Hsph1 (heat shock protein family H (Hsp110) member 1) - Rat Genome Database

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Gene: Hsph1 (heat shock protein family H (Hsp110) member 1) Rattus norvegicus
Analyze
Symbol: Hsph1
Name: heat shock protein family H (Hsp110) member 1
RGD ID: 1311609
Description: Predicted to enable adenyl-nucleotide exchange factor activity and alpha-tubulin binding activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm and microtubule. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleus. Orthologous to human HSPH1 (heat shock protein family H (Hsp110) member 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: heat shock 105/110 protein 1; heat shock 105kDa; heat shock 105kDa/110kDa protein 1; heat shock 110 kDa protein; heat shock protein 105; heat shock protein 105 kDa; Hsp105; LOC288444
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,427,368 - 10,446,602 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1210,427,297 - 10,446,891 (+)EnsemblGRCr8
mRatBN7.2125,390,916 - 5,410,224 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl125,390,922 - 5,410,224 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx126,069,228 - 6,088,216 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,692,653 - 6,711,641 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0125,720,173 - 5,739,161 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0126,322,685 - 6,341,898 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl126,322,668 - 6,341,902 (-)Ensemblrn6Rnor6.0
Rnor_5.0128,423,546 - 8,442,481 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4125,794,645 - 5,811,453 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,162,640 - 7,181,902 (+)NCBICelera
RGSC_v3.1125,794,644 - 5,811,451 (+)NCBI
Cytogenetic Map12p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(E)-cinnamyl alcohol  (ISO)
(S)-amphetamine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
albendazole  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
amphibole asbestos  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
atrazine  (ISO)
Aurin  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
cefaloridine  (EXP)
celastrol  (ISO)
chlordecone  (ISO)
chloroethene  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cinnamyl alcohol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elesclomol  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
eugenol  (ISO)
fenofibrate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (ISO)
furfural  (ISO)
gedunin  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glyoxal  (ISO)
haloperidol  (ISO)
hemin  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin  (ISO)
inulin  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
isoeugenol  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
Licochalcone B  (ISO)
linalool  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
metacetamol  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
NCX-4040  (ISO)
nefazodone  (EXP)
nickel atom  (EXP,ISO)
nimesulide  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
organoselenium compound  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
PhIP  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
prostaglandin A1  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
ritonavir  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trans-isoeugenol  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tungsten  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO)
extracellular region  (IEA)
microtubule  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9931472   PMID:12477932   PMID:12749852   PMID:14644449   PMID:15489334   PMID:16396499   PMID:16857185   PMID:17643418   PMID:18681888   PMID:19028714   PMID:19284651   PMID:19754877  
PMID:20458337   PMID:21231916   PMID:22871113   PMID:23349634   PMID:24318877   PMID:30053369   PMID:32360748  


Genomics

Comparative Map Data
Hsph1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,427,368 - 10,446,602 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1210,427,297 - 10,446,891 (+)EnsemblGRCr8
mRatBN7.2125,390,916 - 5,410,224 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl125,390,922 - 5,410,224 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx126,069,228 - 6,088,216 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,692,653 - 6,711,641 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0125,720,173 - 5,739,161 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0126,322,685 - 6,341,898 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl126,322,668 - 6,341,902 (-)Ensemblrn6Rnor6.0
Rnor_5.0128,423,546 - 8,442,481 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4125,794,645 - 5,811,453 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,162,640 - 7,181,902 (+)NCBICelera
RGSC_v3.1125,794,644 - 5,811,451 (+)NCBI
Cytogenetic Map12p11NCBI
HSPH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381331,134,973 - 31,162,388 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1331,134,876 - 31,162,388 (-)Ensemblhg38GRCh38
GRCh371331,709,110 - 31,736,525 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361330,608,762 - 30,634,117 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341330,608,764 - 30,634,117NCBI
Celera1312,778,480 - 12,803,835 (-)NCBICelera
Cytogenetic Map13q12.3NCBI
HuRef1312,522,150 - 12,547,508 (-)NCBIHuRef
CHM1_11331,678,336 - 31,703,689 (-)NCBICHM1_1
T2T-CHM13v2.01330,358,018 - 30,385,432 (-)NCBIT2T-CHM13v2.0
Hsph1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395149,540,308 - 149,562,594 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5149,537,752 - 149,559,841 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385149,616,843 - 149,636,498 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5149,614,287 - 149,636,376 (-)Ensemblmm10GRCm38
MGSCv375150,419,420 - 150,438,890 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365149,885,224 - 149,904,597 (-)NCBIMGSCv36mm8
Celera5147,617,650 - 147,637,130 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.18NCBI
Hsph1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543114,680,498 - 14,706,182 (+)Ensembl
ChiLan1.0NW_00495543114,680,364 - 14,706,182 (+)NCBIChiLan1.0ChiLan1.0
HSPH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21430,719,315 - 30,747,378 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11321,826,106 - 21,854,186 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01312,412,826 - 12,438,563 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11330,845,938 - 30,871,455 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1330,846,631 - 30,871,161 (-)EnsemblpanPan2panpan1.1
HSPH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1258,972,942 - 8,998,404 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl258,972,724 - 8,997,893 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha259,015,922 - 9,040,982 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0259,077,842 - 9,102,910 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,077,554 - 9,102,903 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1258,977,129 - 9,002,182 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,985,129 - 9,010,177 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,027,003 - 9,052,061 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hsph1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945170,073,174 - 170,096,453 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647225,855,694 - 25,879,062 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647225,855,873 - 25,879,062 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl117,733,878 - 7,759,576 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1117,733,874 - 7,759,528 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,585,525 - 7,587,259 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2117,637,260 - 7,661,067 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSPH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.139,999,471 - 10,026,106 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl310,000,109 - 10,026,449 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605734,342,051 - 34,369,001 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsph1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247766,988,576 - 7,015,846 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247766,988,591 - 7,013,621 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hsph1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1164,221,532 - 4,240,800 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hsph1
67 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:93
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000001201
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12111869600Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat

Markers in Region
RH129540  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2125,404,469 - 5,404,655 (-)MAPPERmRatBN7.2
Rnor_6.0126,328,232 - 6,328,417NCBIRnor6.0
Rnor_5.0128,429,093 - 8,429,278UniSTSRnor5.0
RGSC_v3.4125,805,613 - 5,805,798UniSTSRGSC3.4
Celera127,176,148 - 7,176,333UniSTS
RH 3.4 Map1240.36UniSTS
Cytogenetic Map12p11UniSTS
AI600071  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2125,409,995 - 5,410,129 (-)MAPPERmRatBN7.2
Rnor_6.0126,322,780 - 6,322,913NCBIRnor6.0
Rnor_5.0128,423,641 - 8,423,774UniSTSRnor5.0
RGSC_v3.4125,811,225 - 5,811,358UniSTSRGSC3.4
Celera127,181,674 - 7,181,807UniSTS
RH 3.4 Map1258.1UniSTS
Cytogenetic Map12p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001201   ⟹   ENSRNOP00000001201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1210,427,392 - 10,446,891 (+)Ensembl
mRatBN7.2 Ensembl125,390,922 - 5,410,224 (+)Ensembl
Rnor_6.0 Ensembl126,322,668 - 6,341,902 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104544   ⟹   ENSRNOP00000095841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1210,427,392 - 10,446,891 (+)Ensembl
mRatBN7.2 Ensembl125,390,922 - 5,410,224 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116960   ⟹   ENSRNOP00000082622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1210,427,297 - 10,446,599 (+)Ensembl
mRatBN7.2 Ensembl125,390,922 - 5,410,224 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119657   ⟹   ENSRNOP00000089171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl125,391,809 - 5,410,224 (+)Ensembl
RefSeq Acc Id: NM_001011901   ⟹   NP_001011901
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81210,427,368 - 10,446,602 (+)NCBI
mRatBN7.2125,390,990 - 5,410,224 (+)NCBI
Rnor_6.0126,322,685 - 6,341,898 (-)NCBI
Rnor_5.0128,423,546 - 8,442,481 (-)NCBI
RGSC_v3.4125,794,645 - 5,811,453 (+)RGD
Celera127,162,640 - 7,181,902 (+)RGD
Sequence:
RefSeq Acc Id: XM_039089153   ⟹   XP_038945081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81210,427,443 - 10,446,602 (+)NCBI
mRatBN7.2125,390,916 - 5,410,224 (+)NCBI
RefSeq Acc Id: XM_063271115   ⟹   XP_063127185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81210,429,777 - 10,446,602 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001011901 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945081 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127185 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81945 (Get FASTA)   NCBI Sequence Viewer  
  EDL89519 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001201
  ENSRNOP00000001201.6
  ENSRNOP00000082622
GenBank Protein Q66HA8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001011901   ⟸   NM_001011901
- UniProtKB: Q66HA8 (UniProtKB/Swiss-Prot),   A6K161 (UniProtKB/TrEMBL),   A0A8I6GLC4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001201   ⟸   ENSRNOT00000001201
RefSeq Acc Id: XP_038945081   ⟸   XM_039089153
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZXF4 (UniProtKB/TrEMBL),   A0A8I6GLC4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082622   ⟸   ENSRNOT00000116960
Ensembl Acc Id: ENSRNOP00000089171   ⟸   ENSRNOT00000119657
Ensembl Acc Id: ENSRNOP00000095841   ⟸   ENSRNOT00000104544
RefSeq Acc Id: XP_063127185   ⟸   XM_063271115
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AB23 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HA8-F1-model_v2 AlphaFold Q66HA8 1-858 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698388
Promoter ID:EPDNEW_R8913
Type:initiation region
Name:Hsph1_1
Description:heat shock protein family H member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0126,341,875 - 6,341,935EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311609 AgrOrtholog
BioCyc Gene G2FUF-20203 BioCyc
Ensembl Genes ENSRNOG00000000902 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001201 ENTREZGENE
  ENSRNOT00000001201.8 UniProtKB/Swiss-Prot
  ENSRNOT00000116960 ENTREZGENE
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot
  3.30.30.30 UniProtKB/Swiss-Prot
  3.30.420.40 UniProtKB/Swiss-Prot
  Actin, Chain A, domain 4 UniProtKB/Swiss-Prot
  Substrate Binding Domain Of DNAk, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7121434 IMAGE-MGC_LOAD
InterPro ATPase_NBD UniProtKB/Swiss-Prot
  Heat_shock_70_CS UniProtKB/Swiss-Prot
  HSP70_C_sf UniProtKB/Swiss-Prot
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot
  Hsp_70_fam UniProtKB/Swiss-Prot
  HSPH1_NBD UniProtKB/Swiss-Prot
KEGG Report rno:288444 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94016 IMAGE-MGC_LOAD
NCBI Gene 288444 ENTREZGENE
PANTHER HEAT SHOCK PROTEIN 105 KDA UniProtKB/Swiss-Prot
  HSC70CB, ISOFORM G-RELATED UniProtKB/Swiss-Prot
Pfam HSP70 UniProtKB/Swiss-Prot
PhenoGen Hsph1 PhenoGen
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot
PROSITE HSP70_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000902 RatGTEx
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot
  SSF100934 UniProtKB/Swiss-Prot
  SSF53067 UniProtKB/Swiss-Prot
UniProt A0A8I5ZXF4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AB23 ENTREZGENE
  A0A8I6GLC4 ENTREZGENE, UniProtKB/TrEMBL
  A6K161 ENTREZGENE, UniProtKB/TrEMBL
  HS105_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Hsph1  heat shock protein family H (Hsp110) member 1  Hsph1  heat shock 105/110 protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-27 Hsph1  heat shock 105/110 protein 1  Hsph1  heat shock 105kDa/110kDa protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07     Hsph1  heat shock 105kDa/110kDa protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04     Hsph1  heat shock 105kDa/110kDa protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Hsph1  heat shock 105kDa/110kDa protein 1  Hsp105  heat shock protein 105  Symbol and Name updated 1299863 APPROVED
2005-12-06 Hsp105  heat shock protein 105  Hsp105_predicted  heat shock protein 105 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Hsp105_predicted  heat shock protein 105 (predicted)      Symbol and Name status set to approved 70820 APPROVED