Cobl (cordon-bleu WH2 repeat protein) - Rat Genome Database

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Gene: Cobl (cordon-bleu WH2 repeat protein) Rattus norvegicus
Analyze
Symbol: Cobl
Name: cordon-bleu WH2 repeat protein
RGD ID: 1312002
Description: Predicted to enable actin monomer binding activity. Predicted to be involved in several processes, including actin filament organization; embryonic pattern specification; and positive regulation of cell projection organization. Predicted to act upstream of or within actin cytoskeleton organization and neural tube closure. Located in cell cortex and plasma membrane. Orthologous to human COBL (cordon-bleu WH2 repeat protein); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cordon-bleu; cordon-bleu homolog; cordon-bleu homolog (mouse); LOC305497; protein cordon-bleu
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81491,041,721 - 91,274,272 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1491,041,721 - 91,274,257 (-)EnsemblGRCr8
mRatBN7.21486,828,137 - 87,060,682 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1486,828,139 - 87,060,800 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1491,237,296 - 91,483,692 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01492,481,631 - 92,728,031 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01488,949,260 - 89,195,657 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01492,341,949 - 92,497,169 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1492,342,957 - 92,577,936 (-)Ensemblrn6Rnor6.0
Rnor_5.01492,142,186 - 92,321,314 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41493,154,637 - 93,309,406 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1485,826,388 - 85,975,943 (-)NCBICelera
RGSC_v3.11492,994,412 - 93,340,571 (-)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenfluramine  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
inulin  (ISO)
lipopolysaccharide  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
p-toluidine  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
propiconazole  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
spermine  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin filament  (IBA,IEA,ISO)
axon  (IEA,ISO)
axonal growth cone  (IBA,IEA,ISO)
cell cortex  (IDA,IEA,ISO)
cytoplasm  (IEA)
cytoskeleton  (IEA)
cytosol  (IEA)
dendrite  (IEA,ISO)
dendritic growth cone  (IBA,IEA,ISO)
membrane  (IEA,ISO)
neuronal cell body  (IBA,IEA,ISO)
perinuclear region of cytoplasm  (IBA,IEA,ISO)
plasma membrane  (IBA,IDA,IEA)
ruffle  (IBA,IEA,ISO)

Molecular Function
actin binding  (IEA)
actin monomer binding  (IBA,IEA,ISO)
protein binding  (IPI,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. Hou W, etal., PLoS Biol. 2015 Sep 3;13(9):e1002233. doi: 10.1371/journal.pbio.1002233. eCollection 2015.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. The functions of the actin nucleator Cobl in cellular morphogenesis critically depend on syndapin I. Schwintzer L, etal., EMBO J. 2011 Jul 1;30(15):3147-59. doi: 10.1038/emboj.2011.207.
Additional References at PubMed
PMID:7586755   PMID:14512015   PMID:17956734   PMID:22114352   PMID:29891944   PMID:34264190  


Genomics

Comparative Map Data
Cobl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81491,041,721 - 91,274,272 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1491,041,721 - 91,274,257 (-)EnsemblGRCr8
mRatBN7.21486,828,137 - 87,060,682 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1486,828,139 - 87,060,800 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1491,237,296 - 91,483,692 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01492,481,631 - 92,728,031 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01488,949,260 - 89,195,657 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01492,341,949 - 92,497,169 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1492,342,957 - 92,577,936 (-)Ensemblrn6Rnor6.0
Rnor_5.01492,142,186 - 92,321,314 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41493,154,637 - 93,309,406 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1485,826,388 - 85,975,943 (-)NCBICelera
RGSC_v3.11492,994,412 - 93,340,571 (-)NCBI
Cytogenetic Map14q21NCBI
COBL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38751,016,212 - 51,316,809 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl751,016,211 - 51,317,187 (-)Ensemblhg38GRCh38
GRCh37751,083,909 - 51,384,506 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36751,051,404 - 51,351,990 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34750,858,118 - 51,158,705NCBI
Celera751,148,737 - 51,449,348 (-)NCBICelera
Cytogenetic Map7p12.1NCBI
HuRef750,933,696 - 51,137,285 (-)NCBIHuRef
CHM1_1751,086,207 - 51,386,564 (-)NCBICHM1_1
T2T-CHM13v2.0751,177,453 - 51,478,069 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2751,089,893 - 51,390,521 (-)NCBI
Cobl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391112,186,676 - 12,415,022 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1112,186,608 - 12,414,960 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381112,236,676 - 12,465,022 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1112,236,608 - 12,464,960 (-)Ensemblmm10GRCm38
MGSCv371112,136,679 - 12,364,963 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361112,136,681 - 12,364,803 (-)NCBIMGSCv36mm8
Celera1112,678,618 - 12,909,422 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map117.3NCBI
COBL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2655,888,527 - 56,188,488 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17104,213,250 - 104,513,211 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0751,652,318 - 51,952,256 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1751,894,468 - 52,114,849 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl751,895,807 - 52,097,841 (-)EnsemblpanPan2panpan1.1
COBL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1182,206,957 - 2,386,333 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl182,208,260 - 2,459,206 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha182,249,781 - 2,393,765 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0182,317,922 - 2,462,079 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl182,264,613 - 2,514,854 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1182,289,962 - 2,433,564 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0182,286,890 - 2,430,828 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0182,423,375 - 2,567,362 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cobl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118105,650,726 - 105,902,001 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936686621,502 - 872,824 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COBL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.19136,850,521 - 137,055,249 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29150,659,325 - 150,667,343 (-)NCBISscrofa10.2Sscrofa10.2susScr3
COBL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1217,501,647 - 7,803,175 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl217,598,126 - 7,803,177 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606214,578,093 - 14,882,079 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cobl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247403,332,977 - 3,399,915 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cobl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11181,178,395 - 81,414,458 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cobl
1247 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:211
Count of miRNA genes:149
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000064483
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)1484164970100078267Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)1486271332100078267Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat

Markers in Region
RH130337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21486,828,142 - 86,828,323 (+)MAPPERmRatBN7.2
Rnor_6.01492,343,002 - 92,343,182NCBIRnor6.0
Rnor_5.01492,142,192 - 92,142,372UniSTSRnor5.0
RGSC_v3.41493,154,641 - 93,154,821UniSTSRGSC3.4
Celera1485,826,392 - 85,826,572UniSTS
RH 3.4 Map14651.1UniSTS
Cytogenetic Map14q21UniSTS
BE120256  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21486,967,283 - 86,967,439 (+)MAPPERmRatBN7.2
Rnor_6.01492,483,656 - 92,483,811NCBIRnor6.0
Rnor_5.01492,280,451 - 92,280,606UniSTSRnor5.0
RGSC_v3.41493,297,149 - 93,297,304UniSTSRGSC3.4
Celera1485,963,686 - 85,963,841UniSTS
RH 3.4 Map14641.1UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
18 13 67 152 91 90 59 31 59 6 305 132 12 132 88 94 31 18 18

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001401101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000064483   ⟹   ENSRNOP00000063258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1491,041,721 - 91,274,201 (-)Ensembl
mRatBN7.2 Ensembl1486,828,139 - 86,979,539 (-)Ensembl
Rnor_6.0 Ensembl1492,342,998 - 92,495,894 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086154   ⟹   ENSRNOP00000072330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1491,060,696 - 91,274,201 (-)Ensembl
mRatBN7.2 Ensembl1486,829,193 - 87,060,800 (-)Ensembl
Rnor_6.0 Ensembl1492,342,957 - 92,577,936 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094227   ⟹   ENSRNOP00000093905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1491,043,091 - 91,274,201 (-)Ensembl
mRatBN7.2 Ensembl1486,829,507 - 87,060,800 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105473   ⟹   ENSRNOP00000097856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1491,041,721 - 91,274,257 (-)Ensembl
mRatBN7.2 Ensembl1486,829,193 - 87,060,800 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110506   ⟹   ENSRNOP00000091350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1491,041,721 - 91,274,201 (-)Ensembl
mRatBN7.2 Ensembl1486,846,112 - 86,979,539 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115686   ⟹   ENSRNOP00000082660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1491,060,696 - 91,274,201 (-)Ensembl
mRatBN7.2 Ensembl1486,829,193 - 87,060,800 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000135785   ⟹   ENSRNOP00000107957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1491,041,721 - 91,274,201 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000141519   ⟹   ENSRNOP00000102446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1491,105,327 - 91,274,201 (-)Ensembl
RefSeq Acc Id: NM_001401101   ⟹   NP_001388030
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,041,721 - 91,274,201 (-)NCBI
mRatBN7.21486,828,137 - 87,060,633 (-)NCBI
RefSeq Acc Id: NM_001401102   ⟹   NP_001388031
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,041,721 - 91,274,201 (-)NCBI
mRatBN7.21486,828,137 - 87,060,633 (-)NCBI
RefSeq Acc Id: NM_001401103   ⟹   NP_001388032
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,041,721 - 91,274,201 (-)NCBI
mRatBN7.21486,828,137 - 87,060,633 (-)NCBI
RefSeq Acc Id: NM_001401104   ⟹   NP_001388033
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,041,721 - 91,274,201 (-)NCBI
mRatBN7.21486,828,137 - 87,060,633 (-)NCBI
RefSeq Acc Id: NM_001401105   ⟹   NP_001388034
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,041,721 - 91,274,201 (-)NCBI
mRatBN7.21486,828,137 - 87,060,633 (-)NCBI
RefSeq Acc Id: NM_001401106   ⟹   NP_001388035
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,041,721 - 91,221,805 (-)NCBI
mRatBN7.21486,828,137 - 87,008,237 (-)NCBI
RefSeq Acc Id: NM_001401108   ⟹   NP_001388037
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,105,327 - 91,274,201 (-)NCBI
mRatBN7.21486,891,753 - 87,060,633 (-)NCBI
RefSeq Acc Id: NM_001401109   ⟹   NP_001388038
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,105,327 - 91,274,201 (-)NCBI
mRatBN7.21486,891,753 - 87,060,633 (-)NCBI
RefSeq Acc Id: NM_001401112   ⟹   NP_001388041
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,105,327 - 91,221,805 (-)NCBI
mRatBN7.21486,891,753 - 87,008,237 (-)NCBI
RefSeq Acc Id: XM_039092053   ⟹   XP_038947981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,041,721 - 91,274,270 (-)NCBI
mRatBN7.21486,828,137 - 87,060,682 (-)NCBI
RefSeq Acc Id: XM_039092055   ⟹   XP_038947983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,058,843 - 91,265,634 (-)NCBI
mRatBN7.21486,828,137 - 87,028,218 (-)NCBI
RefSeq Acc Id: XM_039092058   ⟹   XP_038947986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,041,721 - 91,274,270 (-)NCBI
mRatBN7.21486,828,137 - 87,060,682 (-)NCBI
RefSeq Acc Id: XM_039092060   ⟹   XP_038947988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,041,721 - 91,274,270 (-)NCBI
mRatBN7.21486,828,137 - 87,060,682 (-)NCBI
RefSeq Acc Id: XM_063273227   ⟹   XP_063129297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,058,843 - 91,274,272 (-)NCBI
RefSeq Acc Id: XM_063273228   ⟹   XP_063129298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,058,843 - 91,235,633 (-)NCBI
RefSeq Acc Id: XM_063273229   ⟹   XP_063129299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,058,843 - 91,274,271 (-)NCBI
RefSeq Acc Id: XM_063273230   ⟹   XP_063129300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,058,843 - 91,274,271 (-)NCBI
RefSeq Acc Id: XM_063273231   ⟹   XP_063129301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,058,843 - 91,274,270 (-)NCBI
RefSeq Acc Id: XM_063273232   ⟹   XP_063129302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81491,041,721 - 91,235,629 (-)NCBI
Ensembl Acc Id: ENSRNOP00000072330   ⟸   ENSRNOT00000086154
Ensembl Acc Id: ENSRNOP00000063258   ⟸   ENSRNOT00000064483
RefSeq Acc Id: XP_038947986   ⟸   XM_039092058
- Peptide Label: isoform X8
- UniProtKB: A0A8I6AEB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947988   ⟸   XM_039092060
- Peptide Label: isoform X9
- UniProtKB: A0A8I6AEB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947981   ⟸   XM_039092053
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AEB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947983   ⟸   XM_039092055
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AEB0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093905   ⟸   ENSRNOT00000094227
Ensembl Acc Id: ENSRNOP00000091350   ⟸   ENSRNOT00000110506
Ensembl Acc Id: ENSRNOP00000082660   ⟸   ENSRNOT00000115686
Ensembl Acc Id: ENSRNOP00000097856   ⟸   ENSRNOT00000105473
RefSeq Acc Id: NP_001388033   ⟸   NM_001401104
- Peptide Label: isoform 4
- UniProtKB: A0A8I6AEB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388031   ⟸   NM_001401102
- Peptide Label: isoform 2
- UniProtKB: A0A8I6ASN2 (UniProtKB/TrEMBL),   A0A8I6AEB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388032   ⟸   NM_001401103
- Peptide Label: isoform 3
- UniProtKB: A0A8I6AEB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388034   ⟸   NM_001401105
- Peptide Label: isoform 5
- UniProtKB: A0A8I5ZV00 (UniProtKB/TrEMBL),   A0A8I6AEB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388030   ⟸   NM_001401101
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K2Q1 (UniProtKB/TrEMBL),   A0A8I6AEB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388035   ⟸   NM_001401106
- Peptide Label: isoform 6
- UniProtKB: A0A8I6AEB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388038   ⟸   NM_001401109
- Peptide Label: isoform 8
- UniProtKB: A0A8I6AJQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388037   ⟸   NM_001401108
- Peptide Label: isoform 7
- UniProtKB: A0A8I6AJQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388041   ⟸   NM_001401112
- Peptide Label: isoform 10
- UniProtKB: A0A8I6AJQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129302   ⟸   XM_063273232
- Peptide Label: isoform X10
- UniProtKB: A0A8I6AEB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129297   ⟸   XM_063273227
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AEB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129299   ⟸   XM_063273229
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AEB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129300   ⟸   XM_063273230
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AEB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129301   ⟸   XM_063273231
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AEB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129298   ⟸   XM_063273228
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AEB0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102446   ⟸   ENSRNOT00000141519
Ensembl Acc Id: ENSRNOP00000107957   ⟸   ENSRNOT00000135785
Protein Domains
Cordon-bleu ubiquitin-like   WH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUI5-F1-model_v2 AlphaFold D3ZUI5 1-1133 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1312002 AgrOrtholog
BioCyc Gene G2FUF-14981 BioCyc
Ensembl Genes ENSRNOG00000004281 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000064483 ENTREZGENE
  ENSRNOT00000064483.2 UniProtKB/Swiss-Prot
  ENSRNOT00000086154 ENTREZGENE
  ENSRNOT00000105473 ENTREZGENE
  ENSRNOT00000110506 ENTREZGENE
  ENSRNOT00000135785 ENTREZGENE
  ENSRNOT00000141519 ENTREZGENE
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
InterPro COBL-like UniProtKB/Swiss-Prot
  Cordon-bleu_ubiquitin_domain UniProtKB/Swiss-Prot
  WH2_dom UniProtKB/Swiss-Prot
NCBI Gene 305497 ENTREZGENE
PANTHER PROTEIN CORDON-BLEU UniProtKB/Swiss-Prot
  PTHR47008 UniProtKB/Swiss-Prot
Pfam Cobl UniProtKB/Swiss-Prot
  WH2 UniProtKB/Swiss-Prot
PhenoGen Cobl PhenoGen
PROSITE WH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004281 RatGTEx
SMART WH2 UniProtKB/Swiss-Prot
UniProt A0A0G2K2Q1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZV00 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEB0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJQ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASN2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LCS1_RAT UniProtKB/TrEMBL
  A0ABK0LUP8_RAT UniProtKB/TrEMBL
  COBL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Cobl  cordon-bleu WH2 repeat protein  Cobl  cordon-bleu homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Cobl  cordon-bleu homolog (mouse)  Cobl  cordon-bleu   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Cobl  cordon-bleu   Cobl_predicted  cordon-bleu (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cobl_predicted  cordon-bleu (predicted)      Symbol and Name status set to approved 70820 APPROVED