Derl1 (derlin 1) - Rat Genome Database

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Gene: Derl1 (derlin 1) Rattus norvegicus
Analyze
Symbol: Derl1
Name: derlin 1
RGD ID: 1311835
Description: Predicted to enable several functions, including enzyme binding activity; misfolded protein binding activity; and signal recognition particle binding activity. Predicted to be involved in several processes, including cellular response to topologically incorrect protein; proteasomal protein catabolic process; and protein destabilization. Predicted to act upstream of or within cellular response to unfolded protein and retrograde protein transport, ER to cytosol. Predicted to be located in endoplasmic reticulum and endosome. Predicted to be part of Derlin-1 retrotranslocation complex; Derlin-1-VIMP complex; and Hrd1p ubiquitin ligase ERAD-L complex. Orthologous to human DERL1 (derlin 1); PARTICIPATES IN amyotrophic lateral sclerosis pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-phenylbutyric acid; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Der1-like domain family, member 1; derlin-1; LOC362912; RGD1311835; similar to RIKEN cDNA 1110021N07
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8791,293,963 - 91,316,639 (-)NCBIGRCr8
mRatBN7.2789,404,413 - 89,427,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl789,404,417 - 89,427,145 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx791,281,684 - 91,304,360 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0793,482,962 - 93,505,640 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0793,300,942 - 93,323,649 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0797,737,176 - 97,759,852 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl797,737,178 - 97,759,852 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0798,344,206 - 98,366,882 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4794,573,472 - 94,596,148 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1794,607,703 - 94,630,378 (-)NCBI
Celera786,177,037 - 86,199,719 (-)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15215855   PMID:15215856   PMID:16186510   PMID:16449189   PMID:17000876   PMID:17872946   PMID:18555783   PMID:19509052   PMID:19946888   PMID:21186355   PMID:24019521   PMID:24089527  
PMID:25239945   PMID:25660456   PMID:26565908   PMID:26692333   PMID:31113930  


Genomics

Comparative Map Data
Derl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8791,293,963 - 91,316,639 (-)NCBIGRCr8
mRatBN7.2789,404,413 - 89,427,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl789,404,417 - 89,427,145 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx791,281,684 - 91,304,360 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0793,482,962 - 93,505,640 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0793,300,942 - 93,323,649 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0797,737,176 - 97,759,852 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl797,737,178 - 97,759,852 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0798,344,206 - 98,366,882 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4794,573,472 - 94,596,148 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1794,607,703 - 94,630,378 (-)NCBI
Celera786,177,037 - 86,199,719 (-)NCBICelera
Cytogenetic Map7q33NCBI
DERL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388123,013,170 - 123,042,302 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8123,013,170 - 123,042,302 (-)EnsemblGRCh38hg38GRCh38
GRCh378124,025,410 - 124,054,542 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368124,094,769 - 124,123,722 (-)NCBINCBI36Build 36hg18NCBI36
Build 348124,094,768 - 124,123,722NCBI
Celera8120,214,755 - 120,243,831 (-)NCBICelera
Cytogenetic Map8q24.13NCBI
HuRef8119,350,888 - 119,380,143 (-)NCBIHuRef
CHM1_18124,065,598 - 124,094,857 (-)NCBICHM1_1
T2T-CHM13v2.08124,144,308 - 124,173,436 (-)NCBIT2T-CHM13v2.0
Derl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391557,732,898 - 57,755,814 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1557,732,898 - 57,755,844 (-)EnsemblGRCm39 Ensembl
GRCm381557,869,502 - 57,892,418 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1557,869,502 - 57,892,448 (-)EnsemblGRCm38mm10GRCm38
MGSCv371557,701,057 - 57,723,973 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361557,699,585 - 57,722,501 (-)NCBIMGSCv36mm8
Celera1559,390,196 - 59,413,106 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1524.06NCBI
Derl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555401,917,655 - 1,944,214 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555401,918,230 - 1,944,186 (-)NCBIChiLan1.0ChiLan1.0
DERL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27140,442,462 - 140,471,451 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18115,955,191 - 115,985,741 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08119,707,397 - 119,736,502 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18122,463,063 - 122,492,137 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8122,463,063 - 122,492,137 (-)Ensemblpanpan1.1panPan2
DERL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11321,423,501 - 21,452,594 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1321,419,352 - 21,482,133 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1321,389,332 - 21,418,411 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01321,760,369 - 21,789,449 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1321,729,205 - 21,818,761 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11321,488,954 - 21,517,996 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01321,594,093 - 21,623,156 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01321,836,798 - 21,865,874 (-)NCBIUU_Cfam_GSD_1.0
Derl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530316,836,301 - 16,860,610 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647024,262,091 - 24,286,577 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647024,262,401 - 24,286,713 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DERL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl416,310,314 - 16,341,433 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1416,310,407 - 16,341,405 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2417,236,667 - 17,252,340 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DERL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18117,587,373 - 117,617,233 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8117,586,496 - 117,617,194 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603922,617,411 - 22,646,929 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Derl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473531,832,701 - 31,857,687 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473531,832,711 - 31,857,687 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Derl1
142 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:203
Count of miRNA genes:160
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000007484
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78022129993595843Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78022129994811326Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat

Markers in Region
RH132372  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2789,405,338 - 89,405,556 (+)MAPPERmRatBN7.2
Rnor_6.0797,738,100 - 97,738,317NCBIRnor6.0
Rnor_5.0798,345,130 - 98,345,347UniSTSRnor5.0
RGSC_v3.4794,574,396 - 94,574,613UniSTSRGSC3.4
Celera786,177,961 - 86,178,178UniSTS
RH 3.4 Map7608.7UniSTS
Cytogenetic Map7q32-q33UniSTS
RH138651  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2789,404,634 - 89,404,768 (+)MAPPERmRatBN7.2
Rnor_6.0797,737,396 - 97,737,529NCBIRnor6.0
Rnor_5.0798,344,426 - 98,344,559UniSTSRnor5.0
RGSC_v3.4794,573,692 - 94,573,825UniSTSRGSC3.4
Celera786,177,257 - 86,177,390UniSTS
Cytogenetic Map7q32-q33UniSTS
RH141575  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q32-q33UniSTS
UniSTS:237297  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.292,761,026 - 2,761,341 (-)MAPPERmRatBN7.2
mRatBN7.292,699,664 - 2,699,979 (-)MAPPERmRatBN7.2
mRatBN7.2789,405,624 - 89,405,943 (+)MAPPERmRatBN7.2
mRatBN7.292,953,602 - 2,953,917 (+)MAPPERmRatBN7.2
Rnor_6.0797,738,386 - 97,738,704NCBIRnor6.0
Rnor_6.098,773,985 - 8,774,299NCBIRnor6.0
Rnor_5.097,795,012 - 7,795,326UniSTSRnor5.0
Rnor_5.0798,345,416 - 98,345,734UniSTSRnor5.0
RGSC_v3.4794,574,682 - 94,575,000UniSTSRGSC3.4
Celera786,178,247 - 86,178,565UniSTS
Cytogenetic Map7q32-q33UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000007484   ⟹   ENSRNOP00000007484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl789,404,420 - 89,427,145 (-)Ensembl
Rnor_6.0 Ensembl797,737,178 - 97,759,852 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111683   ⟹   ENSRNOP00000079461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl789,404,417 - 89,426,829 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115125   ⟹   ENSRNOP00000094989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl789,404,659 - 89,427,139 (-)Ensembl
RefSeq Acc Id: NM_001014202   ⟹   NP_001014224
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8791,293,963 - 91,316,639 (-)NCBI
mRatBN7.2789,404,415 - 89,427,095 (-)NCBI
Rnor_6.0797,737,176 - 97,759,852 (-)NCBI
Rnor_5.0798,344,206 - 98,366,882 (-)NCBI
RGSC_v3.4794,573,472 - 94,596,148 (-)RGD
Celera786,177,037 - 86,199,719 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079517   ⟹   XP_038935445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8791,293,963 - 91,316,176 (-)NCBI
mRatBN7.2789,404,413 - 89,426,836 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001014224 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935445 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85877 (Get FASTA)   NCBI Sequence Viewer  
  EDM16237 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007484
  ENSRNOP00000007484.5
  ENSRNOP00000079461
  ENSRNOP00000079461.1
  ENSRNOP00000094989.1
RefSeq Acc Id: NP_001014224   ⟸   NM_001014202
- UniProtKB: Q5RKH9 (UniProtKB/TrEMBL),   F7FNS3 (UniProtKB/TrEMBL),   A0A9K3Y8E4 (UniProtKB/TrEMBL),   A0A8I6AIT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007484   ⟸   ENSRNOT00000007484
RefSeq Acc Id: XP_038935445   ⟸   XM_039079517
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZMS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079461   ⟸   ENSRNOT00000111683
RefSeq Acc Id: ENSRNOP00000094989   ⟸   ENSRNOT00000115125

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FNS3-F1-model_v2 AlphaFold F7FNS3 1-251 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695341
Promoter ID:EPDNEW_R5865
Type:initiation region
Name:Derl1_1
Description:derlin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0797,759,906 - 97,759,966EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311835 AgrOrtholog
BioCyc Gene G2FUF-33341 BioCyc
Ensembl Genes ENSRNOG00000005551 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007484 ENTREZGENE
  ENSRNOT00000007484.6 UniProtKB/TrEMBL
  ENSRNOT00000111683.1 UniProtKB/TrEMBL
  ENSRNOT00000115125.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7191715 IMAGE-MGC_LOAD
InterPro DER1 UniProtKB/TrEMBL
  Rhomboid-like_sf UniProtKB/TrEMBL
KEGG Report rno:362912 UniProtKB/TrEMBL
MGC_CLONE MGC:94650 IMAGE-MGC_LOAD
NCBI Gene 362912 ENTREZGENE
PANTHER DER1-LIKE PROTEIN, DERLIN UniProtKB/TrEMBL
  DERLIN-1 UniProtKB/TrEMBL
Pfam DER1 UniProtKB/TrEMBL
PhenoGen Derl1 PhenoGen
RatGTEx ENSRNOG00000005551 RatGTEx
Superfamily-SCOP SSF144091 UniProtKB/TrEMBL
UniProt A0A8I5ZMS4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIT0 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y8E4 ENTREZGENE, UniProtKB/TrEMBL
  F7FNS3 ENTREZGENE
  Q5RKH9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F7FNS3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-16 Derl1  derlin 1  Derl1  Der1-like domain family, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-27 Derl1  Der1-like domain family, member 1  RGD1311835  similar to RIKEN cDNA 1110021N07  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1311835  similar to RIKEN cDNA 1110021N07  RGD1311835_predicted  similar to RIKEN cDNA 1110021N07 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1311835_predicted  similar to RIKEN cDNA 1110021N07 (predicted)  LOC362912_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362912_predicted  similar to RIKEN cDNA 1110021N07 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL