Pcdhga5 (protocadherin gamma subfamily A, 5) - Rat Genome Database

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Gene: Pcdhga5 (protocadherin gamma subfamily A, 5) Rattus norvegicus
Analyze
Symbol: Pcdhga5 (Ensembl: Pcdhgc3)
Name: protocadherin gamma subfamily A, 5 (Ensembl:protocadherin gamma subfamily C, 3)
RGD ID: 1311949
Description: Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in cell adhesion. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including PCDHGA7 (protocadherin gamma subfamily A, 7); INTERACTS WITH bisphenol A; C60 fullerene; doxorubicin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC291637; protocadherin gamma-A5
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81829,770,940 - 29,919,095 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21829,519,705 - 29,667,865 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1829,493,954 - 29,667,868 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1829,624,045 - 29,772,190 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01830,386,060 - 30,534,170 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01829,721,383 - 29,869,511 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01830,840,700 - 30,971,113 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1830,840,868 - 30,843,291 (+)Ensemblrn6Rnor6.0
Rnor_5.01830,534,927 - 30,662,065 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41830,600,858 - 30,754,205 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1829,166,201 - 29,311,954 (+)NCBICelera
RGSC_v3.11830,627,671 - 30,630,116 (+)NCBI
Cytogenetic Map18p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA,ISO)
plasma membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10650949   PMID:14672974   PMID:15347688   PMID:15744052   PMID:17110050  


Genomics

Comparative Map Data
Pcdhga5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81829,770,940 - 29,919,095 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21829,519,705 - 29,667,865 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1829,493,954 - 29,667,868 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1829,624,045 - 29,772,190 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01830,386,060 - 30,534,170 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01829,721,383 - 29,869,511 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01830,840,700 - 30,971,113 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1830,840,868 - 30,843,291 (+)Ensemblrn6Rnor6.0
Rnor_5.01830,534,927 - 30,662,065 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41830,600,858 - 30,754,205 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1829,166,201 - 29,311,954 (+)NCBICelera
RGSC_v3.11830,627,671 - 30,630,116 (+)NCBI
Cytogenetic Map18p11NCBI
PCDHGA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385141,364,162 - 141,512,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5141,364,162 - 141,512,975 (+)Ensemblhg38GRCh38
GRCh375140,743,729 - 140,892,542 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365140,724,082 - 140,872,730 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345140,724,081 - 140,726,523NCBI
Celera5136,820,723 - 136,969,282 (+)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5135,888,973 - 136,037,386 (+)NCBIHuRef
CHM1_15140,177,105 - 140,325,823 (+)NCBICHM1_1
T2T-CHM13v2.05141,889,786 - 142,038,959 (+)NCBIT2T-CHM13v2.0
Pcdhga5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391837,827,428 - 37,974,923 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1837,827,433 - 37,974,926 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381837,694,375 - 37,841,870 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1837,694,380 - 37,841,873 (+)Ensemblmm10GRCm38
MGSCv371837,854,155 - 38,001,524 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361837,820,375 - 37,967,844 (+)NCBIMGSCv36mm8
Celera1839,027,566 - 39,185,349 (+)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1819.55NCBI

Variants

.
Variants in Pcdhga5
832 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:170
Count of miRNA genes:119
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000027026
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181564228031610627Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181221668431644508Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181522610142690662Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181221668431644508Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228031610627Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18381190230809809Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat

Markers in Region
D18Rat100  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21829,607,001 - 29,607,214 (+)MAPPERmRatBN7.2
Rnor_6.01830,928,541 - 30,928,753NCBIRnor6.0
Rnor_5.01830,622,699 - 30,622,911UniSTSRnor5.0
RGSC_v3.41830,688,754 - 30,688,967RGDRGSC3.4
RGSC_v3.41830,688,755 - 30,688,967UniSTSRGSC3.4
Celera1829,253,446 - 29,253,658UniSTS
RGSC_v3.11830,715,400 - 30,715,613RGD
SHRSP x BN Map1813.7599RGD
SHRSP x BN Map1813.7599UniSTS
Cytogenetic Map18p11UniSTS
D18Wox21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21829,666,368 - 29,666,447 (+)MAPPERmRatBN7.2
Rnor_6.01830,969,617 - 30,969,695NCBIRnor6.0
Rnor_5.01830,660,569 - 30,660,647UniSTSRnor5.0
RGSC_v3.41830,752,709 - 30,752,787UniSTSRGSC3.4
Celera1829,310,458 - 29,310,536UniSTS
Cytogenetic Map18p11UniSTS
RH129840  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21829,632,404 - 29,632,572 (+)MAPPERmRatBN7.2
Rnor_6.01830,953,941 - 30,954,108NCBIRnor6.0
Rnor_5.01830,648,099 - 30,648,266UniSTSRnor5.0
RGSC_v3.41830,713,933 - 30,714,100UniSTSRGSC3.4
Celera1829,279,250 - 29,279,417UniSTS
Cytogenetic Map18p11UniSTS
BF398325  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21829,579,114 - 29,579,264 (+)MAPPERmRatBN7.2
Rnor_6.01830,900,106 - 30,900,255NCBIRnor6.0
Rnor_5.01830,594,333 - 30,594,482UniSTSRnor5.0
RGSC_v3.41830,660,266 - 30,660,415UniSTSRGSC3.4
Celera1829,225,604 - 29,225,753UniSTS
RH 3.4 Map8610.9UniSTS
Cytogenetic Map18p11UniSTS
RH138098  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21829,586,544 - 29,586,696 (+)MAPPERmRatBN7.2
Rnor_6.01830,907,536 - 30,907,687NCBIRnor6.0
Rnor_5.01830,601,763 - 30,601,914UniSTSRnor5.0
RGSC_v3.41830,667,696 - 30,667,847UniSTSRGSC3.4
Celera1829,233,034 - 29,233,185UniSTS
RH 3.4 Map18426.4UniSTS
Cytogenetic Map18p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 12 67 155 87 86 55 66 55 6 314 165 9 135 72 91 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000027026   ⟹   ENSRNOP00000027026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1830,840,868 - 30,843,291 (+)Ensembl
RefSeq Acc Id: NM_001037137   ⟹   NP_001032214
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81829,770,940 - 29,919,095 (+)NCBI
mRatBN7.21829,519,705 - 29,667,865 (+)NCBI
Rnor_6.01830,840,700 - 30,971,113 (+)NCBI
Rnor_5.01830,534,927 - 30,662,065 (+)NCBI
RGSC_v3.41830,600,858 - 30,754,205 (+)RGD
Celera1829,166,201 - 29,311,954 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001032214 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT77598 (Get FASTA)   NCBI Sequence Viewer  
  EDL76375 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000103533.1
  ENSRNOP00000111317.1
RefSeq Acc Id: NP_001032214   ⟸   NM_001037137
- Peptide Label: precursor
- UniProtKB: I6LBX3 (UniProtKB/TrEMBL),   D3ZQX5 (UniProtKB/TrEMBL),   A0A9K3Y883 (UniProtKB/TrEMBL),   A6J393 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027026   ⟸   ENSRNOT00000027026
Protein Domains
Cadherin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQX5-F1-model_v2 AlphaFold D3ZQX5 1-808 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311949 AgrOrtholog
BioCyc Gene G2FUF-7807 BioCyc
Ensembl Genes ENSRNOG00000027299 Ensembl
  ENSRNOG00000063070 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000121581.1 UniProtKB/TrEMBL
  ENSRNOT00000136693.1 UniProtKB/TrEMBL
Gene3D-CATH Cadherins UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/TrEMBL
  Cadherin-like UniProtKB/TrEMBL
  Cadherin_C UniProtKB/TrEMBL
  Cadherin_CBD UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  Cadherin_N UniProtKB/TrEMBL
  Protocadherin/Cadherin-CA UniProtKB/TrEMBL
KEGG Report rno:291637 UniProtKB/TrEMBL
NCBI Gene 291637 ENTREZGENE
PANTHER CADHERIN-87A UniProtKB/TrEMBL
  PROTOCADHERIN GAMMA-A5 UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
  Cadherin_2 UniProtKB/TrEMBL
  Cadherin_C_2 UniProtKB/TrEMBL
  Cadherin_tail UniProtKB/TrEMBL
PhenoGen Pcdhga5 PhenoGen
PRINTS CADHERIN UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027299 RatGTEx
  ENSRNOG00000063070 RatGTEx
SMART SM00112 UniProtKB/TrEMBL
Superfamily-SCOP Cadherin UniProtKB/TrEMBL
UniProt A0A9K3Y883 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LFG0_RAT UniProtKB/TrEMBL
  A0ABK0M7M9_RAT UniProtKB/TrEMBL
  A6J393 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQX5 ENTREZGENE
  I6LBX3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Pcdhga5  protocadherin gamma subfamily A, 5  Pcdhga5_predicted  protocadherin gamma subfamily A, 5 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Pcdhga5_predicted  protocadherin gamma subfamily A, 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED