Fcgbpl1 (Fc fragment of IgG binding protein-like 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Fcgbpl1 (Fc fragment of IgG binding protein-like 1) Rattus norvegicus
Analyze
Symbol: Fcgbpl1
Name: Fc fragment of IgG binding protein-like 1
RGD ID: 1311906
Description: Predicted to be an extracellular matrix structural constituent. Predicted to be located in mucus layer. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human FCGBP (Fc gamma binding protein); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fc fragment of IgG binding protein-like; IgG Fc binding protein; LOC292746; RGD1311906; similar to Fc fragment of IgG binding protein
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,552,363 - 92,590,377 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl192,552,363 - 92,590,374 (+)EnsemblGRCr8
mRatBN7.2183,424,788 - 83,462,802 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,424,788 - 83,462,799 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx188,835,057 - 88,873,042 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,293,291 - 97,331,283 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,590,920 - 90,628,905 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,058,541 - 85,096,492 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,058,548 - 85,096,346 (+)Ensemblrn6Rnor6.0
Rnor_5.0186,274,837 - 86,312,788 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,226,922 - 83,264,936 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera177,824,833 - 77,862,724 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin. Chu Q, etal., Clin Experiment Ophthalmol. 2011 Mar;39(2):142-51. doi: 10.1111/j.1442-9071.2010.02437.x.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Fcgbpl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,552,363 - 92,590,377 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl192,552,363 - 92,590,374 (+)EnsemblGRCr8
mRatBN7.2183,424,788 - 83,462,802 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,424,788 - 83,462,799 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx188,835,057 - 88,873,042 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,293,291 - 97,331,283 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,590,920 - 90,628,905 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,058,541 - 85,096,492 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,058,548 - 85,096,346 (+)Ensemblrn6Rnor6.0
Rnor_5.0186,274,837 - 86,312,788 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,226,922 - 83,264,936 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera177,824,833 - 77,862,724 (+)NCBICelera
Cytogenetic Map1q21NCBI
Fcgbpl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,828,891 - 27,864,236 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,828,891 - 27,864,236 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38728,129,466 - 28,164,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,129,466 - 28,164,811 (+)Ensemblmm10GRCm38
MGSCv37728,914,485 - 28,949,830 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36727,838,226 - 27,852,398 (+)NCBIMGSCv36mm8
Celera722,690,689 - 22,726,036 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.54NCBI

Variants

.
Variants in Fcgbpl1
240 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:57
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000057120
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat

Markers in Region
AA955367  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,412,974 - 83,413,066 (+)MAPPERmRatBN7.2
mRatBN7.2183,462,694 - 83,462,786 (+)MAPPERmRatBN7.2
Rnor_6.0185,096,385 - 85,096,476NCBIRnor6.0
Rnor_6.0185,046,732 - 85,046,823NCBIRnor6.0
Rnor_5.0186,312,681 - 86,312,772UniSTSRnor5.0
Rnor_5.0186,263,028 - 86,263,119UniSTSRnor5.0
RGSC_v3.4183,215,160 - 83,215,251UniSTSRGSC3.4
RGSC_v3.4183,264,829 - 83,264,920UniSTSRGSC3.4
Celera177,862,617 - 77,862,708UniSTS
Celera177,813,024 - 77,813,115UniSTS
RH 3.4 Map1828.9UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 5 36 88 24 30 7 8 7 6 135 56 3 80 53 80 23 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000057120   ⟹   ENSRNOP00000053948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,552,363 - 92,590,374 (+)Ensembl
mRatBN7.2 Ensembl183,424,788 - 83,462,799 (+)Ensembl
Rnor_6.0 Ensembl185,058,548 - 85,096,346 (+)Ensembl
RefSeq Acc Id: NM_001164656   ⟹   NP_001158128
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,552,363 - 92,590,377 (+)NCBI
mRatBN7.2183,424,788 - 83,462,802 (+)NCBI
Rnor_6.0185,058,541 - 85,096,492 (+)NCBI
Rnor_5.0186,274,837 - 86,312,788 (+)NCBI
RGSC_v3.4183,226,922 - 83,264,936 (+)RGD
Celera177,824,833 - 77,862,724 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001158128 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99756 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000053948
  ENSRNOP00000053948.3
RefSeq Acc Id: NP_001158128   ⟸   NM_001164656
- Peptide Label: precursor
- UniProtKB: F7EZQ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053948   ⟸   ENSRNOT00000057120
Protein Domains
VWFD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7EZQ4-F1-model_v2 AlphaFold F7EZQ4 1-2537 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689862
Promoter ID:EPDNEW_R387
Type:single initiation site
Name:Fcgbpl1_1
Description:Fc fragment of IgG binding protein-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0185,058,531 - 85,058,591EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311906 AgrOrtholog
BioCyc Gene G2FUF-60263 BioCyc
Ensembl Genes ENSRNOG00000042899 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057120 ENTREZGENE
  ENSRNOT00000057120.5 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623759 IMAGE-MGC_LOAD
InterPro Conserved-cysteine-rich_domain UniProtKB/TrEMBL
  Fol_N UniProtKB/TrEMBL
  Mucin_vWF_Thrombospondin_sf UniProtKB/TrEMBL
  Prot_Inh_CR_TIL UniProtKB/TrEMBL
  Ser_inhib-like_sf UniProtKB/TrEMBL
  TILa_dom UniProtKB/TrEMBL
  von_Willebrand_fac_D UniProtKB/TrEMBL
  VWF_C UniProtKB/TrEMBL
KEGG Report rno:292746 UniProtKB/TrEMBL
MGC_CLONE MGC:124882 IMAGE-MGC_LOAD
NCBI Gene 292746 ENTREZGENE
PANTHER EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED UniProtKB/TrEMBL
  RIKEN CDNA 9530053A07 GENE UniProtKB/TrEMBL
Pfam PF08742 UniProtKB/TrEMBL
  TIL UniProtKB/TrEMBL
  TILa UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
PhenoGen Fcgbpl1 PhenoGen
PROSITE VWFD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042899 RatGTEx
SMART FOLN UniProtKB/TrEMBL
  SM00832 UniProtKB/TrEMBL
  VWC_out UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
Superfamily-SCOP Cysrich_TIL UniProtKB/TrEMBL
UniProt F7EZQ4 ENTREZGENE, UniProtKB/TrEMBL
  Q499U7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-23 Fcgbpl1  Fc fragment of IgG binding protein-like 1  RGD1311906  similar to Fc fragment of IgG binding protein; IgG Fc binding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1311906  similar to Fc fragment of IgG binding protein; IgG Fc binding protein  RGD1311906_predicted  similar to Fc fragment of IgG binding protein; IgG Fc binding protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1311906_predicted  similar to Fc fragment of IgG binding protein; IgG Fc binding protein (predicted)  LOC292746_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC292746_predicted  similar to Fc fragment of IgG binding protein; IgG Fc binding protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL