Asph (aspartate-beta-hydroxylase) - Rat Genome Database

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Gene: Asph (aspartate-beta-hydroxylase) Rattus norvegicus
Analyze
Symbol: Asph
Name: aspartate-beta-hydroxylase
RGD ID: 1312000
Description: Predicted to enable calcium ion binding activity. Involved in regulation of cytosolic calcium ion concentration. Predicted to be located in endoplasmic reticulum subcompartment; myofibril; and plasma membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in cholangiocarcinoma. Orthologous to human ASPH (aspartate beta-hydroxylase); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aspartyl/asparaginyl beta-hydroxylase; junctate; junctin; LOC100910356; LOC312981; uncharacterized LOC100910356
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8527,398,933 - 27,611,519 (-)NCBIGRCr8
mRatBN7.2522,601,581 - 22,814,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl522,603,486 - 22,813,876 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx524,829,597 - 25,041,330 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0526,421,579 - 26,633,838 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0526,201,866 - 26,414,127 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0522,577,680 - 22,799,333 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl522,577,675 - 22,799,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0527,312,094 - 27,529,901 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4523,495,780 - 23,520,672 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1523,337,888 - 23,733,050 (-)NCBI
Celera521,856,777 - 22,069,140 (-)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinous acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
haloperidol  (ISO)
hydralazine  (ISO)
indometacin  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
nicotinic acid  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
Soman  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
warfarin  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Junctin is a prominent regulator of contractility in cardiomyocytes. Fan GC, etal., Biochem Biophys Res Commun. 2007 Jan 19;352(3):617-22. Epub 2006 Nov 27.
2. Detection of human aspartyl (asparaginyl) beta-hydroxylase and homeobox B7 mRNA in brush cytology specimens from patients with bile duct cancer. Feldmann G, etal., Endoscopy. 2006 Jun;38(6):604-9. Epub 2006 Apr 27.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Immunization with aspartate-beta-hydroxylase-loaded dendritic cells produces antitumor effects in a rat model of intrahepatic cholangiocarcinoma. Noda T, etal., Hepatology. 2012 Jan;55(1):86-97. doi: 10.1002/hep.24629.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:8530521   PMID:11773073   PMID:12477932   PMID:15302852   PMID:15798210   PMID:17400717   PMID:18387192   PMID:21062895   PMID:22123818   PMID:22586105   PMID:33450132  


Genomics

Comparative Map Data
Asph
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8527,398,933 - 27,611,519 (-)NCBIGRCr8
mRatBN7.2522,601,581 - 22,814,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl522,603,486 - 22,813,876 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx524,829,597 - 25,041,330 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0526,421,579 - 26,633,838 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0526,201,866 - 26,414,127 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0522,577,680 - 22,799,333 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl522,577,675 - 22,799,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0527,312,094 - 27,529,901 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4523,495,780 - 23,520,672 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1523,337,888 - 23,733,050 (-)NCBI
Celera521,856,777 - 22,069,140 (-)NCBICelera
Cytogenetic Map5q13NCBI
ASPH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38861,500,556 - 61,714,592 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl861,500,556 - 61,714,640 (-)EnsemblGRCh38hg38GRCh38
GRCh37862,413,115 - 62,627,151 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36862,578,374 - 62,789,560 (-)NCBINCBI36Build 36hg18NCBI36
Build 34862,699,648 - 62,764,919NCBI
Celera858,402,958 - 58,617,392 (-)NCBICelera
Cytogenetic Map8q12.3NCBI
HuRef857,901,587 - 58,116,117 (-)NCBIHuRef
CHM1_1862,465,102 - 62,679,146 (-)NCBICHM1_1
T2T-CHM13v2.0861,924,301 - 62,138,323 (-)NCBIT2T-CHM13v2.0
Asph
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3949,449,085 - 9,669,344 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl49,448,069 - 9,669,344 (-)EnsemblGRCm39 Ensembl
GRCm3849,449,085 - 9,669,344 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl49,448,069 - 9,669,344 (-)EnsemblGRCm38mm10GRCm38
MGSCv3749,376,232 - 9,596,309 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3649,376,232 - 9,596,231 (-)NCBIMGSCv36mm8
Celera49,289,732 - 9,501,866 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map44.17NCBI
Asph
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544417,121,559 - 17,318,295 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544417,116,060 - 17,320,966 (+)NCBIChiLan1.0ChiLan1.0
ASPH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2777,157,601 - 77,371,678 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1852,817,397 - 53,030,622 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0857,921,580 - 58,134,778 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1859,629,707 - 59,843,921 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl859,629,707 - 59,843,658 (-)Ensemblpanpan1.1panPan2
ASPH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12911,812,275 - 12,022,755 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2911,814,554 - 12,022,680 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2912,127,227 - 12,309,441 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02911,908,475 - 12,120,515 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2911,910,753 - 12,120,515 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12911,900,440 - 12,082,741 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02912,036,855 - 12,218,830 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02912,307,233 - 12,489,655 (-)NCBIUU_Cfam_GSD_1.0
Asph
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530362,970,453 - 63,180,486 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649611,604,680 - 11,816,852 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649611,604,992 - 11,815,680 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASPH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl471,903,318 - 72,107,044 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1471,902,891 - 72,107,047 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2478,382,152 - 78,505,768 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASPH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1857,378,019 - 57,599,812 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl857,375,894 - 57,565,259 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603984,051,765 - 84,274,334 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asph
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474430,190,513 - 30,418,467 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474430,190,625 - 30,420,501 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Asph
1400 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:94
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000047805
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat

Markers in Region
RH133103  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2522,760,555 - 22,760,770 (+)MAPPERmRatBN7.2
Rnor_6.0522,745,859 - 22,746,073NCBIRnor6.0
Rnor_5.0527,476,382 - 27,476,596UniSTSRnor5.0
RGSC_v3.4523,495,888 - 23,496,102UniSTSRGSC3.4
Celera522,015,735 - 22,015,949UniSTS
RH 3.4 Map5133.71UniSTS
Cytogenetic Map5q13UniSTS
RH133181  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2522,724,932 - 22,725,114 (+)MAPPERmRatBN7.2
Rnor_6.0522,710,265 - 22,710,446NCBIRnor6.0
Rnor_5.0527,440,703 - 27,440,884UniSTSRnor5.0
RGSC_v3.4523,459,744 - 23,459,925UniSTSRGSC3.4
Celera521,980,125 - 21,980,306UniSTS
RH 3.4 Map5133.8UniSTS
Cytogenetic Map5q13UniSTS
BE097198  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2522,772,063 - 22,772,218 (+)MAPPERmRatBN7.2
Rnor_6.0522,757,343 - 22,757,497NCBIRnor6.0
Rnor_5.0527,487,907 - 27,488,061UniSTSRnor5.0
RGSC_v3.4523,508,218 - 23,508,372UniSTSRGSC3.4
Celera522,027,279 - 22,027,433UniSTS
RH 3.4 Map5133.8UniSTS
Cytogenetic Map5q13UniSTS
BE106090  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2522,616,606 - 22,616,756 (+)MAPPERmRatBN7.2
Rnor_6.0522,592,828 - 22,592,977NCBIRnor6.0
Rnor_5.0527,324,933 - 27,325,082UniSTSRnor5.0
RGSC_v3.4523,349,236 - 23,349,385UniSTSRGSC3.4
Celera521,872,173 - 21,872,322UniSTS
RH 3.4 Map5130.8UniSTS
Cytogenetic Map5q13UniSTS
RH138910  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2522,770,107 - 22,770,236 (+)MAPPERmRatBN7.2
Rnor_6.0522,755,411 - 22,755,539NCBIRnor6.0
Rnor_5.0527,485,934 - 27,486,062UniSTSRnor5.0
RGSC_v3.4523,505,440 - 23,505,568UniSTSRGSC3.4
Celera522,025,287 - 22,025,415UniSTS
RH 3.4 Map5158.0UniSTS
Cytogenetic Map5q13UniSTS
RH139586  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2522,769,095 - 22,769,300 (+)MAPPERmRatBN7.2
Rnor_6.0522,754,399 - 22,754,603NCBIRnor6.0
Rnor_5.0527,484,922 - 27,485,126UniSTSRnor5.0
RGSC_v3.4523,504,428 - 23,504,632UniSTSRGSC3.4
Celera522,024,275 - 22,024,479UniSTS
RH 3.4 Map5133.8UniSTS
Cytogenetic Map5q13UniSTS
RH140434  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2522,769,095 - 22,769,246 (+)MAPPERmRatBN7.2
Rnor_6.0522,754,399 - 22,754,549NCBIRnor6.0
Rnor_5.0527,484,922 - 27,485,072UniSTSRnor5.0
RGSC_v3.4523,504,428 - 23,504,578UniSTSRGSC3.4
Celera522,024,275 - 22,024,425UniSTS
Cytogenetic Map5q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 25 12 12 12 8 11 46 26 29 8 8
Low 2 18 45 29 19 29 28 9 12 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001098239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010066377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ865348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000047805   ⟹   ENSRNOP00000048656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl522,745,751 - 22,769,907 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076113   ⟹   ENSRNOP00000068228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl522,748,839 - 22,769,932 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076167   ⟹   ENSRNOP00000068254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl522,748,985 - 22,769,919 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076204   ⟹   ENSRNOP00000068059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl522,603,486 - 22,813,876 (-)Ensembl
Rnor_6.0 Ensembl522,581,310 - 22,799,349 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076426   ⟹   ENSRNOP00000068479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl522,603,486 - 22,813,876 (-)Ensembl
Rnor_6.0 Ensembl522,577,675 - 22,799,090 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076507   ⟹   ENSRNOP00000067926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl522,723,822 - 22,784,518 (-)Ensembl
Rnor_6.0 Ensembl522,709,158 - 22,769,925 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077044   ⟹   ENSRNOP00000068402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl522,723,822 - 22,813,876 (-)Ensembl
Rnor_6.0 Ensembl522,709,158 - 22,799,113 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079432   ⟹   ENSRNOP00000075358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl522,746,780 - 22,765,429 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083779   ⟹   ENSRNOP00000072176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl522,603,486 - 22,784,518 (-)Ensembl
Rnor_6.0 Ensembl522,578,943 - 22,770,008 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096794   ⟹   ENSRNOP00000082455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl522,768,913 - 22,813,876 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099512   ⟹   ENSRNOP00000083516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl522,603,486 - 22,813,876 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106256   ⟹   ENSRNOP00000097341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl522,603,486 - 22,780,679 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113533   ⟹   ENSRNOP00000090443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl522,723,822 - 22,784,518 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118158   ⟹   ENSRNOP00000082407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl522,603,486 - 22,813,876 (-)Ensembl
RefSeq Acc Id: NM_001098239   ⟹   NP_001091709
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,557,792 - 27,581,859 (-)NCBI
mRatBN7.2522,760,448 - 22,784,518 (-)NCBI
RefSeq Acc Id: NM_001401939   ⟹   NP_001388868
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,398,949 - 27,611,215 (-)NCBI
mRatBN7.2522,601,581 - 22,813,876 (-)NCBI
RefSeq Acc Id: XM_006237859   ⟹   XP_006237921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,398,933 - 27,586,797 (-)NCBI
mRatBN7.2522,603,879 - 22,786,294 (-)NCBI
Rnor_6.0522,577,680 - 22,771,612 (-)NCBI
Rnor_5.0527,312,094 - 27,529,901 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237860   ⟹   XP_006237922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,398,933 - 27,586,790 (-)NCBI
mRatBN7.2522,603,879 - 22,786,280 (-)NCBI
Rnor_6.0522,577,680 - 22,771,612 (-)NCBI
Rnor_5.0527,312,094 - 27,529,901 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237861   ⟹   XP_006237923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,398,933 - 27,611,231 (-)NCBI
mRatBN7.2522,603,879 - 22,814,103 (-)NCBI
Rnor_6.0522,577,680 - 22,799,333 (-)NCBI
Rnor_5.0527,312,094 - 27,529,901 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237862   ⟹   XP_006237924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,398,933 - 27,586,800 (-)NCBI
mRatBN7.2522,603,879 - 22,789,453 (-)NCBI
Rnor_6.0522,577,680 - 22,771,613 (-)NCBI
Rnor_5.0527,312,094 - 27,529,901 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237863   ⟹   XP_006237925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,557,776 - 27,611,519 (-)NCBI
mRatBN7.2522,760,432 - 22,814,070 (-)NCBI
Rnor_6.0522,745,735 - 22,799,333 (-)NCBI
Rnor_5.0527,312,094 - 27,529,901 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763575   ⟹   XP_008761797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,565,879 - 27,611,430 (-)NCBI
mRatBN7.2522,768,531 - 22,814,100 (-)NCBI
Rnor_6.0522,755,799 - 22,799,332 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109773   ⟹   XP_038965701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,521,179 - 27,611,231 (-)NCBI
mRatBN7.2522,723,822 - 22,814,104 (-)NCBI
RefSeq Acc Id: XM_063287526   ⟹   XP_063143596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,398,933 - 27,586,793 (-)NCBI
RefSeq Acc Id: XM_063287527   ⟹   XP_063143597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,469,758 - 27,611,234 (-)NCBI
RefSeq Acc Id: XM_063287528   ⟹   XP_063143598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,521,179 - 27,611,229 (-)NCBI
RefSeq Acc Id: XM_063287529   ⟹   XP_063143599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,521,179 - 27,611,257 (-)NCBI
RefSeq Acc Id: XM_063287530   ⟹   XP_063143600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,557,776 - 27,582,125 (-)NCBI
RefSeq Acc Id: XM_063287531   ⟹   XP_063143601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,565,879 - 27,586,791 (-)NCBI
RefSeq Acc Id: XR_010066377
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8527,521,179 - 27,611,233 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001091709 (Get FASTA)   NCBI Sequence Viewer  
  NP_001388868 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237921 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237922 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237923 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237924 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237925 (Get FASTA)   NCBI Sequence Viewer  
  XP_008761797 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965701 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143596 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143597 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143598 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143599 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143600 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143601 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85901 (Get FASTA)   NCBI Sequence Viewer  
  CAI26291 (Get FASTA)   NCBI Sequence Viewer  
  EDM11656 (Get FASTA)   NCBI Sequence Viewer  
  EDM11657 (Get FASTA)   NCBI Sequence Viewer  
  EDM11658 (Get FASTA)   NCBI Sequence Viewer  
  EDM11659 (Get FASTA)   NCBI Sequence Viewer  
  EDM11660 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067926.1
  ENSRNOP00000068059.2
  ENSRNOP00000068402
  ENSRNOP00000068402.2
  ENSRNOP00000068479
  ENSRNOP00000068479.1
  ENSRNOP00000072176
  ENSRNOP00000072176.2
  ENSRNOP00000082407
  ENSRNOP00000082407.1
  ENSRNOP00000082455
  ENSRNOP00000082455.1
  ENSRNOP00000083516.1
  ENSRNOP00000090443.1
  ENSRNOP00000097341.1
RefSeq Acc Id: XP_006237923   ⟸   XM_006237861
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZX44 (UniProtKB/TrEMBL),   A0A096MJA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237924   ⟸   XM_006237862
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K2B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237921   ⟸   XM_006237859
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237922   ⟸   XM_006237860
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K2B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237925   ⟸   XM_006237863
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_008761797   ⟸   XM_008763575
- Peptide Label: isoform X12
- UniProtKB: A0A8I5ZX27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075358   ⟸   ENSRNOT00000079432
RefSeq Acc Id: ENSRNOP00000068402   ⟸   ENSRNOT00000077044
RefSeq Acc Id: ENSRNOP00000048656   ⟸   ENSRNOT00000047805
RefSeq Acc Id: ENSRNOP00000072176   ⟸   ENSRNOT00000083779
RefSeq Acc Id: ENSRNOP00000068059   ⟸   ENSRNOT00000076204
RefSeq Acc Id: ENSRNOP00000068254   ⟸   ENSRNOT00000076167
RefSeq Acc Id: ENSRNOP00000068228   ⟸   ENSRNOT00000076113
RefSeq Acc Id: ENSRNOP00000068479   ⟸   ENSRNOT00000076426
RefSeq Acc Id: ENSRNOP00000067926   ⟸   ENSRNOT00000076507
RefSeq Acc Id: XP_038965701   ⟸   XM_039109773
- Peptide Label: isoform X7
RefSeq Acc Id: NP_001091709   ⟸   NM_001098239
- Peptide Label: isoform 2
- UniProtKB: Q5U2Q8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000082407   ⟸   ENSRNOT00000118158
RefSeq Acc Id: ENSRNOP00000083516   ⟸   ENSRNOT00000099512
RefSeq Acc Id: ENSRNOP00000090443   ⟸   ENSRNOT00000113533
RefSeq Acc Id: ENSRNOP00000097341   ⟸   ENSRNOT00000106256
RefSeq Acc Id: ENSRNOP00000082455   ⟸   ENSRNOT00000096794
RefSeq Acc Id: NP_001388868   ⟸   NM_001401939
- Peptide Label: isoform 1
- UniProtKB: A0A096MKE0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143596   ⟸   XM_063287526
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063143597   ⟸   XM_063287527
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063143599   ⟸   XM_063287529
- Peptide Label: isoform X9
- UniProtKB: A0A096MK70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143598   ⟸   XM_063287528
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063143600   ⟸   XM_063287530
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063143601   ⟸   XM_063287531
- Peptide Label: isoform X13
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2B5-F1-model_v2 AlphaFold A0A0G2K2B5 1-789 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693566
Promoter ID:EPDNEW_R4082
Type:multiple initiation site
Name:Asph_1
Description:aspartate-beta-hydroxylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0522,799,091 - 22,799,151EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1312000 AgrOrtholog
BioCyc Gene G2FUF-41999 BioCyc
Ensembl Genes ENSRNOG00000007445 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076204.3 UniProtKB/TrEMBL
  ENSRNOT00000076426 ENTREZGENE
  ENSRNOT00000076426.3 UniProtKB/TrEMBL
  ENSRNOT00000076507.3 UniProtKB/TrEMBL
  ENSRNOT00000077044.3 UniProtKB/TrEMBL
  ENSRNOT00000083779.2 UniProtKB/TrEMBL
  ENSRNOT00000096794.1 UniProtKB/TrEMBL
  ENSRNOT00000099512.1 UniProtKB/TrEMBL
  ENSRNOT00000106256.1 UniProtKB/TrEMBL
  ENSRNOT00000113533.1 UniProtKB/TrEMBL
  ENSRNOT00000118158.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193538 IMAGE-MGC_LOAD
InterPro Asp-B-hydro/Triadin UniProtKB/TrEMBL
  Asp_Arg_Pro-Hydrxlase UniProtKB/TrEMBL
  ASPH UniProtKB/TrEMBL
  IPNS-like UniProtKB/TrEMBL
  TPR-like_helical_dom UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
MGC_CLONE MGC:94733 IMAGE-MGC_LOAD
NCBI Gene 312981 ENTREZGENE
PANTHER ASP-B-HYDRO_N DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE UniProtKB/TrEMBL
  PTHR12366 UniProtKB/TrEMBL
Pfam Asp-B-Hydro_N UniProtKB/TrEMBL
  Asp_Arg_Hydrox UniProtKB/TrEMBL
  TPR_16 UniProtKB/TrEMBL
  TPR_8 UniProtKB/TrEMBL
PhenoGen Asph PhenoGen
PROSITE TPR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007445 RatGTEx
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP Clavaminate synthase-like UniProtKB/TrEMBL
  SSF48452 UniProtKB/TrEMBL
UniProt A0A096MIY8_RAT UniProtKB/TrEMBL
  A0A096MJA9 ENTREZGENE, UniProtKB/TrEMBL
  A0A096MK70 ENTREZGENE, UniProtKB/TrEMBL
  A0A096MKE0 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K2B5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZX27 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZX44 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A050_RAT UniProtKB/TrEMBL
  A0A8I6GIW1_RAT UniProtKB/TrEMBL
  A0A8I6GM10_RAT UniProtKB/TrEMBL
  Q5U2Q8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Asph  aspartate-beta-hydroxylase  LOC100910356  uncharacterized LOC100910356  Data merged from RGD:6498886 737654 PROVISIONAL
2012-07-05 LOC100910356  uncharacterized LOC100910356      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Asph  aspartate-beta-hydroxylase   Asph_predicted  aspartate-beta-hydroxylase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Asph_predicted  aspartate-beta-hydroxylase (predicted)      Symbol and Name status set to approved 70820 APPROVED