Ttbk2 (tau tubulin kinase 2) - Rat Genome Database

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Gene: Ttbk2 (tau tubulin kinase 2) Rattus norvegicus
Analyze
Symbol: Ttbk2
Name: tau tubulin kinase 2
RGD ID: 1311661
Description: Predicted to enable kinesin binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including hindbrain development; negative regulation of microtubule depolymerization; and negative regulation of protein localization to microtubule. Predicted to act upstream of or within several processes, including embryonic brain development; nervous system development; and positive regulation of non-motile cilium assembly. Predicted to be located in centriole; ciliary base; and cytosol. Predicted to be active in several cellular components, including ciliary basal body; ciliary transition zone; and nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 11. Orthologous to human TTBK2 (tau tubulin kinase 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC311349; tau tubulin kinase 1; tau-tubulin kinase 2; Ttbk1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83128,144,851 - 128,256,630 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3128,144,851 - 128,258,738 (-)EnsemblGRCr8
mRatBN7.23107,691,123 - 107,802,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3107,697,340 - 107,803,223 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3111,371,126 - 111,476,248 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03119,966,695 - 120,071,815 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03117,627,094 - 117,732,202 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03112,677,932 - 112,789,615 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3112,684,152 - 112,789,289 (-)Ensemblrn6Rnor6.0
Rnor_5.03119,221,653 - 119,333,065 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43107,517,280 - 107,623,425 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3106,601,980 - 106,707,371 (-)NCBICelera
RGSC_v3.13107,413,708 - 107,520,191 (-)NCBI
Cytogenetic Map3q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centriole  (IEA,ISO)
ciliary basal body  (IBA,IEA,ISO)
ciliary base  (IEA,ISO)
ciliary transition zone  (IBA,IEA,ISO)
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISO)
microtubule cytoskeleton  (IEA)
nucleus  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation. Watanabe T, etal., J Cell Biol. 2015 Aug 31;210(5):737-51. doi: 10.1083/jcb.201412075.
Additional References at PubMed
PMID:11257498   PMID:21548880   PMID:22664934   PMID:23141541   PMID:24469809  


Genomics

Comparative Map Data
Ttbk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83128,144,851 - 128,256,630 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3128,144,851 - 128,258,738 (-)EnsemblGRCr8
mRatBN7.23107,691,123 - 107,802,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3107,697,340 - 107,803,223 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3111,371,126 - 111,476,248 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03119,966,695 - 120,071,815 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03117,627,094 - 117,732,202 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03112,677,932 - 112,789,615 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3112,684,152 - 112,789,289 (-)Ensemblrn6Rnor6.0
Rnor_5.03119,221,653 - 119,333,065 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43107,517,280 - 107,623,425 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3106,601,980 - 106,707,371 (-)NCBICelera
RGSC_v3.13107,413,708 - 107,520,191 (-)NCBI
Cytogenetic Map3q35NCBI
TTBK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381542,738,730 - 42,921,000 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1542,738,730 - 42,920,850 (-)Ensemblhg38GRCh38
GRCh371543,030,928 - 43,212,976 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361540,823,828 - 41,000,299 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341540,825,024 - 41,000,204NCBI
Celera1519,804,468 - 19,983,827 (-)NCBICelera
Cytogenetic Map15q15.2NCBI
HuRef1519,885,126 - 20,061,358 (-)NCBIHuRef
CHM1_11543,154,908 - 43,331,376 (-)NCBICHM1_1
T2T-CHM13v2.01540,545,862 - 40,728,127 (-)NCBIT2T-CHM13v2.0
Ttbk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392120,563,297 - 120,681,111 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2120,563,297 - 120,681,085 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382120,732,816 - 120,850,584 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2120,732,816 - 120,850,604 (-)Ensemblmm10GRCm38
MGSCv372120,558,552 - 120,676,320 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362120,430,707 - 120,542,045 (-)NCBIMGSCv36mm8
Celera2121,886,115 - 121,989,494 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.37NCBI
Ttbk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554169,412,297 - 9,559,655 (-)Ensembl
ChiLan1.0NW_0049554169,412,297 - 9,518,561 (-)NCBIChiLan1.0ChiLan1.0
TTBK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21631,988,968 - 32,168,171 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11536,145,918 - 36,329,978 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01521,699,674 - 21,877,481 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11539,854,291 - 40,035,481 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1539,861,102 - 40,034,982 (-)EnsemblpanPan2panpan1.1
TTBK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1309,674,911 - 9,844,860 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl309,676,828 - 9,844,838 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha309,727,322 - 9,903,940 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0309,805,161 - 9,980,329 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl309,810,229 - 9,980,091 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1309,723,659 - 9,897,884 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0309,830,739 - 10,018,715 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0309,963,590 - 10,137,901 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ttbk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864088,154,791 - 88,260,615 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364716,009,091 - 6,154,529 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364716,003,294 - 6,108,677 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTBK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1128,489,744 - 128,635,511 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11128,489,676 - 128,640,094 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21143,333,492 - 143,478,045 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TTBK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12640,048,802 - 40,228,083 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2640,048,943 - 40,231,228 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048100,786,504 - 100,953,851 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ttbk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248049,848,512 - 10,002,693 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248049,841,401 - 10,002,592 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ttbk2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1598,868,337 - 98,974,331 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ttbk2
556 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:84
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000066181
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
AI326283  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23107,703,087 - 107,703,201 (+)MAPPERmRatBN7.2
Rnor_6.03112,689,900 - 112,690,013NCBIRnor6.0
Rnor_5.03119,233,621 - 119,233,734UniSTSRnor5.0
RGSC_v3.43107,523,029 - 107,523,142UniSTSRGSC3.4
Celera3106,607,728 - 106,607,841UniSTS
Cytogenetic Map3q35UniSTS
RH134184  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23107,702,923 - 107,703,127 (+)MAPPERmRatBN7.2
Rnor_6.03112,689,736 - 112,689,939NCBIRnor6.0
Rnor_5.03119,233,457 - 119,233,660UniSTSRnor5.0
RGSC_v3.43107,522,865 - 107,523,068UniSTSRGSC3.4
Celera3106,607,564 - 106,607,767UniSTS
RH 3.4 Map3940.8UniSTS
Cytogenetic Map3q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000066181   ⟹   ENSRNOP00000060585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3128,144,851 - 128,231,098 (-)Ensembl
mRatBN7.2 Ensembl3107,697,340 - 107,802,456 (-)Ensembl
Rnor_6.0 Ensembl3112,684,152 - 112,789,289 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090680   ⟹   ENSRNOP00000070846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3128,155,962 - 128,256,416 (-)Ensembl
mRatBN7.2 Ensembl3107,697,340 - 107,802,456 (-)Ensembl
Rnor_6.0 Ensembl3112,684,411 - 112,789,282 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107545   ⟹   ENSRNOP00000090935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3128,144,851 - 128,256,742 (-)Ensembl
mRatBN7.2 Ensembl3107,697,340 - 107,803,223 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000128561   ⟹   ENSRNOP00000108687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3128,144,851 - 128,256,416 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000133561   ⟹   ENSRNOP00000100128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3128,144,851 - 128,258,738 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167521   ⟹   ENSRNOP00000109873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3128,144,851 - 128,256,416 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000168510   ⟹   ENSRNOP00000108922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3128,144,851 - 128,230,219 (-)Ensembl
RefSeq Acc Id: NM_001415701   ⟹   NP_001402630
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,144,851 - 128,256,416 (-)NCBI
mRatBN7.23107,691,123 - 107,802,695 (-)NCBI
RefSeq Acc Id: XM_006234834   ⟹   XP_006234896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,144,851 - 128,256,041 (-)NCBI
mRatBN7.23107,691,123 - 107,802,323 (-)NCBI
Rnor_6.03112,677,932 - 112,789,171 (-)NCBI
Rnor_5.03119,221,653 - 119,333,065 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234835   ⟹   XP_006234897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,144,851 - 128,256,346 (-)NCBI
mRatBN7.23107,691,123 - 107,802,720 (-)NCBI
Rnor_6.03112,677,932 - 112,789,555 (-)NCBI
Rnor_5.03119,221,653 - 119,333,065 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234837   ⟹   XP_006234899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,144,851 - 128,256,630 (-)NCBI
mRatBN7.23107,691,123 - 107,802,911 (-)NCBI
Rnor_6.03112,677,932 - 112,789,615 (-)NCBI
Rnor_5.03119,221,653 - 119,333,065 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104949   ⟹   XP_038960877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,144,851 - 128,256,347 (-)NCBI
mRatBN7.23107,691,123 - 107,802,721 (-)NCBI
RefSeq Acc Id: XM_039104952   ⟹   XP_038960880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,158,347 - 128,256,630 (-)NCBI
mRatBN7.23107,704,631 - 107,802,909 (-)NCBI
RefSeq Acc Id: XP_006234899   ⟸   XM_006234837
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AER0 (UniProtKB/TrEMBL),   A6HPL4 (UniProtKB/TrEMBL),   D3ZN60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234897   ⟸   XM_006234835
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JYZ1 (UniProtKB/TrEMBL),   A6HPL4 (UniProtKB/TrEMBL),   D3ZN60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234896   ⟸   XM_006234834
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JYZ1 (UniProtKB/TrEMBL),   A6HPL4 (UniProtKB/TrEMBL),   D3ZN60 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070846   ⟸   ENSRNOT00000090680
Ensembl Acc Id: ENSRNOP00000060585   ⟸   ENSRNOT00000066181
RefSeq Acc Id: XP_038960877   ⟸   XM_039104949
- Peptide Label: isoform X3
- UniProtKB: A6HPL4 (UniProtKB/TrEMBL),   D3ZN60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960880   ⟸   XM_039104952
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000090935   ⟸   ENSRNOT00000107545
RefSeq Acc Id: NP_001402630   ⟸   NM_001415701
- UniProtKB: A6HPL4 (UniProtKB/TrEMBL),   D3ZN60 (UniProtKB/TrEMBL),   A0A0G2JYZ1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000109873   ⟸   ENSRNOT00000167521
Ensembl Acc Id: ENSRNOP00000108687   ⟸   ENSRNOT00000128561
Ensembl Acc Id: ENSRNOP00000108922   ⟸   ENSRNOT00000168510
Ensembl Acc Id: ENSRNOP00000100128   ⟸   ENSRNOT00000133561
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JYZ1-F1-model_v2 AlphaFold A0A0G2JYZ1 1-1242 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311661 AgrOrtholog
BioCyc Gene G2FUF-48156 BioCyc
Ensembl Genes ENSRNOG00000011059 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066181.4 UniProtKB/TrEMBL
  ENSRNOT00000090680.3 UniProtKB/TrEMBL
  ENSRNOT00000107545 ENTREZGENE
  ENSRNOT00000107545.2 UniProtKB/TrEMBL
  ENSRNOT00000128561 ENTREZGENE
  ENSRNOT00000128561.1 UniProtKB/TrEMBL
  ENSRNOT00000133561.1 UniProtKB/TrEMBL
  ENSRNOT00000167521.1 UniProtKB/TrEMBL
  ENSRNOT00000168510 ENTREZGENE
  ENSRNOT00000168510.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CK1_Ser-Thr_kinase UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  TTBK2_STKc UniProtKB/TrEMBL
NCBI Gene 311349 ENTREZGENE
PANTHER CASEIN KINASE-RELATED UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Ttbk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011059 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2JYZ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AER0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LAC1_RAT UniProtKB/TrEMBL
  A0ABK0LDW6_RAT UniProtKB/TrEMBL
  A0ABK0LWM8_RAT UniProtKB/TrEMBL
  A0ABK0M2A2_RAT UniProtKB/TrEMBL
  A6HPL4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZN60 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Ttbk2  tau tubulin kinase 2  Ttbk1_predicted  tau tubulin kinase 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Ttbk1_predicted  tau tubulin kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED