Gemin8 (gem (nuclear organelle) associated protein 8) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gemin8 (gem (nuclear organelle) associated protein 8) Rattus norvegicus
Analyze
Symbol: Gemin8
Name: gem (nuclear organelle) associated protein 8
RGD ID: 1359160
Description: Predicted to be involved in spliceosomal snRNP assembly. Predicted to be located in cytosol and nucleus. Predicted to be part of SMN complex. Orthologous to human GEMIN8 (gem nuclear organelle associated protein 8); PARTICIPATES IN RNA transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fam51a1; family with sequence similarity 51, member A1 homolog; family with sequence similarity 51, member A1 homolog (human); gem-associated protein 8; MGC94189; similar to hypothetical protein FLJ20514
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X31,891,446 - 31,910,280 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX31,891,449 - 31,910,280 (-)EnsemblGRCr8
mRatBN7.2X28,259,806 - 28,278,641 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX28,259,793 - 28,278,663 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX29,293,841 - 29,312,708 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X32,729,459 - 32,748,293 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X28,908,466 - 28,927,334 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X29,806,605 - 29,825,439 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX29,806,606 - 29,825,439 (-)Ensemblrn6Rnor6.0
Rnor_5.0X30,198,492 - 30,217,341 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X48,952,035 - 48,970,869 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX28,632,945 - 28,651,779 (-)NCBICelera
RGSC_v3.1X49,005,503 - 49,024,338 (-)NCBI
Cytogenetic MapXq14NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
cytosol  (ISO)
nucleus  (ISO)
SMN complex  (IBA,IEA,ISO)
SMN-Sm protein complex  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:16434402   PMID:17023415   PMID:18984161  


Genomics

Comparative Map Data
Gemin8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X31,891,446 - 31,910,280 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX31,891,449 - 31,910,280 (-)EnsemblGRCr8
mRatBN7.2X28,259,806 - 28,278,641 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX28,259,793 - 28,278,663 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX29,293,841 - 29,312,708 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X32,729,459 - 32,748,293 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X28,908,466 - 28,927,334 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X29,806,605 - 29,825,439 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX29,806,606 - 29,825,439 (-)Ensemblrn6Rnor6.0
Rnor_5.0X30,198,492 - 30,217,341 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X48,952,035 - 48,970,869 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX28,632,945 - 28,651,779 (-)NCBICelera
RGSC_v3.1X49,005,503 - 49,024,338 (-)NCBI
Cytogenetic MapXq14NCBI
GEMIN8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X13,984,185 - 14,029,892 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX13,998,099 - 14,029,928 (-)Ensemblhg38GRCh38
GRCh37X14,024,845 - 14,048,011 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X13,934,766 - 13,957,956 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X13,786,054 - 13,807,668NCBI
CeleraX18,140,750 - 18,163,940 (-)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX11,782,027 - 11,801,284 (-)NCBIHuRef
CHM1_1X14,055,283 - 14,078,493 (-)NCBICHM1_1
T2T-CHM13v2.0X13,566,300 - 13,610,205 (-)NCBIT2T-CHM13v2.0
Gemin8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X164,953,412 - 164,973,508 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX164,953,450 - 164,973,508 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X166,170,454 - 166,190,512 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX166,170,454 - 166,190,512 (+)Ensemblmm10GRCm38
MGSCv37X162,608,412 - 162,628,444 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X161,514,600 - 161,534,615 (+)NCBIMGSCv36mm8
MGSCv36X143,321,578 - 143,341,655 (+)NCBIMGSCv36mm8
CeleraX149,351,031 - 149,370,817 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.75NCBI
Gemin8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555194,205,651 - 4,228,059 (+)Ensembl
ChiLan1.0NW_0049555194,205,660 - 4,228,174 (+)NCBIChiLan1.0ChiLan1.0
GEMIN8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X15,777,401 - 15,808,331 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X15,778,281 - 15,811,923 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X6,608,925 - 6,636,008 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X13,901,769 - 13,923,039 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX13,901,769 - 13,923,039 (-)EnsemblpanPan2panpan1.1
GEMIN8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X10,428,712 - 10,448,740 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX10,428,713 - 10,448,942 (-)EnsemblcanFam3CanFam3.1
Gemin8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X3,554,073 - 3,576,315 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364703,553,468 - 3,576,314 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364703,553,462 - 3,576,281 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GEMIN8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX10,647,028 - 10,671,184 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X10,647,019 - 10,671,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X11,600,477 - 11,624,646 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GEMIN8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X12,492,827 - 12,513,893 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605614,305,467 - 14,328,238 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gemin8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624882132,300 - 153,018 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624882132,410 - 156,396 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gemin8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X30,298,175 - 30,316,922 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gemin8
111 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:79
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000048155
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2447036044931007Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2447036045082063Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000048155   ⟹   ENSRNOP00000044281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX31,891,449 - 31,910,280 (-)Ensembl
mRatBN7.2 EnsemblX28,259,793 - 28,278,663 (-)Ensembl
Rnor_6.0 EnsemblX29,806,606 - 29,825,439 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000131638   ⟹   ENSRNOP00000102034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX31,891,449 - 31,906,902 (-)Ensembl
RefSeq Acc Id: NM_001007756   ⟹   NP_001007757
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X31,891,446 - 31,910,280 (-)NCBI
mRatBN7.2X28,259,806 - 28,278,641 (-)NCBI
Rnor_6.0X29,806,605 - 29,825,439 (-)NCBI
Rnor_5.0X30,198,492 - 30,217,341 (-)NCBI
RGSC_v3.4X48,952,035 - 48,970,869 (-)RGD
CeleraX28,632,945 - 28,651,779 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001007757 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79160 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044281
  ENSRNOP00000044281.3
  ENSRNOP00000102034.1
RefSeq Acc Id: NP_001007757   ⟸   NM_001007756
- UniProtKB: Q6AY77 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044281   ⟸   ENSRNOT00000048155
Ensembl Acc Id: ENSRNOP00000102034   ⟸   ENSRNOT00000131638

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AY77-F1-model_v2 AlphaFold Q6AY77 1-239 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701792
Promoter ID:EPDNEW_R12315
Type:initiation region
Name:Gemin8_1
Description:gem associated protein 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X29,825,496 - 29,825,556EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359160 AgrOrtholog
BioCyc Gene G2FUF-2606 BioCyc
Ensembl Genes ENSRNOG00000029038 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048155 ENTREZGENE
  ENSRNOT00000048155.6 UniProtKB/TrEMBL
  ENSRNOT00000131638.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7129380 IMAGE-MGC_LOAD
InterPro GEMIN8 UniProtKB/TrEMBL
KEGG Report rno:363462 UniProtKB/TrEMBL
MGC_CLONE MGC:94189 IMAGE-MGC_LOAD
NCBI Gene 363462 ENTREZGENE
PANTHER GEM-ASSOCIATED PROTEIN 8 UniProtKB/TrEMBL
  PTHR16238 UniProtKB/TrEMBL
Pfam GEMIN8 UniProtKB/TrEMBL
PhenoGen Gemin8 PhenoGen
RatGTEx ENSRNOG00000029038 RatGTEx
UniProt A0ABK0LL53_RAT UniProtKB/TrEMBL
  Q6AY77 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Gemin8  gem (nuclear organelle) associated protein 8  Fam51a1  family with sequence similarity 51, member A1 homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Fam51a1  family with sequence similarity 51, member A1 homolog (human)  MGC94189  similar to hypothetical protein FLJ20514  Symbol and Name updated 1299863 APPROVED
2005-07-29 MGC94189  similar to hypothetical protein FLJ20514      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference