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Gene: Nfxl1 (nuclear transcription factor, X-box binding-like 1) Rattus norvegicus

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Symbol:

Nfxl1

Name:

nuclear transcription factor, X-box binding-like 1

RGD ID:

1359201

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in membrane. Predicted to be active in nucleus. Orthologous to human NFXL1 (nuclear transcription factor, X-box binding like 1); INTERACTS WITH (+)-schisandrin B; amitrole; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC289595; NF-X1-type zinc finger protein NFXL1; RGD1359201; similar to CG15011-PA; similar to nuclear transcription factor, X-box binding-like 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	35,980,058 - 36,021,478 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	35,980,057 - 36,023,281 (+)	Ensembl				GRCr8
mRatBN7.2	14	35,626,086 - 35,667,505 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	35,626,066 - 35,667,498 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	35,991,372 - 36,032,388 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	37,296,126 - 37,337,142 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	35,784,495 - 35,825,508 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	38,192,462 - 38,233,852 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	38,192,446 - 38,233,852 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	38,003,494 - 38,044,774 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	38,054,861 - 38,095,844 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	34,878,053 - 34,918,828 (+)	NCBI		Celera
RGSC_v3.1	14	38,082,031 - 38,099,193 (+)	NCBI
Cytogenetic Map	14	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

cholestasis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

amitrole (EXP)

atazanavir sulfate (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chenodeoxycholic acid (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

coumarin (ISO)

cyclosporin A (ISO)

deoxycholic acid (ISO)

Dibutyl phosphate (ISO)

formaldehyde (ISO)

FR900359 (ISO)

gallic acid (ISO)

glycochenodeoxycholic acid (ISO)

glycocholic acid (ISO)

glycodeoxycholic acid (ISO)

heptanal (ISO)

hexanal (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

N-methyl-4-phenylpyridinium (EXP)

nefazodone (ISO)

nonanal (ISO)

octanal (ISO)

paracetamol (ISO)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

propanal (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

triticonazole (EXP)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of DNA-templated transcription (IBA,IEA)

regulation of transcription by RNA polymerase II (IEA)

Cellular Component

nucleus (IBA,IEA)

Molecular Function

DNA-binding transcription factor activity (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

metal ion binding (IEA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IBA)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:19946888

Genomics

Comparative Map Data

Nfxl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	35,980,058 - 36,021,478 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	35,980,057 - 36,023,281 (+)	Ensembl				GRCr8
mRatBN7.2	14	35,626,086 - 35,667,505 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	35,626,066 - 35,667,498 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	35,991,372 - 36,032,388 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	37,296,126 - 37,337,142 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	35,784,495 - 35,825,508 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	38,192,462 - 38,233,852 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	38,192,446 - 38,233,852 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	38,003,494 - 38,044,774 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	38,054,861 - 38,095,844 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	34,878,053 - 34,918,828 (+)	NCBI		Celera
RGSC_v3.1	14	38,082,031 - 38,099,193 (+)	NCBI
Cytogenetic Map	14	p11	NCBI

NFXL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	47,847,233 - 47,914,667 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	47,847,233 - 47,914,667 (-)	Ensembl			hg38	GRCh38
GRCh37	4	47,849,250 - 47,916,684 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	47,544,014 - 47,611,390 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	4	48,298,135 - 48,365,585 (-)	NCBI		Celera
Cytogenetic Map	4	p12	NCBI
HuRef	4	47,168,755 - 47,236,269 (-)	NCBI		HuRef
CHM1_1	4	47,848,204 - 47,915,792 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	47,814,565 - 47,881,968 (-)	NCBI		T2T-CHM13v2.0

Nfxl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	72,670,647 - 72,717,078 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	72,670,644 - 72,717,027 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	72,513,304 - 72,559,735 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	72,513,301 - 72,559,684 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	72,904,543 - 72,950,884 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	72,835,570 - 72,838,148 (-)	NCBI		MGSCv36	mm8
Celera	5	69,767,855 - 69,808,087 (-)	NCBI		Celera
Cytogenetic Map	5	C3.2	NCBI
cM Map	5	38.44	NCBI

Nfxl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955443	668,031 - 713,481 (+)	Ensembl
ChiLan1.0	NW_004955443	665,235 - 714,627 (+)	NCBI	ChiLan1.0	ChiLan1.0

NFXL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	79,944,440 - 80,013,688 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	80,207,453 - 80,274,861 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	74,234,523 - 74,301,966 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	84,966,959 - 85,034,154 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	84,967,076 - 85,034,154 (+)	Ensembl			panPan2	panpan1.1

NFXL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	43,743,271 - 43,814,899 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	43,744,181 - 43,814,520 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	43,695,854 - 43,767,093 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	44,342,939 - 44,414,377 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	44,342,946 - 44,414,375 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	44,020,805 - 44,091,824 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	43,552,949 - 43,623,828 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	44,435,784 - 44,507,011 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Nfxl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	32,235,545 - 32,289,403 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936482	14,009,724 - 14,062,207 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936482	14,008,825 - 14,062,654 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NFXL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	37,812,911 - 37,875,540 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	37,812,378 - 37,875,582 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	39,788,607 - 39,845,909 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NFXL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	2,333,158 - 2,401,008 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	2,333,809 - 2,400,084 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666047	48,351,769 - 48,419,293 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nfxl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624761	19,029,434 - 19,084,307 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624761	19,029,537 - 19,084,156 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Nfxl1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	29,357,650 - 29,400,514 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Nfxl1
391 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	382
Count of miRNA genes:	229
Interacting mature miRNAs:	283
Transcripts:	ENSRNOT00000003131
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631528	Scl11	Serum cholesterol level QTL 11	4.9		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	14	17875645	36079022	Rat
7411573	Bw139	Body weight QTL 139	4.7	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	14	1	40068101	Rat
9589814	Gluco67	Glucose level QTL 67	4.54	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	40068101	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9393298	39411170	Rat
1300154	Bp189	Blood pressure QTL 189	3.04		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	14	31238080	72970315	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30674469	85041098	Rat
2324617	Coatc2	Coat color QTL 2		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	14	31121333	39507682	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	33424686	102238540	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8621398	53621398	Rat
61420	Pia6	Pristane induced arthritis QTL 6	4.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	14	18915454	42433608	Rat
7387267	Uae42	Urinary albumin excretion QTL 42		0.61	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	14	22521517	67521517	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11334716	100078267	Rat
2313397	Coatc1	Coat color QTL1			coat/hair pigmentation trait (VT:0010463)	coat/hair color measurement (CMO:0001808)	14	18895192	63895192	Rat
631262	Tcas4	Tongue tumor susceptibility QTL 4	7.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	14	17906726	54251504	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41415516	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8621398	53621398	Rat

Markers in Region

RH141380

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	35,627,844 - 35,628,044 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	38,194,221 - 38,194,420	NCBI	Rnor6.0
Rnor_5.0	14	38,005,239 - 38,005,438	UniSTS	Rnor5.0
RGSC_v3.4	14	38,056,212 - 38,056,411	UniSTS	RGSC3.4
Celera	14	34,879,812 - 34,880,011	UniSTS
Cytogenetic Map	14	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001170438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091704	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091705	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272918	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272919	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC111383	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC121481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC088853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000077080 ⟹ ENSRNOP00000074217

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	35,980,083 - 36,021,478 (+)	Ensembl
mRatBN7.2 Ensembl	14	35,626,086 - 35,667,498 (+)	Ensembl
Rnor_6.0 Ensembl	14	38,192,870 - 38,233,852 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000090242 ⟹ ENSRNOP00000075378

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	35,980,057 - 36,021,478 (+)	Ensembl
mRatBN7.2 Ensembl	14	35,626,066 - 35,667,498 (+)	Ensembl
Rnor_6.0 Ensembl	14	38,192,446 - 38,233,534 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000136600 ⟹ ENSRNOP00000109616

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	35,980,083 - 36,023,281 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000144997 ⟹ ENSRNOP00000101110

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	35,980,083 - 36,021,671 (+)	Ensembl

RefSeq Acc Id:

NM_001170438 ⟹ NP_001163909

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	35,980,083 - 36,021,478 (+)	NCBI
mRatBN7.2	14	35,626,086 - 35,667,498 (+)	NCBI
Rnor_6.0	14	38,192,462 - 38,233,852 (+)	NCBI
Rnor_5.0	14	38,003,494 - 38,044,774 (+)	NCBI
RGSC_v3.4	14	38,054,861 - 38,095,844 (+)	RGD
Celera	14	34,878,053 - 34,918,828 (+)	NCBI

Sequence:

show sequence

CGCGGGCAGAGGCTTCTGGGAGTTGTAGTCGCTGGCGGTGGGCGCCGTCGGTAAGGAGACGTAG
CTTTCGGTGCGGTCCACTTCAGCAGTTGGTTCCCGGCCGCGGCGTCACGGGATGGACGCTTCCT
GGCGCCAGGTGGCCGCTGGCCGAGGCCGAGCCCGAGGAAGGGGTACCGCAGTGCCCCTCTCAGG
AAATGGAGTCCCTCTTAGCGGCGCAGGGGGAGGGCGAGCCAAAGGGTCTGGGGGCGCGGTGCCC
TCGGCCCCCGGCCCGAGGAGAGCAGCAACTCCGGGCCCTGCGGGTCACAAGCAGCGCTCTGCTG
GAGGCGAAGCCCCGCAGCCCCTGTGGGTCGGCGGTGAGGATGGCTCAGAGCTAATATCTCAGAG
GAAATTTGAGGAGATCAAGAAGGCCAATCAAGCTGCAGCCAGAAAGCTCGTGGAGGAACACTGC
AGCTCTTCCTCTGAAGAAGAAGAAGGGGATGAAGACTTTGAAGGAAAACAGGGGAAAATTGTTG
CTAATACATTCATAACATACACCACTCACACAGATGGAGATGTACATGAATTGGAGAAAACAAA
ACAGTATCTGAATGAGGCTTTCCAAGCAGGGGCTATGACGTGCCTGATTTGTATTGCTTCAGTG
AAGAGAAACCAGGCAGTTTGGAGCTGTTCAGGATGTTTCTGTATATTCCACATGCCCTGTATTC
AGAAGTGGGCTAAGGACAGCCAGTTTCTTGTATCTTCTGTGACAGACGATGATTTTGGAAAGAA
AGATTATCCCTGGCCATGTCCAAAATGTAGATTTGAATACAAAAGGTCGGAAACACCTAGTCGA
TATTATTGCTACTGTGGAAAAGTAGAAGACCCACCTTTAGATCCCTGGCTTGTTCCTCATTCGT
GTGGCCAAGTGTGTGAGAGAGAATTTAAACCTTCCTGTGGTCATAAATGTCTACTACTCTGCCA
TCCAGGTCCCTGCCCTCCTTGTCCAAAGATGGTCACAACTACTTGCTACTGTAAGAAAGCAAAA
CCTATCCCTCGTAGGTGCAGTGCCAAGCAGTGGTCCTGTCAGCTGCCATGTGGGCGAAAGCTGC
TTTGTGGGCAGCATTCGTGTGAAAATCCTTGCCATGCAGGAAACTGTCAGCCTTGTCCAAGAGT
TAGTAGACAAAAATGTGTATGTGGCAAAAAAGTAGCAGAAAGAAGTTGTGCGAGTCCAGTGTGG
CACTGTGACCAAGTATGTAGAAAGACACTGCCGTGTGGTAATCATACATGTGAGCAAGTTTGTC
ATGTTGGTGCTTGTGGAGAATGTCCTCGCTCTGGGAAGAGGTCTTGTCCCTGTCAGAAATCAAA
GTTTTCTTTGCCTTGTACAGAAGATGTACCAACTTGTGGAGACAGCTGTGACAAAATACTCGAA
TGTGGAATCCACAGGTGTTCACAGCGTTGCCATCGAGGTCCTTGTGAAACGTGCAGACAAGAAG
TGGAAAAGCAGTGTCGTTGTGGAAAACATACAAAGCGAATGCCTTGTCACAAGACTTACCTTTG
TGAAACGAAGTGTGTAAAAATGCGGGACTGTCAAAAGCATCAGTGTAGGAGAAAGTGTTGCCCT
GGAAACTGTCCACCTTGTGATCAAAATTGTGGACGGACTTTAGGATGTAGAAACCATAAGTGTC
CGTCTGTCTGCCACAGAGGCAGCTGCTATCCATGCCCAGAAACGGTAGATGTGAAGTGCAACTG
TGGTAACGCAAAGGTGACAGTACCCTGTGGCCGAGAGCGGACTACAAGGCCACCTAAGTGCAAA
GAGCTGTGCAGTCGACCACCAACATGTCATCATTCAAGTCAAGAAAAACACCGCTGTCACTTTG
GCCCATGCCCACCATGTCATCAGCCTTGCCAAAAAGTTCTGGAGAAATGTGGGCACTTGTGTCC
CATTTCATGTCATGATCAAGCATTAGTAAAGCAGACCGGCAGGCATCAGCTGTCAGGCCCTTGG
GAGCAGCCAGCCGAGCCAGCGTTTATTCAGACTGCGTTGCCTTGTCCTCCGTGTCAAGTTCCCA
TTCCTGTGGAATGTCTGGGGAAGCATGAGGTAAGCCCACTACCATGCCATGCTGTAGGACCCTA
TTCATGCAAGAGACTTTGTGGAAGAATGTTGAACTGTCAGAATCATACGTGTACGAAAGAATGC
CACAAAGTGACTGAAGTTGATGGCTGTCCTGGCAGACATAAGGCTGGCCCAGAATGCCTTCAGT
GTGAAGAAGGGTGTTCTAAGTCACGGCCTGCAGGTTGTCCTCACCCTTGTGTTTTGCCATGTCA
CCCTGGAAAATGCCCTCCTTGTGTCCAGATGCTTAGAATAAAATGTCACTGCAAGATCACAAAC
CTGTATGTGGAATGTAGAAAAATAACCACAGCTGATGTGAGTGAGAAGAACCTCCTCAGTTGTT
GCAAAAACCAGTGCCCCAAAGAGCTTCCTTGTGGCCATAGATGCAAAGAGATGTGTCATCCTGG
TGAATGCCCCTATAATTGCAACCAGAAGGTAAAACTTAGATGCCCTTGTAAAAGAATAAAACGG
GAATTGCCTTGCAATAAAATCCGTGGGAATCAGGTTTCAGTGGAATGCGATGCGGCGTGCAAGG
AGATGAAGCGGAAAGCATCTGAGATTAAAGAAGCGGAAGCCAACGCTGCTCTGGAAGAAGAAAA
GCGAAGGCAGCAGGCTGAGCTGGAGGCTTTTGAGAACAGACTGAAGGGCCGGCGGAAGAAGAAC
AGGAAACGCGATGAAGTGGCCGTGCAGCTCTCGCCTTGGCAGAAGTACAAGTCCTACCTCTTTC
CGGTGTGTGGAGTTGTGGTGGCGGTGCTTGTGTGGTACATCTGCCATCATGCGGATTAATGATC
CTTTAGATCTCACTTACCTCAGACTGGAGTTATATAAACGTTGACTCTAGGACGTTAGAACGTG
CGCTGTAGCATATGATACACATTCACATTCCTCTCTGTGTCCTTGTCTGGCTGTAGGTAGGACA
GGATGTTTTAGTGTTCTCTGAACCAGCAGTTCCCGGGCCTGTGAGATACTGTACAGTCATCATG
GCTGCAGGTAGAAACAGGTCAGGAAGCTTCGTCAGGAGCACTGTGCCCCTGTGTATTAAGTTAG
TCTTTGTCCTCAGATGTGTCCACGTCCAACACTTCATCCTGTGAATTCAGATAGAACTGAGCCA
TATGTGCAGCCACAAGGATATTTCTCTGTGATATTTCACTTACTGGGTACTTTTCTTGATCATG
TAACTTTCTACTTTTTTAAAGAAATGATTCTGTAACAGAATCTTAAATTCTAACAGGAAGTTTT
ATAGTTAGATTTCAGATTATCAGAGAGGAATTTTTATTGGTAATTGAAGCAAATTTTACACTGC
GTATTCCTCGGATATATAAACAAGTGCCAGACGAGGTTCCTTTTAGGACGTTGTTGGGTTGGGT
TTTTTTTTTTTTTTTTTTTTTTTTTGGTGTAAGAAGCTTTAATTGATGTTGGCATGTTTTGTAA
AACTTGTGTGTATCTTTTTATGATCATAATAAAGGAAAACTAATATTTATGAGCAATATGTGCA
GAGCACAGGGCTGGTGGGTGTAATGTACTTGATTCCATTTTTTTTTTACTGTAATTTTTGATAT
AGCTGAGAATAATCCATTTTGTGAAATCAAACTGATAGAGAAATAATAAGCCAAATTGCATAGA
TTTGTAAGTCATTTAAAGTAGTTTTGCTATTTAATTTTATGATTGTTTTCATTAAAAGTTTTCA
TACCAAA

hide sequence

RefSeq Acc Id:

XM_039091704 ⟹ XP_038947632

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	35,980,139 - 36,021,478 (+)	NCBI
mRatBN7.2	14	35,626,139 - 35,667,505 (+)	NCBI

RefSeq Acc Id:

XM_039091705 ⟹ XP_038947633

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	35,987,691 - 36,021,478 (+)	NCBI
mRatBN7.2	14	35,633,694 - 35,667,505 (+)	NCBI

RefSeq Acc Id:

XM_063272918 ⟹ XP_063128988

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	35,980,058 - 36,021,478 (+)	NCBI

RefSeq Acc Id:

XM_063272919 ⟹ XP_063128989

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	35,980,137 - 36,021,478 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001163909	(Get FASTA)	NCBI Sequence Viewer
	XP_038947632	(Get FASTA)	NCBI Sequence Viewer
	XP_038947633	(Get FASTA)	NCBI Sequence Viewer
	XP_063128988	(Get FASTA)	NCBI Sequence Viewer
	XP_063128989	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88853	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000074217
	ENSRNOP00000074217.3
	ENSRNOP00000075378
	ENSRNOP00000075378.2
	ENSRNOP00000101110.1
	ENSRNOP00000109616.1

RefSeq Acc Id:

NP_001163909 ⟸ NM_001170438

- UniProtKB:

F1LNF3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDASWRQVAAGRGRARGRGTAVPLSGNGVPLSGAGGGRAKGSGGAVPSAPGPRRAATPGPAGHK
QRSAGGEAPQPLWVGGEDGSELISQRKFEEIKKANQAAARKLVEEHCSSSSEEEEGDEDFEGKQ
GKIVANTFITYTTHTDGDVHELEKTKQYLNEAFQAGAMTCLICIASVKRNQAVWSCSGCFCIFH
MPCIQKWAKDSQFLVSSVTDDDFGKKDYPWPCPKCRFEYKRSETPSRYYCYCGKVEDPPLDPWL
VPHSCGQVCEREFKPSCGHKCLLLCHPGPCPPCPKMVTTTCYCKKAKPIPRRCSAKQWSCQLPC
GRKLLCGQHSCENPCHAGNCQPCPRVSRQKCVCGKKVAERSCASPVWHCDQVCRKTLPCGNHTC
EQVCHVGACGECPRSGKRSCPCQKSKFSLPCTEDVPTCGDSCDKILECGIHRCSQRCHRGPCET
CRQEVEKQCRCGKHTKRMPCHKTYLCETKCVKMRDCQKHQCRRKCCPGNCPPCDQNCGRTLGCR
NHKCPSVCHRGSCYPCPETVDVKCNCGNAKVTVPCGRERTTRPPKCKELCSRPPTCHHSSQEKH
RCHFGPCPPCHQPCQKVLEKCGHLCPISCHDQALVKQTGRHQLSGPWEQPAEPAFIQTALPCPP
CQVPIPVECLGKHEVSPLPCHAVGPYSCKRLCGRMLNCQNHTCTKECHKVTEVDGCPGRHKAGP
ECLQCEEGCSKSRPAGCPHPCVLPCHPGKCPPCVQMLRIKCHCKITNLYVECRKITTADVSEKN
LLSCCKNQCPKELPCGHRCKEMCHPGECPYNCNQKVKLRCPCKRIKRELPCNKIRGNQVSVECD
AACKEMKRKASEIKEAEANAALEEEKRRQQAELEAFENRLKGRRKKNRKRDEVAVQLSPWQKYK
SYLFPVCGVVVAVLVWYICHHAD

hide sequence

Ensembl Acc Id:

ENSRNOP00000074217 ⟸ ENSRNOT00000077080

Ensembl Acc Id:

ENSRNOP00000075378 ⟸ ENSRNOT00000090242

RefSeq Acc Id:	XP_038947632 ⟸ XM_039091704
- Peptide Label:	isoform X2
- UniProtKB:	F1LNF3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947633 ⟸ XM_039091705
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063128988 ⟸ XM_063272918
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAF4 (UniProtKB/TrEMBL), F1LNF3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128989 ⟸ XM_063272919
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAF4 (UniProtKB/TrEMBL), F1LNF3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000109616 ⟸ ENSRNOT00000136600

Ensembl Acc Id:

ENSRNOP00000101110 ⟸ ENSRNOT00000144997

Protein Domains

RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LNF3-F1-model_v2	AlphaFold	F1LNF3	1-919	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699308

Promoter ID:

EPDNEW_R9825

Type:

initiation region

Name:

Nfxl1_1

Description:

nuclear transcription factor, X-box binding-like 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	38,192,541 - 38,192,601	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359201	AgrOrtholog
BioCyc Gene	G2FUF-15850	BioCyc
Ensembl Genes	ENSRNOG00000058588	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000077080	ENTREZGENE
	ENSRNOT00000077080.3	UniProtKB/TrEMBL
	ENSRNOT00000090242	ENTREZGENE
	ENSRNOT00000090242.3	UniProtKB/TrEMBL
	ENSRNOT00000136600.1	UniProtKB/TrEMBL
	ENSRNOT00000144997.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7317845	IMAGE-MGC_LOAD
InterPro	NFX1_fam	UniProtKB/TrEMBL
	Znf_NFX1	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
MGC_CLONE	MGC:105619	IMAGE-MGC_LOAD
NCBI Gene	289595	ENTREZGENE
PANTHER	NF-X1-TYPE ZINC FINGER PROTEIN NFXL1	UniProtKB/TrEMBL
	PTHR12360	UniProtKB/TrEMBL
Pfam	zf-NF-X1	UniProtKB/TrEMBL
PhenoGen	Nfxl1	PhenoGen
PROSITE	ZF_RING_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000058588	RatGTEx
SMART	ZnF_NFX	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
UniProt	A0A0G2KAF4	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L071_RAT	UniProtKB/TrEMBL
	A0ABK0M432_RAT	UniProtKB/TrEMBL
	F1LNF3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-04-23	Nfxl1	nuclear transcription factor, X-box binding-like 1	RGD1359201	similar to nuclear transcription factor, X-box binding-like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	RGD1359201	similar to nuclear transcription factor, X-box binding-like 1			Symbol and Name updated	1299863	APPROVED
2005-07-29	LOC289595	similar to CG15011-PA			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD