Gphb5 (glycoprotein hormone subunit beta 5) - Rat Genome Database

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Gene: Gphb5 (glycoprotein hormone subunit beta 5) Rattus norvegicus
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Symbol: Gphb5
Name: glycoprotein hormone subunit beta 5
RGD ID: 1359264
Description: Predicted to enable protein heterodimerization activity and thyrotropin-releasing hormone receptor binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of thyroid hormone receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Orthologous to human GPHB5 (glycoprotein hormone subunit beta 5); INTERACTS WITH bisphenol A; trichloroethene; vinclozolin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glycoprotein hormone beta 5; glycoprotein hormone beta-5; glycoprotein-beta 5; Gpb5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8699,865,691 - 99,870,308 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl699,865,691 - 99,870,308 (-)EnsemblGRCr8
mRatBN7.2694,129,968 - 94,134,585 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl694,131,021 - 94,133,570 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx694,528,120 - 94,530,669 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0694,826,640 - 94,829,189 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0694,255,503 - 94,258,052 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0698,380,500 - 98,383,049 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl698,380,500 - 98,383,049 (-)Ensemblrn6Rnor6.0
Rnor_5.06107,798,558 - 107,802,156 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4698,009,256 - 98,011,805 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera692,559,648 - 92,562,197 (-)NCBICelera
RGSC_v3.1698,012,711 - 98,015,261 (-)NCBI
Cytogenetic Map6q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5. Macdonald LE, etal., Proc Natl Acad Sci U S A 2005 Feb 15;102(7):2496-501. Epub 2005 Feb 7.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12045258   PMID:15841792   PMID:16901922   PMID:20223276  


Genomics

Comparative Map Data
Gphb5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8699,865,691 - 99,870,308 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl699,865,691 - 99,870,308 (-)EnsemblGRCr8
mRatBN7.2694,129,968 - 94,134,585 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl694,131,021 - 94,133,570 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx694,528,120 - 94,530,669 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0694,826,640 - 94,829,189 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0694,255,503 - 94,258,052 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0698,380,500 - 98,383,049 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl698,380,500 - 98,383,049 (-)Ensemblrn6Rnor6.0
Rnor_5.06107,798,558 - 107,802,156 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4698,009,256 - 98,011,805 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera692,559,648 - 92,562,197 (-)NCBICelera
RGSC_v3.1698,012,711 - 98,015,261 (-)NCBI
Cytogenetic Map6q24NCBI
GPHB5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381463,312,835 - 63,318,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1463,312,835 - 63,318,935 (-)Ensemblhg38GRCh38
GRCh371463,779,549 - 63,785,649 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361462,849,395 - 62,854,316 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341462,849,394 - 62,854,316NCBI
Celera1443,830,335 - 43,835,256 (-)NCBICelera
Cytogenetic Map14q23.2NCBI
HuRef1443,945,986 - 43,952,030 (-)NCBIHuRef
CHM1_11463,718,600 - 63,724,645 (-)NCBICHM1_1
T2T-CHM13v2.01457,520,199 - 57,526,299 (-)NCBIT2T-CHM13v2.0
Gphb5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391275,458,494 - 75,463,555 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1275,458,496 - 75,463,555 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381275,411,720 - 75,416,781 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1275,411,722 - 75,416,781 (-)Ensemblmm10GRCm38
MGSCv371276,512,707 - 76,517,768 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361276,330,560 - 76,335,621 (-)NCBIMGSCv36mm8
Celera1276,495,898 - 76,500,957 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1232.71NCBI
Gphb5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554666,461,388 - 6,467,012 (+)Ensembl
ChiLan1.0NW_0049554666,461,641 - 6,466,777 (+)NCBIChiLan1.0ChiLan1.0
GPHB5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21564,420,555 - 64,427,809 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11463,637,071 - 63,644,325 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01443,890,572 - 43,897,826 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11462,147,503 - 62,153,580 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1462,147,503 - 62,153,580 (-)EnsemblpanPan2panpan1.1
GPHB5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1837,893,610 - 37,899,386 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl837,894,210 - 37,901,337 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha837,650,913 - 37,656,600 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0838,120,432 - 38,126,122 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl838,121,378 - 38,127,483 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1837,737,351 - 37,743,038 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0837,816,890 - 37,822,579 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0838,170,145 - 38,175,832 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gphb5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864067,000,010 - 67,005,646 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364957,187,160 - 7,192,745 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364957,186,985 - 7,192,745 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPHB5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1194,736,877 - 194,743,043 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11194,737,061 - 194,743,053 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21216,811,064 - 216,821,989 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPHB5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12440,486,552 - 40,494,277 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605328,698,946 - 28,711,380 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gphb5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473437,720,679 - 37,725,352 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473437,708,890 - 37,729,120 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gphb5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1789,578,592 - 89,581,618 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:49
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000031076
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
4 2 7 28 14 22 2 13 2 1 39 25 27 7 35 20 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000031076   ⟹   ENSRNOP00000033047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl694,131,021 - 94,133,570 (-)Ensembl
Rnor_6.0 Ensembl698,380,500 - 98,383,049 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140696   ⟹   ENSRNOP00000099825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl699,865,691 - 99,870,308 (-)Ensembl
RefSeq Acc Id: NM_001007013   ⟹   NP_001007014
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8699,865,691 - 99,870,308 (-)NCBI
mRatBN7.2694,129,968 - 94,134,585 (-)NCBI
Rnor_6.0698,380,500 - 98,383,049 (-)NCBI
Rnor_5.06107,798,558 - 107,802,156 (-)NCBI
RGSC_v3.4698,009,256 - 98,011,805 (-)RGD
Celera692,559,648 - 92,562,197 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001007014 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAR92145 (Get FASTA)   NCBI Sequence Viewer  
  CCP37927 (Get FASTA)   NCBI Sequence Viewer  
  EDM03633 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000099825
  ENSRNOP00000099825.1
RefSeq Acc Id: NP_001007014   ⟸   NM_001007013
- Peptide Label: precursor
- UniProtKB: Q5VJF5 (UniProtKB/TrEMBL),   A0A0F7RPV3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000033047   ⟸   ENSRNOT00000031076
Ensembl Acc Id: ENSRNOP00000099825   ⟸   ENSRNOT00000140696
Protein Domains
Glycoprotein hormone subunit beta

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5VJF5-F1-model_v2 AlphaFold Q5VJF5 1-129 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359264 AgrOrtholog
BioCyc Gene G2FUF-37082 BioCyc
Ensembl Genes ENSRNOG00000021885 Ensembl
  ENSRNOG00000083703 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000140696 ENTREZGENE
  ENSRNOT00000140696.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cys_knot UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  Gonadotropin_bsu UniProtKB/TrEMBL
KEGG Report rno:366668 UniProtKB/TrEMBL
NCBI Gene 366668 ENTREZGENE
PANTHER Gly_hormoneB UniProtKB/TrEMBL
  GLYCOPROTEIN HORMONE BETA-5 UniProtKB/TrEMBL
Pfam Cys_knot UniProtKB/TrEMBL
PhenoGen Gphb5 PhenoGen
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021885 RatGTEx
  ENSRNOG00000083703 RatGTEx
SMART GHB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A0F7RPV3 ENTREZGENE, UniProtKB/TrEMBL
  Q5VJF5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-05-23 Gphb5  glycoprotein hormone subunit beta 5  Gphb5  glycoprotein hormone beta 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Gphb5  glycoprotein hormone beta 5  Gpb5  glycoprotein hormone subunit beta 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 Gpb5  glycoprotein hormone subunit beta 5      Symbol and Name status set to provisional 70820 PROVISIONAL