(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ASPH mRNA] CTD PMID:31150632 1,2-dimethylhydrazine affects expression ISO Asph (Mus musculus) 6480464 1 and 2-Dimethylhydrazine affects the expression of ASPH mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO Asph (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ASPH mRNA CTD PMID:22206623 17alpha-ethynylestradiol affects expression ISO Asph (Mus musculus) 6480464 Ethinyl Estradiol affects the expression of ASPH mRNA CTD PMID:17555576 17beta-estradiol multiple interactions ISO ASPH (Homo sapiens) 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of ASPH mRNA and [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ASPH mRNA CTD PMID:19619570 and PMID:20660070 17beta-estradiol affects expression ISO ASPH (Homo sapiens) 6480464 Estradiol affects the expression of ASPH mRNA CTD PMID:22574217 17beta-estradiol increases expression ISO ASPH (Homo sapiens) 6480464 Estradiol results in increased expression of ASPH mRNA CTD PMID:19619570 and PMID:21185374 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Asph (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Asph (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO ASPH (Homo sapiens) 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ASPH mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of ASPH mRNA CTD PMID:33387578 and PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Asph (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of ASPH mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO ASPH (Homo sapiens) 6480464 Tetrachlorodibenzodioxin affects the expression of ASPH mRNA CTD PMID:22574217 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO ASPH (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of ASPH mRNA CTD PMID:19619570 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO ASPH (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of ASPH mRNA CTD PMID:28628672 4,4'-diaminodiphenylmethane increases expression ISO Asph (Mus musculus) 6480464 4 and 4'-diaminodiphenylmethane results in increased expression of ASPH mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol multiple interactions ISO ASPH (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of ASPH mRNA CTD PMID:28628672 4-hydroxyphenyl retinamide decreases expression ISO Asph (Mus musculus) 6480464 Fenretinide results in decreased expression of ASPH mRNA CTD PMID:28973697 aflatoxin B1 decreases expression ISO Asph (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of ASPH mRNA CTD PMID:19770486 all-trans-retinoic acid decreases expression ISO ASPH (Homo sapiens) 6480464 Tretinoin results in decreased expression of ASPH mRNA CTD PMID:21934132 and PMID:33167477 aristolochic acid A decreases expression ISO ASPH (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of ASPH mRNA CTD PMID:33212167 arsane affects methylation ISO ASPH (Homo sapiens) 6480464 Arsenic affects the methylation of ASPH gene CTD PMID:25304211 arsenic atom affects methylation ISO ASPH (Homo sapiens) 6480464 Arsenic affects the methylation of ASPH gene CTD PMID:25304211 arsenite(3-) decreases expression ISO Asph (Mus musculus) 6480464 arsenite results in decreased expression of ASPH mRNA CTD PMID:33053406 arsenous acid decreases response to substance ISO ASPH (Homo sapiens) 6480464 ASPH protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 avobenzone increases expression ISO ASPH (Homo sapiens) 6480464 avobenzone results in increased expression of ASPH mRNA CTD PMID:31016361 benzatropine increases expression ISO ASPH (Homo sapiens) 6480464 Benztropine results in increased expression of ASPH protein CTD PMID:34122009 benzo[a]pyrene increases mutagenesis ISO ASPH (Homo sapiens) 6480464 Benzo(a)pyrene results in increased mutagenesis of ASPH gene CTD PMID:25435355 benzo[a]pyrene increases methylation ISO ASPH (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of ASPH promoter CTD PMID:27901495 benzo[a]pyrene affects methylation ISO Asph (Mus musculus) 6480464 Benzo(a)pyrene affects the methylation of ASPH intron CTD PMID:27901495 benzo[a]pyrene increases expression ISO ASPH (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of ASPH mRNA CTD PMID:21871943 and PMID:26238291 benzo[a]pyrene decreases expression ISO Asph (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of ASPH mRNA CTD PMID:19770486 and PMID:22228805 benzo[a]pyrene multiple interactions ISO Asph (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ASPH mRNA and AHR protein affects the reaction [Benzo(a)pyrene affects the expression of ASPH mRNA] CTD PMID:22228805 and PMID:27858113 benzo[a]pyrene increases expression ISO Asph (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of ASPH mRNA CTD PMID:22228805 benzo[b]fluoranthene multiple interactions ISO Asph (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ASPH mRNA CTD PMID:27858113 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of ASPH mRNA CTD PMID:25181051 bisphenol A increases expression ISO ASPH (Homo sapiens) 6480464 bisphenol A results in increased expression of ASPH protein CTD PMID:37567409 bisphenol A decreases expression ISO ASPH (Homo sapiens) 6480464 bisphenol A results in decreased expression of ASPH protein CTD PMID:37664457 bisphenol A multiple interactions ISO ASPH (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] affects the methylation of ASPH gene CTD PMID:31601247 bisphenol A decreases methylation ISO ASPH (Homo sapiens) 6480464 bisphenol A results in decreased methylation of ASPH gene CTD PMID:31601247 bisphenol A affects expression ISO ASPH (Homo sapiens) 6480464 bisphenol A affects the expression of ASPH mRNA CTD PMID:30903817 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ASPH mRNA CTD PMID:30816183 Bisphenol B increases expression ISO ASPH (Homo sapiens) 6480464 bisphenol B results in increased expression of ASPH protein CTD PMID:34186270 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of ASPH promoter CTD PMID:22457795 calcitriol decreases expression ISO ASPH (Homo sapiens) 6480464 Calcitriol results in decreased expression of ASPH mRNA CTD PMID:21592394 calcitriol multiple interactions ISO ASPH (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of ASPH mRNA CTD PMID:21592394 cannabidiol increases expression ISO ASPH (Homo sapiens) 6480464 Cannabidiol results in increased expression of ASPH protein CTD PMID:34122009 carbon nanotube decreases expression ISO Asph (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 and PMID:25620056 CGP 52608 multiple interactions ISO ASPH (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to ASPH gene] CTD PMID:28238834 chlordecone increases expression ISO Asph (Mus musculus) 6480464 Chlordecone results in increased expression of ASPH mRNA CTD PMID:33711761 chlordecone decreases expression ISO Asph (Mus musculus) 6480464 Chlordecone results in decreased expression of ASPH mRNA CTD PMID:29980752 choline multiple interactions ISO Asph (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ASPH gene CTD PMID:20938992 chromium atom multiple interactions ISO Asph (Mus musculus) 6480464 LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of ASPH mRNA] CTD PMID:16940432 chromium(6+) affects expression ISO Asph (Mus musculus) 6480464 chromium hexavalent ion affects the expression of ASPH mRNA CTD PMID:28472532 chrysene multiple interactions ISO Asph (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ASPH mRNA CTD PMID:27858113 clozapine increases expression ISO ASPH (Homo sapiens) 6480464 Clozapine results in increased expression of ASPH protein CTD PMID:34122009 cobalt dichloride decreases expression ISO ASPH (Homo sapiens) 6480464 cobaltous chloride results in decreased expression of ASPH mRNA CTD PMID:19376846 copper atom multiple interactions ISO ASPH (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in increased expression of ASPH mRNA CTD PMID:20971185 copper(0) multiple interactions ISO ASPH (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in increased expression of ASPH mRNA CTD PMID:20971185 copper(II) sulfate increases expression ISO ASPH (Homo sapiens) 6480464 Copper Sulfate results in increased expression of ASPH mRNA CTD PMID:19549813 Cuprizon decreases expression EXP 6480464 Cuprizone results in decreased expression of ASPH mRNA CTD PMID:26577399 cyclosporin A increases expression ISO ASPH (Homo sapiens) 6480464 Cyclosporine results in increased expression of ASPH mRNA CTD PMID:20106945 and PMID:25562108 dexamethasone increases expression ISO Asph (Mus musculus) 6480464 Dexamethasone results in increased expression of ASPH mRNA CTD PMID:22733784 dexamethasone multiple interactions ISO ASPH (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of ASPH mRNA CTD PMID:28628672 diarsenic trioxide decreases response to substance ISO ASPH (Homo sapiens) 6480464 ASPH protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 dimethylarsinous acid increases expression ISO ASPH (Homo sapiens) 6480464 dimethylarsinous acid results in increased expression of ASPH mRNA CTD PMID:23487506 dorsomorphin multiple interactions ISO ASPH (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ASPH mRNA CTD PMID:27188386 doxorubicin multiple interactions ISO Asph (Mus musculus) 6480464 [[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of ASPH mRNA CTD PMID:21040762 doxorubicin decreases expression ISO ASPH (Homo sapiens) 6480464 Doxorubicin results in decreased expression of ASPH mRNA CTD PMID:28940058 and PMID:29803840 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of ASPH mRNA CTD PMID:29391264 ethanol affects splicing ISO Asph (Mus musculus) 6480464 Ethanol affects the splicing of ASPH mRNA CTD PMID:30319688 ethyl methanesulfonate decreases expression ISO ASPH (Homo sapiens) 6480464 Ethyl Methanesulfonate results in decreased expression of ASPH mRNA CTD PMID:23649840 folic acid multiple interactions ISO Asph (Mus musculus) 6480464 [1 more ... CTD PMID:20938992 and PMID:22206623 folic acid decreases expression ISO Asph (Mus musculus) 6480464 Folic Acid results in decreased expression of ASPH mRNA CTD PMID:25629700 fonofos increases methylation ISO ASPH (Homo sapiens) 6480464 Fonofos results in increased methylation of ASPH promoter CTD PMID:22847954 formaldehyde decreases expression ISO ASPH (Homo sapiens) 6480464 Formaldehyde results in decreased expression of ASPH mRNA CTD PMID:23649840 FR900359 decreases phosphorylation ISO ASPH (Homo sapiens) 6480464 FR900359 results in decreased phosphorylation of ASPH protein CTD PMID:37730182 fulvestrant multiple interactions ISO ASPH (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] affects the methylation of ASPH gene CTD PMID:31601247 genistein increases expression ISO Asph (Mus musculus) 6480464 Genistein results in increased expression of ASPH mRNA CTD PMID:32186404 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of ASPH mRNA CTD PMID:33387578 haloperidol increases expression ISO ASPH (Homo sapiens) 6480464 Haloperidol results in increased expression of ASPH protein CTD PMID:34122009 hydralazine multiple interactions ISO ASPH (Homo sapiens) 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of ASPH mRNA CTD PMID:17183730 indometacin multiple interactions ISO ASPH (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of ASPH mRNA CTD PMID:28628672 isoflavones increases expression ISO ASPH (Homo sapiens) 6480464 Isoflavones results in increased expression of ASPH mRNA CTD PMID:17374662 isoprenaline decreases expression ISO Asph (Mus musculus) 6480464 Isoproterenol results in decreased expression of ASPH mRNA CTD PMID:20003209 ivermectin decreases expression ISO ASPH (Homo sapiens) 6480464 Ivermectin results in decreased expression of ASPH protein CTD PMID:32959892 L-methionine multiple interactions ISO Asph (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ASPH gene CTD PMID:20938992 lead diacetate increases expression ISO ASPH (Homo sapiens) 6480464 lead acetate results in increased expression of ASPH mRNA CTD PMID:22839698 lead(0) affects expression ISO ASPH (Homo sapiens) 6480464 Lead affects the expression of ASPH mRNA CTD PMID:22313790 methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of ASPH gene CTD PMID:35440735 methyl methanesulfonate decreases expression ISO ASPH (Homo sapiens) 6480464 Methyl Methanesulfonate results in decreased expression of ASPH mRNA CTD PMID:23649840 methylparaben increases expression ISO ASPH (Homo sapiens) 6480464 methylparaben results in increased expression of ASPH mRNA CTD PMID:31745603 nicotinic acid multiple interactions ISO Asph (Mus musculus) 6480464 LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of ASPH mRNA] CTD PMID:16940432 paracetamol increases expression ISO ASPH (Homo sapiens) 6480464 Acetaminophen results in increased expression of ASPH mRNA CTD PMID:22230336 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of ASPH mRNA CTD PMID:33387578 parathion increases methylation ISO ASPH (Homo sapiens) 6480464 Parathion results in increased methylation of ASPH promoter CTD PMID:22847954 PCB138 multiple interactions ISO Asph (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 perfluorooctanoic acid increases expression ISO Asph (Mus musculus) 6480464 perfluorooctanoic acid results in increased expression of ASPH protein CTD PMID:37422089 phenylmercury acetate decreases expression ISO ASPH (Homo sapiens) 6480464 Phenylmercuric Acetate results in decreased expression of ASPH mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO ASPH (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ASPH mRNA CTD PMID:27188386 pirinixic acid multiple interactions ISO ASPH (Homo sapiens) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ASPH mRNA CTD PMID:19710929 progesterone multiple interactions ISO ASPH (Homo sapiens) 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of ASPH mRNA CTD PMID:20660070 propiconazole increases expression ISO Asph (Mus musculus) 6480464 propiconazole results in increased expression of ASPH mRNA CTD PMID:21278054 quercetin increases expression ISO ASPH (Homo sapiens) 6480464 Quercetin results in increased expression of ASPH mRNA CTD PMID:21632981 resveratrol increases expression ISO Asph (Mus musculus) 6480464 resveratrol results in increased expression of ASPH protein CTD PMID:25505154 resveratrol multiple interactions ISO ASPH (Homo sapiens) 6480464 [Plant Extracts co-treated with Resveratrol] results in increased expression of ASPH mRNA CTD PMID:23557933 resveratrol decreases expression ISO ASPH (Homo sapiens) 6480464 resveratrol results in decreased expression of ASPH mRNA CTD PMID:25888808 SB 431542 multiple interactions ISO ASPH (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ASPH mRNA CTD PMID:27188386 silicon dioxide decreases expression ISO Asph (Mus musculus) 6480464 Silicon Dioxide results in decreased expression of ASPH mRNA CTD PMID:19073995 silicon dioxide increases expression ISO Asph (Mus musculus) 6480464 Silicon Dioxide results in increased expression of ASPH mRNA CTD PMID:19073995 and PMID:33720480 silver atom increases expression ISO ASPH (Homo sapiens) 6480464 Silver results in increased expression of ASPH mRNA CTD PMID:26014281 silver(0) increases expression ISO ASPH (Homo sapiens) 6480464 Silver results in increased expression of ASPH mRNA CTD PMID:26014281 Soman decreases expression EXP 6480464 Soman results in decreased expression of ASPH mRNA CTD PMID:19281266 succimer multiple interactions ISO Asph (Mus musculus) 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ASPH mRNA CTD PMID:26378955 succimer multiple interactions ISO ASPH (Homo sapiens) 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ASPH mRNA CTD PMID:26378955 sulforaphane increases expression ISO ASPH (Homo sapiens) 6480464 sulforaphane results in increased expression of ASPH mRNA CTD PMID:31838189 sunitinib decreases expression ISO ASPH (Homo sapiens) 6480464 Sunitinib results in decreased expression of ASPH mRNA CTD PMID:31533062 tamoxifen affects expression ISO Asph (Mus musculus) 6480464 Tamoxifen affects the expression of ASPH mRNA CTD PMID:17555576 temozolomide decreases expression ISO ASPH (Homo sapiens) 6480464 Temozolomide results in decreased expression of ASPH mRNA CTD PMID:31758290 terbufos increases methylation ISO ASPH (Homo sapiens) 6480464 terbufos results in increased methylation of ASPH promoter CTD PMID:22847954 tert-butyl hydroperoxide decreases expression ISO ASPH (Homo sapiens) 6480464 tert-Butylhydroperoxide results in decreased expression of ASPH mRNA CTD PMID:15336504 testosterone multiple interactions ISO ASPH (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of ASPH mRNA CTD PMID:21592394 testosterone decreases expression ISO ASPH (Homo sapiens) 6480464 Testosterone results in decreased expression of ASPH mRNA CTD PMID:21592394 tetrachloromethane decreases expression ISO Asph (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of ASPH mRNA CTD PMID:17484886 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ASPH mRNA] CTD PMID:31150632 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of ASPH mRNA CTD PMID:31150632 tetraphene decreases expression ISO Asph (Mus musculus) 6480464 benz(a)anthracene results in decreased expression of ASPH mRNA CTD PMID:26377693 tetraphene multiple interactions ISO Asph (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ASPH mRNA CTD PMID:27858113 thapsigargin increases expression ISO Asph (Mus musculus) 6480464 Thapsigargin results in increased expression of ASPH protein CTD PMID:24648495 titanium dioxide affects expression ISO Asph (Mus musculus) 6480464 titanium dioxide affects the expression of ASPH mRNA CTD PMID:17656681 tremolite asbestos increases expression ISO Asph (Mus musculus) 6480464 tremolite results in increased expression of ASPH mRNA CTD PMID:29279043 trichostatin A decreases expression ISO ASPH (Homo sapiens) 6480464 trichostatin A results in decreased expression of ASPH mRNA CTD PMID:24935251 trimellitic anhydride decreases expression ISO Asph (Mus musculus) 6480464 trimellitic anhydride results in decreased expression of ASPH mRNA CTD PMID:19042947 triptonide increases expression ISO Asph (Mus musculus) 6480464 triptonide results in increased expression of ASPH mRNA CTD PMID:33045310 valproic acid multiple interactions ISO ASPH (Homo sapiens) 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of ASPH mRNA CTD PMID:17183730 valproic acid increases expression ISO ASPH (Homo sapiens) 6480464 Valproic Acid results in increased expression of ASPH mRNA CTD PMID:23179753 and PMID:28001369 valproic acid affects expression ISO ASPH (Homo sapiens) 6480464 Valproic Acid affects the expression of ASPH mRNA CTD PMID:25979313 valproic acid decreases methylation ISO ASPH (Homo sapiens) 6480464 Valproic Acid results in decreased methylation of ASPH gene CTD PMID:29154799 warfarin affects response to substance ISO ASPH (Homo sapiens) 6480464 ASPH gene SNP affects the susceptibility to Warfarin CTD PMID:27488176