Lilrb4 (leukocyte immunoglobulin like receptor B4) - Rat Genome Database

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Gene: Lilrb4 (leukocyte immunoglobulin like receptor B4) Rattus norvegicus
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Symbol: Lilrb4
Name: leukocyte immunoglobulin like receptor B4
RGD ID: 1359090
Description: Predicted to enable several functions, including apolipoprotein binding activity; fibronectin binding activity; and transmembrane receptor protein tyrosine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of signal transduction; and regulation of leukocyte activation. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human LILRB4 (leukocyte immunoglobulin like receptor B4); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glycoprotein 49A; glycoprotein 49b; glycoprotein 49B1; glycoprotein 49B2; gp49A; Gp49b; gp49B1; GP49B2; gp49v1-1; gp49v1-2; gp49v2; Leukocyte immunoglobulin-like receptor subfamily B member 4; leukocyte immunoglobulin-like receptor, subfamily B, member 4; leukocyte surface receptor
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,847,685 - 78,853,294 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl178,847,685 - 78,853,326 (-)EnsemblGRCr8
mRatBN7.2169,805,020 - 69,810,628 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,805,250 - 69,810,660 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx175,164,131 - 75,169,435 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,728,450 - 83,733,754 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,872,043 - 76,877,344 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0173,393,854 - 73,399,448 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,393,850 - 73,399,579 (-)Ensemblrn6Rnor6.0
Rnor_5.0175,149,247 - 75,154,729 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4169,165,498 - 69,170,800 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera167,336,070 - 67,340,685 (+)NCBICelera
RGSC_v3.1169,243,608 - 69,248,911 (-)NCBI
Cytogenetic Map1q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell surface receptor signaling pathway  (IEA)
Fc receptor mediated inhibitory signaling pathway  (ISO)
immune response-inhibiting cell surface receptor signaling pathway  (IBA)
interleukin-10-mediated signaling pathway  (ISO)
mast cell activation  (ISO)
negative regulation of activated T cell proliferation  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of chemokine production  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of cytotoxic T cell differentiation  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of interleukin-10 production  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of interleukin-5 production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of intracellular signal transduction  (ISO)
negative regulation of IP-10 production  (ISO)
negative regulation of MAPK cascade  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of monocyte activation  (ISO)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of T cell costimulation  (ISO)
negative regulation of T cell cytokine production  (ISO)
negative regulation of T cell proliferation  (ISO)
negative regulation of T cell receptor signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of type II interferon production  (ISO)
positive regulation of CD8-positive, alpha-beta T cell differentiation  (ISO)
positive regulation of regulatory T cell differentiation  (ISO)
positive regulation of T cell anergy  (ISO)
receptor internalization  (ISO)
tolerance induction  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The rat orthologue to the inhibitory receptor gp49B is expressed by neutrophils and monocytes, but not by NK cells or mast cells. Bryceson YT, etal., Eur J Immunol 2005 Apr;35(4):1230-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18802077   PMID:22387553   PMID:23376485   PMID:23533145   PMID:38367899  


Genomics

Comparative Map Data
Lilrb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,847,685 - 78,853,294 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl178,847,685 - 78,853,326 (-)EnsemblGRCr8
mRatBN7.2169,805,020 - 69,810,628 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,805,250 - 69,810,660 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx175,164,131 - 75,169,435 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,728,450 - 83,733,754 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,872,043 - 76,877,344 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0173,393,854 - 73,399,448 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,393,850 - 73,399,579 (-)Ensemblrn6Rnor6.0
Rnor_5.0175,149,247 - 75,154,729 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4169,165,498 - 69,170,800 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera167,336,070 - 67,340,685 (+)NCBICelera
RGSC_v3.1169,243,608 - 69,248,911 (-)NCBI
Cytogenetic Map1q12NCBI
LILRB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381954,662,985 - 54,668,718 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1954,643,889 - 54,670,359 (+)Ensemblhg38GRCh38
GRCh371955,174,437 - 55,180,169 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361959,865,936 - 59,871,660 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341959,866,263 - 59,873,621NCBI
Celera1952,214,265 - 52,220,001 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,497,246 - 51,504,797 (+)NCBIHuRef
CHM1_11955,167,838 - 55,175,378 (+)NCBICHM1_1
T2T-CHM13v2.01957,737,351 - 57,762,244 (+)NCBIT2T-CHM13v2.0
Lilrb4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391051,356,757 - 51,362,417 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1051,356,728 - 51,362,799 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381051,480,612 - 51,486,329 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1051,480,632 - 51,486,703 (+)Ensemblmm10GRCm38
MGSCv371051,200,485 - 51,206,025 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361051,169,094 - 51,174,634 (+)NCBIMGSCv36mm8
Celera1052,324,193 - 52,329,733 (+)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1025.5NCBI
LILRB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22060,682,282 - 60,688,657 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,605,700 - 62,612,079 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01951,606,681 - 51,612,751 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,392,690 - 60,453,555 (+)NCBIPanPan1.1PanPan1.1panPan2
LOC484306
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,779,562 - 102,786,924 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,843,014 - 102,849,207 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01103,426,664 - 103,432,846 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11103,068,755 - 103,074,937 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,827,945 - 102,834,107 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,541,899 - 103,548,063 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100517285
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1658,996,449 - 59,001,088 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2653,920,421 - 53,925,036 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103235563
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,299,764 - 47,333,711 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607327,574,619 - 27,579,928 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Lilrb4
13 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000038898
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
RH139689  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8178,848,014 - 78,848,303 (+)Marker Load Pipeline
Cytogenetic Map1q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 57 138 78 77 46 92 46 6 333 182 11 116 81 83 31 9 9

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001013894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001419406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001419407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001419408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB196927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB196928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB196929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB196930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB196931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB196932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY359280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY359281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000038898   ⟹   ENSRNOP00000030632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,847,685 - 78,853,326 (-)Ensembl
mRatBN7.2 Ensembl169,805,250 - 69,810,552 (-)Ensembl
Rnor_6.0 Ensembl173,394,075 - 73,399,377 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077186   ⟹   ENSRNOP00000069484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,847,685 - 78,853,326 (-)Ensembl
mRatBN7.2 Ensembl169,805,250 - 69,810,660 (-)Ensembl
Rnor_6.0 Ensembl173,393,850 - 73,399,579 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095592   ⟹   ENSRNOP00000083948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,847,685 - 78,853,252 (-)Ensembl
mRatBN7.2 Ensembl169,805,250 - 69,810,552 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098988   ⟹   ENSRNOP00000083730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,847,685 - 78,853,252 (-)Ensembl
mRatBN7.2 Ensembl169,805,250 - 69,810,552 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109192   ⟹   ENSRNOP00000087354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,849,466 - 78,853,252 (-)Ensembl
mRatBN7.2 Ensembl169,805,250 - 69,810,543 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110970   ⟹   ENSRNOP00000092281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,847,685 - 78,853,252 (-)Ensembl
mRatBN7.2 Ensembl169,805,250 - 69,810,552 (-)Ensembl
RefSeq Acc Id: NM_001013894   ⟹   NP_001013916
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,847,685 - 78,853,252 (-)NCBI
mRatBN7.2169,805,020 - 69,810,587 (-)NCBI
Rnor_6.0173,394,075 - 73,399,377 (-)NCBI
Rnor_5.0175,149,247 - 75,154,729 (+)NCBI
RGSC_v3.4169,165,498 - 69,170,800 (-)RGD
Celera167,336,070 - 67,340,685 (+)RGD
Sequence:
RefSeq Acc Id: NM_001419406   ⟹   NP_001406335
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,847,685 - 78,853,252 (-)NCBI
mRatBN7.2169,805,020 - 69,810,587 (-)NCBI
RefSeq Acc Id: NM_001419407   ⟹   NP_001406336
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,847,685 - 78,853,252 (-)NCBI
mRatBN7.2169,805,020 - 69,810,587 (-)NCBI
RefSeq Acc Id: NM_001419408   ⟹   NP_001406337
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,847,685 - 78,853,252 (-)NCBI
mRatBN7.2169,805,020 - 69,810,587 (-)NCBI
RefSeq Acc Id: XM_039103861   ⟹   XP_038959789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,847,786 - 78,853,294 (-)NCBI
mRatBN7.2169,805,020 - 69,810,628 (-)NCBI
RefSeq Acc Id: XM_039103862   ⟹   XP_038959790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,847,786 - 78,853,294 (-)NCBI
mRatBN7.2169,805,020 - 69,810,628 (-)NCBI
RefSeq Acc Id: XM_063283021   ⟹   XP_063139091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,848,235 - 78,853,294 (-)NCBI
RefSeq Acc Id: XM_063283028   ⟹   XP_063139098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,848,704 - 78,853,294 (-)NCBI
RefSeq Acc Id: XM_063283032   ⟹   XP_063139102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,848,235 - 78,853,294 (-)NCBI
RefSeq Acc Id: XM_063283034   ⟹   XP_063139104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,848,233 - 78,853,294 (-)NCBI
RefSeq Acc Id: XR_010064555
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,848,233 - 78,853,294 (-)NCBI
RefSeq Acc Id: NP_001013916   ⟸   NM_001013894
- Peptide Label: isoform 3 precursor
- UniProtKB: Q67EV2 (UniProtKB/TrEMBL),   E9PTH5 (UniProtKB/TrEMBL),   A0A0G2JVH3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069484   ⟸   ENSRNOT00000077186
Ensembl Acc Id: ENSRNOP00000030632   ⟸   ENSRNOT00000038898
RefSeq Acc Id: XP_038959790   ⟸   XM_039103862
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A0J7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959789   ⟸   XM_039103861
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A095 (UniProtKB/TrEMBL),   A0A8I6A469 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083730   ⟸   ENSRNOT00000098988
Ensembl Acc Id: ENSRNOP00000087354   ⟸   ENSRNOT00000109192
Ensembl Acc Id: ENSRNOP00000083948   ⟸   ENSRNOT00000095592
Ensembl Acc Id: ENSRNOP00000092281   ⟸   ENSRNOT00000110970
RefSeq Acc Id: NP_001406337   ⟸   NM_001419408
- Peptide Label: isoform 4 precursor
- UniProtKB: A0A8I6A0J7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001406336   ⟸   NM_001419407
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A8I6GJM6 (UniProtKB/TrEMBL),   A0A8I6A469 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001406335   ⟸   NM_001419406
- Peptide Label: isoform 1 precursor
- UniProtKB: Q67EV3 (UniProtKB/TrEMBL),   A0A0G2JVH3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139104   ⟸   XM_063283034
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063139102   ⟸   XM_063283032
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063139091   ⟸   XM_063283021
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063139098   ⟸   XM_063283028
- Peptide Label: isoform X4
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVH3-F1-model_v2 AlphaFold A0A0G2JVH3 1-412 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689710
Promoter ID:EPDNEW_R234
Type:multiple initiation site
Name:Lilrb4_1
Description:leukocyte immunoglobulin like receptor B4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0173,399,412 - 73,399,472EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359090 AgrOrtholog
BioCyc Gene G2FUF-60826 BioCyc
Ensembl Genes ENSRNOG00000027811 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038898 ENTREZGENE
  ENSRNOT00000038898.6 UniProtKB/TrEMBL
  ENSRNOT00000077186 ENTREZGENE
  ENSRNOT00000077186.3 UniProtKB/TrEMBL
  ENSRNOT00000095592 ENTREZGENE
  ENSRNOT00000095592.2 UniProtKB/TrEMBL
  ENSRNOT00000098988 ENTREZGENE
  ENSRNOT00000098988.2 UniProtKB/TrEMBL
  ENSRNOT00000109192 ENTREZGENE
  ENSRNOT00000109192.2 UniProtKB/TrEMBL
  ENSRNOT00000110970 ENTREZGENE
  ENSRNOT00000110970.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig-like_Receptors_ImmuneReg UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
KEGG Report rno:292594 UniProtKB/TrEMBL
NCBI Gene 292594 ENTREZGENE
PANTHER LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY B MEMBER 4A-RELATED UniProtKB/TrEMBL
  MHC CLASS I NK CELL RECEPTOR UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
  PF00047 UniProtKB/TrEMBL
PhenoGen Lilrb4 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027811 RatGTEx
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2JVH3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A095 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0J7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A469 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GJM6 ENTREZGENE, UniProtKB/TrEMBL
  A0ABZ3NN90_RAT UniProtKB/TrEMBL
  E9PTH5 ENTREZGENE
  Q67EV2 ENTREZGENE, UniProtKB/TrEMBL
  Q67EV3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E9PTH5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-07 Lilrb4  leukocyte immunoglobulin like receptor B4  Lilrb4  leukocyte immunoglobulin-like receptor, subfamily B, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Lilrb4  leukocyte immunoglobulin-like receptor, subfamily B, member 4  LOC499078  similar to GP49B1  Data merged from RGD:1584882 1643240 APPROVED
2008-03-04 Lilrb4  leukocyte immunoglobulin-like receptor, subfamily B, member 4  Gp49b  glycoprotein 49b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC499078  similar to GP49B1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-07-29 Gp49b  glycoprotein 49b      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains the third, more membrane-proximal ITIM motif is phosphorylated by several Src family tyrosine kinases and is responsible for the binding of Gp49b to Ptpn11/SHP-2 1359741
gene_expression expressed in neutrophils and monocytes, but not primary or activated NK cells, resting or stimulated T cells, or mast cells, in contrast to mouse where expression is constitutive in mast cells and inducible in both NK and T cells 1359741
gene_physical_interaction binding to the SH2 domains of both Ptpn6/SHP-1 and Ptpn11/SHP-2 requires the presence of intact, phosphorylated immunoreceptor tyrosine-based inhibition motifs (ITIMs) 1359741