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Gene: Pir (pirin) Rattus norvegicus

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Symbol:

Pir

Name:

pirin

RGD ID:

1359212

Description:

Predicted to enable metal ion binding activity; quercetin 2,3-dioxygenase activity; and transcription coregulator activity. Predicted to be involved in monocyte differentiation. Predicted to act upstream of or within myeloid cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human PIR (pirin); INTERACTS WITH 1,3-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC109484; pirin (iron-binding nuclear protein); probable quercetin 2,3-dioxygenase PIR; probable quercetinase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PIR (pirin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Pir (pirin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pir (pirin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PIR (pirin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PIR (pirin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pir (pirin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PIR (pirin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PIR (pirin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pir (pirin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pir (pirin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PIR (pirin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pir (pirin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pir (pirin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pir	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	pir	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	33,740,428 - 33,851,049 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	33,740,429 - 33,851,049 (-)	Ensembl				GRCr8
mRatBN7.2	X	30,108,536 - 30,219,269 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	30,108,538 - 30,219,218 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	31,147,941 - 31,251,719 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	34,578,429 - 34,689,049 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	30,772,761 - 30,876,540 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	31,852,322 - 31,968,152 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	31,852,323 - 31,968,152 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	32,226,073 - 32,341,358 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	50,864,981 - 50,974,861 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	30,455,202 - 30,563,741 (-)	NCBI		Celera
RGSC_v3.1	X	50,918,450 - 51,028,330 (-)	NCBI
Cytogenetic Map	X	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cholangiocarcinoma (ISO)

contact dermatitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

1,4-phenylenediamine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

1-nitropyrene (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2,4,6-trinitrotoluene (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-amino-4,6-dinitrotoluene (EXP)

2-methylcholine (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-phenylprop-2-enal (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

9-cis-retinoic acid (ISO)

acetamide (EXP)

acrolein (ISO)

acrylamide (ISO)

adefovir pivoxil (ISO)

aflatoxin B1 (EXP,ISO)

Aflatoxin B2 alpha (ISO)

all-trans-4-oxoretinoic acid (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

ampicillin (ISO)

antimonite (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

benzylpenicillin (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

bortezomib (ISO)

bromobenzene (EXP)

cadmium dichloride (ISO)

cadmium sulfate (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

CGP 52608 (ISO)

chloroacetaldehyde (ISO)

chlorohydrocarbon (EXP)

chloroprene (EXP,ISO)

chlorpromazine (EXP)

cidofovir anhydrous (ISO)

cisplatin (ISO)

clodronic acid (ISO)

cobalt atom (ISO)

cobalt dichloride (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) chloride (ISO)

curcumin (EXP)

cyclosporin A (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

diethyl maleate (ISO)

diethylstilbestrol (EXP)

dioxygen (ISO)

dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (ISO)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

fenofibrate (EXP)

finasteride (EXP)

fipronil (EXP)

flutamide (EXP)

formaldehyde (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

indometacin (ISO)

inulin (ISO)

isoflavones (ISO)

isoprenaline (ISO)

isotretinoin (ISO)

ivermectin (ISO)

lead diacetate (ISO)

lead(0) (ISO)

leflunomide (EXP)

lipopolysaccharide (ISO)

mercury dibromide (ISO)

mercury dichloride (ISO)

metformin (EXP)

methapyrilene (ISO)

methylmercury chloride (EXP,ISO)

mitomycin C (ISO)

N(6)-dimethylallyladenine (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nevirapine (EXP)

nickel sulfate (ISO)

nimesulide (EXP)

oxaliplatin (EXP)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (EXP,ISO)

paraquat (EXP,ISO)

pentachlorophenol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenoxymethylpenicillin (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

quercetin (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

succimer (ISO)

sulfamethoxazole (ISO)

sulforaphane (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

thimerosal (ISO)

thioacetamide (EXP)

topotecan (EXP)

trichloroethene (EXP)

triphenyl phosphate (EXP)

triptonide (ISO)

Tungsten carbide (ISO)

tunicamycin (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vincaleukoblastine (ISO)

vinclozolin (EXP)

xylitol (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA-templated transcription (IEA)

monocyte differentiation (IBA,ISO)

myeloid cell differentiation (IEA,ISO)

Cellular Component

cytoplasm (IEA,ISO,ISS)

cytosol (IEA,ISO)

nuclear body (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO,ISS)

Molecular Function

dioxygenase activity (IEA)

metal ion binding (IEA,ISO,ISS)

oxidoreductase activity (IEA)

protein binding (ISO)

quercetin 2,3-dioxygenase activity (IBA,IEA,ISO,ISS)

transcription coregulator activity (IEA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Identification of key genes and pathways associated with cholangiocarcinoma development based on weighted gene correlation network analysis.	Liu J, etal., PeerJ. 2019 Oct 31;7:e7968. doi: 10.7717/peerj.7968. eCollection 2019.
4.	Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor.	Pang H, etal., J Biol Chem 2004 Jan 9;279(2):1491-8. Epub 2003 Oct 22.
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8.	Identification of pirin, a novel highly conserved nuclear protein.	Wendler WM, etal., J Biol Chem 1997 Mar 28;272(13):8482-9.

Additional References at PubMed

PMID:15951572	PMID:20010624	PMID:20089166	PMID:20711196	PMID:23716661

Genomics

Comparative Map Data

Pir
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	33,740,428 - 33,851,049 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	33,740,429 - 33,851,049 (-)	Ensembl				GRCr8
mRatBN7.2	X	30,108,536 - 30,219,269 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	30,108,538 - 30,219,218 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	31,147,941 - 31,251,719 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	34,578,429 - 34,689,049 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	30,772,761 - 30,876,540 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	31,852,322 - 31,968,152 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	31,852,323 - 31,968,152 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	32,226,073 - 32,341,358 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	50,864,981 - 50,974,861 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	30,455,202 - 30,563,741 (-)	NCBI		Celera
RGSC_v3.1	X	50,918,450 - 51,028,330 (-)	NCBI
Cytogenetic Map	X	q14	NCBI

PIR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	15,384,799 - 15,493,333 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	15,384,799 - 15,493,635 (-)	Ensembl			hg38	GRCh38
GRCh37	X	15,402,921 - 15,511,456 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	15,312,842 - 15,421,385 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	X	15,162,582 - 15,271,113	NCBI
Celera	X	19,518,436 - 19,626,837 (-)	NCBI		Celera
Cytogenetic Map	X	p22.2	NCBI
HuRef	X	13,159,639 - 13,268,835 (-)	NCBI		HuRef
CHM1_1	X	15,433,843 - 15,542,647 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	14,967,733 - 15,076,309 (-)	NCBI		T2T-CHM13v2.0

Pir
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	163,052,427 - 163,156,009 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	163,052,367 - 163,156,007 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	X	164,269,431 - 164,373,013 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	164,269,371 - 164,373,011 (+)	Ensembl			mm10	GRCm38
MGSCv37	X	160,707,363 - 160,810,945 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	X	159,613,542 - 159,717,010 (+)	NCBI		MGSCv36	mm8
Celera	X	147,485,273 - 147,588,412 (+)	NCBI		Celera
Cytogenetic Map	X	F5	NCBI
cM Map	X	76.12	NCBI

Pir
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955519	2,698,172 - 2,813,206 (+)	Ensembl
ChiLan1.0	NW_004955519	2,698,207 - 2,813,201 (+)	NCBI	ChiLan1.0	ChiLan1.0

PIR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	17,184,000 - 17,294,535 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	17,187,666 - 17,297,896 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	8,011,382 - 8,121,994 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	15,294,094 - 15,403,506 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	15,294,099 - 15,404,004 (-)	Ensembl			panPan2	panpan1.1

PIR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	11,627,337 - 11,733,489 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	11,627,337 - 11,733,489 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	11,534,820 - 11,640,316 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	11,589,671 - 11,695,482 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	11,589,671 - 11,695,478 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	11,652,577 - 11,758,046 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	11,643,915 - 11,752,389 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	11,672,015 - 11,777,580 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pir
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	4,794,803 - 4,902,157 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	4,793,823 - 4,902,471 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	4,794,803 - 4,902,211 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PIR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	11,934,163 - 12,033,746 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	X	11,934,157 - 12,034,629 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	12,894,760 - 12,994,430 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PIR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	13,854,356 - 13,966,554 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	13,854,236 - 13,966,506 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666056	15,690,384 - 15,800,824 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pir
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624829	180,129 - 286,429 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624829	181,918 - 286,348 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pir
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	X	24,845,258 - 24,949,867 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pir
386 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	112
Count of miRNA genes:	85
Interacting mature miRNAs:	100
Transcripts:	ENSRNOT00000004884
Prediction methods:	Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598873	Memor2	Memory QTL 2	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	X	24470360	44931007	Rat
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	4001493	44939387	Rat
2290375	Gluco34	Glucose level QTL 34	2.75		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	24470360	45082063	Rat
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1970440	46970440	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	8111486	53111486	Rat

Markers in Region

DXGot128

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	X	33,753,125 - 33,753,206 (+)	Marker Load Pipeline
mRatBN7.2	X	30,121,236 - 30,121,317 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	31,864,308 - 31,864,388	NCBI	Rnor6.0
Rnor_5.0	X	32,238,059 - 32,238,139	UniSTS	Rnor5.0
RGSC_v3.4	X	50,877,681 - 50,877,761	UniSTS	RGSC3.4
Celera	X	30,467,840 - 30,467,920	UniSTS
Cytogenetic Map	X	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	73	59	6	334	173	11	141	78	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001009474	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC088290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000004884 ⟹ ENSRNOP00000004884

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	33,740,429 - 33,851,049 (-)	Ensembl
mRatBN7.2 Ensembl	X	30,108,538 - 30,219,218 (-)	Ensembl
Rnor_6.0 Ensembl	X	31,852,323 - 31,968,152 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111021 ⟹ ENSRNOP00000083645

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	33,740,429 - 33,851,049 (-)	Ensembl
mRatBN7.2 Ensembl	X	30,108,538 - 30,219,146 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112847 ⟹ ENSRNOP00000096940

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	33,740,429 - 33,851,049 (-)	Ensembl
mRatBN7.2 Ensembl	X	30,108,538 - 30,219,218 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000122305 ⟹ ENSRNOP00000099013

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	33,740,429 - 33,851,044 (-)	Ensembl

RefSeq Acc Id:

NM_001009474 ⟹ NP_001009474

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	33,740,428 - 33,851,049 (-)	NCBI
mRatBN7.2	X	30,108,536 - 30,219,169 (-)	NCBI
Rnor_6.0	X	31,852,322 - 31,968,152 (-)	NCBI
Rnor_5.0	X	32,226,073 - 32,341,358 (-)	NCBI
RGSC_v3.4	X	50,864,981 - 50,974,861 (-)	RGD
Celera	X	30,455,202 - 30,563,741 (-)	RGD

Sequence:

show sequence

CGCTGACTGACGGCAGGCGCTTTGCAAACCCTGCGCTGTATCCCTGCCGCTGTGGAGTCTAGGC
ACCGCCGGTCGTGGCCTCCCTCCTGGGCCTGCGCTACTGCCGAGTCAACACTAGAACTTTTTTT
ATACACTTCAAAATGGCGTCCTCTAAAAAGGTTACTCTCTCCGTCCTCAGCCGGGAACAGTCAG
AGGGGGTTGGAGCACGGGTGCGCAGAAGCATTGGCGGACCTGAGTTGAAAATGCTGGATCCATT
TTTGCTGTTTGATGAATTTAAAGGAGGAAGGCCGGGAGGATTTCCTGATCATCCACACCGAGGA
TTTGAAACAGTATCTTATCTTCTAGAAGGTGGCAGCATGGCCCATGAAGACTTCTGTGGACATG
TTGGTAAAATGAACCCAGGAGACCTACAGTGGATGACTGCAGGACGAGGCATTCTACATGCTGA
GATGCCCTGCTCAGAGGAGCCAGCCCATGGCTTACAGCTCTGGGTGAATTTGAAACGCTCAGAA
AAGATGGTGGAGCCTCAGTACCAGGAACTGAAAAGTGAAGAGATCCCGAAACCCAGCAAAGATG
GTGTGACAGTCGCTGTCATTTCAGGAGAAGCCTTGGGAATAAAGTCGAAGGTTTACACTCGCAC
ACCAACCTTATATCTGGACTTCAAGTTGGACCAAGGAGCAAAGCATTCCCAGCCTATTCCTAAA
GGGTGGACAAGCTTCATTTATACCATCTCTGGAGATGTGTATATTGGGCCTGATGATGCTCAAC
AAAAGATAGAACCGCATCGCACAGCAGTGCTTGGAGAAGGTGACACTGTCCAGTTGGAAAATAA
GGATCCCAAAAGAAGTCATTTTGTCTTAATTGCCGGGGAGCCATTAAGAGAACCAGTTGTCCAA
CATGGTCCGTTTGTGATGAATACCAATGAGGAGATTTCTGAGGCCATTCTTGATTTCAGGAATG
CAAAAAATGGTTTTGAGGGGGCCAAAACCTGGAAGTCAAAGATTGGAAACCAATGATGGGCTGA
AATGCTGCCATTTGTATGATCTGACCATTCATTATATTCAATTTTCAAAGCTGATTTAGCTGAA
ACGTCTAAAGAATTCTACATTGAGATGGACATAGTGACACATTCCTTTAGTCCCAGCACTCCAG
GGGTCAGACATCGGGATCTCTGATTTCGAAGCCCATCTATCTACGGACTCAGTTCTAGGACAGC
TGGGCTACACAGAGAAACCCTGTCTTGAAAATGCAAAAATAAAAAAATAGAATTTCACATTAGA
ATGAAAGGACTTTTTTGTAGTGAGTCTTCAGAATACATTATATACATGTATGAAATTGTCAAAG
AACAGGGTAACTAATTTTAAAAGGAAATGTATAAACAATAAAAAATGGTAGTGATATATGTAAG
ATATTTCCTGACACATGCAAATAAGTTTAATTGTTGCTTTAAAAAAAAAGACAATGTTCATTTG
ATGGAAATTATTAAGTGCCTATTAAAAATAATTGCTATGTAAAAAAAAAAAAAAAAAAAAAAAA
A

hide sequence

RefSeq Acc Id:

XM_039099890 ⟹ XP_038955818

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	33,740,428 - 33,848,997 (-)	NCBI
mRatBN7.2	X	30,108,536 - 30,217,105 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001009474	(Get FASTA)	NCBI Sequence Viewer
	XP_038955818	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88290	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000004884
	ENSRNOP00000004884.5
	ENSRNOP00000099013
GenBank Protein	Q5M827	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001009474 ⟸ NM_001009474

- UniProtKB:

Q5M827 (UniProtKB/Swiss-Prot), A0A8I5ZXG1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASSKKVTLSVLSREQSEGVGARVRRSIGGPELKMLDPFLLFDEFKGGRPGGFPDHPHRGFETV
SYLLEGGSMAHEDFCGHVGKMNPGDLQWMTAGRGILHAEMPCSEEPAHGLQLWVNLKRSEKMVE
PQYQELKSEEIPKPSKDGVTVAVISGEALGIKSKVYTRTPTLYLDFKLDQGAKHSQPIPKGWTS
FIYTISGDVYIGPDDAQQKIEPHRTAVLGEGDTVQLENKDPKRSHFVLIAGEPLREPVVQHGPF
VMNTNEEISEAILDFRNAKNGFEGAKTWKSKIGNQ

hide sequence

Ensembl Acc Id:

ENSRNOP00000004884 ⟸ ENSRNOT00000004884

RefSeq Acc Id:	XP_038955818 ⟸ XM_039099890
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZXG1 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000083645 ⟸ ENSRNOT00000111021

Ensembl Acc Id:

ENSRNOP00000096940 ⟸ ENSRNOT00000112847

Ensembl Acc Id:

ENSRNOP00000099013 ⟸ ENSRNOT00000122305

Protein Domains

Pirin C-terminal Pirin N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5M827-F1-model_v2	AlphaFold	Q5M827	1-291	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701796

Promoter ID:

EPDNEW_R12320

Type:

initiation region

Name:

Pir_1

Description:

pirin

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	31,968,113 - 31,968,173	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359212	AgrOrtholog
BioCyc Gene	G2FUF-2591	BioCyc
Ensembl Genes	ENSRNOG00000003674	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000004884	ENTREZGENE
	ENSRNOT00000004884.6	UniProtKB/Swiss-Prot
	ENSRNOT00000122305	ENTREZGENE
Gene3D-CATH	2.60.120.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7322321	IMAGE-MGC_LOAD
InterPro	Pirin	UniProtKB/Swiss-Prot
	Pirin_C_dom	UniProtKB/Swiss-Prot
	Pirin_N_dom	UniProtKB/Swiss-Prot
	RmlC-like_jellyroll	UniProtKB/Swiss-Prot
	RmlC_Cupin_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:363465	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109484	IMAGE-MGC_LOAD
NCBI Gene	363465	ENTREZGENE
PANTHER	PIRIN	UniProtKB/Swiss-Prot
	PTHR13903	UniProtKB/Swiss-Prot
Pfam	Pirin	UniProtKB/Swiss-Prot
	Pirin_C	UniProtKB/Swiss-Prot
PhenoGen	Pir	PhenoGen
PIRSF	Pirin	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000003674	RatGTEx
Superfamily-SCOP	SSF51182	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZXG1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ATI7_RAT	UniProtKB/TrEMBL
	A0ABK0L4V4_RAT	UniProtKB/TrEMBL
	PIR_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-10	Pir	pirin	Pir	pirin (iron-binding nuclear protein)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-09	Pir	pirin (iron-binding nuclear protein)	Pir	pirin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	Pir	pirin			Symbol and Name status set to approved	1299863	APPROVED
2005-07-29	Pir	pirin			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD