Message Center
{{ messageCount }} Messages
Watched Genes
{{$index + 1}}. {{ watchedObject.symbol }} (RGD ID:{{watchedObject.rgdId}})
Watched Ontology Terms
{{$index + 1}}. {{ watchedTerm.term }} ({{watchedTerm.accId}})
{{gene.symbol}}: {{ gene.description }}
You must be logged in to use this feature
{{ loginError }}
Select categories you would like to watch. Updates to this gene will be sent to {{ username }}
x
Send Message
Gene: Sap130 (Sin3A associated protein 130) Rattus norvegicus
Analyze
Symbol:
Sap130
Name:
Sin3A associated protein 130
RGD ID:
1311657
Description:
Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within embryonic placenta development. Predicted to be located in nucleus. Predicted to be part of Sin3-type complex. Orthologous to human SAP130 (Sin3A associated protein 130); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type:
protein-coding
RefSeq Status:
INFERRED
Previously known as:
histone deacetylase complex subunit SAP130; LOC307527; RGD1311657; similar to hypothetical protein 2610304F09; Sin3A associated protein
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 18 23,518,773 - 23,619,840 (+) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 18 23,518,680 - 23,619,840 (+) Ensembl GRCr8 mRatBN7.2 18 23,244,337 - 23,345,368 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 18 23,267,256 - 23,345,359 (+) Ensembl mRatBN7.2 Rnor_6.0 18 24,397,523 - 24,497,831 (+) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 18 24,397,369 - 24,497,832 (+) Ensembl rn6 Rnor6.0 Rnor_5.0 18 24,114,972 - 24,215,235 (+) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 18 24,053,607 - 24,132,624 (+) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 18 22,998,465 - 23,098,152 (+) NCBI Celera RGSC_v3.1 18 24,055,529 - 24,158,546 (+) NCBI Cytogenetic Map 18 p12 NCBI
JBrowse:
Imported Disease Annotations - CTD
Imported Disease Annotations - MGI
Only show annotations with direct experimental evidence (0 objects hidden)
Sap130 Rat 1,2-dimethylhydrazine decreases expression ISO Sap130 (Mus musculus) 6480464 1,2-Dimethylhydrazine results in decreased expression of SAP130 mRNA CTD PMID:22206623 Sap130 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Sap130 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of SAP130 mRNA CTD PMID:21570461 Sap130 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SAP130 mRNA CTD PMID:33387578 Sap130 Rat 2-methylcholine affects expression ISO SAP130 (Homo sapiens) 6480464 beta-methylcholine affects the expression of SAP130 mRNA CTD PMID:21179406 Sap130 Rat 4,4'-sulfonyldiphenol decreases expression ISO Sap130 (Mus musculus) 6480464 bisphenol S results in decreased expression of SAP130 mRNA CTD PMID:39298647 Sap130 Rat aflatoxin B1 decreases methylation ISO SAP130 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of SAP130 3' UTR CTD PMID:30157460 Sap130 Rat Aflatoxin B2 alpha decreases methylation ISO SAP130 (Homo sapiens) 6480464 aflatoxin B2 results in decreased methylation of SAP130 intron CTD PMID:30157460 Sap130 Rat amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of SAP130 mRNA CTD PMID:30779732 Sap130 Rat aristolochic acid A decreases expression ISO SAP130 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of SAP130 mRNA CTD PMID:33212167 Sap130 Rat arsane multiple interactions ISO SAP130 (Homo sapiens) 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SAP130 more ... CTD PMID:39836092 Sap130 Rat arsenic atom multiple interactions ISO SAP130 (Homo sapiens) 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SAP130 more ... CTD PMID:39836092 Sap130 Rat benzo[a]pyrene increases expression ISO Sap130 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of SAP130 mRNA CTD PMID:22228805 Sap130 Rat benzo[a]pyrene decreases methylation ISO SAP130 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of SAP130 promoter CTD PMID:27901495 Sap130 Rat benzo[a]pyrene affects methylation ISO SAP130 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of SAP130 intron CTD PMID:30157460 Sap130 Rat benzo[e]pyrene decreases methylation ISO SAP130 (Homo sapiens) 6480464 benzo(e)pyrene results in decreased methylation of SAP130 3' UTR CTD PMID:30157460 Sap130 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SAP130 mRNA CTD PMID:25181051 Sap130 Rat bisphenol A decreases expression ISO Sap130 (Mus musculus) 6480464 bisphenol A results in decreased expression of SAP130 mRNA CTD PMID:33221593 Sap130 Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of SAP130 mRNA CTD PMID:30816183 Sap130 Rat cadmium atom multiple interactions ISO SAP130 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SAP130 more ... CTD PMID:35301059 Sap130 Rat cadmium atom multiple interactions ISO Sap130 (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SAP130 more ... CTD PMID:37236586 Sap130 Rat cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of SAP130 mRNA CTD PMID:33453195 Sap130 Rat cadmium dichloride multiple interactions ISO Sap130 (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SAP130 more ... CTD PMID:37236586 Sap130 Rat cadmium dichloride multiple interactions ISO SAP130 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SAP130 more ... CTD PMID:35301059 Sap130 Rat caffeine increases phosphorylation ISO SAP130 (Homo sapiens) 6480464 Caffeine results in increased phosphorylation of SAP130 protein CTD PMID:35688186 Sap130 Rat carbamazepine affects expression ISO SAP130 (Homo sapiens) 6480464 Carbamazepine affects the expression of SAP130 mRNA CTD PMID:25979313 Sap130 Rat CGP 52608 multiple interactions ISO SAP130 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to SAP130 gene] CTD PMID:28238834 Sap130 Rat cobalt dichloride increases expression ISO SAP130 (Homo sapiens) 6480464 cobaltous chloride results in increased expression of SAP130 mRNA CTD PMID:19320972 Sap130 Rat cyclosporin A increases expression ISO SAP130 (Homo sapiens) 6480464 Cyclosporine results in increased expression of SAP130 mRNA CTD PMID:25562108 Sap130 Rat Dibutyl phosphate affects expression ISO SAP130 (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of SAP130 mRNA CTD PMID:37042841 Sap130 Rat dicrotophos increases expression ISO SAP130 (Homo sapiens) 6480464 dicrotophos results in increased expression of SAP130 mRNA CTD PMID:28302478 Sap130 Rat enzyme inhibitor multiple interactions ISO SAP130 (Homo sapiens) 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ... CTD PMID:23301498 Sap130 Rat ethanol affects expression ISO Sap130 (Mus musculus) 6480464 Ethanol affects the expression of SAP130 mRNA CTD PMID:30319688 Sap130 Rat ethanol affects splicing ISO Sap130 (Mus musculus) 6480464 Ethanol affects the splicing of SAP130 mRNA CTD PMID:30319688 Sap130 Rat fenthion decreases expression ISO Sap130 (Mus musculus) 6480464 Fenthion results in decreased expression of SAP130 mRNA CTD PMID:34813904 Sap130 Rat FR900359 affects phosphorylation ISO SAP130 (Homo sapiens) 6480464 FR900359 affects the phosphorylation of SAP130 protein CTD PMID:37730182 Sap130 Rat ivermectin decreases expression ISO SAP130 (Homo sapiens) 6480464 Ivermectin results in decreased expression of SAP130 protein CTD PMID:32959892 Sap130 Rat methapyrilene decreases methylation ISO SAP130 (Homo sapiens) 6480464 Methapyrilene results in decreased methylation of SAP130 3' UTR CTD PMID:30157460 Sap130 Rat methidathion decreases expression ISO Sap130 (Mus musculus) 6480464 methidathion results in decreased expression of SAP130 mRNA CTD PMID:34813904 Sap130 Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of SAP130 gene CTD PMID:35440735 Sap130 Rat N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in decreased methylation of SAP130 gene; [Permethrin co-treated with DEET] more ... CTD PMID:33148267 Sap130 Rat nitrates multiple interactions ISO Sap130 (Mus musculus) 6480464 [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of SAP130 more ... CTD PMID:35964746 Sap130 Rat okadaic acid increases expression ISO SAP130 (Homo sapiens) 6480464 Okadaic Acid results in increased expression of SAP130 mRNA CTD PMID:38832940 Sap130 Rat paracetamol increases expression ISO SAP130 (Homo sapiens) 6480464 Acetaminophen results in increased expression of SAP130 mRNA CTD PMID:22230336 Sap130 Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of SAP130 mRNA CTD PMID:33387578 Sap130 Rat permethrin multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in decreased methylation of SAP130 gene; [Permethrin co-treated with DEET] more ... CTD PMID:33148267 Sap130 Rat pirinixic acid increases expression ISO Sap130 (Mus musculus) 6480464 pirinixic acid results in increased expression of SAP130 mRNA CTD PMID:23811191 Sap130 Rat potassium dichromate decreases expression ISO Sap130 (Mus musculus) 6480464 Potassium Dichromate results in decreased expression of SAP130 mRNA CTD PMID:23608068 Sap130 Rat sodium arsenite increases expression ISO SAP130 (Homo sapiens) 6480464 sodium arsenite results in increased expression of SAP130 mRNA CTD PMID:38568856 Sap130 Rat sodium arsenite multiple interactions ISO SAP130 (Homo sapiens) 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SAP130 more ... CTD PMID:39836092 Sap130 Rat titanium dioxide decreases methylation ISO Sap130 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of SAP130 gene CTD PMID:35295148 Sap130 Rat trichostatin A affects expression ISO SAP130 (Homo sapiens) 6480464 trichostatin A affects the expression of SAP130 mRNA CTD PMID:28542535 Sap130 Rat triphenyl phosphate affects expression ISO SAP130 (Homo sapiens) 6480464 triphenyl phosphate affects the expression of SAP130 mRNA CTD PMID:37042841 Sap130 Rat tungsten decreases expression ISO Sap130 (Mus musculus) 6480464 Tungsten results in decreased expression of SAP130 mRNA CTD PMID:30912803 Sap130 Rat urethane increases expression ISO SAP130 (Homo sapiens) 6480464 Urethane results in increased expression of SAP130 mRNA CTD PMID:28818685
QTLs in Region (GRCr8)
2301410 Bp317 Blood pressure QTL 317 0.004 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 12219237 26822399 Rat 2301409 Cm70 Cardiac mass QTL 70 0.001 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 18 7065728 52065728 Rat 1358358 Sradr6 Stress Responsive Adrenal Weight QTL 6 2.49 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) 18 22015562 61600538 Rat 1331735 Rf44 Renal function QTL 44 2.981 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 18 15642280 31610627 Rat 61382 Bp46 Blood pressure QTL 46 18.8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 18 12216684 31644508 Rat 12904716 Am21 Aortic mass QTL 21 0.005 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) 18 7065728 52065728 Rat 1331741 Bp232 Blood pressure QTL 232 3.59112 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 18 23494057 85487725 Rat 8552968 Pigfal19 Plasma insulin-like growth factor 1 level QTL 19 11.4 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 18 1 26032889 Rat 12904714 Cm131 Cardiac mass QTL 131 0.002 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 18 7065728 52065728 Rat 12904715 Cm132 Cardiac mass QTL 132 0.001 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) 18 7065728 52065728 Rat 1331781 Scl28 Serum cholesterol level QTL 28 3.995 blood HDL cholesterol amount (VT:0000184) serum high density lipoprotein cholesterol level (CMO:0000361) 18 1 25071266 Rat 6903345 Bp349 Blood pressure QTL 349 3.9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 3917226 48917226 Rat 2313082 Bss85 Bone structure and strength QTL 85 0.8 0.0001 long bone metaphysis morphology trait (VT:0000133) tibia midshaft total cross-sectional area (CMO:0001715) 18 15226101 42690662 Rat 6903347 Bp350 Blood pressure QTL 350 4.4 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 1 31610627 Rat 2312568 Glom21 Glomerulus QTL 21 2 0.005 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) 18 5460455 42690191 Rat 6903349 Bp351 Blood pressure QTL 351 3.5 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 3917226 48917226 Rat 6903351 Bp352 Blood pressure QTL 352 3.3 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 3917226 48917226 Rat 1331766 Bp236 Blood pressure QTL 236 3.022 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 1 31610627 Rat 631264 Scl22 Serum cholesterol level QTL 22 6.2 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 18 12216684 31644508 Rat 1331775 Bp235 Blood pressure QTL 235 3.201 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 15642280 31610627 Rat 2325839 Bp348 Blood pressure QTL 348 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 1 44930869 Rat 12904680 Bw189 Body weight QTL 189 0.019 body mass (VT:0001259) body weight (CMO:0000012) 18 12219237 26822399 Rat 1600373 Mamtr6 Mammary tumor resistance QTL 6 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 18 19553532 85493247 Rat 2293708 Bss46 Bone structure and strength QTL 46 8.8 0.0001 lumbar vertebra morphology trait (VT:0010494) lumbar vertebra cortical cross-sectional area (CMO:0001690) 18 12066482 57066482 Rat 1641910 Colcr3 Colorectal carcinoma resistance QTL 3 5.02 0.000007 intestine integrity trait (VT:0010554) poorly differentiated malignant colorectal tumor number (CMO:0002076) 18 1 25022372 Rat 12904693 Am20 Aortic mass QTL 20 0.001 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) 18 12219237 26822399 Rat 1578667 Bss21 Bone structure and strength QTL 21 3.5 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) 18 12066482 85493247 Rat 12904695 Kidm73 Kidney mass QTL 73 0.001 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 18 12219237 26822399 Rat 2312598 Bp340 Blood pressure QTL 340 0.05 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 18 3811902 30809809 Rat 12904689 Cm128 Cardiac mass QTL 128 0.001 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) 18 12219237 26822399 Rat 12904690 Cm129 Cardiac mass QTL 129 0.001 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 18 12219237 26822399 Rat 2300180 Bmd67 Bone mineral density QTL 67 4.8 0.0001 femur mineral mass (VT:0010011) bone mineral density (CMO:0001226) 18 1 34566578 Rat 12904691 Cm130 Cardiac mass QTL 130 0.001 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) 18 12219237 26822399 Rat 9590248 Scort10 Serum corticosterone level QTL 10 19.71 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 18 1 26032889 Rat 2299160 Iddm35 Insulin dependent diabetes mellitus QTL 35 2.79 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) 18 4482648 49482648 Rat 1331753 Bp231 Blood pressure QTL 231 3.643 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 18 1 54490981 Rat 1578661 Bss20 Bone structure and strength QTL 20 3.7 femur morphology trait (VT:0000559) femoral neck cross-sectional area (CMO:0001697) 18 12066482 85493247 Rat 11565454 Kidm59 Kidney mass QTL 59 0.001 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 18 7065728 52065728 Rat 1331754 Bp230 Blood pressure QTL 230 4.61609 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 15642280 86134022 Rat 2293661 Bss50 Bone structure and strength QTL 50 4.64 0.0003 lumbar vertebra size trait (VT:0010518) lumbar vertebra trabecular cross-sectional area (CMO:0001692) 18 1 34566578 Rat 61375 Bp41 Blood pressure QTL 41 2.4 blood pressure trait (VT:0000183) systolic blood pressure (CMO:0000004) 18 4307354 49307354 Rat