Or6c7 (olfactory receptor family 6 subfamily C member 7) - Rat Genome Database

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Pathways
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Gene: Or6c7 (olfactory receptor family 6 subfamily C member 7) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Or6c7
Name: olfactory receptor family 6 subfamily C member 7
RGD ID: 1332702
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Orthologous to human OR6C75 (olfactory receptor family 6 subfamily C member 75); INTERACTS WITH dibenzofurans (ortholog); folic acid (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1012; olfactory receptor gene Olr1012; olfactory receptor Olr1012; Olr1012
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr876,015,857 - 6,016,795 (+)NCBIGRCr8
mRatBN7.275,365,024 - 5,365,962 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl75,362,978 - 5,367,644 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx78,259,343 - 8,260,281 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0710,135,001 - 10,135,939 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.077,970,269 - 7,971,207 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.077,068,703 - 7,069,641 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl77,068,703 - 7,069,641 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.077,165,984 - 7,166,922 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.476,761,553 - 6,762,491 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.176,761,552 - 6,762,491 (+)NCBI
Celera73,611,622 - 3,612,560 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Or6c7
12 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system appendage
High
Medium
Low
Below cutoff 4 3 1 3 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001000071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000074567   ⟹   ENSRNOP00000065575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl77,068,703 - 7,069,641 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110586   ⟹   ENSRNOP00000079022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl75,362,978 - 5,367,644 (+)Ensembl
RefSeq Acc Id: NM_001000071   ⟹   NP_001000071
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr876,015,857 - 6,016,795 (+)NCBI
mRatBN7.275,365,024 - 5,365,962 (+)NCBI
Rnor_6.077,068,703 - 7,069,641 (+)NCBI
Rnor_5.077,165,984 - 7,166,922 (+)NCBI
RGSC_v3.476,761,553 - 6,762,491 (+)RGD
Celera73,611,622 - 3,612,560 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000071 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000079022
  ENSRNOP00000079022.1
Reference Protein Sequences
RefSeq Acc Id: NP_001000071   ⟸   NM_001000071
- UniProtKB: A0A8I5ZLZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065575   ⟸   ENSRNOT00000074567
RefSeq Acc Id: ENSRNOP00000079022   ⟸   ENSRNOT00000110586
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R7Y7-F1-model_v2 AlphaFold M0R7Y7 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1332702 AgrOrtholog
BioCyc Gene G2FUF-35151 BioCyc
Ensembl Genes ENSRNOG00000054207 Ensembl
  ENSRNOG00000070885 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000110586 ENTREZGENE
  ENSRNOT00000110586.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfact_rcpt_6C-like UniProtKB/TrEMBL
NCBI Gene 288861 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or6c7 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054207 RatGTEx
  ENSRNOG00000070885 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I5ZLZ6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or6c7  olfactory receptor family 6 subfamily C member 7  Olr1012  olfactory receptor 1012  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1012  olfactory receptor 1012   Olr1012_predicted  olfactory receptor 1012 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1012_predicted  olfactory receptor 1012 (predicted)      Symbol and Name status set to approved 70820 APPROVED