Tcf7l1 (transcription factor 7 like 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Tcf7l1 (transcription factor 7 like 1) Rattus norvegicus
Analyze
Symbol: Tcf7l1
Name: transcription factor 7 like 1
RGD ID: 1311671
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Predicted to be involved in canonical Wnt signaling pathway and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including axial mesoderm morphogenesis; regulation of DNA-templated transcription; and somatic stem cell population maintenance. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of beta-catenin-TCF complex. Predicted to be active in chromatin. Orthologous to human TCF7L1 (transcription factor 7 like 1); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC312451; Tcf3; transcription factor 3; transcription factor 7-like 1; transcription factor 7-like 1 (T-cell specific, HMG-box)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,238,892 - 106,404,012 (-)NCBIGRCr8
mRatBN7.24104,680,734 - 104,846,086 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,680,739 - 104,845,287 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4110,059,625 - 110,224,156 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,834,747 - 105,999,257 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,448,498 - 104,613,031 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,492,796 - 100,660,401 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,491,798 - 100,660,140 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04165,263,179 - 165,427,206 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44106,128,203 - 106,149,229 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14106,372,784 - 106,393,874 (-)NCBI
Celera493,833,646 - 93,998,059 (-)NCBICelera
Cytogenetic Map4q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tcf7l1RatThyroid Neoplasms  ISOTCF7L1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23811263

1 to 20 of 95 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tcf7l1Rat1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of TCF7L1 mRNACTDPMID:27840820
Tcf7l1Rat17beta-estradiol decreases expressionISOTCF7L1 (Homo sapiens)6480464Estradiol results in decreased expression of TCF7L1 mRNACTDPMID:31614463
Tcf7l1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTcf7l1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TCF7L1 mRNACTDPMID:24058054
Tcf7l1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of TCF7L1 mRNACTDPMID:34747641
Tcf7l1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOTcf7l1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of TCF7L1 mRNACTDPMID:37172768
Tcf7l1Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISOTcf7l1 (Mus musculus)6480464tetrabromobisphenol A results in decreased expression of TCF7L1 mRNACTDPMID:25172293
Tcf7l1Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOTCF7L1 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of TCF7L1 mRNACTDPMID:28628672
Tcf7l1Rat4,4'-sulfonyldiphenol multiple interactionsISOTCF7L1 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of TCF7L1 mRNACTDPMID:28628672
Tcf7l1Rat4,4'-sulfonyldiphenol affects methylationISOTcf7l1 (Mus musculus)6480464bisphenol S affects the methylation of TCF7L1 geneCTDPMID:31683443
Tcf7l1Rat4,4'-sulfonyldiphenol increases methylationISOTCF7L1 (Homo sapiens)6480464bisphenol S results in increased methylation of TCF7L1 geneCTDPMID:31601247
Tcf7l1Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of TCF7L1 mRNACTDPMID:28959563
Tcf7l1Rataflatoxin B1 increases methylationISOTCF7L1 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of TCF7L1 intronCTDPMID:30157460
Tcf7l1RatAflatoxin B2 alpha decreases methylationISOTCF7L1 (Homo sapiens)6480464aflatoxin B2 results in decreased methylation of TCF7L1 intronCTDPMID:30157460
Tcf7l1Ratalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in increased expression of TCF7L1 mRNACTDPMID:35163327
Tcf7l1Ratantirheumatic drug increases expressionISOTCF7L1 (Homo sapiens)6480464Antirheumatic Agents results in increased expression of TCF7L1 mRNACTDPMID:24449571
Tcf7l1Ratarsane multiple interactionsISOTCF7L1 (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of TCF7L1 mRNACTDPMID:39836092
Tcf7l1Ratarsenic atom multiple interactionsISOTCF7L1 (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of TCF7L1 mRNACTDPMID:39836092
Tcf7l1Ratarsenite(3-) multiple interactionsISOTCF7L1 (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to TCF7L1 mRNA]CTDPMID:32406909
Tcf7l1Ratarsenous acid decreases expressionISOTCF7L1 (Homo sapiens)6480464Arsenic Trioxide results in decreased expression of TCF7L1 mRNACTDPMID:29633893
Tcf7l1Ratbenzo[a]pyrene decreases methylationISOTCF7L1 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of TCF7L1 promoterCTDPMID:27901495

1 to 20 of 95 rows

Biological Process
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tcf7l1Ratanterior/posterior axis specification, embryo acts_upstream_of_or_withinISOTcf7l1 (Mus musculus)1624291MGI:3044616 PMID:14668413RGDPMID:14668413
Tcf7l1Rataxial mesoderm morphogenesis acts_upstream_of_or_withinISOTcf7l1 (Mus musculus)1624291MGI:3044616 PMID:14668413RGDPMID:14668413
Tcf7l1Ratbiological_process  ND 159840701/07: no relevant rat dataRGD 
Tcf7l1Ratcanonical Wnt signaling pathway involved_inIBAFB:FBgn0085432 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tcf7l1Ratnegative regulation of DNA-templated transcription acts_upstream_of_or_withinISOTcf7l1 (Mus musculus)1624291 PMID:16894029RGDPMID:16894029
Tcf7l1Ratpositive regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOTcf7l1 (Mus musculus)1624291 PMID:15907834RGDPMID:15907834
Tcf7l1Ratregulation of somatic stem cell population maintenance acts_upstream_of_or_withinISOTcf7l1 (Mus musculus)1624291 PMID:18467660RGDPMID:18467660
Tcf7l1Ratregulation of stem cell population maintenance acts_upstream_of_or_withinISOTcf7l1 (Mus musculus)1624291 PMID:18347094RGDPMID:18347094
Tcf7l1Ratregulation of transcription by RNA polymerase II involved_inIBAFB:FBgn0085432 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tcf7l1Ratskin development acts_upstream_of_or_withinISOTcf7l1 (Mus musculus)1624291MGI:1202879 PMID:19718027RGDPMID:19718027
Tcf7l1Ratsomatic stem cell population maintenance acts_upstream_of_or_withinISOTcf7l1 (Mus musculus)1624291MGI:1202879 PMID:19718027RGDPMID:19718027
Tcf7l1Ratstem cell differentiation acts_upstream_of_or_withinISOTcf7l1 (Mus musculus)1624291MGI:3044616 PMID:16894029RGDPMID:16894029
Tcf7l1Rattissue development involved_inIEAARBA:ARBA000280651600115GO_REF:0000117UniProtGO_REF:0000117
Tcf7l1Rattranscription by RNA polymerase II acts_upstream_ofISOTcf7l1 (Mus musculus)1624291 PMID:15907834RGDPMID:15907834
Tcf7l1RatWnt signaling pathway involved_inIEAUniProtKB-KW:KW-08791600115GO_REF:0000043UniProtGO_REF:0000043
Tcf7l1RatWnt signaling pathway involved_inIEAInterPro:IPR0249401600115GO_REF:0000002InterProGO_REF:0000002
1 to 16 of 16 rows

Cellular Component
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tcf7l1Ratbeta-catenin-TCF complex part_ofIBAFB:FBgn0085432 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tcf7l1Ratchromatin is_active_inIBAMGI:98507 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tcf7l1Ratcytosol located_inIEAUniProtKB:Q9HCS4 and ensembl:ENSP000002821111600115GO_REF:0000107EnsemblGO_REF:0000107
Tcf7l1Ratcytosol located_inISOTCF7L1 (Homo sapiens)1624291 RGDGO_REF:0000052
Tcf7l1Ratnucleoplasm located_inIEAUniProtKB:Q9HCS4 and ensembl:ENSP000002821111600115GO_REF:0000107EnsemblGO_REF:0000107
Tcf7l1Ratnucleoplasm located_inISOTCF7L1 (Homo sapiens)1624291 RGDGO_REF:0000052
Tcf7l1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Tcf7l1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Tcf7l1Ratnucleus located_inIEAUniRule:UR0004008111600115GO_REF:0000104UniProtGO_REF:0000104
Tcf7l1Ratnucleus located_inISOTcf7l1 (Mus musculus)1624291 PMID:10498690 more ...RGDPMID:10498690 more ...
1 to 10 of 10 rows

Molecular Function
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tcf7l1Ratbeta-catenin binding enablesISOTcf7l1 (Mus musculus)1624291PR:Q02248 PMID:18202148 and PMID:9488439RGDPMID:18202148 and PMID:9488439
Tcf7l1Ratchromatin binding enablesISOTcf7l1 (Mus musculus)1624291 PMID:18202148 and PMID:18467660RGDPMID:18202148 and PMID:18467660
Tcf7l1RatDNA binding enablesISOTcf7l1 (Mus musculus)1624291 PMID:16894029RGDPMID:16894029
Tcf7l1RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Tcf7l1RatDNA binding enablesIEAUniRule:UR0004008111600115GO_REF:0000104UniProtGO_REF:0000104
Tcf7l1RatDNA-binding transcription factor activity enablesISOTcf7l1 (Mus musculus)1624291 PMID:16894029RGDPMID:16894029
Tcf7l1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0085432 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tcf7l1Ratprotein binding enablesISOTCF7L1 (Homo sapiens)1624291UniProtKB:Q15038 and PMID:19304756RGDPMID:19304756
Tcf7l1Ratprotein binding enablesISOTcf7l1 (Mus musculus)1624291PR:P19785 more ...RGDPMID:18202148
Tcf7l1RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIBAFB:FBgn0085432 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tcf7l1Ratsequence-specific double-stranded DNA binding enablesISOTCF7L1 (Homo sapiens)1624291 PMID:28473536RGDPMID:28473536
Tcf7l1Ratsequence-specific double-stranded DNA binding enablesIEAUniProtKB:Q9HCS4 and ensembl:ENSP000002821111600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 12 of 12 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tcf7l1RatWnt signaling, canonical pathway   ISOTcf7l1 (Mus musculus)2301908 RGD 

1 to 9 of 9 rows
#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Korinek V, etal., Mol Cell Biol. 1998 Mar;18(3):1248-56.
4. Tcf3: a transcriptional regulator of axis induction in the early embryo. Merrill BJ, etal., Development. 2004 Jan;131(2):263-74. Epub 2003 Dec 10.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. TCF transcription factors: molecular switches in carcinogenesis. Roose J and Clevers H, Biochim Biophys Acta. 1999 Oct 29;1424(2-3):M23-37.
1 to 9 of 9 rows
PMID:10498690   PMID:15907834   PMID:16055439   PMID:16894029   PMID:18202148   PMID:18347094   PMID:18467660   PMID:19272376   PMID:19718027   PMID:19828133  



Tcf7l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,238,892 - 106,404,012 (-)NCBIGRCr8
mRatBN7.24104,680,734 - 104,846,086 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,680,739 - 104,845,287 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4110,059,625 - 110,224,156 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,834,747 - 105,999,257 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,448,498 - 104,613,031 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,492,796 - 100,660,401 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,491,798 - 100,660,140 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04165,263,179 - 165,427,206 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44106,128,203 - 106,149,229 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14106,372,784 - 106,393,874 (-)NCBI
Celera493,833,646 - 93,998,059 (-)NCBICelera
Cytogenetic Map4q32NCBI
TCF7L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,133,392 - 85,310,387 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,133,392 - 85,310,387 (+)EnsemblGRCh38hg38GRCh38
GRCh37285,360,515 - 85,537,510 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,214,245 - 85,391,016 (+)NCBINCBI36Build 36hg18NCBI36
Build 34285,272,391 - 85,449,162NCBI
Celera285,189,038 - 85,365,500 (+)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,257,850 - 85,434,099 (+)NCBIHuRef
CHM1_1285,290,354 - 85,467,245 (+)NCBICHM1_1
T2T-CHM13v2.0285,135,301 - 85,312,378 (+)NCBIT2T-CHM13v2.0
Tcf7l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,603,354 - 72,766,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl672,603,361 - 72,766,237 (-)EnsemblGRCm39 Ensembl
GRCm38672,626,371 - 72,789,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,626,378 - 72,789,254 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,576,374 - 72,738,950 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36672,555,889 - 72,718,465 (-)NCBIMGSCv36mm8
Celera674,727,941 - 74,893,703 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.27NCBI
Tcf7l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554242,137,865 - 2,286,181 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554242,139,576 - 2,286,183 (-)NCBIChiLan1.0ChiLan1.0
TCF7L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21241,072,932 - 41,249,313 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A41,075,694 - 41,252,075 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A85,186,660 - 85,363,033 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A86,739,422 - 86,914,829 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A86,739,417 - 86,913,905 (+)Ensemblpanpan1.1panPan2
TCF7L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,699,958 - 39,859,167 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1739,699,958 - 39,858,182 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1739,371,581 - 39,530,084 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01740,509,531 - 40,668,072 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1740,509,321 - 40,668,674 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11739,576,919 - 39,735,480 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01739,648,692 - 39,807,230 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01740,048,459 - 40,208,222 (-)NCBIUU_Cfam_GSD_1.0
Tcf7l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629278,895,196 - 79,009,978 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367121,848,464 - 1,962,650 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367121,848,478 - 1,962,644 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCF7L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1359,438,152 - 59,458,988 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2362,435,512 - 62,533,066 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TCF7L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,849,585 - 22,028,147 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604590,408,016 - 90,615,179 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tcf7l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474917,803,772 - 17,829,805 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474917,804,630 - 17,956,504 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Tcf7l1
1017 total Variants

Predicted Target Of
Summary Value
Count of predictions:178
Count of miRNA genes:123
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000020005
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 53 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat

1 to 10 of 53 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000020005   ⟹   ENSRNOP00000020005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4104,680,739 - 104,845,287 (-)Ensembl
Rnor_6.0 Ensembl4100,491,798 - 100,660,140 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106765   ⟹   ENSRNOP00000081559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4104,680,739 - 104,845,287 (-)Ensembl
RefSeq Acc Id: NM_001107865   ⟹   NP_001101335
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84106,238,896 - 106,403,421 (-)NCBI
mRatBN7.24104,680,739 - 104,845,287 (-)NCBI
Rnor_6.04100,492,800 - 100,660,142 (-)NCBI
Rnor_5.04165,263,179 - 165,427,206 (-)NCBI
Celera493,833,646 - 93,998,059 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236674   ⟹   XP_006236736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84106,238,892 - 106,403,993 (-)NCBI
mRatBN7.24104,680,734 - 104,846,082 (-)NCBI
Rnor_6.04100,492,796 - 100,660,401 (-)NCBI
Rnor_5.04165,263,179 - 165,427,206 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107580   ⟹   XP_038963508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84106,238,892 - 106,404,012 (-)NCBI
mRatBN7.24104,680,734 - 104,846,086 (-)NCBI
RefSeq Acc Id: XM_039107582   ⟹   XP_038963510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84106,238,892 - 106,403,993 (-)NCBI
mRatBN7.24104,680,734 - 104,846,082 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_001101335 (Get FASTA)   NCBI Sequence Viewer  
  XP_006236736 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963508 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963510 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL91050 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020005
  ENSRNOP00000020005.7
  ENSRNOP00000081559
  ENSRNOP00000081559.1
1 to 9 of 9 rows
RefSeq Acc Id: NP_001101335   ⟸   NM_001107865
- UniProtKB: A6IAD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236736   ⟸   XM_006236674
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZT78 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020005   ⟸   ENSRNOT00000020005
RefSeq Acc Id: XP_038963508   ⟸   XM_039107580
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038963510   ⟸   XM_039107582
- Peptide Label: isoform X3
- UniProtKB: F1M1R9 (UniProtKB/TrEMBL)
HMG box

Name Modeler Protein Id AA Range Protein Structure
AF-F1M1R9-F1-model_v2 AlphaFold F1M1R9 1-587 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693133
Promoter ID:EPDNEW_R3658
Type:multiple initiation site
Name:Tcf7l1_1
Description:transcription factor 7 like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04100,660,239 - 100,660,299EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-44135 BioCyc
Ensembl Genes ENSRNOG00000014753 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020005 ENTREZGENE
  ENSRNOT00000020005.8 UniProtKB/TrEMBL
  ENSRNOT00000106765 ENTREZGENE
  ENSRNOT00000106765.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
  4.10.900.10 UniProtKB/TrEMBL
InterPro Catenin_binding_dom UniProtKB/TrEMBL
  CTNNB1-bd_N UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  HMG_superfamily UniProtKB/TrEMBL
  TCF/LEF UniProtKB/TrEMBL
KEGG Report rno:312451 UniProtKB/TrEMBL
NCBI Gene 312451 ENTREZGENE
PANTHER PTHR10373 UniProtKB/TrEMBL
  PTHR10373:SF25 UniProtKB/TrEMBL
Pfam CTNNB1_binding UniProtKB/TrEMBL
  HMG_box UniProtKB/TrEMBL
PhenoGen Tcf7l1 PhenoGen
PROSITE HMG_BOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014753 RatGTEx
SMART HMG UniProtKB/TrEMBL
Superfamily-SCOP HMG-box UniProtKB/TrEMBL
UniProt A0A8I5ZT78 ENTREZGENE, UniProtKB/TrEMBL
  A6IAD2 ENTREZGENE, UniProtKB/TrEMBL
  F1M1R9 ENTREZGENE, UniProtKB/TrEMBL
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Tcf7l1  transcription factor 7 like 1  Tcf7l1  transcription factor 7-like 1 (T-cell specific, HMG-box)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Tcf7l1  transcription factor 7-like 1 (T-cell specific, HMG-box)  LOC100361823  transcription factor 3  Data merged from RGD:2319352 1643240 APPROVED
2010-05-05 LOC100361823  transcription factor 3      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-12-16 Tcf7l1  transcription factor 7-like 1 (T-cell specific, HMG-box)  Tcf3  transcription factor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tcf3  transcription factor 3   Tcf3_predicted  transcription factor 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tcf3_predicted  transcription factor 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED