - 29,641,656 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem204
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913666,884 - 693,072 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624913666,884 - 692,476 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmem204
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v192,325,991 - 2,351,805 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmem204
165 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:60
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000022142
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
RH127790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,076,808 - 14,077,001 (+)MAPPERmRatBN7.2
Rnor_6.01014,417,899 - 14,418,091NCBIRnor6.0
Rnor_5.01014,233,321 - 14,233,513UniSTSRnor5.0
RGSC_v3.41014,304,856 - 14,305,048UniSTSRGSC3.4
Celera1013,749,486 - 13,749,678UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022142   ⟹   ENSRNOP00000022142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,581,026 - 14,606,427 (-)Ensembl
mRatBN7.2 Ensembl1014,076,519 - 14,101,920 (-)Ensembl
Rnor_6.0 Ensembl1014,417,609 - 14,443,010 (-)Ensembl
RefSeq Acc Id: NM_001009620   ⟹   NP_001009620
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,581,025 - 14,606,427 (-)NCBI
mRatBN7.21014,076,518 - 14,101,920 (-)NCBI
Rnor_6.01014,417,608 - 14,443,010 (-)NCBI
Rnor_5.01014,233,030 - 14,258,432 (-)NCBI
RGSC_v3.41014,304,565 - 14,329,967 (-)RGD
Celera1013,749,195 - 13,774,597 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085358   ⟹   XP_038941286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,581,025 - 14,608,878 (-)NCBI
mRatBN7.21014,076,518 - 14,104,849 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001009620 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941286 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87601 (Get FASTA)   NCBI Sequence Viewer  
  EDM03900 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022142
  ENSRNOP00000022142.5
GenBank Protein Q5M962 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001009620   ⟸   NM_001009620
- Peptide Label: precursor
- UniProtKB: Q5M962 (UniProtKB/Swiss-Prot),   A6HCZ5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022142   ⟸   ENSRNOT00000022142
RefSeq Acc Id: XP_038941286   ⟸   XM_039085358
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M962-F1-model_v2 AlphaFold Q5M962 1-226 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697041
Promoter ID:EPDNEW_R7565
Type:multiple initiation site
Name:Tmem204_1
Description:transmembrane protein 204
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01014,443,030 - 14,443,090EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359314 AgrOrtholog
BioCyc Gene G2FUF-25808 BioCyc
Ensembl Genes ENSRNOG00000016494 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022142 ENTREZGENE
  ENSRNOT00000022142.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.140.150 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7314703 IMAGE-MGC_LOAD
InterPro TMEM204 UniProtKB/Swiss-Prot
KEGG Report rno:287129 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105601 IMAGE-MGC_LOAD
NCBI Gene 287129 ENTREZGENE
PANTHER PTHR14627 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 204 UniProtKB/Swiss-Prot
PhenoGen Tmem204 PhenoGen
RatGTEx ENSRNOG00000016494 RatGTEx
UniProt A6HCZ5 ENTREZGENE, UniProtKB/TrEMBL
  Q5M962 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-17 Tmem204  transmembrane protein 204  MGC105601  similar to hypothetical protein FLJ20898  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 MGC105601  similar to hypothetical protein FLJ20898      Symbol and Name status set to provisional 70820 PROVISIONAL