Enpp5 (ectonucleotide pyrophosphatase/phosphodiesterase family member 5) - Rat Genome Database

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Gene: Enpp5 (ectonucleotide pyrophosphatase/phosphodiesterase family member 5) Rattus norvegicus
Analyze
Symbol: Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase family member 5
RGD ID: 1359199
Description: Predicted to enable NAD+ diphosphatase activity and zinc ion binding activity. Involved in cell communication. Located in plasma membrane. Orthologous to human ENPP5 (ectonucleotide pyrophosphatase/phosphodiesterase family member 5); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E-NPP 5; E-NPP5; ectonucleotide pyrophosphatase/phosphodiesterase 5; MGC105517; NPP-5; Npp5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8924,407,574 - 24,415,029 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl924,408,218 - 24,414,867 (-)EnsemblGRCr8
mRatBN7.2916,910,187 - 16,917,633 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl916,910,831 - 16,917,480 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx925,494,836 - 25,501,470 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0930,569,359 - 30,575,993 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0928,858,569 - 28,865,203 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0919,469,276 - 19,476,684 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl919,469,706 - 19,476,646 (-)Ensemblrn6Rnor6.0
Rnor_5.0918,347,773 - 18,355,164 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4912,574,480 - 12,581,130 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera914,637,055 - 14,643,705 (-)NCBICelera
RGSC_v3.1912,571,802 - 12,578,452 (-)NCBI
Cytogenetic Map9q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Characterization of nucleotide pyrophosphatase-5 as an oligomannosidic glycoprotein in rat brain. Ohe Y, etal., Biochem Biophys Res Commun 2003 Sep 5;308(4):719-25.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:15489334  


Genomics

Comparative Map Data
Enpp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8924,407,574 - 24,415,029 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl924,408,218 - 24,414,867 (-)EnsemblGRCr8
mRatBN7.2916,910,187 - 16,917,633 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl916,910,831 - 16,917,480 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx925,494,836 - 25,501,470 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0930,569,359 - 30,575,993 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0928,858,569 - 28,865,203 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0919,469,276 - 19,476,684 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl919,469,706 - 19,476,646 (-)Ensemblrn6Rnor6.0
Rnor_5.0918,347,773 - 18,355,164 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4912,574,480 - 12,581,130 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera914,637,055 - 14,643,705 (-)NCBICelera
RGSC_v3.1912,571,802 - 12,578,452 (-)NCBI
Cytogenetic Map9q13NCBI
ENPP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38646,159,185 - 46,170,980 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl646,158,482 - 46,171,113 (-)Ensemblhg38GRCh38
GRCh37646,126,922 - 46,138,717 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36646,235,721 - 46,246,676 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34646,235,720 - 46,246,676NCBI
Celera647,680,299 - 47,691,261 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef645,850,807 - 45,861,762 (-)NCBIHuRef
CHM1_1646,131,010 - 46,141,952 (-)NCBICHM1_1
T2T-CHM13v2.0645,994,273 - 46,006,158 (-)NCBIT2T-CHM13v2.0
Enpp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391744,389,693 - 44,397,458 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1744,389,704 - 44,397,458 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381744,078,802 - 44,086,567 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1744,078,813 - 44,086,567 (+)Ensemblmm10GRCm38
MGSCv371744,215,795 - 44,223,516 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361743,541,924 - 43,549,614 (+)NCBIMGSCv36mm8
Celera1747,500,370 - 47,508,072 (+)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1720.3NCBI
Enpp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543711,195,391 - 11,204,728 (-)Ensembl
ChiLan1.0NW_00495543711,195,846 - 11,204,000 (-)NCBIChiLan1.0ChiLan1.0
ENPP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2560,642,891 - 60,664,298 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1656,508,953 - 56,530,294 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0645,735,167 - 45,751,671 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1647,013,701 - 47,025,523 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl647,013,699 - 47,025,523 (-)EnsemblpanPan2panpan1.1
ENPP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11214,376,278 - 14,387,883 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1214,377,565 - 14,385,171 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1214,408,235 - 14,419,802 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01214,876,522 - 14,888,437 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1214,877,806 - 14,888,470 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11214,392,730 - 14,404,121 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01214,480,941 - 14,492,536 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01214,577,456 - 14,589,058 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Enpp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494649,781,793 - 49,790,968 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647614,169,148 - 14,179,151 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647614,169,298 - 14,178,930 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENPP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl740,920,031 - 40,933,326 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1740,920,030 - 40,936,380 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2747,233,579 - 47,249,978 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ENPP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11726,082,427 - 26,091,526 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1726,082,451 - 26,092,900 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604446,165,201 - 46,175,504 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enpp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475414,286,371 - 14,295,501 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475414,286,337 - 14,294,529 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Enpp5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1485,780,424 - 85,787,271 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Enpp5
75 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:138
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000013703
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000013703   ⟹   ENSRNOP00000013703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl924,408,218 - 24,414,867 (-)Ensembl
mRatBN7.2 Ensembl916,910,831 - 16,917,480 (-)Ensembl
Rnor_6.0 Ensembl919,469,706 - 19,476,646 (-)Ensembl
RefSeq Acc Id: NM_001012744   ⟹   NP_001012762
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8924,408,217 - 24,414,867 (-)NCBI
mRatBN7.2916,910,830 - 16,917,480 (-)NCBI
Rnor_6.0919,469,915 - 19,476,565 (-)NCBI
Rnor_5.0918,347,773 - 18,355,164 (-)NCBI
RGSC_v3.4912,574,480 - 12,581,130 (-)RGD
Celera914,637,055 - 14,643,705 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244607   ⟹   XP_006244669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8924,407,574 - 24,415,029 (-)NCBI
mRatBN7.2916,910,187 - 16,917,633 (-)NCBI
Rnor_6.0919,469,276 - 19,476,684 (-)NCBI
Rnor_5.0918,347,773 - 18,355,164 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001012762 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244669 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH90331 (Get FASTA)   NCBI Sequence Viewer  
  EDM18711 (Get FASTA)   NCBI Sequence Viewer  
  EDM18712 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013703
  ENSRNOP00000013703.4
GenBank Protein P84039 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012762   ⟸   NM_001012744
- Peptide Label: precursor
- UniProtKB: Q5EAN9 (UniProtKB/Swiss-Prot),   P84039 (UniProtKB/Swiss-Prot),   A6JJ21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244669   ⟸   XM_006244607
- Peptide Label: isoform X1
- UniProtKB: Q5EAN9 (UniProtKB/Swiss-Prot),   P84039 (UniProtKB/Swiss-Prot),   A6JJ21 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013703   ⟸   ENSRNOT00000013703

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P84039-F1-model_v2 AlphaFold P84039 1-477 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696552
Promoter ID:EPDNEW_R7075
Type:multiple initiation site
Name:Enpp5_1
Description:ectonucleotide pyrophosphatase/phosphodiesterase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0919,476,618 - 19,476,678EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359199 AgrOrtholog
BioCyc Gene G2FUF-28123 BioCyc
Ensembl Genes ENSRNOG00000010232 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013703 ENTREZGENE
  ENSRNOT00000013703.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1360.180 UniProtKB/Swiss-Prot
  3.40.720.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7300780 IMAGE-MGC_LOAD
InterPro Alkaline_phosphatase_core_sf UniProtKB/Swiss-Prot
  Phosphodiest/P_Trfase UniProtKB/Swiss-Prot
KEGG Report rno:316249 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105517 IMAGE-MGC_LOAD
NCBI Gene 316249 ENTREZGENE
PANTHER ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE UniProtKB/Swiss-Prot
  ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 5 UniProtKB/Swiss-Prot
Pfam Phosphodiest UniProtKB/Swiss-Prot
PharmGKB ENPP5 RGD
PhenoGen Enpp5 PhenoGen
RatGTEx ENSRNOG00000010232 RatGTEx
Superfamily-SCOP SSF53649 UniProtKB/Swiss-Prot
UniProt A6JJ21 ENTREZGENE, UniProtKB/TrEMBL
  ENPP5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5EAN9 ENTREZGENE
UniProt Secondary Q5EAN9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 Enpp5  ectonucleotide pyrophosphatase/phosphodiesterase family member 5  Enpp5  ectonucleotide pyrophosphatase/phosphodiesterase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Enpp5  ectonucleotide pyrophosphatase/phosphodiesterase 5      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Enpp5  ectonucleotide pyrophosphatase/phosphodiesterase 5      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_other despite similarities in sequence between the rat, mouse and human proteins, neither NPP activity nor lysophospholipase D activity could be detected in the immunoprecipitated rat protein 1359752