Hes6 (hes family bHLH transcription factor 6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Hes6 (hes family bHLH transcription factor 6) Rattus norvegicus
Analyze
Symbol: Hes6
Name: hes family bHLH transcription factor 6
RGD ID: 1312047
Description: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription regulator inhibitor activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human HES6 (hes family bHLH transcription factor 6); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hairy and enhancer of split 6; hairy and enhancer of split 6 (Drosophila); LOC316626; transcription cofactor HES-6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,449,375 - 99,451,343 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl999,449,371 - 99,451,096 (-)EnsemblGRCr8
mRatBN7.2992,001,849 - 92,003,562 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl992,001,841 - 92,003,559 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9100,428,608 - 100,430,321 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,564,366 - 105,566,079 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,927,959 - 103,929,671 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,549,698 - 98,551,438 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,549,705 - 98,551,438 (-)Ensemblrn6Rnor6.0
Rnor_5.0998,225,746 - 98,227,482 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4990,639,890 - 90,641,596 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera989,542,889 - 89,544,595 (-)NCBICelera
RGSC_v3.1990,844,659 - 90,846,365 (-)NCBI
Cytogenetic Map9q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
amiodarone  (EXP)
amitrole  (EXP)
androgen antagonist  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buspirone  (EXP)
butanal  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
DDE  (EXP,ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloromethane  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP,ISO)
flutamide  (EXP)
fonofos  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
glafenine  (EXP)
GW 7647  (EXP)
hydrogen peroxide  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
lead diacetate  (ISO)
Licochalcone B  (ISO)
linuron  (EXP)
menadione  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
propiconazole  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
styrene  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
Triptolide  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. ERCC5, HES6 and RORA are potential diagnostic markers of coronary artery disease. Bai Z, etal., FEBS Open Bio. 2022 Oct;12(10):1814-1827. doi: 10.1002/2211-5463.13469. Epub 2022 Aug 7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10851137   PMID:11959828  


Genomics

Comparative Map Data
Hes6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,449,375 - 99,451,343 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl999,449,371 - 99,451,096 (-)EnsemblGRCr8
mRatBN7.2992,001,849 - 92,003,562 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl992,001,841 - 92,003,559 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9100,428,608 - 100,430,321 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,564,366 - 105,566,079 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,927,959 - 103,929,671 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,549,698 - 98,551,438 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,549,705 - 98,551,438 (-)Ensemblrn6Rnor6.0
Rnor_5.0998,225,746 - 98,227,482 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4990,639,890 - 90,641,596 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera989,542,889 - 89,544,595 (-)NCBICelera
RGSC_v3.1990,844,659 - 90,846,365 (-)NCBI
Cytogenetic Map9q36NCBI
HES6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,238,267 - 238,240,038 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,238,267 - 238,240,662 (-)Ensemblhg38GRCh38
GRCh372239,146,908 - 239,148,679 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,811,647 - 238,813,409 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342238,928,909 - 238,930,670NCBI
Celera2232,859,462 - 232,861,235 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2230,937,958 - 230,939,843 (-)NCBIHuRef
CHM1_12239,152,761 - 239,154,534 (-)NCBICHM1_1
T2T-CHM13v2.02238,728,009 - 238,729,780 (-)NCBIT2T-CHM13v2.0
Hes6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39191,339,204 - 91,342,901 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,339,205 - 91,341,760 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38191,411,483 - 91,414,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,411,483 - 91,414,038 (-)Ensemblmm10GRCm38
MGSCv37193,308,060 - 93,309,799 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36193,241,889 - 93,243,628 (-)NCBIMGSCv36mm8
Celera194,348,702 - 94,350,441 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.12NCBI
Hes6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555422,373,370 - 2,374,272 (+)Ensembl
ChiLan1.0NW_0049555422,373,241 - 2,374,827 (+)NCBIChiLan1.0ChiLan1.0
HES6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213140,871,107 - 140,872,884 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B140,886,074 - 140,887,851 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B125,471,244 - 125,473,025 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B244,321,070 - 244,322,237 (-)NCBIPanPan1.1PanPan1.1panPan2
HES6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12548,710,694 - 48,713,392 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2549,206,100 - 49,207,791 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02549,096,318 - 49,098,006 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2549,096,963 - 49,097,953 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12548,971,418 - 48,973,122 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02548,760,071 - 48,761,750 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02548,992,417 - 48,994,109 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hes6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303190,670,176 - 190,671,955 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936525267,753 - 269,527 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936525267,791 - 269,511 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HES6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15137,785,810 - 137,787,694 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115137,785,808 - 137,787,689 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215152,217,871 - 152,219,649 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HES6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110124,263,894 - 124,266,345 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10124,264,456 - 124,265,542 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604075,152,402 - 75,154,849 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hes6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248473,354,501 - 3,355,378 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248473,353,997 - 3,355,484 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hes6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14163,407,054 - 163,408,785 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hes6
10 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:71
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000066346
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000066346   ⟹   ENSRNOP00000063598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl992,001,845 - 92,003,550 (-)Ensembl
Rnor_6.0 Ensembl998,549,705 - 98,551,410 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086678   ⟹   ENSRNOP00000073966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl999,449,371 - 99,451,096 (-)Ensembl
mRatBN7.2 Ensembl992,001,841 - 92,003,559 (-)Ensembl
Rnor_6.0 Ensembl998,550,022 - 98,551,438 (-)Ensembl
RefSeq Acc Id: NM_001399167   ⟹   NP_001386096
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,449,383 - 99,451,096 (-)NCBI
mRatBN7.2992,001,849 - 92,003,562 (-)NCBI
RefSeq Acc Id: XM_063267318   ⟹   XP_063123388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,449,375 - 99,451,110 (-)NCBI
RefSeq Acc Id: XM_063267319   ⟹   XP_063123389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,449,375 - 99,451,343 (-)NCBI
RefSeq Acc Id: XM_063267320   ⟹   XP_063123390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,449,375 - 99,451,119 (-)NCBI
Ensembl Acc Id: ENSRNOP00000063598   ⟸   ENSRNOT00000066346
Ensembl Acc Id: ENSRNOP00000073966   ⟸   ENSRNOT00000086678
RefSeq Acc Id: NP_001386096   ⟸   NM_001399167
- UniProtKB: A0A0G2K6W4 (UniProtKB/TrEMBL),   A6JQS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123389   ⟸   XM_063267319
- Peptide Label: isoform X2
- UniProtKB: A6JQS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123390   ⟸   XM_063267320
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063123388   ⟸   XM_063267318
- Peptide Label: isoform X1
- UniProtKB: Q5PPN0 (UniProtKB/TrEMBL)
Protein Domains
bHLH   Orange

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PPN0-F1-model_v2 AlphaFold Q5PPN0 1-234 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696860
Promoter ID:EPDNEW_R7385
Type:initiation region
Name:Hes6_1
Description:hes family bHLH transcription factor 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0998,551,422 - 98,551,482EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1312047 AgrOrtholog
BioCyc Gene G2FUF-26714 BioCyc
Ensembl Genes ENSRNOG00000020194 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086678 ENTREZGENE
  ENSRNOT00000086678.3 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
  6.10.250.980 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7311379 IMAGE-MGC_LOAD
InterPro HES_HEY UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  HLH_DNA_bd UniProtKB/TrEMBL
  Orange UniProtKB/TrEMBL
MGC_CLONE MGC:105712 IMAGE-MGC_LOAD
NCBI Gene 316626 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/TrEMBL
Pfam Hairy_orange UniProtKB/TrEMBL
  HLH UniProtKB/TrEMBL
PhenoGen Hes6 PhenoGen
PROSITE HLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020194 RatGTEx
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP HLH_basic UniProtKB/TrEMBL
  Orange domain-like UniProtKB/TrEMBL
UniProt A0A0G2K6W4 ENTREZGENE, UniProtKB/TrEMBL
  A6JQS2 ENTREZGENE, UniProtKB/TrEMBL
  A6JQS3 ENTREZGENE, UniProtKB/TrEMBL
  A6JQS4_RAT UniProtKB/TrEMBL
  Q5PPN0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Hes6  hes family bHLH transcription factor 6  Hes6  hairy and enhancer of split 6 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Hes6  hairy and enhancer of split 6 (Drosophila)  Hes6_predicted  hairy and enhancer of split 6 (Drosophila) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Hes6_predicted  hairy and enhancer of split 6 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED