Or4c3 (olfactory receptor family 4 subfamily C member 3) - Rat Genome Database

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Gene: Or4c3 (olfactory receptor family 4 subfamily C member 3) Rattus norvegicus
Analyze
Symbol: Or4c3
Name: olfactory receptor family 4 subfamily C member 3
RGD ID: 1333798
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human OR4C3 (olfactory receptor family 4 subfamily C member 3); INTERACTS WITH bisphenol A; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog); 1,2-dichloroethane (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 729; olfactory receptor gene Olr729; olfactory receptor Olr729; Olr729; ratchr3-74342019-74341093_ORF
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8396,498,768 - 96,499,694 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl396,498,768 - 96,499,694 (-)EnsemblGRCr8
mRatBN7.2376,042,658 - 76,043,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl376,038,539 - 76,047,053 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx379,513,985 - 79,514,911 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0388,112,518 - 88,113,444 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0385,833,855 - 85,834,781 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0378,885,170 - 78,886,096 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl378,885,170 - 78,886,096 (-)Ensemblrn6Rnor6.0
Rnor_5.0385,600,914 - 85,601,840 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4374,444,721 - 74,445,647 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera375,286,624 - 75,287,550 (-)NCBICelera
RGSC_v3.1374,341,092 - 74,342,019 (-)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or4c3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8396,498,768 - 96,499,694 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl396,498,768 - 96,499,694 (-)EnsemblGRCr8
mRatBN7.2376,042,658 - 76,043,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl376,038,539 - 76,047,053 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx379,513,985 - 79,514,911 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0388,112,518 - 88,113,444 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0385,833,855 - 85,834,781 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0378,885,170 - 78,886,096 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl378,885,170 - 78,886,096 (-)Ensemblrn6Rnor6.0
Rnor_5.0385,600,914 - 85,601,840 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4374,444,721 - 74,445,647 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera375,286,624 - 75,287,550 (-)NCBICelera
RGSC_v3.1374,341,092 - 74,342,019 (-)NCBI
Cytogenetic Map3q24NCBI
OR4C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381148,324,920 - 48,325,955 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1148,324,920 - 48,325,955 (+)Ensemblhg38GRCh38
GRCh371148,346,472 - 48,347,507 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,303,069 - 48,304,058 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341148,303,068 - 48,304,058NCBI
Celera1148,496,460 - 48,497,449 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1148,057,325 - 48,058,314 (+)NCBIHuRef
CHM1_11148,345,992 - 48,346,981 (+)NCBICHM1_1
T2T-CHM13v2.01148,494,513 - 48,495,548 (+)NCBIT2T-CHM13v2.0
Or4c3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39289,851,482 - 89,852,408 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl289,848,870 - 89,855,921 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38290,021,138 - 90,022,064 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl290,018,526 - 90,025,577 (-)Ensemblmm10GRCm38
MGSCv37289,861,295 - 89,862,221 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36289,821,977 - 89,822,903 (-)NCBIMGSCv36mm8
Celera291,557,963 - 91,558,889 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.13NCBI
LOC100992635
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2950,540,277 - 50,541,312 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11150,560,179 - 50,561,214 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01148,285,340 - 48,286,363 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11148,826,896 - 48,827,919 (+)NCBIPanPan1.1PanPan1.1panPan2
OR4C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11841,248,987 - 41,249,898 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1841,248,987 - 41,249,895 (-)EnsemblcanFam3CanFam3.1
LOC101967866
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494718,703,502 - 18,709,547 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936562815,150 - 821,189 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0

Variants

.
Variants in Or4c3
2 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000008864
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat


Expression

RNA-SEQ Expression

endoderm
hemolymphoid system
mesenchyme
mesoderm
renal system
reproductive system
respiratory system
1 1 2 1 1 9 1

Sequence


Ensembl Acc Id: ENSRNOT00000008864   ⟹   ENSRNOP00000008864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl378,885,170 - 78,886,096 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118513   ⟹   ENSRNOP00000079473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl376,038,539 - 76,047,053 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119726   ⟹   ENSRNOP00000083746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl376,038,539 - 76,047,053 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000143883   ⟹   ENSRNOP00000106533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl396,498,768 - 96,499,694 (-)Ensembl
RefSeq Acc Id: NM_001000574   ⟹   NP_001000574
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8396,498,768 - 96,499,694 (-)NCBI
mRatBN7.2376,042,658 - 76,043,584 (-)NCBI
Rnor_6.0378,885,170 - 78,886,096 (-)NCBI
Rnor_5.0385,600,914 - 85,601,840 (-)NCBI
RGSC_v3.4374,444,721 - 74,445,647 (-)RGD
Celera375,286,624 - 75,287,550 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000574 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL79456 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000106533
  ENSRNOP00000106533.1
RefSeq Acc Id: NP_001000574   ⟸   NM_001000574
- UniProtKB: D3ZCV3 (UniProtKB/TrEMBL),   A6HN55 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008864   ⟸   ENSRNOT00000008864
Ensembl Acc Id: ENSRNOP00000079473   ⟸   ENSRNOT00000118513
Ensembl Acc Id: ENSRNOP00000083746   ⟸   ENSRNOT00000119726
Ensembl Acc Id: ENSRNOP00000106533   ⟸   ENSRNOT00000143883
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCV3-F1-model_v2 AlphaFold D3ZCV3 1-308 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333798 AgrOrtholog
BioCyc Gene G2FUF-48796 BioCyc
Ensembl Genes ENSRNOG00000006771 Ensembl
  ENSRNOG00000069972 Ensembl
  ENSRNOG00000081832 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000143883 ENTREZGENE
  ENSRNOT00000143883.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_Receptors UniProtKB/TrEMBL
KEGG Report rno:366116 UniProtKB/TrEMBL
NCBI Gene 366116 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or4c3 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006771 RatGTEx
  ENSRNOG00000069972 RatGTEx
  ENSRNOG00000081832 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6HN55 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCV3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or4c3  olfactory receptor family 4 subfamily C member 3  Olr729  olfactory receptor 729  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr729  olfactory receptor 729   Olr729_predicted  olfactory receptor 729 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr729_predicted  olfactory receptor 729 (predicted)      Symbol and Name status set to approved 70820 APPROVED