Hhipl1 (HHIP-like 1) - Rat Genome Database

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Gene: Hhipl1 (HHIP-like 1) Rattus norvegicus
Analyze
Symbol: Hhipl1
Name: HHIP-like 1
RGD ID: 1311698
Description: Predicted to act upstream of or within several processes, including artery development; cell population proliferation; and smoothened signaling pathway. Predicted to be located in membrane. Predicted to be active in extracellular region. Orthologous to human HHIPL1 (HHIP like 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hedgehog interacting protein-like 1; HHIP-like protein 1; LOC362781; RGD1311698; similar to KIAA1822 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86132,984,028 - 133,008,248 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6132,984,032 - 133,006,947 (+)EnsemblGRCr8
mRatBN7.26127,219,616 - 127,243,839 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,220,014 - 127,242,564 (+)EnsemblmRatBN7.2
Rnor_6.06132,218,583 - 132,242,852 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,219,088 - 132,240,356 (+)Ensemblrn6Rnor6.0
Rnor_5.06141,388,894 - 141,413,125 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46132,677,314 - 132,698,582 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6124,778,556 - 124,800,026 (+)NCBICelera
RGSC_v3.16132,660,073 - 132,704,769 (+)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular region  (IEA,ISO)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Hhipl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86132,984,028 - 133,008,248 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6132,984,032 - 133,006,947 (+)EnsemblGRCr8
mRatBN7.26127,219,616 - 127,243,839 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,220,014 - 127,242,564 (+)EnsemblmRatBN7.2
Rnor_6.06132,218,583 - 132,242,852 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,219,088 - 132,240,356 (+)Ensemblrn6Rnor6.0
Rnor_5.06141,388,894 - 141,413,125 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46132,677,314 - 132,698,582 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6124,778,556 - 124,800,026 (+)NCBICelera
RGSC_v3.16132,660,073 - 132,704,769 (+)NCBI
Cytogenetic Map6q32NCBI
HHIPL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381499,604,538 - 99,680,569 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1499,645,129 - 99,680,569 (+)Ensemblhg38GRCh38
GRCh3714100,070,875 - 100,146,906 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,181,233 - 99,205,364 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1480,166,356 - 80,197,860 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1480,294,691 - 80,326,268 (+)NCBIHuRef
CHM1_114100,049,238 - 100,080,775 (+)NCBICHM1_1
T2T-CHM13v2.01493,835,981 - 93,912,020 (+)NCBIT2T-CHM13v2.0
Hhipl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,272,100 - 108,294,559 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,272,529 - 108,297,128 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812108,305,968 - 108,328,300 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,306,270 - 108,330,869 (+)Ensemblmm10GRCm38
MGSCv3712109,544,480 - 109,566,510 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612108,754,006 - 108,778,969 (+)NCBIMGSCv36mm8
MGSCv3612102,567,490 - 102,592,533 (+)NCBIMGSCv36mm8
Celera12109,547,979 - 109,569,932 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.37NCBI
Hhipl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543820,936,314 - 20,950,550 (+)Ensembl
ChiLan1.0NW_00495543820,936,314 - 20,951,466 (+)NCBIChiLan1.0ChiLan1.0
HHIPL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215100,760,410 - 100,838,421 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11499,976,878 - 100,048,091 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01480,229,854 - 80,304,418 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11499,549,560 - 99,614,970 (+)NCBIPanPan1.1PanPan1.1panPan2
HHIPL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1868,033,492 - 68,063,727 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha867,528,699 - 67,579,713 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0868,292,398 - 68,343,452 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1867,953,303 - 68,004,251 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0868,019,653 - 68,070,672 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0868,417,012 - 68,468,264 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hhipl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086406,636,356 - 6,662,789 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366043,419,694 - 3,446,118 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366043,426,361 - 3,446,103 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HHIPL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.17120,627,491 - 120,655,484 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27128,241,839 - 128,263,051 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HHIPL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12477,602,306 - 77,633,281 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2477,602,532 - 77,632,232 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605364,741,284 - 64,773,131 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hhipl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247344,271,206 - 4,289,040 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247344,260,655 - 4,289,040 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hhipl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17125,981,248 - 126,002,782 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hhipl1
1820 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:147
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000034883, ENSRNOT00000057165
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
RH139036  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map1824.1UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 53 59 6 316 152 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000034883   ⟹   ENSRNOP00000038254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6132,984,032 - 133,006,947 (+)Ensembl
mRatBN7.2 Ensembl6127,220,014 - 127,242,564 (+)Ensembl
Rnor_6.0 Ensembl6132,219,088 - 132,240,356 (+)Ensembl
RefSeq Acc Id: XM_039113374   ⟹   XP_038969302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86132,993,119 - 133,008,248 (+)NCBI
mRatBN7.26127,228,704 - 127,243,839 (+)NCBI
RefSeq Acc Id: XM_039113375   ⟹   XP_038969303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86132,990,479 - 133,008,248 (+)NCBI
mRatBN7.26127,226,828 - 127,243,839 (+)NCBI
RefSeq Acc Id: XM_063262802   ⟹   XP_063118872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86132,989,915 - 133,008,248 (+)NCBI
RefSeq Acc Id: XM_343107   ⟹   XP_343108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86132,984,028 - 133,008,248 (+)NCBI
mRatBN7.26127,219,616 - 127,243,839 (+)NCBI
Rnor_6.06132,218,583 - 132,242,852 (+)NCBI
Rnor_5.06141,388,894 - 141,413,125 (+)NCBI
RGSC_v3.46132,677,314 - 132,698,582 (+)RGD
Sequence:
RefSeq Acc Id: XP_343108   ⟸   XM_343107
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000038254   ⟸   ENSRNOT00000034883
RefSeq Acc Id: XP_038969303   ⟸   XM_039113375
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038969302   ⟸   XM_039113374
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063118872   ⟸   XM_063262802
- Peptide Label: isoform X3
Protein Domains
SRCR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A9N1-F1-model_v2 AlphaFold D4A9N1 1-791 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694829
Promoter ID:EPDNEW_R5343
Type:single initiation site
Name:Hhipl1_1
Description:HHIP-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06132,219,074 - 132,219,134EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311698 AgrOrtholog
BioCyc Gene G2FUF-36302 BioCyc
Ensembl Genes ENSRNOG00000028390 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034883 ENTREZGENE
  ENSRNOT00000034883.7 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  3.10.250.10 UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  Folate_rcpt_cons-reg UniProtKB/TrEMBL
  Glc/Sorbosone_DH UniProtKB/TrEMBL
  Quinoprot_gluc/sorb_DH UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/TrEMBL
  Srcr_rcpt UniProtKB/TrEMBL
NCBI Gene 362781 ENTREZGENE
PANTHER HEDGEHOG-INTERACTING PROTEIN UniProtKB/TrEMBL
  HHIP-LIKE PROTEIN 1 UniProtKB/TrEMBL
Pfam Folate_rec UniProtKB/TrEMBL
  GSDH UniProtKB/TrEMBL
  SRCR UniProtKB/TrEMBL
PhenoGen Hhipl1 PhenoGen
PRINTS SPERACTRCPTR UniProtKB/TrEMBL
PROSITE SRCR_1 UniProtKB/TrEMBL
  SRCR_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028390 RatGTEx
SMART SM00202 UniProtKB/TrEMBL
Superfamily-SCOP Quino_gluc_DH UniProtKB/TrEMBL
  Srcr_receptor UniProtKB/TrEMBL
UniProt A6KBF8 ENTREZGENE, UniProtKB/TrEMBL
  D4A9N1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-24 Hhipl1  HHIP-like 1  Hhipl1  hedgehog interacting protein-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-11 Hhipl1  hedgehog interacting protein-like 1  RGD1311698_predicted  similar to KIAA1822 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1311698_predicted  similar to KIAA1822 protein (predicted)  LOC362781_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362781_predicted  similar to KIAA1822 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL