Hsph1 (heat shock protein family H (Hsp110) member 1) - Rat Genome Database

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Gene: Hsph1 (heat shock protein family H (Hsp110) member 1) Rattus norvegicus
Analyze
Symbol: Hsph1
Name: heat shock protein family H (Hsp110) member 1
RGD ID: 1311609
Description: Predicted to enable adenyl-nucleotide exchange factor activity and alpha-tubulin binding activity. Predicted to be involved in protein folding. Predicted to act upstream of or within chaperone cofactor-dependent protein refolding. Predicted to be located in cytoplasm; microtubule; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleus. Orthologous to human HSPH1 (heat shock protein family H (Hsp110) member 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: heat shock 105/110 protein 1; heat shock 105kDa; heat shock 105kDa/110kDa protein 1; heat shock 110 kDa protein; heat shock protein 105; heat shock protein 105 kDa; Hsp105; LOC288444
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,427,368 - 10,446,602 (+)NCBIGRCr8
mRatBN7.2125,390,916 - 5,410,224 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl125,390,922 - 5,410,224 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx126,069,228 - 6,088,216 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,692,653 - 6,711,641 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0125,720,173 - 5,739,161 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0126,322,685 - 6,341,898 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl126,322,668 - 6,341,902 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0128,423,546 - 8,442,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4125,794,645 - 5,811,453 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1125,794,644 - 5,811,451 (+)NCBI
Celera127,162,640 - 7,181,902 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(E)-cinnamyl alcohol  (ISO)
(S)-amphetamine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
albendazole  (ISO)
all-trans-retinoic acid  (EXP)
amitrole  (EXP)
amphibole asbestos  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
atrazine  (ISO)
Aurin  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
cefaloridine  (EXP)
celastrol  (ISO)
chlordecone  (ISO)
chloroethene  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cinnamyl alcohol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elesclomol  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
eugenol  (ISO)
fenofibrate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (ISO)
gedunin  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glyoxal  (ISO)
haloperidol  (ISO)
hemin  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin  (ISO)
inulin  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
isoeugenol  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
Licochalcone B  (ISO)
linalool  (EXP)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
metacetamol  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
motexafin gadolinium  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (EXP,ISO)
nimesulide  (EXP)
organoselenium compound  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
prostaglandin A1  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
ritonavir  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trans-isoeugenol  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tungsten  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,ISO)
microtubule  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA)
protein-containing complex  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9931472   PMID:12477932   PMID:12749852   PMID:14644449   PMID:15489334   PMID:16396499   PMID:16857185   PMID:17643418   PMID:18681888   PMID:19028714   PMID:19284651   PMID:19754877  
PMID:20458337   PMID:21231916   PMID:22871113   PMID:23349634   PMID:24318877   PMID:30053369   PMID:32360748  


Genomics

Comparative Map Data
Hsph1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,427,368 - 10,446,602 (+)NCBIGRCr8
mRatBN7.2125,390,916 - 5,410,224 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl125,390,922 - 5,410,224 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx126,069,228 - 6,088,216 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,692,653 - 6,711,641 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0125,720,173 - 5,739,161 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0126,322,685 - 6,341,898 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl126,322,668 - 6,341,902 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0128,423,546 - 8,442,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4125,794,645 - 5,811,453 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1125,794,644 - 5,811,451 (+)NCBI
Celera127,162,640 - 7,181,902 (+)NCBICelera
Cytogenetic Map12p11NCBI
HSPH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381331,134,973 - 31,162,388 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1331,134,973 - 31,162,388 (-)EnsemblGRCh38hg38GRCh38
GRCh371331,709,110 - 31,736,525 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361330,608,762 - 30,634,117 (-)NCBINCBI36Build 36hg18NCBI36
Build 341330,608,764 - 30,634,117NCBI
Celera1312,778,480 - 12,803,835 (-)NCBICelera
Cytogenetic Map13q12.3NCBI
HuRef1312,522,150 - 12,547,508 (-)NCBIHuRef
CHM1_11331,678,336 - 31,703,689 (-)NCBICHM1_1
T2T-CHM13v2.01330,358,018 - 30,385,432 (-)NCBIT2T-CHM13v2.0
Hsph1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395149,540,308 - 149,562,594 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5149,537,752 - 149,559,841 (-)EnsemblGRCm39 Ensembl
GRCm385149,616,843 - 149,636,498 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5149,614,287 - 149,636,376 (-)EnsemblGRCm38mm10GRCm38
MGSCv375150,419,420 - 150,438,890 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365149,885,224 - 149,904,597 (-)NCBIMGSCv36mm8
Celera5147,617,650 - 147,637,130 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.18NCBI
Hsph1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543114,680,498 - 14,706,182 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543114,680,364 - 14,706,182 (+)NCBIChiLan1.0ChiLan1.0
HSPH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21430,719,315 - 30,747,378 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11321,826,106 - 21,854,186 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01312,412,826 - 12,438,563 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11330,845,938 - 30,871,455 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1330,846,631 - 30,871,161 (-)Ensemblpanpan1.1panPan2
HSPH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1258,972,942 - 8,998,404 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl258,972,724 - 8,997,893 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha259,015,922 - 9,040,982 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,077,842 - 9,102,910 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,077,554 - 9,102,903 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1258,977,129 - 9,002,182 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,985,129 - 9,010,177 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,027,003 - 9,052,061 (+)NCBIUU_Cfam_GSD_1.0
Hsph1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945170,073,174 - 170,096,453 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647225,855,694 - 25,879,062 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647225,855,873 - 25,879,062 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl117,733,878 - 7,759,576 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1117,733,874 - 7,759,528 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,585,525 - 7,587,259 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2117,637,260 - 7,661,067 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSPH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.139,999,471 - 10,026,106 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl310,000,109 - 10,026,449 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605734,342,051 - 34,369,001 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsph1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247766,988,576 - 7,015,846 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247766,988,591 - 7,013,621 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hsph1
113 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:93
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000001201
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12390696910373166Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat

Markers in Region
RH129540  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2125,404,469 - 5,404,655 (-)MAPPERmRatBN7.2
Rnor_6.0126,328,232 - 6,328,417NCBIRnor6.0
Rnor_5.0128,429,093 - 8,429,278UniSTSRnor5.0
RGSC_v3.4125,805,613 - 5,805,798UniSTSRGSC3.4
Celera127,176,148 - 7,176,333UniSTS
RH 3.4 Map1240.36UniSTS
Cytogenetic Map12p11UniSTS
AI600071  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2125,409,995 - 5,410,129 (-)MAPPERmRatBN7.2
Rnor_6.0126,322,780 - 6,322,913NCBIRnor6.0
Rnor_5.0128,423,641 - 8,423,774UniSTSRnor5.0
RGSC_v3.4125,811,225 - 5,811,358UniSTSRGSC3.4
Celera127,181,674 - 7,181,807UniSTS
RH 3.4 Map1258.1UniSTS
Cytogenetic Map12p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000001201   ⟹   ENSRNOP00000001201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl125,390,922 - 5,410,224 (+)Ensembl
Rnor_6.0 Ensembl126,322,668 - 6,341,902 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104544   ⟹   ENSRNOP00000095841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl125,390,922 - 5,410,224 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116960   ⟹   ENSRNOP00000082622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl125,390,922 - 5,410,224 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119657   ⟹   ENSRNOP00000089171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl125,391,809 - 5,410,224 (+)Ensembl
RefSeq Acc Id: NM_001011901   ⟹   NP_001011901
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81210,427,368 - 10,446,602 (+)NCBI
mRatBN7.2125,390,990 - 5,410,224 (+)NCBI
Rnor_6.0126,322,685 - 6,341,898 (-)NCBI
Rnor_5.0128,423,546 - 8,442,481 (-)NCBI
RGSC_v3.4125,794,645 - 5,811,453 (+)RGD
Celera127,162,640 - 7,181,902 (+)RGD
Sequence:
RefSeq Acc Id: XM_039089153   ⟹   XP_038945081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81210,427,443 - 10,446,602 (+)NCBI
mRatBN7.2125,390,916 - 5,410,224 (+)NCBI
RefSeq Acc Id: XM_063271115   ⟹   XP_063127185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81210,429,777 - 10,446,602 (+)NCBI
RefSeq Acc Id: NP_001011901   ⟸   NM_001011901
- UniProtKB: Q66HA8 (UniProtKB/Swiss-Prot),   A6K161 (UniProtKB/TrEMBL),   A0A8I6GLC4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001201   ⟸   ENSRNOT00000001201
RefSeq Acc Id: XP_038945081   ⟸   XM_039089153
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZXF4 (UniProtKB/TrEMBL),   A0A8I6GLC4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082622   ⟸   ENSRNOT00000116960
Ensembl Acc Id: ENSRNOP00000089171   ⟸   ENSRNOT00000119657
Ensembl Acc Id: ENSRNOP00000095841   ⟸   ENSRNOT00000104544
RefSeq Acc Id: XP_063127185   ⟸   XM_063271115
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HA8-F1-model_v2 AlphaFold Q66HA8 1-858 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698388
Promoter ID:EPDNEW_R8913
Type:initiation region
Name:Hsph1_1
Description:heat shock protein family H member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0126,341,875 - 6,341,935EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311609 AgrOrtholog
BioCyc Gene G2FUF-20203 BioCyc
Ensembl Genes ENSRNOG00000000902 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055003922 UniProtKB/Swiss-Prot
  ENSRNOG00060002220 UniProtKB/Swiss-Prot
  ENSRNOG00065006176 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001201.8 UniProtKB/Swiss-Prot
  ENSRNOT00000104544.1 UniProtKB/TrEMBL
  ENSRNOT00000116960.1 UniProtKB/TrEMBL
  ENSRNOT00000119657.1 UniProtKB/TrEMBL
  ENSRNOT00055006245 UniProtKB/Swiss-Prot
  ENSRNOT00060003473 UniProtKB/Swiss-Prot
  ENSRNOT00065009424 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.30.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7121434 IMAGE-MGC_LOAD
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSPH1_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:288444 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94016 IMAGE-MGC_LOAD
NCBI Gene 288444 ENTREZGENE
PANTHER HEAT SHOCK PROTEIN 105 KDA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSC70CB, ISOFORM G-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsph1 PhenoGen
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000902 RatGTEx
  ENSRNOG00055003922 RatGTEx
  ENSRNOG00060002220 RatGTEx
  ENSRNOG00065006176 RatGTEx
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZXF4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AB23_RAT UniProtKB/TrEMBL
  A0A8I6GLC4 ENTREZGENE, UniProtKB/TrEMBL
  A6K161 ENTREZGENE, UniProtKB/TrEMBL
  HS105_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Hsph1  heat shock protein family H (Hsp110) member 1  Hsph1  heat shock 105/110 protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-27 Hsph1  heat shock 105/110 protein 1  Hsph1  heat shock 105kDa/110kDa protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07     Hsph1  heat shock 105kDa/110kDa protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04     Hsph1  heat shock 105kDa/110kDa protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Hsph1  heat shock 105kDa/110kDa protein 1  Hsp105  heat shock protein 105  Symbol and Name updated 1299863 APPROVED
2005-12-06 Hsp105  heat shock protein 105  Hsp105_predicted  heat shock protein 105 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Hsp105_predicted  heat shock protein 105 (predicted)      Symbol and Name status set to approved 70820 APPROVED